A physical isolation system based on PCI (peripheral component interconnect),embedded with intelligence card technology, strong identity authentication technology and securityaudit, etc., is introduced. The system can...A physical isolation system based on PCI (peripheral component interconnect),embedded with intelligence card technology, strong identity authentication technology and securityaudit, etc., is introduced. The system can physically isolate the internaland external networks. Thehardware of the system, including PCI interface control circuits, network interface circuits andlogic control circuits, is designed to automatically adapt its operation speed and mode to thenetwork and securely isolate the internal and external networks; the software of the system,including the security strategy management module, the security audit module, the database recordexchanging module, the file exchanging module and the mail exchanging module, is designed toefficiently exchange and manage the data transference between the internal and external networks.Also the driver of the system is implemented with Windows driver development kits (DDK) based onNetwork Driver Interface Specification (NDIS). The prototype ofthe system developed has beenemployed in the Police Fire Protection Bureau of Hubei Province, which performs consistently andefficiently. The technological cruxes discussed have practical values for related subjects.展开更多
The existing literature on innovation concentrates mostly on large industrial firms and high-technology industries, whereas, little attention has been given to agribusiness. Empirical evidence regarding the driving fo...The existing literature on innovation concentrates mostly on large industrial firms and high-technology industries, whereas, little attention has been given to agribusiness. Empirical evidence regarding the driving forces behind innovation in agribusinesses in developing countries, China in particular is scarce. This paper helps fill that void. It develops a framework in which innovation results from synergies between internal resources and external networks. This paper applies and tests the framework using 2003-2005 data from a panel survey of 32 leading agribusiness firms in Shandong Province, China. The empirical results indicate the importance of internal resources, external networks and the synergies between them. We find that R＆D expenditures and the number of technical employees are internal resources that are both important to product innovation. Surprisingly, management quality is negatively related to the possession of a unique technology and new products as a proportion of all products. It is possible that management quality is associated with more formalization and rigidity in decision-making, hindering creativity and lengthening the new product development cycle. In order to develop innovative products, our results suggest that investing in R＆D and hiring more technical staff may be more effective approaches than spending on managerial talent.展开更多
Salusins are regulatory peptides that affect cardiovascular function. We previously reported that salusin-a and -β protected cultured cardiomyocytes from serum deprivation-induced cell death through upregulating gluc...Salusins are regulatory peptides that affect cardiovascular function. We previously reported that salusin-a and -β protected cultured cardiomyocytes from serum deprivation-induced cell death through upregulating glucose-regulated protein 78 （GRP78）, an endoplasmic reticulum （ER） resident protein whose overexpression acts as a marker and suppressor of ER stress. The present study examined whether salusin-α and -β inhibit ER stress in ischemic myocardium. In a rat model of myocardial infarction created by ligating the left anterior descending coronary artery （LAD）, salusin-α or -β was intravenously injected at 5 or 15 nmol kg-1 15 min prior to 2 h of LAD occlusion. The high dose of salusin-α and -β3 significantly improved heart function and hemodynamics in LAD-occluded rats, but had no effects in sham-operated rats. The arrhythmias caused by LAD oc- clusion were markedly attenuated by salusin-α and -β. The apoptotic rate in ischemic myocardium was reduced from 31.5%±3.7% to 19.8%±2.2% and 12.3%±2.2%, and the infarct size was reduced from 53.4%±4.0% of the risk area to 26.5%±9.7% and 23.7%±8.9% by 15 nmol kg-1 salusin-α and -β, respectively. Furthermore, salusin-α and -β prevented the ac- tivation of GRP78 and ER stress-specific apoptotic effectors caspase-12 and CHOP （C/EBP homologous protein）, and attenu- ated the reduction of an ER stress-associated antiapoptotic protein Bcl-2 in ischemic cardiac tissue. The salusins also inhibited the ER stress induced by tunicamycin in cultured rat H9c2 cardiomyocytes. These results indicate that salusins protect myo- cardium against ischemic injury by inhibiting ER stress and ER stress-associated apoptosis.展开更多
文摘A physical isolation system based on PCI (peripheral component interconnect),embedded with intelligence card technology, strong identity authentication technology and securityaudit, etc., is introduced. The system can physically isolate the internaland external networks. Thehardware of the system, including PCI interface control circuits, network interface circuits andlogic control circuits, is designed to automatically adapt its operation speed and mode to thenetwork and securely isolate the internal and external networks; the software of the system,including the security strategy management module, the security audit module, the database recordexchanging module, the file exchanging module and the mail exchanging module, is designed toefficiently exchange and manage the data transference between the internal and external networks.Also the driver of the system is implemented with Windows driver development kits (DDK) based onNetwork Driver Interface Specification (NDIS). The prototype ofthe system developed has beenemployed in the Police Fire Protection Bureau of Hubei Province, which performs consistently andefficiently. The technological cruxes discussed have practical values for related subjects.
文摘The existing literature on innovation concentrates mostly on large industrial firms and high-technology industries, whereas, little attention has been given to agribusiness. Empirical evidence regarding the driving forces behind innovation in agribusinesses in developing countries, China in particular is scarce. This paper helps fill that void. It develops a framework in which innovation results from synergies between internal resources and external networks. This paper applies and tests the framework using 2003-2005 data from a panel survey of 32 leading agribusiness firms in Shandong Province, China. The empirical results indicate the importance of internal resources, external networks and the synergies between them. We find that R＆D expenditures and the number of technical employees are internal resources that are both important to product innovation. Surprisingly, management quality is negatively related to the possession of a unique technology and new products as a proportion of all products. It is possible that management quality is associated with more formalization and rigidity in decision-making, hindering creativity and lengthening the new product development cycle. In order to develop innovative products, our results suggest that investing in R＆D and hiring more technical staff may be more effective approaches than spending on managerial talent.
基金supported by the National Basic Research Program of China (Grant Nos. 2006CB503807 and 2009CB521902)the National Natural Science Foundation of China (Grant Nos. 30600763, 30870906, and 31071023)+2 种基金the Pujiang Project of Shanghai, China (Grant No.08PJ14001)the Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of China (Grant No. [2008]891)the Fund for Outstanding Young Teachers in Higher Education Institutions of Shanghai, China (Grant No.[2009]63)
文摘Salusins are regulatory peptides that affect cardiovascular function. We previously reported that salusin-a and -β protected cultured cardiomyocytes from serum deprivation-induced cell death through upregulating glucose-regulated protein 78 （GRP78）, an endoplasmic reticulum （ER） resident protein whose overexpression acts as a marker and suppressor of ER stress. The present study examined whether salusin-α and -β inhibit ER stress in ischemic myocardium. In a rat model of myocardial infarction created by ligating the left anterior descending coronary artery （LAD）, salusin-α or -β was intravenously injected at 5 or 15 nmol kg-1 15 min prior to 2 h of LAD occlusion. The high dose of salusin-α and -β3 significantly improved heart function and hemodynamics in LAD-occluded rats, but had no effects in sham-operated rats. The arrhythmias caused by LAD oc- clusion were markedly attenuated by salusin-α and -β. The apoptotic rate in ischemic myocardium was reduced from 31.5%±3.7% to 19.8%±2.2% and 12.3%±2.2%, and the infarct size was reduced from 53.4%±4.0% of the risk area to 26.5%±9.7% and 23.7%±8.9% by 15 nmol kg-1 salusin-α and -β, respectively. Furthermore, salusin-α and -β prevented the ac- tivation of GRP78 and ER stress-specific apoptotic effectors caspase-12 and CHOP （C/EBP homologous protein）, and attenu- ated the reduction of an ER stress-associated antiapoptotic protein Bcl-2 in ischemic cardiac tissue. The salusins also inhibited the ER stress induced by tunicamycin in cultured rat H9c2 cardiomyocytes. These results indicate that salusins protect myo- cardium against ischemic injury by inhibiting ER stress and ER stress-associated apoptosis.
