手性溶液萃取分离氧氟沙星对映体

目的 研究氧氟沙星对映体在手性环境中的萃取分配行为 ,为外消旋体膜萃取拆分提供理论和设计依据。方法 以 0 2 5mol·L- 1 L 二苯甲酰酒石酸醇溶液为有机相 ,含 0 14g·L- 1 氧氟沙星的 0 1mol·L- 1 磷酸氢二钠 磷酸缓冲液为水相 ,考察了pH对氧氟沙星对映体在水 有机相分配系数 (k)和分离因子 (α)的影响 ,研究了不同碳数醇的溶剂化效应 ,同时运用中空纤维膜对氧氟沙星外消旋体进行初步分离。结果 以癸醇为溶剂 ,pH 6 86时 ,L 二苯甲酰酒石酸对氧氟沙星外消旋体萃取分配系数大于 4 7,α达 1 18;用中空纤维支载液膜双有机相逆流分级萃取技术 ,11个 2 2cm长膜器串联 ,产品光学纯度达 90 %以上。结论 L 二苯甲酰酒石酸在醇溶剂中对磷酸氢二钠缓冲液中的RS 氧氟沙星对映体有较强的立体选择性 ,其中癸醇的效果最好 ,pH对k和α有较大影响 ,综合k和α值 ,取pH6 86时 ,手性萃取效果最佳 ;利用高效中空纤维膜 ,可使RS氧氟沙星对映体得到不同程度的分离。

Hollow fiber liquid-supported membrane technology for enantioseparation of racemic salbutamol by combinatorial chiral selectors

Enantioseparation of salbutamol solute was carried out in liquid-supported membrane by using a polyvinylidene fluoride hollow-fiber module. The enantioselective transport of solute was facilitated by combinatorial chiral selectors, which were dissolved in toluene organic solvent. The effects of molar concentration ratios of salbutamol to combinatorial chiral selectors, and the pH value of buffer solution on enantioseparation were investigated. The results show that when the molar concentration ratio is 2∶1∶1, the maximum separation factor and enantiomer excess are 1.49 and 19.74%, respectively, and the R-enantiomer flux is more than S-enantiomer; the pH value of buffer solution influences the performances of enantioseparartion obviously, and the appropriate range of pH value is 7.07.2.