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卡托普利缓释微囊的制备及其溶出度的测定 被引量:2
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作者 孔晓龙 黄振光 《广西医科大学学报》 CAS 1998年第1期52-53,共2页
目的:利用明胶-邻苯二甲酸醋酸纤维素(CAP)为囊材制备卡托普利缓释微囊。方法:采用复凝聚法,通过控制温度及pH值制备符合要求的微囊。结果:制得的微囊在光学显微镜下呈规则圆球体,粒径分布在200~550μm范围内的占... 目的:利用明胶-邻苯二甲酸醋酸纤维素(CAP)为囊材制备卡托普利缓释微囊。方法:采用复凝聚法,通过控制温度及pH值制备符合要求的微囊。结果:制得的微囊在光学显微镜下呈规则圆球体,粒径分布在200~550μm范围内的占微囊总数的97.7%,平均粒径为(286.56±35.8)μm,包封率为(76.8±1.2)%,载药量为(86.6±2.5)mg/g,微囊中药物溶出率与溶出时间的平方根为一线性方程。结论:卡托普利微囊具有明显的缓释作用。其释药特性符合Higuchi方程。 展开更多
关键词 卡托普利 微囊 复凝聚层 溶出度
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The interfacial fracture behavior of foam core composite sandwich structures by a viscoelastic cohesive model 被引量:9
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作者 SUN ShiYong CHEN HaoRan 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2011年第8期1481-1487,共7页
A sandwich beam model consisting of two face sheets and a foam core bonded by a viscoelastic adhesive layer is considered in order to investigate interfacial fracture behavior. Firstly, a cohesive zone model in conjun... A sandwich beam model consisting of two face sheets and a foam core bonded by a viscoelastic adhesive layer is considered in order to investigate interfacial fracture behavior. Firstly, a cohesive zone model in conjunction with a Maxwell element in parallel, or with a Kelvin element in series, respectively, is employed to describe the characteristics of viscoelasticity for the adhesive layer. The models can be implemented into the implicit finite element code. Next, the parametric study shows that the in- fluences of loading rates on the cohesive zone energy and strength are quite different for different models. Finally, a sandwich double cantilever beam model is adopted to simulate the interface crack growth between the face sheet and core. Numerical examples are presented for various loading rates to demonstrate the efficacy of the rate-dependent cohesive models. 展开更多
关键词 VISCOELASTICITY interfacial crack rate-dependent cohesive model composite sandwich beam
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