Objective: To investigate the role of transcription factor Egr-1 in liver injury following hemorrhagic shock (HS) /resuscitation (R). Methods: Both Egr-1 knockout (KO) and wild-type (WT) mice were subjected to HS and ...Objective: To investigate the role of transcription factor Egr-1 in liver injury following hemorrhagic shock (HS) /resuscitation (R). Methods: Both Egr-1 knockout (KO) and wild-type (WT) mice were subjected to HS and HSR injuries. The expressions of TNF-α, IL-6, G-CSF and ICAM-1 mRNAs in the liver were examined by RT-PCR, and their serum levels were measured by ELISA. The liver inflammatory infiltration and liver injury in both Egr-1 WT and KO mice following HS/R were evaluated by liver MPO content, serum ALT level and histological examination. Results: Egr-1 inhibition resulted in less mRNA expression of TNF-α, IL-6 , G-CSF and ICAM-1 in the liver, and lower serum levels of TNF-α, IL-6, G-CSF and ICAM-1 antigens in Egr-1 KO mice following HS/R. The liver inflammatory infiltration and liver injury were less severe in Egr-1 KO mice following HS/R, as evidenced by lower serum ALT level, lower hepatic MPO content and histological manifestations. Conclusion: Our data suggest that transcription factor Egr-1 is involved in regulating the expression of inflammatory response genes and plays a role in liver injury following HS/R.展开更多
We report a rare case of massive recurrent synovial sarcoma of the neck in a 25-year-old woman.Physical exami- nation showed a 30×28 cm well-defined subcutaneous mass in the left cervical region,compressing the t...We report a rare case of massive recurrent synovial sarcoma of the neck in a 25-year-old woman.Physical exami- nation showed a 30×28 cm well-defined subcutaneous mass in the left cervical region,compressing the trachea to the right. Systemic examination revealed no metastasis to other organs.The diagnosis of sarcoma was established by percutaneous needle biopsy.Branches of the left subclavian artery and the left external carotid artery were found to supply the tumor,their embolization successfully shrank the tumor preoperatively allowing subsequent resection.Pathological analysis confirmed the diagnosis of synovial sarcoma.The patient was without recurrence 12 months after operation.展开更多
文摘Objective: To investigate the role of transcription factor Egr-1 in liver injury following hemorrhagic shock (HS) /resuscitation (R). Methods: Both Egr-1 knockout (KO) and wild-type (WT) mice were subjected to HS and HSR injuries. The expressions of TNF-α, IL-6, G-CSF and ICAM-1 mRNAs in the liver were examined by RT-PCR, and their serum levels were measured by ELISA. The liver inflammatory infiltration and liver injury in both Egr-1 WT and KO mice following HS/R were evaluated by liver MPO content, serum ALT level and histological examination. Results: Egr-1 inhibition resulted in less mRNA expression of TNF-α, IL-6 , G-CSF and ICAM-1 in the liver, and lower serum levels of TNF-α, IL-6, G-CSF and ICAM-1 antigens in Egr-1 KO mice following HS/R. The liver inflammatory infiltration and liver injury were less severe in Egr-1 KO mice following HS/R, as evidenced by lower serum ALT level, lower hepatic MPO content and histological manifestations. Conclusion: Our data suggest that transcription factor Egr-1 is involved in regulating the expression of inflammatory response genes and plays a role in liver injury following HS/R.
文摘We report a rare case of massive recurrent synovial sarcoma of the neck in a 25-year-old woman.Physical exami- nation showed a 30×28 cm well-defined subcutaneous mass in the left cervical region,compressing the trachea to the right. Systemic examination revealed no metastasis to other organs.The diagnosis of sarcoma was established by percutaneous needle biopsy.Branches of the left subclavian artery and the left external carotid artery were found to supply the tumor,their embolization successfully shrank the tumor preoperatively allowing subsequent resection.Pathological analysis confirmed the diagnosis of synovial sarcoma.The patient was without recurrence 12 months after operation.
