A rotundine-polyion complex(PIC)release system was prepared first by granulation of rotundine containing chitosan acetate solution and then by complexing with carboxymethyl glucomannan(CMGM)solution on the granular su...A rotundine-polyion complex(PIC)release system was prepared first by granulation of rotundine containing chitosan acetate solution and then by complexing with carboxymethyl glucomannan(CMGM)solution on the granular surface.The granules have an average diameter of 1.38-1.53 mm and the drug content reaches 62.89％.The external release tests showed T_(50) to be 45 rain and the total release time 4 h in an artificial gastric juice,while no more than 60％ of the drug was released in the same period of time in an ar- tificial intestinal fluid.The various factors affecting the external release were examined.展开更多
This research investigates the formation of chitosan/poly （L-lactide） （CS/PLLA） porous composite scaffold using a novel emulsion freeze-drying technique. First, an oil in-water （O/W） emulsification system was us...This research investigates the formation of chitosan/poly （L-lactide） （CS/PLLA） porous composite scaffold using a novel emulsion freeze-drying technique. First, an oil in-water （O/W） emulsification system was used in the presence of surfactant Tween-80, in which CS solution was used as the water phase and PLLA solution was used as the oil phase. The emulsion was observed by inverted microscope （× 200）. The emulsion droplet was spherical and uniform in size. FT-IR analysis revealed that there were hydrogen bonding interactions between CS and PLLA components. The microstructure and physical properties of the scaffolds were also analyzed. The SEM results showed that composite scaffolds formed well interconnected pore structure and homogenous distribution of CS and PLLA. When the content of PLLA reached 50%, the porosity of CS/PLLA composite scaffolds were between 83 %-91% and density in the range of 0.047 to 0.11 g/era3. The porosity showed a slight decrease and the density increased with the increase of PLLA dose. The compressive strength increased from 0.32 to 0.43 MPa, while the compressive modulus increased from 1.99 to 3.91 MPa as the PLLA contents increased from 10% to 50%.展开更多
基金This project was supported by National Natural Science Foundation of China
文摘A rotundine-polyion complex(PIC)release system was prepared first by granulation of rotundine containing chitosan acetate solution and then by complexing with carboxymethyl glucomannan(CMGM)solution on the granular surface.The granules have an average diameter of 1.38-1.53 mm and the drug content reaches 62.89％.The external release tests showed T_(50) to be 45 rain and the total release time 4 h in an artificial gastric juice,while no more than 60％ of the drug was released in the same period of time in an ar- tificial intestinal fluid.The various factors affecting the external release were examined.
基金National Nature Science Foundation of China grant number: 50803032, 10925208, 11032012, 11002016 and 30800217Fundamental Research Funds for the Central Universities
文摘This research investigates the formation of chitosan/poly （L-lactide） （CS/PLLA） porous composite scaffold using a novel emulsion freeze-drying technique. First, an oil in-water （O/W） emulsification system was used in the presence of surfactant Tween-80, in which CS solution was used as the water phase and PLLA solution was used as the oil phase. The emulsion was observed by inverted microscope （× 200）. The emulsion droplet was spherical and uniform in size. FT-IR analysis revealed that there were hydrogen bonding interactions between CS and PLLA components. The microstructure and physical properties of the scaffolds were also analyzed. The SEM results showed that composite scaffolds formed well interconnected pore structure and homogenous distribution of CS and PLLA. When the content of PLLA reached 50%, the porosity of CS/PLLA composite scaffolds were between 83 %-91% and density in the range of 0.047 to 0.11 g/era3. The porosity showed a slight decrease and the density increased with the increase of PLLA dose. The compressive strength increased from 0.32 to 0.43 MPa, while the compressive modulus increased from 1.99 to 3.91 MPa as the PLLA contents increased from 10% to 50%.
