Integrin-mediated adhesions play critical roles in diverse cell functions. Integrins offers a platform on which mechanical stimuli, cytoskeletal organization, biochemical signals can concentrate. Mechanical stimuli tr...Integrin-mediated adhesions play critical roles in diverse cell functions. Integrins offers a platform on which mechanical stimuli, cytoskeletal organization, biochemical signals can concentrate. Mechanical stimuli transmitted by integrins influence the cytoskeleton, in turn, the cytoskeleton influences cell adhesion via integrins, then cell adhesion results in a series of signal transduction cascades. In skeleton, integrins also have a key role for bone resoption by osteoclasts and reformation by osteoblasts. In present review, the proteins involved in integrin signal transduction and integrin signal transduction pathways were discussed, mainly on the basic mechanisms of integrin signaling and the roles of integrins in bone signal transduction, which may give insight into new therapeutic agents to all kinds of skeletal diseases and new strategies for bone tissue engineering.展开更多
The general relativistic frame dragging effect on the properties,such as the moments of inertia and the radiiof gyration of fast rotating neutron stars with a uniform strong magnetic field,is calculated accurate to th...The general relativistic frame dragging effect on the properties,such as the moments of inertia and the radiiof gyration of fast rotating neutron stars with a uniform strong magnetic field,is calculated accurate to the first orderin the uniform angular velocity.The results show that compared with the corresponding non-rotating static sphericalsymmetric neutron star with a weaker magnetic field,a fast rotating neutron star(millisecond pulsar)with a strongermagnetic field has a relative smaller moment of inertia and radius of gyration.展开更多
An experimental investigation is carded out to study fluid flow and heat transfer characteristics on the endwall fitted with arrays （ 7 × 7 ） of short rectangular plate fins of different pattern （co-angular an...An experimental investigation is carded out to study fluid flow and heat transfer characteristics on the endwall fitted with arrays （ 7 × 7 ） of short rectangular plate fins of different pattern （co-angular and zigzag） for different pitch ratio. Experiments were conducted in a rectangular duct of 50 mm height for an air flow of Reynolds number ranged from 18750 to 62500 based on the equivalent diameter and air velocity of the duct. Infrared image analysis technique was employed to make clear the characteristics of local heat transfer coefficients on fin base, endwall and overall surface. Flow pattern around the short rectangular plates were visualized by inducing fluorescent dye in a water channel and longitudinal vortices were observed. Increasing the distance between plates in flow direction causes heat transfer enhancement for co-angular pattern, while decreasing the distance causes heat transfer enhancement for zigzag pattern. Zigzag pattern with pitch ratio 2 is found to be more effective in heat transfer enhancement than any other cases investigated.展开更多
文摘Integrin-mediated adhesions play critical roles in diverse cell functions. Integrins offers a platform on which mechanical stimuli, cytoskeletal organization, biochemical signals can concentrate. Mechanical stimuli transmitted by integrins influence the cytoskeleton, in turn, the cytoskeleton influences cell adhesion via integrins, then cell adhesion results in a series of signal transduction cascades. In skeleton, integrins also have a key role for bone resoption by osteoclasts and reformation by osteoblasts. In present review, the proteins involved in integrin signal transduction and integrin signal transduction pathways were discussed, mainly on the basic mechanisms of integrin signaling and the roles of integrins in bone signal transduction, which may give insight into new therapeutic agents to all kinds of skeletal diseases and new strategies for bone tissue engineering.
基金National Natural Science Foundation of China under Grant Nos.10647116 and 10575140the China Postdoctoral Science Foundation under Grant No.2005037175
文摘The general relativistic frame dragging effect on the properties,such as the moments of inertia and the radiiof gyration of fast rotating neutron stars with a uniform strong magnetic field,is calculated accurate to the first orderin the uniform angular velocity.The results show that compared with the corresponding non-rotating static sphericalsymmetric neutron star with a weaker magnetic field,a fast rotating neutron star(millisecond pulsar)with a strongermagnetic field has a relative smaller moment of inertia and radius of gyration.
文摘An experimental investigation is carded out to study fluid flow and heat transfer characteristics on the endwall fitted with arrays （ 7 × 7 ） of short rectangular plate fins of different pattern （co-angular and zigzag） for different pitch ratio. Experiments were conducted in a rectangular duct of 50 mm height for an air flow of Reynolds number ranged from 18750 to 62500 based on the equivalent diameter and air velocity of the duct. Infrared image analysis technique was employed to make clear the characteristics of local heat transfer coefficients on fin base, endwall and overall surface. Flow pattern around the short rectangular plates were visualized by inducing fluorescent dye in a water channel and longitudinal vortices were observed. Increasing the distance between plates in flow direction causes heat transfer enhancement for co-angular pattern, while decreasing the distance causes heat transfer enhancement for zigzag pattern. Zigzag pattern with pitch ratio 2 is found to be more effective in heat transfer enhancement than any other cases investigated.
