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复合装甲防护材料对其抗弹性能影响研究
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作者 徐海 岳文泉 权国政 《包装工程》 CAS 北大核心 2024年第21期268-273,共6页
目的复合装甲防护材料是影响其抗弹效应的重要影响因素,合理应用防护材料可在质量、尺寸等约束条件限制下,大幅度提高复合装甲的抗弹能力。方法针对装甲车辆不同角度的防护需求,通过建立不同防护材料组成的复合装甲仿真模型,研究其在不... 目的复合装甲防护材料是影响其抗弹效应的重要影响因素,合理应用防护材料可在质量、尺寸等约束条件限制下,大幅度提高复合装甲的抗弹能力。方法针对装甲车辆不同角度的防护需求,通过建立不同防护材料组成的复合装甲仿真模型,研究其在不同角度下抗弹性能,并通过靶试试验验证模型的有效性。结果在100 mm、防54式12.7 mm穿甲燃烧弹,陶瓷复合装甲抗弹性能随着入射角的增大先高于钛合金复合装甲,后逐渐下降,当入射角达到45°时,陶瓷复合板的抗弹性能接近于钛合金复合板,随着角度的继续增大,钛合金复合板的抗弹性能逐渐优于陶瓷复合板。结论通过在100 m射距、48°法线角下的陶瓷及钛合金防护复合装甲靶试试验,验证所建立仿真模型的有效性,进而后续复合装甲抗弹性能设计研究,可基于仿真模型确立最优包装材料及其结构,减少靶试试验,提高设计效率及增加经济效应。 展开更多
关键词 陶瓷组成复合装甲 钛合金组成复合装甲 抗弹性能 仿真模型
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去泛素化酶组成型光形态发生因子9信号复合体5上调甲硫氨酸腺苷转移酶2A表达促进肝癌细胞增殖 被引量:1
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作者 谢培一 陈磊峰 +3 位作者 卢虹成 杜栋年 李家娟 邵江华 《实用医学杂志》 CAS 北大核心 2021年第12期1539-1543,共5页
目的研究去泛素化酶组成型光形态发生因子9信号复合体5(CSN5)调控肝癌细胞增殖的的分子机制。方法采用实时荧光定量PCR和蛋白质印迹法以及免疫组织化学法检测并比较CSN5在肝癌和癌旁组织表达的差异性。在肝癌细胞转染CSN5干扰片段并采... 目的研究去泛素化酶组成型光形态发生因子9信号复合体5(CSN5)调控肝癌细胞增殖的的分子机制。方法采用实时荧光定量PCR和蛋白质印迹法以及免疫组织化学法检测并比较CSN5在肝癌和癌旁组织表达的差异性。在肝癌细胞转染CSN5干扰片段并采用实时荧光定量PCR和蛋白质印迹法验证CSN5和甲硫氨酸腺苷转移酶2A(MAT2A)表达的变化,同时用EdU法检测肝癌细胞增殖的变化。结果CSN5在肝癌组织和肝癌细胞中的表达水平明显增高(P<0.05)。干扰CSN5后肝癌细胞中CSN5 mRNA及蛋白的水平和肝癌细胞增殖能力显著降低(P<0.001)。在肝癌细胞中干扰CSN5的表达可以明显降低MAT2A蛋白水平(P<0.01)并进而影响肝癌细胞的增殖能力。结论CSN5可以通过调控甲硫氨酸腺苷转移酶2A的表达进而调控肝癌细胞的增殖。 展开更多
关键词 肝癌 去泛素化酶 增殖 组成型光形态发生因子9信号复合体5 甲硫氨酸腺苷转移酶2A
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厌氧胶用复合型氧化还原引发剂 被引量:2
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作者 杨颖泰 刘伟塘 陈锡来 《粘接》 CAS 2003年第1期14-17,共4页
介绍了过氧化物-叔胺-糖精(胺体系)和过氧化物-取代肼-糖精(肼体系)两种厌氧胶引发剂体系的组成和性能。试验表明,采用多成分的复合引发剂是兼顾厌氧胶固化速度和贮存稳定性的较好途径。
关键词 厌氧胶 复合型氧化还原引发剂 复合组成
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碱金属助剂类型及前驱物对改性NiAl复合氧化物催化分解N_2O活性的影响 被引量:8
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作者 武海鹏 李文静 +2 位作者 郭丽 潘燕飞 徐秀峰 《燃料化学学报》 EI CAS CSCD 北大核心 2011年第7期550-555,共6页
制备了不同Ni/Al原子比的NiAl类水滑石样品,焙烧获得NiAl复合氧化物,用于N2O分解反应,研究了NiAl复合氧化物组成对催化活性的影响。在活性较高的NiAl复合氧化物表面浸渍碱金属碳酸盐溶液,制备改性NiAl复合氧化物,考察了碱金属类型(Na、K... 制备了不同Ni/Al原子比的NiAl类水滑石样品,焙烧获得NiAl复合氧化物,用于N2O分解反应,研究了NiAl复合氧化物组成对催化活性的影响。在活性较高的NiAl复合氧化物表面浸渍碱金属碳酸盐溶液,制备改性NiAl复合氧化物,考察了碱金属类型(Na、K、Cs)和钾前驱物(K2CO3、K2C2O4、CH3COOK、KNO3)对改性催化剂活性的影响。用XRD、ICP-AES、FT-IR、BET、H2-TPR、XPS技术表征了催化剂的组成结构。结果表明,Ni/Al原子比为2.7的NiAl复合氧化物催化活性较高;Na、K、Cs碳酸盐改性NiAl复合氧化物均提高了催化剂活性,其中K的助剂效应最强。钾前驱物对K改性NiAl复合氧化物的催化活性有显著影响,其中碳酸钾、醋酸钾、草酸钾的加入明显提高了改性催化剂的催化活性,而加入硝酸钾反而降低了催化剂活性。 展开更多
关键词 N2O催化分解 改性NiAl复合氧化物 NiAl复合氧化物组成 碱金属类型 K前驱物
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不锈钢复合板(Q235B+316L)施工工艺
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作者 苏焰 《福建建筑》 2014年第10期73-75,共3页
以往纸业工程浆塔的做法,一般采用碳钢板,另加不锈钢内衬板做法,施工周期较长,不锈钢内衬板需做试漏试验,漏点检测麻烦,生产过程中不锈钢内衬板也容易脱落,检修费用高,并且耗时。现在采用新型材料:不锈钢复合板(Q235B+316L),在能推进施... 以往纸业工程浆塔的做法,一般采用碳钢板,另加不锈钢内衬板做法,施工周期较长,不锈钢内衬板需做试漏试验,漏点检测麻烦,生产过程中不锈钢内衬板也容易脱落,检修费用高,并且耗时。现在采用新型材料:不锈钢复合板(Q235B+316L),在能推进施工进度和保证质量的前提下,还能大大减少生产检修费用。 展开更多
关键词 不锈钢复合板(Q235B+316L)组成及特点 生产方法 施工注意事项 焊接工艺
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Effect of NiAl content on phases and microstructures of TiC-TiB_2-NiAl composites fabricated by reaction synthesis 被引量:5
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作者 崔洪芝 马丽 +2 位作者 曹丽丽 滕方磊 崔宁 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第2期346-353,共8页
TiC-TiB2-NiAl composites were fabricated by self-propagating high temperature reaction synthesis(SHS) with Ti, B4C, Ni and Al powders as raw materials. The effects of NiAl content on phase constituents and microstru... TiC-TiB2-NiAl composites were fabricated by self-propagating high temperature reaction synthesis(SHS) with Ti, B4C, Ni and Al powders as raw materials. The effects of NiAl content on phase constituents and microstructures were investigated. The results show that the reaction products are composed of TiB2, TiC and NiAl. The content of NiAl increases with the adding of Ni+Al in green compacts. TiB2, TiC and NiAl grains present in different shapes in the matrix, TiB2 being in hexagonal or rectangular shapes, TiC in spherical shapes, and NiAl squeezed into the gaps of TiC and TiB2 grains. With the increase of NiAl content, the grains of TiC-TiB2-NiAl composites are refined, their density and compressive strength are improved, and the shapes of TiC grains become spherical instead of irregular ones. Finally, the fracture mechanism of the composites transforms from intergranular fracture mode to the compounded fracture mode of intergranular fracture and transgranular fracture. 展开更多
关键词 TiC-TiB2-NiAl TiC-TiB2-NiAl COMPOSITES MICROSTRUCTURE
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Tensile and wear properties of TiC reinforced 420 stainless steel fabricated by in situ synthesis 被引量:2
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作者 汪黎 孙扬善 +2 位作者 樊泉 薛烽 段志超 《Journal of Southeast University(English Edition)》 EI CAS 2004年第4期486-491,共6页
TiC particle reinforced 420 stainless steel matrix composites were fabricated, and the microstructure, tensile properties and wear resistance of the composites were studied. The experimental results indicate that the ... TiC particle reinforced 420 stainless steel matrix composites were fabricated, and the microstructure, tensile properties and wear resistance of the composites were studied. The experimental results indicate that the distribution of TiC particles with size of 5 to 10 μm in diameter is uniform if the volume fraction of TiC is lower than 6%. However, slight agglomeration can be observed when the TiC content exceeds 6%. With the increase of TiC content the tensile and yield strength of the composites prepared increases and reaches the maximum when the volume fraction of TiC increases to 5%. Further increase of TiC content causes reductions of yield and tensile strength. The ductility of the composites shows a monotone decrease with the increase of TiC addition. The introduction of TiC into 420 stainless steel results in significant improvement on wear resistance, which reaches a steady level when the volume fraction of TiC increases to 11% and does not show obvious variation if the TiC content is further increased. 展开更多
关键词 AGGLOMERATION Composite materials In situ processing Microstructure Stainless steel Tensile properties Wear resistance
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Microstructure evolution and nitrides precipitation in in-situ Ti_2 AlN/TiAl composites during isothermal aging at 900°C 被引量:3
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作者 刘懿文 胡锐 +2 位作者 张铁邦 寇宏超 李金山 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第5期1372-1378,共7页
Microstructures of Ti2AlN/TiAl composites prepared by in-situ method were characterized in in-situ and aging treatment conditions and the nitride precipitation was investigated in Ti2AlN/TiAl composites aged at 900 ℃... Microstructures of Ti2AlN/TiAl composites prepared by in-situ method were characterized in in-situ and aging treatment conditions and the nitride precipitation was investigated in Ti2AlN/TiAl composites aged at 900 ℃ for 24 h after being heat treated at 1400 ℃ for 0.5 h. The in-situ composites consist of γ+α2 lamellar colonies, equiaxed y grains and Ti2AlN reinforcements. Matrix with nearly fully lamellar structure formed after solution and subsequently aging treatment. With the increase of Ti2AlN content, the nearly fully lamellar structure becomes instable for the aged composites. According to TEM study, fine Ti2AlN precipitates are found to distribute at the grain boundaries of lamellar colony. Needle-like Ti3AlN precipitates arrange in line with growing axis parallel to [001] direction of the γ-TiAl matrix and another needle-like Ti3AlN precipitates with lager size distribute at the dislocations. Key words: 展开更多
关键词 TiAl composites Ti2AlN in-situ synthesis microstructure PRECIPITATES aging treatment
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宫颈癌中CSN6对E6AP的调节作用及其临床意义 被引量:3
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作者 王超 宋昱 +2 位作者 郭奇桑 刘艳梅 高蜀君 《中国临床医学》 2015年第3期272-279,共8页
目的:探讨宫颈癌中组成型光形态发生因子9信号复合体亚单位6(constitutive photomorphogenesis 9 signalosome subunit 6,CSN6)对E6AP的调节作用。方法:在癌症和肿瘤基因图谱(The Cancer Genome Atlas,TCGA)数据库中检索CSN6和E6AP基因... 目的:探讨宫颈癌中组成型光形态发生因子9信号复合体亚单位6(constitutive photomorphogenesis 9 signalosome subunit 6,CSN6)对E6AP的调节作用。方法:在癌症和肿瘤基因图谱(The Cancer Genome Atlas,TCGA)数据库中检索CSN6和E6AP基因,比较分析其相关性。采用质粒转染、蛋白质印迹(Western blotting)、四甲基偶氮唑蓝(methyl thiazolyl tetrazolium,MTT)、流式细胞术等方法检测CSN6对E6AP表达及细胞生物学的影响。通过在裸鼠皮下接种不同CSN6表达状态的Hela细胞株建立动物模型,观察CSN6对肿瘤生长的影响。结果:数据库资料显示,CSN6和E6AP在肿瘤中有过表达和突变的现象。CSN6可以上调E6AP蛋白的表达,抑制CSN6的表达可以使E6AP表达下降,细胞增殖能力降低,细胞周期停滞于G0-G1期。动物实验显示,敲除CSN6可以显著抑制肿瘤生长,且肿瘤中E6AP蛋白表达水平下降,p53蛋白表达水平增加。结论:CSN6可以通过上调E6AP蛋白的表达而促进宫颈癌的发生发展。 展开更多
关键词 宫颈癌 人乳头瘤病毒 感染 组成型光形态发生因子9信号复合 E6AP
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CSN6在食管鳞状细胞癌中的表达及临床意义
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作者 陈智伟 林海凤 +1 位作者 刘晓丽 刘芳芳 《齐齐哈尔医学院学报》 2021年第20期1749-1753,共5页
目的探讨食管鳞状细胞癌中组成型光形态发生因子9信号复合体亚单位6(CSN6)的表达及临床意义。方法选择2019年1月—2020年12月本院80例食管鳞状细胞癌患者、68例Barrett食管患者、120名健康体检者作为研究对象,收集所有研究对象的血清,... 目的探讨食管鳞状细胞癌中组成型光形态发生因子9信号复合体亚单位6(CSN6)的表达及临床意义。方法选择2019年1月—2020年12月本院80例食管鳞状细胞癌患者、68例Barrett食管患者、120名健康体检者作为研究对象,收集所有研究对象的血清,采用酶联免疫吸附试验(ELISA)检测血清中CSN6蛋白的表达量,采用电化学发光法检测癌胚抗原(CEA)、鳞状细胞癌相关抗原(SCCA)的表达量。绘制ROC曲线比较上述指标的诊断价值。采用免疫组织化学实验检测2013年9月—2016年1月本院病理科存档的食管鳞状细胞癌手术标本共180例,检测癌及癌旁石蜡组织标本中CSN6的表达,分析CSN6与临床病理特征及预后的关系。结果食管鳞状细胞癌患者血清中CSN6的表达量高于Barrett食管患者和健康体检者,差异具有统计学意义(P<0.05)。ROC曲线表明:CSN6、CEA和SCCA的诊断效能低于三者联合检测,差异具有统计学意义(P<0.05)。食管鳞状细胞癌组织中CSN6的阳性率与癌旁正常组织比较,差异具有统计学意义,CSN6的阳性表达与肿瘤大小、病理分期、浸润深度、淋巴结转移有关(P<0.05)。CSN6阳性表达患者的5年生存率与阴性表达比较,差异具有统计学意义(P<0.05)。多因素分析表明CSN6阳性表达是判断食管鳞状细胞癌不良预后的独立危险因素(P<0.05)。结论CSN6可能作为食管鳞状细胞癌早期诊断、预测不良预后的分子标志物。 展开更多
关键词 食管鳞状细胞癌 组成型光形态发生因子9信号复合体亚单位6 预后
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New composite grouting materials:Modified urea-formaldehyde resin with cement 被引量:22
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作者 Duan Hongfei Jiang Zhenquan +2 位作者 Zhu Shuyun Yao Pu Sun Qiang 《International Journal of Mining Science and Technology》 2012年第2期195-200,共6页
A new composite two component grout comprised of modified urea-formaldehyde resin and cement was formulated to take account of the advantages and disadvantages of both the cement grout and the chem- ical grout. The ne... A new composite two component grout comprised of modified urea-formaldehyde resin and cement was formulated to take account of the advantages and disadvantages of both the cement grout and the chem- ical grout. The new grout is designed for water blocking by reinforcing as well as seepage control by bore grouting. The A component consists of a modified urea-formaldehyde resin A component, some cement, and some water. The B component is an alkaline coagulant. An orthogonal test of four factors at three lev- els showed that gel time increased with increased water content and with urea-formaldehyde resin con- tent. Gel time decreased at increased levels of alkaline coagulant. The A component of this new composite grout is stable over time. A mixed cross-over test showed that as the volume ratio of A to B increases the gel time falls at first but then increases. The solid strength decreases with increasing levels of the B com- ponent. The solid strength increases over time and becomes stable by the 28th day after mixing. The vis- cosity increases with increasing levels of resin A component. The increase is exponential and may be fit to: μ = 8.162e0.0286x. 展开更多
关键词 Modified urea-formaldehyde resin A liquidGrouting materialsOrthogonal testGel timeSolidification strength
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The retromer component SNX6 interacts with dynactin p150Glued and mediates endosome-to-TGN transport 被引量:8
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作者 Zhi Hong Yanrui Yang +4 位作者 Cheng Zhang Yang Niu Ke Li Xi Zhao Jia-JiaLiu 《Cell Research》 SCIE CAS CSCD 2009年第12期1334-1349,共16页
The retromer is a protein complex that mediates retrograde transport of transmembrane cargoes from endosomes to the trans-Golgi network (TGN). It is comprised of a cargo-selection subcomplex of Vps26, Vps29 and Vps3... The retromer is a protein complex that mediates retrograde transport of transmembrane cargoes from endosomes to the trans-Golgi network (TGN). It is comprised of a cargo-selection subcomplex of Vps26, Vps29 and Vps35 and a membrane-binding coat subcomplex of sorting nexins (SNXs). Previous studies identified SNX1/2 as one of the components of the SNX subcomplex, and SNX5/6 as candidates for the second SNX. How the retromer-associated cargoes are recognized and transported by molecular motors are largely unknown. In this study, we found that one of SNX1/2's dimerization partners, SNX6, interacts with the p150Gued subunit of the dynein/dynactin motor complex. We present evidence that SNX6 is a component of the retromer, and that recruitment of the motor complex to the membrane-associated retromer requires the SNX6-pl50Gued interaction. Disruption of the SNX6-pl50Glued interaction causes failure in formation and detachment of the tubulovesicular sorting structures from endosomes and results in block of CI-MPR retrieval from endosomes to the TGN. These observations indicate that in addition to SNX1/2, SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates. 展开更多
关键词 sorting nexin RETROMER p 150Glued retrograde transport dynein/dynactin CI-MPR
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Preparation and characterization of a composite membrane based on the asphaltene component of coal 被引量:7
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作者 Zhang Liying Qin Zhihong Li Xinyan Chen Juan Liu Peng Wang Xiaoyan 《Mining Science and Technology》 EI CAS 2011年第3期407-411,共5页
Asphaltene-ceramic composite membranes were fabricated from ceramic supports and an asphaltene component, which was obtained from the separation of coal to give a kind of new carbonaceous precursor material. Using SEM... Asphaltene-ceramic composite membranes were fabricated from ceramic supports and an asphaltene component, which was obtained from the separation of coal to give a kind of new carbonaceous precursor material. Using SEM and thermogravimetric analysis to measure the microstructure and properties of the asphaltene component allowed the porosity, permeability, and retention ratios to be determined. The results show that the asphaltene component can be regarded as a good carbon membrane precursor material because of its high carbon content and strong bonding capacity. When ceramic supports are impregnated with asphaltene colloid the asphaltene easily combines with the support surface and forms a good carbonaceous film after carbonization. Little of the asphaltene component permeates into the internal pores of the ceramic support. Although the number of coats applied to the substrate had little affect on the porosity of the asphaltene-ceramic composite membranes the permeability varied depend- ing upon the number of times the substrate was treated. The way bubbles escape from the film, and the phenomenon of coalescence, as affected by different film thicknesses also seem closely related to the number of coats. A composite membrane carbonized at a final temperature of 600℃ is relatively dense and the permeability of Fe(OH)3 colloid through it is very low. A membrane fired at 800℃ is porous and its permeability and retention of Fe(OH)3 colloid are 88 L/(m2 h MPa) and 85.3%, respectively when the trans-membrane pressure is 0.22 MPa. 展开更多
关键词 Asphaltene Composite membrane Porosity Permeability Fe(OH)3 colloid
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Effects of SiC amount on phase compositions and properties of Ti_3SiC_2-based composites 被引量:2
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作者 蔡艳芝 殷小玮 尹洪峰 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第1期14-22,共9页
The phase compositions and properties of Ti3SiC2-based composites with SiC addition of 5%-30% in mass fraction fabricated by in-situ reaction and hot pressing sintering were studied. SiC addition effectively prevented... The phase compositions and properties of Ti3SiC2-based composites with SiC addition of 5%-30% in mass fraction fabricated by in-situ reaction and hot pressing sintering were studied. SiC addition effectively prevented TiC synthesis but facilitated SiC synthesis. The Ti3SiC2/Ti C-SiC composite had better oxidation resistance when SiC added quantity reached 20% but poorer oxidation resistance with SiC addition under 15% than Ti3SiC2/TiC composite at higher temperatures. There were more than half of the original SiC and a few Ti3SiC2 remaining in Ti3SiC2/Ti C-SiC with 20% SiC addition, but all constituents in Ti3Si2/TiC composite were oxidized after 12 h in air at 1500 °C. The oxidation scale thickness of TS30, 1505.78 μm, was near a half of that of T,2715 μm, at 1500 °C for 20 h. Ti3SiC2/Ti C composite had a flexural strength of 474 MPa, which was surpassed by Ti3SiC2/TiC-SiC composites when SiC added amount reached 15%. The strength reached the peak of 518 MPa at 20% SiC added amount. 展开更多
关键词 in-situ reaction composites oxidation mechanical properties
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Effect of CaO composition on oxidation and burning behaviors of AM50 Mg alloy
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作者 Jin-Kyu LEE Shae K.KIM 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2011年第A01期23-27,共5页
Oxidation and burning behaviors were studied for CaO added AM50 Mg composites which were manufactured by conventional melting and casting processes without SF6 protective gas. CaO added AM50 Mg composites show the sta... Oxidation and burning behaviors were studied for CaO added AM50 Mg composites which were manufactured by conventional melting and casting processes without SF6 protective gas. CaO added AM50 Mg composites show the stable oxidation resistance, while AMS0 Mg alloys show the poor oxidation resistance. The effects of CaO addition on the burning resistance under ambient, nitrogen and dry air atmospheres were examined for CaO added AM50 Mg composites. With increasing CaO addition, the burning temperature increases under ambient, nitrogen and dry air atmospheres. The burning temperatures of small test specimen under all conditions greatly increase even by 0.3% CaO (mass fraction) addition into AM50 Mg alloys. 展开更多
关键词 Mg alloy CAO oxidation behavior burning behavior
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Triangular Halogen Bond and Hydrogen Bond Supramolecular Complex Consisting of Carbon Tetrabromide, Halide, and Solvent Molecule: A Theoretical and Spectroscopic Study
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作者 Yu-jie Wu Xiao-ran Zhao +1 位作者 Hai-yue Gao Wei-jun Jin 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2014年第3期265-273,共9页
The theoretical calculation and spectroscopic experiments indicate a kind of triangular three bonding supramolecular complexes CBr4…X^-…-H-C, which consist of carbon tetrabromide, halide, and protic solvent molecule... The theoretical calculation and spectroscopic experiments indicate a kind of triangular three bonding supramolecular complexes CBr4…X^-…-H-C, which consist of carbon tetrabromide, halide, and protic solvent molecule (referring to dichloromethane, chloroform and acetonitrile), can be formed in solution. The strength of halogen and hydrogen bonds in the triangular complexes using halide as common acceptor obeys the order of iodide〉bromide〉chloride. The halogen and hydrogen bonds work weak-cooperatively. Charge transfer bands of halogen bonding complexes between CBra and halide are observed in UV-Vis absorption spectroscopy in three solvents, and then the stoichiometry of 1:1, formation constants K and molar extinction coefficients ε of the halogen bonding complexes are obtained by Benesi-Hildebrand method. The K and ε show a dependence on the solvent dielectric constant and, on the whole, obey an order of iodide〉bromide〉chloride in the same solvents. Furthermore, the C-H vibrational frequencies of solvent molecules vary obviously with the addition of halide, which indicates the C-H…X- interaction. The experimental data indicate that the halogen bond and hydrogen bond coexist by sharing a common halide acceptor as predicted by calculation. 展开更多
关键词 Halogen bond Hydrogen bond HALIDE Carbon tetrabromide Charge transfer
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CSN6对宫颈癌细胞自噬的调节作用 被引量:1
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作者 毛尊 李玉玲 巩玉森 《徐州医科大学学报》 CAS 2019年第1期42-45,共4页
目的探讨组成型光形态发生因子9信号复合体亚基6(constitutive photomorphogenesis 9 signalosome subunit 6,CSN6)对宫颈癌HeLa细胞和SiHa细胞自噬能力的影响。方法用自噬双标腺病毒mRFP-GFP-LC3感染宫颈癌细胞示踪自噬流的水平,将阴... 目的探讨组成型光形态发生因子9信号复合体亚基6(constitutive photomorphogenesis 9 signalosome subunit 6,CSN6)对宫颈癌HeLa细胞和SiHa细胞自噬能力的影响。方法用自噬双标腺病毒mRFP-GFP-LC3感染宫颈癌细胞示踪自噬流的水平,将阴性对照序列(siCtrl)、CSN6 siRNA(siCSN6)、空载体质粒(Vector)及CSN6过表达质粒(CSN6)分别转染宫颈癌细胞,Western blot检测CSN6及微管相关蛋白1轻链3(microtubule-associated proteinl light chain 3,LC3)的表达。结果与siCtrl组相比,siCSN6组CSN6表达下降,而自噬体数量和LC3表达增加;与Vector组相比,CSN6组CSN6表达增加,而自噬体数量和LC3表达下降。结论转染小干扰CSN6增加宫颈癌细胞自噬水平,CSN6过表达抑制自噬活性。 展开更多
关键词 组成型光形态发生因子9信号复合体亚基6 宫颈癌 微管相关蛋白1轻链3 自噬
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Identification of two Major Histocompatibility(MH) Class Ⅱ A Genes and Their Association to Vibrio anguillarum Infection in Half-smooth Tongue Sole(Cynoglossus semilaevis)
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作者 LI Chunmei WANG Xubo +6 位作者 ZHANG Quanqi WANG Zhigang QI Jie YI Qilin LIU Zhipeng WANG Yanan YU Haiyang 《Journal of Ocean University of China》 SCIE CAS 2012年第1期32-44,共13页
Major histocompatibility complex class II antigens are important in vertebrate immune system.In the present study,the full cDNA sequence of class II A gene was synthesized by RACE-PCR from half-smooth tongue sole(Cyno... Major histocompatibility complex class II antigens are important in vertebrate immune system.In the present study,the full cDNA sequence of class II A gene was synthesized by RACE-PCR from half-smooth tongue sole(Cynoglossus semilaevis),and its open reading frame(ORF) polymorphism was studied.The whole cDNA sequence was 992 bp in length,including the ORF with 717 bp.Twenty-five alleles were identified and clustered into two distinct groups according to the specific nucleotides/amino acids in specific positions.Eleven alleles belonged to Cyse-DAA while fourteen alleles belonged to Cyse-DBA.Four Cyse-DAA alleles were observed in one individual,and three to five Cyse-DBA alleles were observed in each of the three detected individuals,which indicated that at least two loci existed in each gene.Moreover,in order to study the function of the alleles in resistance to infection,200 individuals were intraperitoneally injected with Vibrio anguillarum and the first 20 dead individuals and 20 surviving ones were selected for genotype analysis.Fifty-six alleles were identified among the 40 individuals.Twenty-nine alleles belonged to Cyse-DAA and the other 27 alleles belonged to Cyse-DBA.Eighteen alleles were selected for studying their function in resistance to infection.Alleles Cyse-DAA*0201,Cyse-DAA*1101,Cyse-DBA*0401,Cyse-DBA*1102,Cyse-DBA*1801 and Cyse-DBA*2201 were identi-fied only in surviving individuals,while alleles Cyse-DAA*0901,Cyse-DBA*1101 and Cyse-DBA*1401 occurred more frequently in dead individuals.This study confirmed the existence and polymorphism of two class II A genes as well as the relationship between alleles of class II A genes and disease susceptibility/resistance in half-smooth tongue sole. 展开更多
关键词 major histocompatibility polymorphism Cyse-DAA Cyse-DBA allele Vibrio anguillarum
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Mn_xCo_(3-x)O_4复合氧化物及改性催化剂催化分解N_2O 被引量:9
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作者 王建 窦喆 +1 位作者 潘燕飞 徐秀峰 《分子催化》 EI CAS CSCD 北大核心 2015年第3期246-255,共10页
用共沉淀法制备了一组不同组成的MnxCo3-xO4尖晶石型复合氧化物,表面负载碱金属助剂制备改性催化剂,用于催化分解N2O.用X射线衍射(XRD)、N2物理吸附(BET)、红外光谱(FTIR)、扫描电镜(SEM)、H2程序升温还原(H2-TPR)、X射线光电子能谱(XPS... 用共沉淀法制备了一组不同组成的MnxCo3-xO4尖晶石型复合氧化物,表面负载碱金属助剂制备改性催化剂,用于催化分解N2O.用X射线衍射(XRD)、N2物理吸附(BET)、红外光谱(FTIR)、扫描电镜(SEM)、H2程序升温还原(H2-TPR)、X射线光电子能谱(XPS)等技术表征催化剂结构.考察了复合氧化物组成、碱金属助剂类型、钾前驱物等制备参数对催化剂结构和催化活性的影响.结果表明:添加助剂K、Cs降低了催化剂表面Co、Mn元素的电子结合能,弱化了Co—O和Mn—O键,有利于氧物种的脱除,提高了催化剂活性.优化出了活性较高的催化剂K/Mn0.4Co2.6O4(K2CO3),有氧无水、有氧有水气氛400℃连续反应50 h,N2O转化率分别保持100%和74.2%,催化剂稳定性较高. 展开更多
关键词 N2O催化分解 MnxCo3-xO4复合氧化物 复合氧化物组成 助剂类型 钾前驱物 催化活性
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CSN5在胃癌中的表达及与患者预后的相关性 被引量:1
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作者 宗帅 肖东杰 +6 位作者 刘华 郏雁飞 马晓丽 李焕杰 黎娉 郑燕 汪运山 《山东大学学报(医学版)》 CAS 北大核心 2017年第7期12-16,共5页
目的探讨CSN5在胃癌中的表达及与患者预后的关系。方法运用cBioportal分析工具,分析CSN5在胃癌中基因水平的改变情况;运用qRT-PCR方法检测CSN5 mRNA在永生化的正常胃黏膜细胞株及不同胃癌细胞株中的表达;运用Oncomine数据库(DErrico、C... 目的探讨CSN5在胃癌中的表达及与患者预后的关系。方法运用cBioportal分析工具,分析CSN5在胃癌中基因水平的改变情况;运用qRT-PCR方法检测CSN5 mRNA在永生化的正常胃黏膜细胞株及不同胃癌细胞株中的表达;运用Oncomine数据库(DErrico、Chen胃癌数据集)和TCGA数据库(375例胃癌组织和32例癌旁组织),分析CSN5 mRNA在胃癌组织与正常胃黏膜表达的差异性;运用生存期分析软件Kaplan-Meier plotter,分析CSN5对876例胃癌患者预后的影响;运用Chen胃癌数据集,分析胃癌患者5年生存状态与CSN5表达的关系。结果在胃癌中CSN5主要的基因改变形式为扩增;CSN5 mRNA在多种胃癌细胞株中的表达水平显著高于正常胃黏膜细胞株;CSN5 mRNA在胃癌中的表达显著高于正常胃黏膜。生存分析结果发现,CSN5高表达的患者总生存期较长,CSN5低表达的患者总生存期较短。结论 CSN5在胃癌组织中高表达,且其表达水平与胃癌患者的预后呈正相关,即CSN5高表达的患者,预后较好。 展开更多
关键词 组成型光形态发生因子9信号复合 胃癌 预后
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