三七醇外敷治疗慢性肝病病人输液所致外周静脉炎

[目的 ]探讨三七醇外敷治疗慢性肝病病人输液所致外周静脉炎的疗效。 [方法 ]将 10 2例因输液致外周静脉炎病人随机分为实验组和对照组 ,每组 5 1例 ,实验组采用三七醇外敷 ,对照组采用硫酸镁外敷 ,观察受损静脉恢复情况。 [结果 ]经2个疗程治疗 ,实验组受损静脉恢复明显优于对照组 (P <0 .0 0 1)。[结论

锁骨下静脉置管化疗病人局部毒性反应临床观察

[目的]预防和减少化疗药物致局部毒性反应的发生。[方法]对320例肿瘤化疗病人随机分为观察组和对照组各160例,观察组采用锁骨下静脉置管化疗,对照组采用外周静脉留置针化疗,观察两组沿静脉走向区域局部毒性反应情况。[结果]对照组出现局部毒性反应发生率为75%,观察组局部毒性反应发生率为0。两组比较,χ2=192,P<0.01。[结论]锁骨下静脉穿刺置管化疗优于外周静脉化疗,但掌握好局部解剖位置和操作要领是锁骨下静脉置管成功的关键。

精索静脉曲张切除术对血浆氧化应激指标的影响

Aim of Study: This study evaluates the long-term effect of varicocelectomy as measured by plasma oxidative stress parameters. Methods: Eleven children aged 10 to 16 years presented with left-sided varicocele and ipsilateral testicular hypoplasia. Peripheral blood samples for C-reactive protein,basal thiobarbituric acid reactive substances (TBARS),and plasma peroxidation susceptibility (lag time and slope) were obtained preoperatively and at 1 year after the varicocelectomy. All patients underwent inguinal microvascular varicocelectomy with testicular-inferior epigastric (spermatic-epigastric) venous shunt,and a blood sample from the pampinous plexus was taken. Student’ s t test for unpaired and paired data was used with a level of significance set at P < 0.05. Results: When compared with controls,the cohort preoperative basal TBARS (mean,2.07 nmol/mL; SD,0.56 nmol/mL) were higher (P = 0.009),and plasma peroxidation susceptibility lag time (mean,132.92 minutes; SD,32.8 minutes) was lower (P = 0.0002). Blood samples from the pampiniform plexus showed similar results. Peroxidative plasma levels were significantly reduced on peripheral venous specimens taken 1 year after varicocelectomy with mean (SD)TBARS of 1.53 (0.41) nmol/mL(P = 0.0003) and mean (SD) lag time of 183.7 (17.46) minutes (P = 0.0025). The slope did not show significant changes compared with controls,or before and after surgery. Conclusion: Peroxidative plasma levels were significantly reduced 1 year after surgery,indicating that surgical varicocelectomy with construction of venous shunt reduces oxidative stress.

Adaptation and validation of pediatric peripheral intravenous catheter insertion and care practices audit tools

Objectives:This study aimed to describe the translation process and establish the validity of the three instruments in Indonesian to assess pediatric peripheral intravenous catheter(PIVC)insertion and care practices.Methods:The six-step forward and backward translation method was used to translate the adapted questionnaires.The English version questionnaires included the point prevalence audit checklist,the nurse survey consisting of the nurse PIVC knowledge questionnaire and the nurse PIVC confidence questionnaire,plus a Patient/parent Experience Survey.Data collection was conducted in Indonesia between October 2019 and February 2020.In total,there were six translators(two for each instrument),nine-panel vascular access experts(three for each instrument),and 30 participants(ten for each in-strument)of the target population involved in the translation and validation of the three instruments.Three-panel experts rated the content relevance of each instrument using a four-point rating scale.Item level and scale level content validity index and kappa index were calculated.Ten-panel members of the target population evaluated each questionnaire regarding feasibility,clarity,logical sequence,and formatting.Qualitative comments from the panel were also reviewed.Results:The translation process indicated relatively low discrepancies between translators except for semantic equivalence.There were nine,eight,and one semantic discrepancies found in the forward translation of the point prevalence audit checklist,nurse survey,and patient/parent experience survey.The semantic discrepancies were less prevalent in the backward translation,with only one,three,and two items reported during the process.The item validity index for all of the three instruments showed relatively high agreement between experts(I-CVI>0.78,S-CVI/Ave>0.90,S-CVI/UA>0.70,and kappa index>0.74).The face validity was established with the panel reporting that the three instruments were easy to understand and presented logically.However,some re-formatting of the nurse survey and pa-tient/parent experience survey were needed to avoid ambiguity and confusion for the participants.Conclusions:The results indicate that the translated three survey instruments that had been widely used in other developed countries show good content validity in the Indonesian context.They can be used as a reference for further testing in different countries and contribute to understanding the pediatric PIVC audit tools used in future clinical research.

Pharmacokinetic comparison between ultraselection of uterine artery and peripheral vein chemotherapy of carboplatin in cervical cancer

Objective:The present study is to compare pharmacokinetics difference of carboplatin by using ultraselection uterine artery with by using peripheral vein in cervical cancer.Methods:Thirteen patients with locally advanced cervical cancer who had been proved by pathobiology were randomly divided into two groups:the ultraselection uterine artery group(group A, n = 6) and the peripheral vein(group B, n = 7).Carboplatin was administered by infusing into artery or vein in both groups at the dosage of 300 mg/m2.Tissues from the cervical tumor were collected at different times after infusion in both groups and then analyzed.Results:The peak concentration of platinum in tumor tissue was about 2.79 times higher in group A than that of group B(P < 0.05).The platinum concentrations in tumor in group A reached its peak levels immediately after infusion.But, group B had delayed time.While, for the time point of 0 min, when the administration finished immediately, the platinum concentration in tumor was significantly higher when compared with group B(P < 0.05).The tumor tissue area under the concentration(AUC) of carboplatin was about 2 times higher in group A than that of group B(P < 0.05).Conclusion:We observed the pharmacological advantages of chemotherapy by using ultraselection uterine artery administration of chemotherapeutic agent carboplatin in tumor tissue which provided theoretical basis and laboratory parameters of the intra-arterial chemotherapy for gynecologic malignancy.

ANTI-INFLAMMATORY EFFECTS OF MAGNOLIAE FARGESII VOLATILE OIL

Objective To explore the anti-inflammatory effects of magnoliae fargesii volatile oil.Methods Human umbilical vein endothelial cells (HUVECs) were stimulated by TNF-α to express the adhesion molecules. Then the anti-adhesion effects of magnoliae fargesii volatile oil between HUVECs and human peripheral neutrophils were observed. The ischemia-reperfusion animal models were established by 60min renal ischemia followed by 1, 3, 6 and 24h reperfusion. Rats were randomly divided into the following groups: the sham-operation controls, ischemic group only treated with normal saline, and treated group infused magnoliae fargesii volatile oil before reperfusion. Then the renal injury of rats was detected. Results High rate of cell adhesion between HUVECs and neutrophils was observed. Magnoliae fargesii volatile oil could inhibit the adhesion process at the concentration of 0.5μL/mL (191.6±8.6), 1.0μL/mL (158.2±9.0) and 2.0μL/mL (155.2±9.7) (P<0.05). The anti-adhesion effects were strengthened with the increase of volatile oil concentration. Blood urea nitrogen and creatinine levels of the animal models were significantly increased after 24h reperfusion while the increase was remarkably attenuated by the treatment with magnoliae fargesii volatile oil. The renal injury was severe after 1h reperfusion, which was significantly attenuated by the treatment of magnoliae fargesii volatile oil. Conclusion Magnoliae fargesii volatile oil has anti-inflammatory effects.

Efficiency and therapeutic effect of modified pigtail probe in anastomosing lacerated lacrimal canaliculus

Objective： To investigate the necessity of modification to the traditional pigtail probe and evaluate its efficiency and therapeutic effect in searching the nasal cut ends and anastomosing the lacerated lacrimal canaliculus. Methods： Eighty-seven patients （including 87 eyes） suffering from canalicular laceration were randomized into two groups： 41 patients treated with traditional pigtail probes （Group A） and 46 with modified pigtail probes （Group B）. During the reconstruction of the lacerated canaliculi, the traditional pigtail probe and the modified pigtail probe were used respectively to seek for the nasal cut ends of lacerated lacrimal canaliculi. Peripherally inserted central catheter （PICCTM） silicone tube with diameter of 0.95 mm was intubated as a stent for 4-6 months. The surgical outcomes were retrospectively analyzed after stent removal. Results： In Group B, the primary success rate of searching the nasal cut ends of lacerated lacrimal canaliculi was 93.48% （43/46） and the final success rate was 97.83% （45/46）. No false passage formed in Group B. Statistical sig- nificance was found between Group A and Group B as the primary success rates of searching the nasal cut ends （ x^2 = 10.522, P〈0.01） and the false passage forming rates were concerned （ x^2=4.704, P〈0.05）, whereas no significance was found between the two groups as the final success rates were concerned （ x^2=0.007, P〉0.05）. The mean time of searching the nasal cut ends of lacerated lacrimal canaliculi in Group B was （5.02±2.73） minutes and the mean time of operation was （33.90±4.84） minutes, and both were significantly shorter than those of Group A （t1=9.779, t2=10.700, P〈0.01）. The cure rate of Group B was 95.65%, though higher than that of Group A, no statistical significance was found （Z=-1.007, P〉0.05）. Totally, 2 patients （2.30%） were found to be absent of common canaliculus and underwent bicanalicular nasal intubation in the two groups. Conclusions： Pigtail probes are efficient and convenient apparatus for searching the nasal cut ends of the lacerated lacrimal canaliculi in the reconstruction of canalicular laceration. Necessary or proper modifications to the pigtail probes can minimize the risk of iatrogenic damages or complications and enhance the efficiency and therapeutic effect of canalicular repair.