复力霉素防治家蚕细菌病的效果研究

复力霉素是一种新研制成功的对家蚕苏云金杆菌和灵菌细菌性疾病有明显治疗作用的新型蚕药。试验证明，在相同浓度下（２００ｍ ｇ／ Ｌ），复力霉素对苏云金杆菌的抑菌圈直径为２５５ｍ ｍ ，高于氯霉素和红霉素。对灵菌的抑菌圈直径为 １９３ｍ ｍ ，而氯霉素和红霉素对灵菌无效。复力霉素的药代动力学表明，复力霉素一般食下 ２０ｍ ｉｎ 后进入血液，８ｈ 血液抑菌圈达到最大值。２６ｈ 后血液中检测不到。

复力霉素治疗鸡巴氏杆菌病疗效试验

复力霉素治疗鸡巴氏杆菌病疗效试验曹洪敬王文志颜世敢崔锦鹏任淑芳沈冰（山东省农业科学院畜牧兽医研究所济南２５０１００）时秀梅高华方王希敏李惠玲（山东省科学院生物研究所）鸡巴氏杆菌病发病急，病程短，发病率及致死率高，给养鸡业造成较严重损失。山东省科学院生...

复力霉素薄层扫描测定方法的研究

本文报道了复力霉素的薄层扫描定量方法的建立及测定结果．发现该法测定复力霉素两个主要成分的变导系数（ＣＶ％）分别为１．６和１．９，加样回收率分别为９８．２７％和１０１．０％，含量分别为７９．６７％和１９．０４％．

复力霉素治疗鸡巴氏杆菌病的疗效

复力霉素治疗鸡巴氏杆菌病的疗效时秀梅高华方王希敏李慧玲（山东省科学院生物研究所济南２５００１４）曹洪敬王文杰颜世敢崔锦鹏任素芳沈冰（山东省农业科学院畜牧兽医研究所）山东省科学院生物研究所研制的新型兽药复力霉素，对多种病原菌有较强的抑杀作用。本试验验证...

新型兽药复力霉素的抑菌试验

新型兽药复力霉素的抑菌试验时秀梅，王希敏，高华方曹洪敬（山东省科学院生物研究所济南２５００１４）（山东省农业科学院畜牧兽医研究所）新型兽药复力霉素（Ｆｕｌｉｍｙｃｉｎ）是一种复合型广谱半合成口服兽用抗生素，国内外的医药工作者做了些试验研究，但就其医药...

环戊基哌嗪力复霉素药代动力学研究

本文用微生物方法测定DL473的血浆蛋白结合率为90．1％。在本实验条件下，其蛋白结合率与药物浓度无关，而血浆中药物游离率（1－结合率）的对数与血浆浓度成直线关系。

环戊基哌嗪力复霉素药代动力学研究

本文用微生物方法测定DL473的血浆蛋白结合率为90.1％。在本实验条件下,其蛋白结合率与药物浓度无关,而血浆中药物游离率(1-结合率)的对数与血浆浓度成直线关系。猴经口给15mg/kg DL473的药代动力学参数为:C_(max) 11.39±3.54μg/ml,t_(max) 12.63±3.34h,t_(1/2)15.41±1.57h,k 0.0453± 0.0049h^(-1),t_(1/2)α 4.76±1.81h,k_a 0.1742±0.0975h^(-1),AUC 429.13±158.73μg·h/ml。健康志愿受试者口服4mg/kgDL473的药代动力学参数为:C_(max) 4.84±1.16μg/ml,t_(max) 6.94±2.15h,t_(1/2) 17.56±5.39h,k 0.0432±0.0150h^(-1),t_(1/2)α1.67±0.71h,k_a 0.5084±0.0297h^(-1),AUC 154.55±51.01μg·h/ml。

Mechanisms underlying feed intolerance in the critically ill: Implications for treatment

Malnutrition is associated with poor outcomes in critically ill patients. Although nutritional support is yet to be proven to improve mortality in non-malnourished critically ill patients, early enteral feeding is considered best practice. However, enteral feeding is often limited by delayed gastric emptying. The best method to clinically identify delayed gastric emptying and feed intolerance is unclear. Gastric residual volume （GRV） measured at the bedside is widely used as a surrogate marker for gastric emptying, but the value of GRV measurement has recently been disputed. While the mechanisms underlying delayed gastric emptying require further investigation, recent research has given a better appreciation of the pathophysiology. A number of pharmacological strategies are available to improve the success of feeding. Recent data suggest a combination of intravenous metoclopramide and en/thromycin to be the most successful treatment, but novel drug therapies should be explored. Simpler methods to access the duodenum and more distal small bowel for feed delivery are also under investigation. This review summarises current understanding of the factors responsible for, and mechanisms underlying feed intolerance in critical illness, together with the evidence for current practices. Areas requiring further research are also highlighted.