86例司法精神医学鉴定案例的专家复鉴分析

目的 通过对司法精神医学专家委员会(专委会)鉴定案例的总结来分析司法精神医学鉴定中可能出现的各种偏差及其原因。方法 收集86例专委会鉴定案例的社会人口学、病史以及各次鉴定资料;先以提请专委会鉴定原因分组对有关资料进行对照分析,然后对各次鉴定之间的一致性进行检验。结果 提请专委会鉴定的案例在案型、鉴定诊断上有一定的特殊性,被鉴定人既往有违法肇祸史者较易提请专委会鉴定;初次鉴定与他处复鉴之间无论在精神症状检查、鉴定诊断还是法定能力评定方面,一致性均较差;他处复鉴与专委会复鉴之间则一致性较高。结论 司法精神医学鉴定由于种种因素的制约而可能出现较大的偏差,除了各鉴定机构应大力提高业务水平外,专委会鉴定的方式目前仍不失为一种有效的消除分歧、解决疑难问题的手段。

2例司法精神病复鉴案例分析

司法精神病鉴定中,无论是医学诊断错误,还是辨认力、控制力判断错误,都会引起责任能力评定的失误。

Research Progress of Bactrocera dorsalis and Its Species Complex

Research progress of B. dorsalis and its species complex in Taiwan region and abroad was summarized from the aspects of classification, origin, transmission, distribution, host, biological characteristics and adaptability to environmental conditions, in order to provide references and basis for researching B. dorsalis and its species complex in China.

A 5-Gbit/s monolithically-integrated low-power clock recovery circuit in 0.18-μm CMOS

In order to make a 10 Gbit/s 2：1 half-rate multiplexer operate without external clocks, a 5 Gbit/s clock recovery （CR） circuit is needed to extract the desired clock from one input data. For the CR circuit, a 3-stage ring voltage-controlled oscillator （VCO） is employed to avoid an unreliable startup of a 2-stage VCO and a low oscillation frequency of a 4-stage VCO. A phase frequency detector （PFD） is used to expand the pull-in range to meet the wide tuning range of a VCO required by process-voltage-temperature （PVT） variation. SMIC 0. 18-μm CMOS technology is adopted and the core area is 170 μm ×270 μm. Measurements show that, under a 1.8 V supply voltage, it consumes only about 90 mW, and has an input sensitivity of less than 25 mV, an output single-ended swing of above 300 mV, a phase noise of - 114 dBc/Hz at 1 MHz offset and a pull-in range of 1 GHz.

2.5Gb/s 0.18μm CMOS Clock and Data Recovery Circuit

A 2.5Gb/s clock and data recovery （CDR） circuit is designed and realized in TSMC＇s standard 0.18/μm CMOS process. The clock recovery is based on a PLL. For phase noise optimization,a dynamic phase and frequency detector （PFD） is used in the PLL. The rms jitter of the recovered 2.5GHz clock is 2.4ps and the SSB phase noise is - 111dBc/Hz at 10kHz offset. The rms jitter of the recovered 2.5Gb/s data is 3.3ps. The power consumption is 120mW.

Follow up of infection of chacma baboons with inoculum containing a and non-a genotypes of hepatitis B virus

AIM: To determine whether one genotype (A or non-A genotypes of HBV) predominated over the other during the course of HBV infection.METHODS: Four baboons were inoculated with HBV. DNA was extracted from serum obtained at monthly intervals postinoculation for 52 weeks and HBV DNA was amplified using primers specific for the core region containing an insert characteristic of genotype A (nt 2 354-2 359, numbering from the EcoRI site). The amplicons were cloned into PCRScriptTM and a minimum of 15 clones per time point were sequenced in both directions.RESULTS: Both genotypes persisted for the entire followup period of 52 weeks. Genotype non-A predominated in two baboons and genotype A in one baboon. Neither genotype predominated in the fourth baboon, as shown at a 5 % level of testing.CONCLUSION: No conclusions concerning the dominance of either genotype or the natural progression or replication rates of HBV could be drawn because the pattern of the genotypes found may have been caused by sampling fluctuations at the time of DNA extraction and cloning as a result of the very low viral loads in the baboon sera.

Clinical and echocardiographic analysis of patients suffering from recurrent takotsubo cardiomyopathy

Background Recurrence of takotsubo cardiomyopathy （TTC） is a well-known complication. However, current literature lists only a few isolated cases. We aimed to determine the incidence and clinical significance of recurrent TTC. Methods ＆ Results Our institutional database constituted a collective of 114 patients diagnosed with TTC since 2003. Close follow-up of these patients revealed a recurrence of TTC in seven of these （6.1%）. The time interval between the index event and its recurrence varied between six months and six years. Arterial hypertension was more revealed in the recurrence group of TTC compared to non-recurrence group, （P = 0.02）. Chronic obstructive pulmo- nary disease and/or asthma was more diagnosed in the recurrence group, （P = 0.04）. Clinical events like fight ventficular involvement, TTC related complications such as life-threatening arrhythmias, pulmonary congestion and in hospital death were observed more frequently in the recurrent episode. Over a mean follow-up of one year the mortality rate was similar in both groups. Conclusions Recurrence of TTC within six years after index event is not an uncommon phenomenon. In the event of right ventricular involvement in the relapse phase, it might be associated with a higher complication rate. TTC recurrence should be the first differential diagnosis in patients with a past history of TTC.

Identification and Characterization of 43 Microsatellite Markers Derived from Expressed Sequence Tags of the Sea Cucumber (Apostichopus japonicus)

The sea cucumber Apostichopus japonicus is a commercially and ecologically important species in China. A total of 3056 potential unigenes were generated after assembling 7597 A. japonicus expressed sequence tags (ESTs) downloaded from Gen-Bank. Two hundred and fifty microsatellite-containing ESTs (8.18%) and 299 simple sequence repeats (SSRs) were detected. The average density of SSRs was 1 per 7.403 kb of EST after redundancy elimination. Di-nucleotide repeat motifs appeared to be the most abundant type with a percentage of 69.90%. Of the 126 primer pairs designed, 90 amplified the expected products and 43 showed polymorphism in 30 individuals tested. The number of alleles per locus ranged from 2 to 26 with an average of 7.0 alleles, and the observed and expected heterozygosities varied from 0.067 to 1.000 and from 0.066 to 0.959, respectively. These new EST-derived microsatellite markers would provide sufficient polymorphism for population genetic studies and genome mapping of this sea cucumber species.

New Exact Traveling Wave Solutions for Compound KdV-Type Equation with Nonlinear Terms of Any Order

The compound KdV-type equation with nonlinear terms of any order is reduced to the integral form. Using the complete discrimination system for polynomial, its all possible exact traveling wave solutions are obtained. Among those, a lot of solutions are new.

Identification and Analysis of SSRs Derived from Protein-coding Genes in Grape

SSR(Simple Sequence Repeats), also known as microsatellites or STRs(short tandem repeats), are a type of PCRbased markers. So far, the version of grape genome has been updated constantly, but SSRs derived from protein-coding genes in grape have not yet been identified. In this study, 4 337 SSR-containing genes were found among 29 971 protein-coding genes in grape(Vitis vinifera L.), and 5 384 SSRs were found. There were 96 types of repeat motifs in SSRs derived from protein-coding genes in grape, and the most frequently occurring repeat motif was A/T. Among various repeat motifs in dinucleotide SSRs, the most frequently occurring repeat motif was AG/CT. Moreover, many genes exhibited codon usage bias, which was affected by the mutation pressure. GO annotation, KEGG annotation and domain analysis of these genes were performed.Several genes were found to be closely related to the synthesis and metabolism of secondary metabolites, synthesis of flavones or anthocyanins, development and morphology of plant organs, and tolerance to biotic or abiotic stresses, including transcription factors in MYB, Hsf, NBS and TPC families. This study laid a solid foundation for the development of SSR markers and research of QTLs controlling complex agronomic traits in grape.

Combination of NMR spectroscopy and X-ray crystallography offers unique advantages for elucidation of the structural basis of protein complex assembly

NMR spectroscopy and X-ray crystallography are two premium methods for determining the atomic structures of macro-biomolecular complexes.Each method has unique strengths and weaknesses.While the two techniques are highly complementary,they have generally been used separately to address the structure and functions of biomolecular complexes.In this review,we emphasize that the combination of NMR spectroscopy and X-ray crystallography offers unique power for elucidating the structures of complicated protein assemblies.We demonstrate,using several recent examples from our own laboratory,that the exquisite sensitivity of NMR spectroscopy in detecting the conformational properties of individual atoms in proteins and their complexes,without any prior knowledge of conformation,is highly valuable for obtaining the high quality crystals necessary for structure determination by X-ray crystallography.Thus NMR spectroscopy,in addition to answering many unique structural biology questions that can be addressed specifically by that technique,can be exceedingly powerful in modern structural biology when combined with other techniques including X-ray crystallography and cryo-electron microscopy.