A new internal waverider inlet with a rectangular shape of entrance and exit in front view is designed at Ma=6.0.The design is based on a better basic flowfield ICFC than traditional one and derived with the technolog...A new internal waverider inlet with a rectangular shape of entrance and exit in front view is designed at Ma=6.0.The design is based on a better basic flowfield ICFC than traditional one and derived with the technology of stream tracing and shock cutting.Comparison between the newly designed inlet and a typical sidewall compression inlet is given.The design Mach number and entrance shape of this new inlet are chosen according to the sidewall compression inlet.Numerical results show that most of the performance parameters of the internal waverider inlet are a bit higher than the sidewall inlet,such as the flow capture coefficient,total pressure recovery and the kinetic efficiency.The performances of these two inlets at off-design points are compared.The internal waverider inlet can capture more than 91% of incoming flow under all simulated conditions.Results show that internal waverider inlet using 3-D compression and high flow capture coefficient is a kind of fixed-geometry inlet with better performance.展开更多
A detailed principle and a rigorous analysis of a new noise,the gate-induced noise,in pixel MOSFET of CMOS imagers are provided.The gate-induced noise of the MOSFET is more notable in the strong reversion region than...A detailed principle and a rigorous analysis of a new noise,the gate-induced noise,in pixel MOSFET of CMOS imagers are provided.The gate-induced noise of the MOSFET is more notable in the strong reversion region than that in the subthreshold region when the applied gate voltage is low.However,the applied gate voltage being up to 3V,the gate-induced noise is more notable with the ω/ω T increasing when the MOSFET operates in the subthreshold region than that in the strong reversion region.Between the photocurrent I D and the root mean square value of the gated-induced noise,current i 2 d presents the relation of i 2 d∝I D in the saturation region of the strong reversion and approximately i 2 d∝I D in the subthreshold region.A deta iled and rigorous study of the gate-induced noise in the reset MOSFET for the p hotodiode APS and improved photodiode APS are provided.The improvement of logari thmic response APS is analyzed and the simulation results show that the gate-in duced noise can be reduced.展开更多
The theory of quantum error correcting codes is a primary tool for fighting decoherence and other quantum noise in quantum communication and quantum computation. Recently, the theory of quantum error correcting codes ...The theory of quantum error correcting codes is a primary tool for fighting decoherence and other quantum noise in quantum communication and quantum computation. Recently, the theory of quantum error correcting codes has developed rapidly and been extended to protect quantum information over asymmetric quantum channels, in which phase-shift and qubit-flip errors occur with different probabilities. In this paper, we generalize the construction of symmetric quantum codes via graphs (or matrices) to the asymmetric case, converting the construction of asymmetric quantum codes to finding matrices with some special properties. We also propose some asymmetric quantum Maximal Distance Separable (MDS) codes as examples constructed in this way.展开更多
Evolutionary game dynamics in finite size populations can be described by a fitness-dependent Wright- Fisher process. We consider symmetric 2×2 games in a well-mixed population. In our model, two parameters to de...Evolutionary game dynamics in finite size populations can be described by a fitness-dependent Wright- Fisher process. We consider symmetric 2×2 games in a well-mixed population. In our model, two parameters to describe the level of player＇s rationality and noise intensity in environment are introduced. In contrast with the fixation probability method that used in a noiseless case, the introducing of the noise intensity parameter makes the process an ergodic Markov process and based on the limit distribution of the process, we can analysis the evolutionary stable strategy （ESS） of the games. We illustrate the effects of the two parameters on the ESS of games using the Prisoner＇s dilemma games （PDG） and the snowdrift games （SG）. We also compare the ESS of our model with that of the replicator dynamics in infinite size populations. The results are determined by simulation experiments.展开更多
A flow control method based on an active jet is developed to restart hypersonic inlets. The dynamic restarting process is numerically reproduced by unsteady Reynolds averaged Navier-Stokes(RANS) modeling to verify the...A flow control method based on an active jet is developed to restart hypersonic inlets. The dynamic restarting process is numerically reproduced by unsteady Reynolds averaged Navier-Stokes(RANS) modeling to verify the effectiveness and reveal the influence of jet conditions. The active jet improves the inlet unstart status by drawing the high-pressure separation bubble from the internal compression duct and performing a full expansion to alleviate the adverse pressure gradient. Moreover, the favorable pressure gradient in the inlet caused by jet expansion allows for a successful restart after turning off the jet. The influence of the jet momentum ratio is then analyzed to guide the design of the active jet control method and choose the proper momentum ratios. A low jet momentum does not eliminate the high-pressure separation bubble, whereas an excessive jet momentum causes severe momentum loss due to the induced shock. The general rule in restarting the inlet using an active jet is to allow a full jet expansion downstream of the jet slot while avoiding excessive momentum loss upstream and preventing the thick low-speed layer.展开更多
Cell disruption focuses on obtaining a desired bioproduct within a cell, and it is the cell wall that must be disrupted to allow access to the contents of the cell. In animal cells, the plasma membrane is the only bar...Cell disruption focuses on obtaining a desired bioproduct within a cell, and it is the cell wall that must be disrupted to allow access to the contents of the cell. In animal cells, the plasma membrane is the only barrier separating cell contents from the environment. Sound waves from sonication, a mechanical technique for cell disintegration, have been used to disrupt as well as to aggregate cells as a step towards purification of a desired bioproduct. In the present study, an improved sonication process for the high yield of Newcastle disease virus （NDV） propagated in tissue culture was described. DF-I cell was cultured in 25cm^2 T flask. When cells were about 80% confluent, a lentogenic strain of NDV （F strain） was used to infect the cell monolayer. With evident cytopathic effect, cells were subjected to cycles of freeze-thaw before sonicating with varying combinations of amplitude, temperature and time. Cells were sonicated using a water bath Sonicator, Jac Ultrasonic 1505 JEIO TECH 4 KHz. From ANOVA analysis, a significant interaction between sonication time and amplitude was observed. This also corresponds to the highest F value observed.展开更多
Electric contact discharge is subject closely related to digital information transmission, and integrity of digital signals for realizing high reliablility transmission. This kind of problem is a part of EMC (electrom...Electric contact discharge is subject closely related to digital information transmission, and integrity of digital signals for realizing high reliablility transmission. This kind of problem is a part of EMC (electromagnetic compatibility). From such a viewpoint, contact noise problems will be mentioned which disturb and degrade digital signals. The induction noise and radiation noise from discharge, electrostatic discharge (ESD), and connector related fundamental subject will be mentioned.展开更多
AIM To evaluate the diagnostic value of gadobenate dimeglumine(Gd-BOPTA)-enhanced hepatocyte-phase magnetic resonance imaging(MRI) in evaluating hepatic fibrosis and hepatitis.METHODS Hepatocyte-phase images of Gd-BOP...AIM To evaluate the diagnostic value of gadobenate dimeglumine(Gd-BOPTA)-enhanced hepatocyte-phase magnetic resonance imaging(MRI) in evaluating hepatic fibrosis and hepatitis.METHODS Hepatocyte-phase images of Gd-BOPTA-enhanced MRI were retrospectively evaluated in 76 patients with chronic liver disease. These patients were classified into five groups according to either the histopathological fibrosis stage(S0-S4) or the histopathological hepatitis grade(G0-G4). The relative enhancement ratio(RE) of the liver parenchyma in the T1-vibe sequence was calculated by measuring the signal intensity before(SI pre) and 90 min after(SI post) intravenous injection of Gd-BOPTA using the following formula: RE =(SI post-SI pre)/SI pre. One-way analysis of variance was used to compare the difference between the relative RE in the hepatocyte phase(REh) and the stage of hepatic fibrosis and the grade of hepatitis. Pearson's productmoment correlation analysis was used to evaluate the relationship between the REh and the levels of serologic liver functional parameters.RESULTS According to histopathological hepatic fibrosis stage, the 76 patients were classified into five groups: 16 in S0, 15 in S1, 21 in S2, 9 in S3, and 15 in S4 group. According to histopathological hepatitis grade, the 76 patients were also classified into five groups: 0 in G0, 44 in G1, 22 in G2, 8 in G3, and 2 in G3 group. With regard to the stage of hepatic fibrosis, REh showed significant differences between the S2 and S3 groups and between the S2 and S4 groups(P < 0.05), but no significant difference was observed between the other groups. With regard to the grade of hepatitis, REh showed significant differences between the G1 and G2 groups and between the G1 and G4 groups(P < 0.05), but no significant difference was observed between the other groups. Increased REh showed correlations with decreased serum levels of TB, ALT and AST(P < 0.05). CONCLUSION To some extent, measuring the REh using Gd-BOPTAenhanced MRI might be a noninvasive technique for assessing the stage of hepatic fibrosis. This method is able to differentiate no/mild hepatitis from advanced hepatitis. TB, ALT and AST levels can predict the degree of liver enhancement in the hepatocyte phase of Gd-BOPTA-enhanced MRI.展开更多
Advanced medical imaging and visualization has a strong impact on research and clinical decision making in gastroenterology. The aim of this paper is to show how imaging and visualization can disclose structural and f...Advanced medical imaging and visualization has a strong impact on research and clinical decision making in gastroenterology. The aim of this paper is to show how imaging and visualization can disclose structural and functional abnormalities of the gastrointestinal (GI) tract. Imaging methods such as ultrasonography, magnetic resonance imaging (MRI), endoscopy, endosonography, and elastography will be outlined and visualization with Virtual Reality and haptic methods. Ultrasonography is a versatile method that can be used to evaluate antral contractility, gastric emptying, transpyloric flow, gastric configuration, intragastric distribution of meals, gastric accommodation and strain measurement of the gastric wall. Advanced methods for endoscopic ultrasound, three-dimensional (3D) ultrasound, and tissue Doppler (Strain Rate Imaging) provide detailed information of the GI tract. Food hypersensitivity reactions including gastrointestinal reactions due to food allergy can be visualized by ultrasonography and MRI. Development of multi-parametric and multi-modal imaging may increase diagnostic benefits and facilitate fusion of diagnostic and therapeutic imaging in the future.展开更多
AIM To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH). METHODS In this retrospective study, 36 patients (19 treated and 17 untreated) w...AIM To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH). METHODS In this retrospective study, 36 patients (19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness (LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologists evaluated morphological features of cirrhosis on conventional magnetic resonance imaging (MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis. RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease (r = 0.88 vs -0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed (3.7 kPa vs 3.84 kPa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis (0.97 vs 0.53-0.80, p < 0.01), and cirrhosis (0.98 vs 0.58-0.80, p < 0.01) and better than conventional MRI for diagnosis of cirrhosis (0.98 vs 0.78, p = 0.002). CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI.展开更多
Ultrasonic aided slurry sampling hydride generation atomic fluorescence spectrometry （USS-HG-AFS） was developed for the determination of Hg in soil samples from a sewage-irrigated farm. 500 mg grounded soil was susp...Ultrasonic aided slurry sampling hydride generation atomic fluorescence spectrometry （USS-HG-AFS） was developed for the determination of Hg in soil samples from a sewage-irrigated farm. 500 mg grounded soil was suspended in agar solution by an ultrasound water bath before the HG-AFS determination. The results for the reference material of soil （serial number GBW-07411） agreed satisfactorily with the certified values. Results obtained by the developed procedure compared well with those after traditional acid digestion of samples. The detection limit are 6.7ngL-1 for Hg respectively, with average relative standard deviation values of 6.4% for analysis of a series of soil samples of different origin. The recoveries of the anatytes varied in the range from 95 to 107%. This observation has stimulated interest in fast, accurate and sensitive analytical methods for determination of metals in soil.展开更多
文摘A new internal waverider inlet with a rectangular shape of entrance and exit in front view is designed at Ma=6.0.The design is based on a better basic flowfield ICFC than traditional one and derived with the technology of stream tracing and shock cutting.Comparison between the newly designed inlet and a typical sidewall compression inlet is given.The design Mach number and entrance shape of this new inlet are chosen according to the sidewall compression inlet.Numerical results show that most of the performance parameters of the internal waverider inlet are a bit higher than the sidewall inlet,such as the flow capture coefficient,total pressure recovery and the kinetic efficiency.The performances of these two inlets at off-design points are compared.The internal waverider inlet can capture more than 91% of incoming flow under all simulated conditions.Results show that internal waverider inlet using 3-D compression and high flow capture coefficient is a kind of fixed-geometry inlet with better performance.
文摘A detailed principle and a rigorous analysis of a new noise,the gate-induced noise,in pixel MOSFET of CMOS imagers are provided.The gate-induced noise of the MOSFET is more notable in the strong reversion region than that in the subthreshold region when the applied gate voltage is low.However,the applied gate voltage being up to 3V,the gate-induced noise is more notable with the ω/ω T increasing when the MOSFET operates in the subthreshold region than that in the strong reversion region.Between the photocurrent I D and the root mean square value of the gated-induced noise,current i 2 d presents the relation of i 2 d∝I D in the saturation region of the strong reversion and approximately i 2 d∝I D in the subthreshold region.A deta iled and rigorous study of the gate-induced noise in the reset MOSFET for the p hotodiode APS and improved photodiode APS are provided.The improvement of logari thmic response APS is analyzed and the simulation results show that the gate-in duced noise can be reduced.
基金supported by the National High Technology Research and Development Program of China under Grant No. 2011AA010803
文摘The theory of quantum error correcting codes is a primary tool for fighting decoherence and other quantum noise in quantum communication and quantum computation. Recently, the theory of quantum error correcting codes has developed rapidly and been extended to protect quantum information over asymmetric quantum channels, in which phase-shift and qubit-flip errors occur with different probabilities. In this paper, we generalize the construction of symmetric quantum codes via graphs (or matrices) to the asymmetric case, converting the construction of asymmetric quantum codes to finding matrices with some special properties. We also propose some asymmetric quantum Maximal Distance Separable (MDS) codes as examples constructed in this way.
基金Supported by the National Natural Science Foundation of China under Grant Nos. 71071119 and 60574071
文摘Evolutionary game dynamics in finite size populations can be described by a fitness-dependent Wright- Fisher process. We consider symmetric 2×2 games in a well-mixed population. In our model, two parameters to describe the level of player＇s rationality and noise intensity in environment are introduced. In contrast with the fixation probability method that used in a noiseless case, the introducing of the noise intensity parameter makes the process an ergodic Markov process and based on the limit distribution of the process, we can analysis the evolutionary stable strategy （ESS） of the games. We illustrate the effects of the two parameters on the ESS of games using the Prisoner＇s dilemma games （PDG） and the snowdrift games （SG）. We also compare the ESS of our model with that of the replicator dynamics in infinite size populations. The results are determined by simulation experiments.
基金supported by the National Key Research and Development Program of China (No.2021YFA0719204)the National Natural Science Foundation of China (No.12272387)。
文摘A flow control method based on an active jet is developed to restart hypersonic inlets. The dynamic restarting process is numerically reproduced by unsteady Reynolds averaged Navier-Stokes(RANS) modeling to verify the effectiveness and reveal the influence of jet conditions. The active jet improves the inlet unstart status by drawing the high-pressure separation bubble from the internal compression duct and performing a full expansion to alleviate the adverse pressure gradient. Moreover, the favorable pressure gradient in the inlet caused by jet expansion allows for a successful restart after turning off the jet. The influence of the jet momentum ratio is then analyzed to guide the design of the active jet control method and choose the proper momentum ratios. A low jet momentum does not eliminate the high-pressure separation bubble, whereas an excessive jet momentum causes severe momentum loss due to the induced shock. The general rule in restarting the inlet using an active jet is to allow a full jet expansion downstream of the jet slot while avoiding excessive momentum loss upstream and preventing the thick low-speed layer.
文摘Cell disruption focuses on obtaining a desired bioproduct within a cell, and it is the cell wall that must be disrupted to allow access to the contents of the cell. In animal cells, the plasma membrane is the only barrier separating cell contents from the environment. Sound waves from sonication, a mechanical technique for cell disintegration, have been used to disrupt as well as to aggregate cells as a step towards purification of a desired bioproduct. In the present study, an improved sonication process for the high yield of Newcastle disease virus （NDV） propagated in tissue culture was described. DF-I cell was cultured in 25cm^2 T flask. When cells were about 80% confluent, a lentogenic strain of NDV （F strain） was used to infect the cell monolayer. With evident cytopathic effect, cells were subjected to cycles of freeze-thaw before sonicating with varying combinations of amplitude, temperature and time. Cells were sonicated using a water bath Sonicator, Jac Ultrasonic 1505 JEIO TECH 4 KHz. From ANOVA analysis, a significant interaction between sonication time and amplitude was observed. This also corresponds to the highest F value observed.
文摘Electric contact discharge is subject closely related to digital information transmission, and integrity of digital signals for realizing high reliablility transmission. This kind of problem is a part of EMC (electromagnetic compatibility). From such a viewpoint, contact noise problems will be mentioned which disturb and degrade digital signals. The induction noise and radiation noise from discharge, electrostatic discharge (ESD), and connector related fundamental subject will be mentioned.
基金Supported by National Natural Science Foundation of China,Nos.81571784 and 81601471Scientific and Technological Support Project for Social Development of Hunan Province,No.2015SF2020-4Project of Development and Reform Commission of Hunan Province,No.Xiang Cai Enterprise Means[2015]83
文摘AIM To evaluate the diagnostic value of gadobenate dimeglumine(Gd-BOPTA)-enhanced hepatocyte-phase magnetic resonance imaging(MRI) in evaluating hepatic fibrosis and hepatitis.METHODS Hepatocyte-phase images of Gd-BOPTA-enhanced MRI were retrospectively evaluated in 76 patients with chronic liver disease. These patients were classified into five groups according to either the histopathological fibrosis stage(S0-S4) or the histopathological hepatitis grade(G0-G4). The relative enhancement ratio(RE) of the liver parenchyma in the T1-vibe sequence was calculated by measuring the signal intensity before(SI pre) and 90 min after(SI post) intravenous injection of Gd-BOPTA using the following formula: RE =(SI post-SI pre)/SI pre. One-way analysis of variance was used to compare the difference between the relative RE in the hepatocyte phase(REh) and the stage of hepatic fibrosis and the grade of hepatitis. Pearson's productmoment correlation analysis was used to evaluate the relationship between the REh and the levels of serologic liver functional parameters.RESULTS According to histopathological hepatic fibrosis stage, the 76 patients were classified into five groups: 16 in S0, 15 in S1, 21 in S2, 9 in S3, and 15 in S4 group. According to histopathological hepatitis grade, the 76 patients were also classified into five groups: 0 in G0, 44 in G1, 22 in G2, 8 in G3, and 2 in G3 group. With regard to the stage of hepatic fibrosis, REh showed significant differences between the S2 and S3 groups and between the S2 and S4 groups(P < 0.05), but no significant difference was observed between the other groups. With regard to the grade of hepatitis, REh showed significant differences between the G1 and G2 groups and between the G1 and G4 groups(P < 0.05), but no significant difference was observed between the other groups. Increased REh showed correlations with decreased serum levels of TB, ALT and AST(P < 0.05). CONCLUSION To some extent, measuring the REh using Gd-BOPTAenhanced MRI might be a noninvasive technique for assessing the stage of hepatic fibrosis. This method is able to differentiate no/mild hepatitis from advanced hepatitis. TB, ALT and AST levels can predict the degree of liver enhancement in the hepatocyte phase of Gd-BOPTA-enhanced MRI.
文摘Advanced medical imaging and visualization has a strong impact on research and clinical decision making in gastroenterology. The aim of this paper is to show how imaging and visualization can disclose structural and functional abnormalities of the gastrointestinal (GI) tract. Imaging methods such as ultrasonography, magnetic resonance imaging (MRI), endoscopy, endosonography, and elastography will be outlined and visualization with Virtual Reality and haptic methods. Ultrasonography is a versatile method that can be used to evaluate antral contractility, gastric emptying, transpyloric flow, gastric configuration, intragastric distribution of meals, gastric accommodation and strain measurement of the gastric wall. Advanced methods for endoscopic ultrasound, three-dimensional (3D) ultrasound, and tissue Doppler (Strain Rate Imaging) provide detailed information of the GI tract. Food hypersensitivity reactions including gastrointestinal reactions due to food allergy can be visualized by ultrasonography and MRI. Development of multi-parametric and multi-modal imaging may increase diagnostic benefits and facilitate fusion of diagnostic and therapeutic imaging in the future.
基金Supported by National Institutes of Health,No.EB001981 to Ehman RL and No.EB017197 to Yin Mthe National Natural Science Foundation of China,No.81271562 to Wang J
文摘AIM To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH). METHODS In this retrospective study, 36 patients (19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness (LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologists evaluated morphological features of cirrhosis on conventional magnetic resonance imaging (MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis. RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease (r = 0.88 vs -0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed (3.7 kPa vs 3.84 kPa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis (0.97 vs 0.53-0.80, p < 0.01), and cirrhosis (0.98 vs 0.58-0.80, p < 0.01) and better than conventional MRI for diagnosis of cirrhosis (0.98 vs 0.78, p = 0.002). CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI.
文摘Ultrasonic aided slurry sampling hydride generation atomic fluorescence spectrometry （USS-HG-AFS） was developed for the determination of Hg in soil samples from a sewage-irrigated farm. 500 mg grounded soil was suspended in agar solution by an ultrasound water bath before the HG-AFS determination. The results for the reference material of soil （serial number GBW-07411） agreed satisfactorily with the certified values. Results obtained by the developed procedure compared well with those after traditional acid digestion of samples. The detection limit are 6.7ngL-1 for Hg respectively, with average relative standard deviation values of 6.4% for analysis of a series of soil samples of different origin. The recoveries of the anatytes varied in the range from 95 to 107%. This observation has stimulated interest in fast, accurate and sensitive analytical methods for determination of metals in soil.
