目的:探讨动静脉内瘘(AVF)失功后介入手术的治疗方法,评估其治疗效果及应用价值。方法:回顾性分析自2006年4月—2015年1月行介入手术治疗的20例自体AVF失功患者的临床资料。结果:20例患者中,16例经静脉端造影,4例经股动脉-主动脉-腋动...目的:探讨动静脉内瘘(AVF)失功后介入手术的治疗方法,评估其治疗效果及应用价值。方法:回顾性分析自2006年4月—2015年1月行介入手术治疗的20例自体AVF失功患者的临床资料。结果:20例患者中,16例经静脉端造影,4例经股动脉-主动脉-腋动脉路径造影;单纯吻合口狭窄4例,行球囊扩张后狭窄明显改善;吻合口狭窄伴血栓形成有5例,切开取栓后再行球囊扩张治疗;静脉端血栓形成3例,切开取栓后返血良好;静脉端狭窄合并血栓形成7例,行切开取栓后再行球囊扩张治疗;头静脉长段闭塞1例,改用人工血管行AVF术。术后全部患者经该血管通路恢复透析治疗,透析时流量均>200 m L/min。共17例患者获得随访,平均随访时间13.2个月,12个月通畅率为47.1%。结论:介入导管技术在治疗AVF失功方面是安全、有效的。展开更多
Objective: To investigate the effect of Shen-Fu (SF) injection on gastrointestinal tract injury and its potential mechanism.Methods: Thirty-eight patients undergoing elective open heart surgery were assigned to Group ...Objective: To investigate the effect of Shen-Fu (SF) injection on gastrointestinal tract injury and its potential mechanism.Methods: Thirty-eight patients undergoing elective open heart surgery were assigned to Group C (control group, n = 18) and Group SF (n = 20) randomly. In Group SF, the patients received intravenous injection of SF (0.5 ml/kg) at the beginning of the surgery followed by a continuous infusion of 100 ml SF (1.0 ml/kg) solution diluted by saline at a rate of 0.004 ml · Kg-1 · min-1 with a Grasby pump. The control group was injected with normal saline in the same volume. Gastric intramucosal pH (pHi), activity of blood diamine oxidase ( DAO ), and concentrations of blood LPS and IL-6 were measured before CPB ( S0) and 1 h ( S1 ) and 2 h ( S2) after aortic declamping, respectively.Results: In Group C, pHi value was significantly lower at S1 and S2 than at S0 ( mean P <0.01) and blood DAO and concentrations of LPS and IL-6 were significantly higher at S1 and S2 than at S0 ( meanP < 0.01). In Group SF, pHi was obviously lower at S1 and S2 than at S0(P< 0.05) but LPS and IL-6 levels and DAO were higher at S, (mean P<0.05). Blood DAO and LPS level demonstrated significant negative correlations with pHi ( mean P < 0.01) while LPS concentration showed a positive correlation with blood DAO (P < 0.01) and IL-6 concentration (P < 0.05). At S1 and S2 after aortic declamping, the levels of pHi were higher in Group SF than in Group C (mean P <0.01 ) but DAO and LPS and IL-6 levels were significantly lower in Group SF than in Group C ( P <0.01).Conclusions: SF has a protective effect on gastrointestinal tract and can reduce inflammatory actions.展开更多
文摘目的:探讨动静脉内瘘(AVF)失功后介入手术的治疗方法,评估其治疗效果及应用价值。方法:回顾性分析自2006年4月—2015年1月行介入手术治疗的20例自体AVF失功患者的临床资料。结果:20例患者中,16例经静脉端造影,4例经股动脉-主动脉-腋动脉路径造影;单纯吻合口狭窄4例,行球囊扩张后狭窄明显改善;吻合口狭窄伴血栓形成有5例,切开取栓后再行球囊扩张治疗;静脉端血栓形成3例,切开取栓后返血良好;静脉端狭窄合并血栓形成7例,行切开取栓后再行球囊扩张治疗;头静脉长段闭塞1例,改用人工血管行AVF术。术后全部患者经该血管通路恢复透析治疗,透析时流量均>200 m L/min。共17例患者获得随访,平均随访时间13.2个月,12个月通畅率为47.1%。结论:介入导管技术在治疗AVF失功方面是安全、有效的。
文摘Objective: To investigate the effect of Shen-Fu (SF) injection on gastrointestinal tract injury and its potential mechanism.Methods: Thirty-eight patients undergoing elective open heart surgery were assigned to Group C (control group, n = 18) and Group SF (n = 20) randomly. In Group SF, the patients received intravenous injection of SF (0.5 ml/kg) at the beginning of the surgery followed by a continuous infusion of 100 ml SF (1.0 ml/kg) solution diluted by saline at a rate of 0.004 ml · Kg-1 · min-1 with a Grasby pump. The control group was injected with normal saline in the same volume. Gastric intramucosal pH (pHi), activity of blood diamine oxidase ( DAO ), and concentrations of blood LPS and IL-6 were measured before CPB ( S0) and 1 h ( S1 ) and 2 h ( S2) after aortic declamping, respectively.Results: In Group C, pHi value was significantly lower at S1 and S2 than at S0 ( mean P <0.01) and blood DAO and concentrations of LPS and IL-6 were significantly higher at S1 and S2 than at S0 ( meanP < 0.01). In Group SF, pHi was obviously lower at S1 and S2 than at S0(P< 0.05) but LPS and IL-6 levels and DAO were higher at S, (mean P<0.05). Blood DAO and LPS level demonstrated significant negative correlations with pHi ( mean P < 0.01) while LPS concentration showed a positive correlation with blood DAO (P < 0.01) and IL-6 concentration (P < 0.05). At S1 and S2 after aortic declamping, the levels of pHi were higher in Group SF than in Group C (mean P <0.01 ) but DAO and LPS and IL-6 levels were significantly lower in Group SF than in Group C ( P <0.01).Conclusions: SF has a protective effect on gastrointestinal tract and can reduce inflammatory actions.
