An 87-year-old,Japanese woman was shown to have a submucosal tumor-like lesion with a deep,central ulceration covered with thick,whitish exudate in the stomach.Biopsy showed Candida tropicalis but not Helicobacter pyl...An 87-year-old,Japanese woman was shown to have a submucosal tumor-like lesion with a deep,central ulceration covered with thick,whitish exudate in the stomach.Biopsy showed Candida tropicalis but not Helicobacter pylori(H.pylori).She had no predisposing factors or history of peptic ulcers nor had taken non-steroidal anti-inflammatory drugs(NSAIDs),diagnosed with Candida-associated gastric ulcer.Though cured of the lesion,she developed another ulcer in a different position,in which Candida was demonstrated but H.pylori was undetectable.This is the first case of recurrent Candida-associated gastric ulcer in the world.Detected in both the original and recurrent lesions in an H.pylori-negative patient with no antecedent ulcers who had not taken NSAIDs,Candida is considered,contrary to the prevailing opinion,to play an etiologic role in ulcer formation.展开更多
AIM:To clarify the characteristic features of biliary le-sions in patients with autoimmune pancreatitis(AIP) and compare them with those of primary sclerosing cholangitis(PSC) .METHODS:The clinicopathological characte...AIM:To clarify the characteristic features of biliary le-sions in patients with autoimmune pancreatitis(AIP) and compare them with those of primary sclerosing cholangitis(PSC) .METHODS:The clinicopathological characteristics of 34 patients with sclerosing cholangitis(SC) associated with AIP were compared with those of 4 patients with PSC.RESULTS:SC with AIP occurred predominantly in el-derly men.Obstructive jaundice was the most frequent initial symptom in SC with AIP.Only SC patients with AIP had elevated serum IgG4 levels,and sclerosing diseases were more frequent in these patients.SC pa-tients with AIP responded well to steroid therapy.Seg-mental stenosis of the lower bile duct was observed only in SC patients with AIP,but a beaded and pruned-tree appearance was detected only in PSC patients.Dense infi ltration of IgG4-positive plasma cells was de-tected in the bile duct wall and the periportal area,as well as in the pancreas,of SC patients with AIP.CONCLUSION:SC with AIP is distinctly different from PSC.The two diseases can be discriminated based on cholangiopancreatographic findings and serum IgG4 levels.展开更多
The first humans （hominids） appeared at about the same geological time in three independent areas： in East Africa, southern Indochina and in the Kazakh steppe. People inhabiting all continents and countries around ...The first humans （hominids） appeared at about the same geological time in three independent areas： in East Africa, southern Indochina and in the Kazakh steppe. People inhabiting all continents and countries around the world descended from hominids that emerged in these three foci then resided elsewhere. The number of people emerged 2-3 million years ago now about 7.0 billion people. They inhabit the planet and the master space. Kazakh steppe, located in the middle of the Eurasian continent, has always had a positive impact on neighboring countries. According to historical geological data obtained in the south near the ridge Karatau, the first people emerged on the territory of Kazakhstan were found about 2 million years ago. Such a conclusion was made on the basis of residual cultural pebble tools of hominids, founded by scientists. As a result of geological survey work carried out in the 1960＇s there were found some primitive people, starting with the era of＂Arystandy culture＂ and including the Late Paleolithic era in the area of ridges Big and Small Karatau. There had been found the fossil remains of large mammals hunted by hominids around the sites of ancient people. Thanks for these residues the corresponding time of residence of primitive people can be judged from the animal world of the Kazakh steppe.展开更多
文摘An 87-year-old,Japanese woman was shown to have a submucosal tumor-like lesion with a deep,central ulceration covered with thick,whitish exudate in the stomach.Biopsy showed Candida tropicalis but not Helicobacter pylori(H.pylori).She had no predisposing factors or history of peptic ulcers nor had taken non-steroidal anti-inflammatory drugs(NSAIDs),diagnosed with Candida-associated gastric ulcer.Though cured of the lesion,she developed another ulcer in a different position,in which Candida was demonstrated but H.pylori was undetectable.This is the first case of recurrent Candida-associated gastric ulcer in the world.Detected in both the original and recurrent lesions in an H.pylori-negative patient with no antecedent ulcers who had not taken NSAIDs,Candida is considered,contrary to the prevailing opinion,to play an etiologic role in ulcer formation.
文摘AIM:To clarify the characteristic features of biliary le-sions in patients with autoimmune pancreatitis(AIP) and compare them with those of primary sclerosing cholangitis(PSC) .METHODS:The clinicopathological characteristics of 34 patients with sclerosing cholangitis(SC) associated with AIP were compared with those of 4 patients with PSC.RESULTS:SC with AIP occurred predominantly in el-derly men.Obstructive jaundice was the most frequent initial symptom in SC with AIP.Only SC patients with AIP had elevated serum IgG4 levels,and sclerosing diseases were more frequent in these patients.SC pa-tients with AIP responded well to steroid therapy.Seg-mental stenosis of the lower bile duct was observed only in SC patients with AIP,but a beaded and pruned-tree appearance was detected only in PSC patients.Dense infi ltration of IgG4-positive plasma cells was de-tected in the bile duct wall and the periportal area,as well as in the pancreas,of SC patients with AIP.CONCLUSION:SC with AIP is distinctly different from PSC.The two diseases can be discriminated based on cholangiopancreatographic findings and serum IgG4 levels.
文摘The first humans （hominids） appeared at about the same geological time in three independent areas： in East Africa, southern Indochina and in the Kazakh steppe. People inhabiting all continents and countries around the world descended from hominids that emerged in these three foci then resided elsewhere. The number of people emerged 2-3 million years ago now about 7.0 billion people. They inhabit the planet and the master space. Kazakh steppe, located in the middle of the Eurasian continent, has always had a positive impact on neighboring countries. According to historical geological data obtained in the south near the ridge Karatau, the first people emerged on the territory of Kazakhstan were found about 2 million years ago. Such a conclusion was made on the basis of residual cultural pebble tools of hominids, founded by scientists. As a result of geological survey work carried out in the 1960＇s there were found some primitive people, starting with the era of＂Arystandy culture＂ and including the Late Paleolithic era in the area of ridges Big and Small Karatau. There had been found the fossil remains of large mammals hunted by hominids around the sites of ancient people. Thanks for these residues the corresponding time of residence of primitive people can be judged from the animal world of the Kazakh steppe.
