壮医针药联合治疗膝骨关节炎30例临床观察

目的:观察壮医针刺联合药物内服外洗治疗膝骨关节炎的临床疗效。方法:将60例符合入组条件的膝骨关节炎患者随机分为对照组和观察组,每组30例。对照组给予艾瑞昔布片治疗;观察组给予壮医针刺“梅花穴+膝关常穴”“膝舒方”内服、“膝痹外洗方”外洗患膝治疗。结果:治疗后观察组VAS评分、Lequesne指数评分及临床疗效优于对照组,差异具有统计学意义。结论:壮医针药联合治疗膝骨关节炎疗效较好,值得临床推广应用。

壮医针药结合治疗黄体功能不全排卵障碍性不孕症160例

目的:观察壮医针药结合治疗黄体功能不全排卵障碍性不孕症的临床疗效。方法:采用随机盲法分组方法,将160例患者分为氯米芬组80例、壮医组80例。氯米芬组予氯米芬治疗,壮医组予壮医针药结合治疗,两组疗程均为3个月。疗程结束后3个月、6个月随访进行疗效观察。结果:治疗后壮医组BBT、卵泡发育情况、子宫内膜厚度、LH、FSH、中医症候疗效均优于对照组,差异均有统计学意义(P<0.05)。结论:壮医针药结合治疗黄体功能不全排卵障碍性不孕症的临床疗效较好,与其改善BBT、卵泡发育质量,增加子宫内膜厚度及提高激素水平有关,其远期疗效更佳。

Clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema

To evaluate the clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema.Methods:One hundred and twenty patients with chronic eczema were randomly divided into an experimental group(60 cases)and a control group(60 cases).The experimental group was treated with skin acupuncture combined with external washing therapy,and the control group was treated with externally applied mometasone furoate cream.The patients’symptoms and total severity were scored and analyzed before and after the 4-week treatment.The symptoms scored included:erythema,papule/hard swelling,epidermal exfoliation,mossy lesion,exudation/scab,and pruritus.Clinical efficacy and adverse reactions were compared before and after the 4-week treatment.Results:Scores for the different kinds of skin derogation,pruritus symptoms,the eczema area,and severity index(EASI)were all reduced after the treatments.Pruritus symptoms and EASI scores in the experimental group were lower than those of the control group(P<0.05).The total effective rate in the experimental group was 81.03%,which was much higher than the 61.11%in the control group(Z=-2.391,P=0.017).Conclusion:The clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema was better than that of mometasone furoate cream.

Effect of acupuncture combined with medicated thread moxibustion of Zhuang medicine on insomnia rats injected with orexin in lateral ventricle

Objective To explore the effect of acupuncture combined with medicated thread moxibustion of Zhuang medicine on insomnia rats. Methods Sixty SPF Wistar rats were randomly divided into four groups, including a normal control group （control group）, a sham operation group, a model group and a treatment group, with 15 rats in each group. In the model group and treatment group, insomnia model were established by injecting orexin into lateral ventricle of rats. In the sham operation group, artificial cerebrospinal fluid was injected into lateral ventricle of rats, and the rats in control group were not treated. On the basis of modeling, the rats in treatment group were treated by acupuncture combined with medicated thread moxibustion of Zhuang medicine which was conducted once a day, and the treatment lasted for 14 days. The expression of orexin mRNA and orexin content were detected, and the changes of associated receptors, including orexin 1 receptor （OX I R） and orexin 2 receptor （OX 2 R） were observed. Results The expression of orexin mRNA in model group （6.54 ± 1.21） significantly increased when compared with control group （0.66±0.12, P〈0.01）, and orexin content in model group [（i 156.35±126.88） pg/mL] significantly increased when compared with control group [（427.12_± 32.54） pg/mL, P〈O.OI]. The expression of orexin mRNA in treatment group （0.87 ± 0.26） significantly reduced when compared with the model group （P〈0.01）, and orexin content in the treatment group [（585.23 ± 89.21） pg/mL] significantly reduced when compared with the model group （P〈O.01）. The percentage of OX I R positive cells in the model group （0.64±0.15） significantly increased when compared with the control group （0.21±0.03, P〈0.01）, and the percentage of OX 2 R positive cells in the model group （0.76±0.18） significantly increased when compared with the control group （0.24±0.01, P〈O.01）. The percentage of OX 1 R positive cells in the treatment group （0.36_±0.08） significantly reduced when compared with the model group （P〈0.01）. The percentage of OX 2 R positive cells in treatment group （0.25_± 0.03） significantly reduced when compared with model group （P〈0.01）. Conclusion It might be an effective link of acupuncture combined with medicated thread moxibustion of Zhuang medicine in treatment of insomnia that the treatment could inhibit the awakening promotion effect of orexin by affecting orexin, OX I R and OX 2 R.