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喹诺酮类抗菌剂的三维构效关系和受体图形
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作者 刘明亮 《国外医药(抗生素分册)》 CAS 1998年第2期130-134,共5页
<正>众所周知,Koga等曾对符合结构式1的71个喹诺酮化合物进行QSAR研究,从而得出了一个从统计学意义看的最佳相关方程(方程1).此方程用对大肠杆菌NIHJ的MIC(mol/L)为生物活性指标.L_1表示R_1长度的Verloop’s STERIMOL参数.E_3~6 ... <正>众所周知,Koga等曾对符合结构式1的71个喹诺酮化合物进行QSAR研究,从而得出了一个从统计学意义看的最佳相关方程(方程1).此方程用对大肠杆菌NIHJ的MIC(mol/L)为生物活性指标.L_1表示R_1长度的Verloop’s STERIMOL参数.E_3~6 表示R_6的Taft-Kutter-Hansch立体参数(E_(?)).∑π_(6,7,8)表示R_6、R_7和R_8三个取代基的疏水常数(π’S)之和,该参数的二次方(∑π_(6,7,8))~2似乎与化合物转运至作用部位(s)的疏水效应有关.I_7是一个与R_7相关的指示变量,当R_7=H时为0,否则用一个单位表示.I_(7n-co)是另一个指示变量.当7—氨基取代的骨架上有酰基时用一个单位表示,否则为0.B_4~8是R_8的STERIMOL参数,它表示相对于R_1垂直方向上的R_8的最大宽度(R_7 —边).∑∏_(6,7,8)表示R_6、R_7和R_8三个取代基的Swain-Lup-ton-Hansch诱导电性参数(F’_2)之和. 展开更多
关键词 喹诺酮 三维构效 多体图形
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Office Furniture Design for Wheelchair User
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作者 Francisca Jose Castillo Rueda Oscar David de Cozar Macias Maria del Carmen Ladron de Guevara Munoz Jose Ignacio Jimenez Gonzalez Elidia Beatriz Blazquez Parra 《Journal of Civil Engineering and Architecture》 2012年第11期1482-1491,共10页
There are an estimated 1.19 million wheelchair users in Spain. People use wheelchairs for a variety of reasons, the most common one is paralysis from spinal cord injuries. Current estimates indicate there are around 5... There are an estimated 1.19 million wheelchair users in Spain. People use wheelchairs for a variety of reasons, the most common one is paralysis from spinal cord injuries. Current estimates indicate there are around 504,000 people alive in Spain with spinal cord injuries. Among other reasons for using wheelchairs are: fatigue from multiple sclerosis, muscle weakness from muscular dystrophy, lower limb spasticity from cerebral palsy, and missing limbs due to amputation. People who use wheelchairs may encounter a variety of obstacles at their workstations depending on their limitations. Some possible accommodations could be adjustable height desk or table for a person who cannot work comfortably at an existing desk, accessible filing system or office supplies, and frequently used materials on most accessible shelves or drawers for a person who cannot reach upper and lower shelves and drawers. This paper presents the graphical design of a workstation for wheelchair users, in this case, technical, anthropometric, ergonomic, aesthetics and scientists aspects have been analyzed. The design of composite structure conduct to explicit safety constraints applied to office furniture requirements kept continuously current and updated as part of innovation. Finally, results are showed in a three-dimensional model. 展开更多
关键词 Computers graphics furniture design wheelchair users ERGONOMIC
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