A new preparation method of the sustained-releasing microspheres containing acetamiprid was developed with carboxymethyl chitosan and acacia as base materials.The preparation condition were optimized using L16(45) ort...A new preparation method of the sustained-releasing microspheres containing acetamiprid was developed with carboxymethyl chitosan and acacia as base materials.The preparation condition were optimized using L16(45) orthogonal experimental design with the drug encapsulation and the shape of the microspheres as criteria.As a result,the optimum preparation conditions of the microspheres were as follows:the concentration ratio of carboxymethyl chitosan to acacia was 1∶3,the dosage of acetamiprid was 1.0 g,the amount of 10 % glutaraldehyde was 16mL.The complex coacervation reation was conducted at 45 ℃ for 80min.The experimental results showed that there were no chemical interactions between acetamiprid and the carboxymethyl chitosan/acacia complex and a good drug releasing performances of the acetamiprid microspheres was obtained.展开更多
以球磨法制备的炭黑、TiO2的四氯乙烯电泳分散体系为囊芯,以明胶、阿拉伯胶为壁材,采用复凝聚法制备了电泳微胶囊。详细研究了壁材比,反应温度、表面活性剂浓度、pH的控制、固化条件等因素对微胶囊性能的影响,并采用落球冲击实验对微胶...以球磨法制备的炭黑、TiO2的四氯乙烯电泳分散体系为囊芯,以明胶、阿拉伯胶为壁材,采用复凝聚法制备了电泳微胶囊。详细研究了壁材比,反应温度、表面活性剂浓度、pH的控制、固化条件等因素对微胶囊性能的影响,并采用落球冲击实验对微胶囊强度进行了表征。结果表明,微胶囊制备的优化条件为明胶与阿拉伯胶用量比为1：1（w：w）,反应温度50℃,十二烷基硫酸钠（SDS）浓度0.001 g mL 1,醋酸浓度5.0%~7.5%,戊二醛浓度10%~15%。囊壁固化条件是在pH=4.5~4.8、5℃时固化1 h后,然后在pH=8~11、50℃时再固化70 min。在此条件下制备的微胶囊机械强度高且表面光滑,粒径分布在30~80μm,产率高于90%。用微胶囊制备的显示器件具有良好的显示效果,反射率达到45%~56%,对比度为5~7,响应时间为190~400 ms。展开更多
文摘A new preparation method of the sustained-releasing microspheres containing acetamiprid was developed with carboxymethyl chitosan and acacia as base materials.The preparation condition were optimized using L16(45) orthogonal experimental design with the drug encapsulation and the shape of the microspheres as criteria.As a result,the optimum preparation conditions of the microspheres were as follows:the concentration ratio of carboxymethyl chitosan to acacia was 1∶3,the dosage of acetamiprid was 1.0 g,the amount of 10 % glutaraldehyde was 16mL.The complex coacervation reation was conducted at 45 ℃ for 80min.The experimental results showed that there were no chemical interactions between acetamiprid and the carboxymethyl chitosan/acacia complex and a good drug releasing performances of the acetamiprid microspheres was obtained.
文摘以球磨法制备的炭黑、TiO2的四氯乙烯电泳分散体系为囊芯,以明胶、阿拉伯胶为壁材,采用复凝聚法制备了电泳微胶囊。详细研究了壁材比,反应温度、表面活性剂浓度、pH的控制、固化条件等因素对微胶囊性能的影响,并采用落球冲击实验对微胶囊强度进行了表征。结果表明,微胶囊制备的优化条件为明胶与阿拉伯胶用量比为1：1（w：w）,反应温度50℃,十二烷基硫酸钠（SDS）浓度0.001 g mL 1,醋酸浓度5.0%~7.5%,戊二醛浓度10%~15%。囊壁固化条件是在pH=4.5~4.8、5℃时固化1 h后,然后在pH=8~11、50℃时再固化70 min。在此条件下制备的微胶囊机械强度高且表面光滑,粒径分布在30~80μm,产率高于90%。用微胶囊制备的显示器件具有良好的显示效果,反射率达到45%~56%,对比度为5~7,响应时间为190~400 ms。
