Smoothed cepstral peak prominence(CPPs)is a measurement of the distance from the prominent cepstral peak to the linear regression line directly beneath it.Variations of CPPs data acquisition and analysis lead to the c...Smoothed cepstral peak prominence(CPPs)is a measurement of the distance from the prominent cepstral peak to the linear regression line directly beneath it.Variations of CPPs data acquisition and analysis lead to the complexity of the clinical cut-off values,and there are no agreeable values for a specific voice disorder,such as hypokinetic dysarthria associated with Parkinson’s disease(PD).This study examined the CPPs in people with hypokinetic dysarthria associated with PD compared with healthy participants.Results demonstrated significant differences in speech tasks of sustained vowel and connected speech,with CPPs of connected speech more sensitive to dysphonia and gender difference in PD participants.Males in PD participants presented higher CPPs for sustained vowels and lower CPPs for connected speech than females.It is implied that a consistent clinical application protocol is necessary,and multiple acoustic measures are needed to ensure the accuracy of clinical decisions.展开更多
At the late stage of solidification with ultrasonic treatment （UST） in Al-Si alloys, a part of semisolid overflows and climbs along the probe. The interesting phenomenon and its influence on the solidification micro...At the late stage of solidification with ultrasonic treatment （UST） in Al-Si alloys, a part of semisolid overflows and climbs along the probe. The interesting phenomenon and its influence on the solidification microstructure were investigated in order to better study the mechanism of UST. It is considered that the overflowing phenomenon occurs due to the changes of vibration and flow in the remaining semisolid. Because the overflowed portion comes from the region with intense UST effect and vibrates with the probe during solidification, great modification of primary and euteetic Si （about 10 pm in length） and refinement of primary a（Al） （about 70 μm in size） are observed in this portion.展开更多
Novel schemes for a charge sensitive amplifier （CSA） and a CR-（RC）, semi-Gaussian shaper in a fully integrated CMOS readout circuit for particle detectors are presented. The CSA is designed with poly-resistors as ...Novel schemes for a charge sensitive amplifier （CSA） and a CR-（RC）, semi-Gaussian shaper in a fully integrated CMOS readout circuit for particle detectors are presented. The CSA is designed with poly-resistors as feedback components to reduce noise. Compared with conventional CSA, the input referred equivalent noise charge（ENC） is simulated to be reduced from 5036e to 2381e with a large detector capacitance of 150pF at the cost of 0.5V output swing loss. The CR-（RC）,semi-Gaussian shaper uses MOS transistors in the triode region in series with poly-resistors to compensate process variation without much linearity reduction.展开更多
This paper presents a new class of semiconductor integrated sensor which consists of sensitive components and flip flop circuit. The sensors have high sensitivity and digital output. This paper describes the operatin...This paper presents a new class of semiconductor integrated sensor which consists of sensitive components and flip flop circuit. The sensors have high sensitivity and digital output. This paper describes the operating principle and structure of the sensor. And noise effect on characteristics of the sensor is analysed in detail. The modulated effect of the triangular wave voltage is quantified. As an example, an integrated pressure sensor is introduced and the experimental results agree with the theoretical analyses.展开更多
In order to investigate the enrichment of ferric iron bound by extracellular polymeric substance （EPS） on the mineral surface during bioleaching of chalcopyrite, several methods including sonication, heating and vor...In order to investigate the enrichment of ferric iron bound by extracellular polymeric substance （EPS） on the mineral surface during bioleaching of chalcopyrite, several methods including sonication, heating and vortexing were used and sonication at 48℃ was shown as a good way to extract ferric iron. Scanning electron microscope （SEM） and energy dispersive X-ray spectrometer （EDX） analysis showed that lots of cracks and pits can be found on the chalcopyrite surface after bioleaching and that iron oxide was filled in these cracks and pits. The variations of contents of ferric iron and EPS on the chalcopyrite surface were investigated. The results indicated that the content of EPS increased rapidly in the first 10 d and then maintained at a stable level, while ferric iron content increased all the time, especially in the later stage of bioleaching.展开更多
AIM: To investigate the rate of complications of endoscopic retrograde cholangio-pancreatography (ERCP) performed immediately after endoscopic ultrasound fine needle aspiration (EUS-FNA) in a large series of patients....AIM: To investigate the rate of complications of endoscopic retrograde cholangio-pancreatography (ERCP) performed immediately after endoscopic ultrasound fine needle aspiration (EUS-FNA) in a large series of patients. METHODS: Patients with the following conditions were considered candidates for EUS-FNA and ERCP: diagnosis of locally advanced or metastatic pancreatic lesion not eligible for surgery, and patients with pancreatic lesion of unknown nature causing jaundice. Data were prospectively collected on the following parameters: indication for FNA, EUS findings, pathological diagnosis, procedure duration of EUS-FNA and combined EUS-FNA and ERCP, and immediate and late complications. RESULTS: From January 2004 to October 2006, 72 patients were deemed eligible for combined EUS and ERCP. In 25/72 EUS-FNA was performed to obtain a pathology diagnosis of lesions causing biliary obstruction, and ERCP sequentially performed to drain the biliary system. No immediate complications occurred except for two mild bleeding episodes post sphincterotomy. No late complications were recorded except for one patient who experienced fever, promptly recovered with antibiotic therapy. CONCLUSION: Simultaneous approach appears to be feasible and safe. When possible, this can be considered the reference standard to avoid double sedation and reduce duration of the procedure and hospital stay.展开更多
Mesenteric ischemia disorders are precipitated by a circulation insufficiency event that deprives one or several abdominal organs of adequate respiration to meet metabolic demands. Although mesenteric ischemia occurs ...Mesenteric ischemia disorders are precipitated by a circulation insufficiency event that deprives one or several abdominal organs of adequate respiration to meet metabolic demands. Although mesenteric ischemia occurs infrequently, the mortality rate is from 60% to 100%, depending on the source of obstruction. The successful outcome is dependent upon a high index of suspicion and prompt management. We briefly review the pathophysiology and presentation of the various ischemic entities and review the current state of the art in diagnosis and treatment. Despite advances in both diagnosis and treatment, prompt diagnosis and supportive care remain critical for successful outcome. New imaging techniques, endovascular therapy and emerging research may improve our approach to this deadly condition.展开更多
Previous studies have shown that reanalysis products contain large uncertainties in the Tibetan Plateau(TP),and the biases are location dependent.Therefore,these products must be evaluated with in situ observations pr...Previous studies have shown that reanalysis products contain large uncertainties in the Tibetan Plateau(TP),and the biases are location dependent.Therefore,these products must be evaluated with in situ observations prior to their applications.In this study,the authors compare the results of several reanalysis projects with independent sounding observations recorded in the Yarlung Tsangpo River valley in the Eastern Himalayas in June 2010.These reanalysis projects include Climate Forecast System Reanalysis(CFSR),Interim European Centre for Medium Range Weather Forecasts Reanalysis(ERA- Interim),Japanese 25-year Reanalysis(JRA-25),Modern Era Retrospective Analysis for Research and Applications(MERRA),National Center for Environmental Prediction and the Department of Energy Reanalysis 2(NCEP-R2),and NCEP Final Analysis(FNL).Statistical quantities such as average,mean bias(MB),root-mean-square difference(RMSD),and correlation coefficient(R) of temperature,specific humidity,u-wind,and v-wind between 100 hPa and 650 hPa were calculated.The authors determined that the performance of each product differed with variables at different levels.The average profiles of the variables were captured by the reanalysis products,with large biases appearing at lower levels.ERA-Interim and NCEP-R2 showed the best and worst performances,respectively,for all variables.This study suggests that users should select appropriate reanalysis products according to their specific purposes for TP research.展开更多
文摘Smoothed cepstral peak prominence(CPPs)is a measurement of the distance from the prominent cepstral peak to the linear regression line directly beneath it.Variations of CPPs data acquisition and analysis lead to the complexity of the clinical cut-off values,and there are no agreeable values for a specific voice disorder,such as hypokinetic dysarthria associated with Parkinson’s disease(PD).This study examined the CPPs in people with hypokinetic dysarthria associated with PD compared with healthy participants.Results demonstrated significant differences in speech tasks of sustained vowel and connected speech,with CPPs of connected speech more sensitive to dysphonia and gender difference in PD participants.Males in PD participants presented higher CPPs for sustained vowels and lower CPPs for connected speech than females.It is implied that a consistent clinical application protocol is necessary,and multiple acoustic measures are needed to ensure the accuracy of clinical decisions.
基金Project(50874022)supported by the National Natural Science Foundation of China
文摘At the late stage of solidification with ultrasonic treatment （UST） in Al-Si alloys, a part of semisolid overflows and climbs along the probe. The interesting phenomenon and its influence on the solidification microstructure were investigated in order to better study the mechanism of UST. It is considered that the overflowing phenomenon occurs due to the changes of vibration and flow in the remaining semisolid. Because the overflowed portion comes from the region with intense UST effect and vibrates with the probe during solidification, great modification of primary and euteetic Si （about 10 pm in length） and refinement of primary a（Al） （about 70 μm in size） are observed in this portion.
文摘Novel schemes for a charge sensitive amplifier （CSA） and a CR-（RC）, semi-Gaussian shaper in a fully integrated CMOS readout circuit for particle detectors are presented. The CSA is designed with poly-resistors as feedback components to reduce noise. Compared with conventional CSA, the input referred equivalent noise charge（ENC） is simulated to be reduced from 5036e to 2381e with a large detector capacitance of 150pF at the cost of 0.5V output swing loss. The CR-（RC）,semi-Gaussian shaper uses MOS transistors in the triode region in series with poly-resistors to compensate process variation without much linearity reduction.
文摘This paper presents a new class of semiconductor integrated sensor which consists of sensitive components and flip flop circuit. The sensors have high sensitivity and digital output. This paper describes the operating principle and structure of the sensor. And noise effect on characteristics of the sensor is analysed in detail. The modulated effect of the triangular wave voltage is quantified. As an example, an integrated pressure sensor is introduced and the experimental results agree with the theoretical analyses.
基金Project(31200382)supported by the National Natural Science Foundation of ChinaProject(2013FJ4068)supported by the Planned Science and Technology Project of Hunan Province,ChinaProject supported by Australia CSIRO OCE Science Leader Grant
文摘In order to investigate the enrichment of ferric iron bound by extracellular polymeric substance （EPS） on the mineral surface during bioleaching of chalcopyrite, several methods including sonication, heating and vortexing were used and sonication at 48℃ was shown as a good way to extract ferric iron. Scanning electron microscope （SEM） and energy dispersive X-ray spectrometer （EDX） analysis showed that lots of cracks and pits can be found on the chalcopyrite surface after bioleaching and that iron oxide was filled in these cracks and pits. The variations of contents of ferric iron and EPS on the chalcopyrite surface were investigated. The results indicated that the content of EPS increased rapidly in the first 10 d and then maintained at a stable level, while ferric iron content increased all the time, especially in the later stage of bioleaching.
文摘AIM: To investigate the rate of complications of endoscopic retrograde cholangio-pancreatography (ERCP) performed immediately after endoscopic ultrasound fine needle aspiration (EUS-FNA) in a large series of patients. METHODS: Patients with the following conditions were considered candidates for EUS-FNA and ERCP: diagnosis of locally advanced or metastatic pancreatic lesion not eligible for surgery, and patients with pancreatic lesion of unknown nature causing jaundice. Data were prospectively collected on the following parameters: indication for FNA, EUS findings, pathological diagnosis, procedure duration of EUS-FNA and combined EUS-FNA and ERCP, and immediate and late complications. RESULTS: From January 2004 to October 2006, 72 patients were deemed eligible for combined EUS and ERCP. In 25/72 EUS-FNA was performed to obtain a pathology diagnosis of lesions causing biliary obstruction, and ERCP sequentially performed to drain the biliary system. No immediate complications occurred except for two mild bleeding episodes post sphincterotomy. No late complications were recorded except for one patient who experienced fever, promptly recovered with antibiotic therapy. CONCLUSION: Simultaneous approach appears to be feasible and safe. When possible, this can be considered the reference standard to avoid double sedation and reduce duration of the procedure and hospital stay.
文摘Mesenteric ischemia disorders are precipitated by a circulation insufficiency event that deprives one or several abdominal organs of adequate respiration to meet metabolic demands. Although mesenteric ischemia occurs infrequently, the mortality rate is from 60% to 100%, depending on the source of obstruction. The successful outcome is dependent upon a high index of suspicion and prompt management. We briefly review the pathophysiology and presentation of the various ischemic entities and review the current state of the art in diagnosis and treatment. Despite advances in both diagnosis and treatment, prompt diagnosis and supportive care remain critical for successful outcome. New imaging techniques, endovascular therapy and emerging research may improve our approach to this deadly condition.
基金supported by the Special Fund for Meteorological Research in the Public Interest (GYHY2012 06041)the National Natural Science Foundation of China (Grant No.40905067)and the Ministry of Science and Technology of the People’s Republic of China (2009CB421403)
文摘Previous studies have shown that reanalysis products contain large uncertainties in the Tibetan Plateau(TP),and the biases are location dependent.Therefore,these products must be evaluated with in situ observations prior to their applications.In this study,the authors compare the results of several reanalysis projects with independent sounding observations recorded in the Yarlung Tsangpo River valley in the Eastern Himalayas in June 2010.These reanalysis projects include Climate Forecast System Reanalysis(CFSR),Interim European Centre for Medium Range Weather Forecasts Reanalysis(ERA- Interim),Japanese 25-year Reanalysis(JRA-25),Modern Era Retrospective Analysis for Research and Applications(MERRA),National Center for Environmental Prediction and the Department of Energy Reanalysis 2(NCEP-R2),and NCEP Final Analysis(FNL).Statistical quantities such as average,mean bias(MB),root-mean-square difference(RMSD),and correlation coefficient(R) of temperature,specific humidity,u-wind,and v-wind between 100 hPa and 650 hPa were calculated.The authors determined that the performance of each product differed with variables at different levels.The average profiles of the variables were captured by the reanalysis products,with large biases appearing at lower levels.ERA-Interim and NCEP-R2 showed the best and worst performances,respectively,for all variables.This study suggests that users should select appropriate reanalysis products according to their specific purposes for TP research.
