stem cell transplantation （allo-SCT） is a potential cure for patients with malignant lymphoma that is based on the graft-versus-lymphoma （GVL） effect. Myeloablative conditioning allo-SCT is associated with high mo...stem cell transplantation （allo-SCT） is a potential cure for patients with malignant lymphoma that is based on the graft-versus-lymphoma （GVL） effect. Myeloablative conditioning allo-SCT is associated with high mortality and morbidity, particularly in patients older than 45 years, heavily pretreated patients （prior hematopoietic stem cell transplantation or more than two lines of conventional chemotherapy） or patients affected by other comorbidities. Therefore, conventional allo-SCT is restricted to younger patients （〈50 to 55 years） in good physical condition. Over the last decade, allo-SCT with reduced-intensity conditioning （RIC-allo-SCT） has been increasingly used to treat patients with lymphoma. This treatment is associated with lower toxicity and substantial decrease in the incidence of transplant- related mortality, and has the potential to lead to long-term remissions. Therefore, patients who are not suitable to undergo conventional allo-SCT can benefit from the potentially curative GVL effects of allo-SCT. Although RIC-allo-SCT has improved the survival of lymphoma patients, high post-transplant relapse rates or disease progression mainly results in treatment failure. Thus, further improvement is clearly needed. The role and timing of RIC-allo-SCT in the treatment of lymphoma remains unclear. Therefore, more prospective studies should clarify the effectiveness of this method. In this article, we review the recent literature on RIC-alIo-SCT as a treatment for major lymphoma subtypes. Areas that require further investigation in the context of clinical trials are also highlighted.展开更多
The hygienic performance of simple storage and biological treatment of manure was evaluated using effluents collected from 44 hog farms across Brittany, France. Analyses were carried out on raw manure, on the sludge s...The hygienic performance of simple storage and biological treatment of manure was evaluated using effluents collected from 44 hog farms across Brittany, France. Analyses were carried out on raw manure, on the sludge stored after biological treatment and on the liquid phase stored in a lagoon after sludge settling or sludge dewatering. The effect of the treatments was evaluated on E. coli, enterococci, Clostridium perfringens, Salmonella and Listeria monocytogenes. Sequential feeding of manure maintained a high level of enteric bacteria in storage tanks regardless the duration of storage, and biological treatment only slightly reduced the concentration of enteric bacteria （average reduction in raw manure and sludge 〈 2.2 log10）. Salmonella and L. monocytogenes were identified in raw manure （50% and 18.2% of samples, respectively）, in sludge （14.8% and 11.1%）, and in lagoons （8.0% and 24%）, suggesting that there is still a sanitary risk after biological treatment of manure. Salmonella Derby and L. monocytogenes serotype 4b each accounted for 50% of the serotypes identified in the samples. There was no correlation between the presence of the two pathogenic bacteria and the size of the herd or the duration of manure storage. However, environmental conditions in the lagoons appeared to favor the presence ofL. monocytogenes and hence a risk of disseminating this pathogen in the environment.展开更多
The study aimed at comparing the effect of selected biopreparations （Boni protect forte, beta-chikol, Trianum P） and fungicide treatment Switch 62.5 WG （cyprodinil ＋ fludioxonil） on the health status of strawberr...The study aimed at comparing the effect of selected biopreparations （Boni protect forte, beta-chikol, Trianum P） and fungicide treatment Switch 62.5 WG （cyprodinil ＋ fludioxonil） on the health status of strawberry grown in the fruiting field at the strawberry farm in Jasionka, Lublin region. The experiment was conducted for three years （2012-2014）. Results showed that the application of all biopreparations and fungicide significantly reduced the number of diseased plants and the disease index. The effect of three biological products was similar. The mycological analysis of plants showed that among the fungi potentially pathogenic to strawberry, Fusarium spp., Cylindrocarpon spp., Botrytis cinerea and Alternaria were predominated. The fewest colonies of pathogenic fungi were isolated from plants treated with Trianum P.展开更多
文摘stem cell transplantation （allo-SCT） is a potential cure for patients with malignant lymphoma that is based on the graft-versus-lymphoma （GVL） effect. Myeloablative conditioning allo-SCT is associated with high mortality and morbidity, particularly in patients older than 45 years, heavily pretreated patients （prior hematopoietic stem cell transplantation or more than two lines of conventional chemotherapy） or patients affected by other comorbidities. Therefore, conventional allo-SCT is restricted to younger patients （〈50 to 55 years） in good physical condition. Over the last decade, allo-SCT with reduced-intensity conditioning （RIC-allo-SCT） has been increasingly used to treat patients with lymphoma. This treatment is associated with lower toxicity and substantial decrease in the incidence of transplant- related mortality, and has the potential to lead to long-term remissions. Therefore, patients who are not suitable to undergo conventional allo-SCT can benefit from the potentially curative GVL effects of allo-SCT. Although RIC-allo-SCT has improved the survival of lymphoma patients, high post-transplant relapse rates or disease progression mainly results in treatment failure. Thus, further improvement is clearly needed. The role and timing of RIC-allo-SCT in the treatment of lymphoma remains unclear. Therefore, more prospective studies should clarify the effectiveness of this method. In this article, we review the recent literature on RIC-alIo-SCT as a treatment for major lymphoma subtypes. Areas that require further investigation in the context of clinical trials are also highlighted.
文摘The hygienic performance of simple storage and biological treatment of manure was evaluated using effluents collected from 44 hog farms across Brittany, France. Analyses were carried out on raw manure, on the sludge stored after biological treatment and on the liquid phase stored in a lagoon after sludge settling or sludge dewatering. The effect of the treatments was evaluated on E. coli, enterococci, Clostridium perfringens, Salmonella and Listeria monocytogenes. Sequential feeding of manure maintained a high level of enteric bacteria in storage tanks regardless the duration of storage, and biological treatment only slightly reduced the concentration of enteric bacteria （average reduction in raw manure and sludge 〈 2.2 log10）. Salmonella and L. monocytogenes were identified in raw manure （50% and 18.2% of samples, respectively）, in sludge （14.8% and 11.1%）, and in lagoons （8.0% and 24%）, suggesting that there is still a sanitary risk after biological treatment of manure. Salmonella Derby and L. monocytogenes serotype 4b each accounted for 50% of the serotypes identified in the samples. There was no correlation between the presence of the two pathogenic bacteria and the size of the herd or the duration of manure storage. However, environmental conditions in the lagoons appeared to favor the presence ofL. monocytogenes and hence a risk of disseminating this pathogen in the environment.
文摘The study aimed at comparing the effect of selected biopreparations （Boni protect forte, beta-chikol, Trianum P） and fungicide treatment Switch 62.5 WG （cyprodinil ＋ fludioxonil） on the health status of strawberry grown in the fruiting field at the strawberry farm in Jasionka, Lublin region. The experiment was conducted for three years （2012-2014）. Results showed that the application of all biopreparations and fungicide significantly reduced the number of diseased plants and the disease index. The effect of three biological products was similar. The mycological analysis of plants showed that among the fungi potentially pathogenic to strawberry, Fusarium spp., Cylindrocarpon spp., Botrytis cinerea and Alternaria were predominated. The fewest colonies of pathogenic fungi were isolated from plants treated with Trianum P.
