In order to improve the performance of the attribute reduction algorithm to deal with the noisy and uncertain large data, a novel co-evolutionary cloud-based attribute ensemble multi-agent reduction(CCAEMR) algorith...In order to improve the performance of the attribute reduction algorithm to deal with the noisy and uncertain large data, a novel co-evolutionary cloud-based attribute ensemble multi-agent reduction(CCAEMR) algorithm is proposed.First, a co-evolutionary cloud framework is designed under the M apReduce mechanism to divide the entire population into different co-evolutionary subpopulations with a self-adaptive scale. Meanwhile, these subpopulations will share their rewards to accelerate attribute reduction implementation.Secondly, a multi-agent ensemble strategy of co-evolutionary elitist optimization is constructed to ensure that subpopulations can exploit any correlation and interdependency between interacting attribute subsets with reinforcing noise tolerance.Hence, these agents are kept within the stable elitist region to achieve the optimal profit. The experimental results show that the proposed CCAEMR algorithm has better efficiency and feasibility to solve large-scale and uncertain dataset problems with complex noise.展开更多
Tea is one of the most popular beverages, consumed by over two thirds of the world’s population; but the aluminum accumulation property of tea plant is becoming the focus of many researches because of aluminum’s kn...Tea is one of the most popular beverages, consumed by over two thirds of the world’s population; but the aluminum accumulation property of tea plant is becoming the focus of many researches because of aluminum’s known adverse effect on human health. Investigation of the interactions of catechins with Al3+ showed that during the interaction of catechins with Al3+, the UV-vis spectrum of catechins was changed. Absorption of EGCG at 274 nm decreased and increased at 322 nm; EC and C’s at 278 nm changed little. The ratio of Al3+ to EGCG was 1:1 in pH 5.0 buffer solution; in pH 6.2 buffer solution, the ratio in the Al-EGCG complex was 1:1. Interestingly, while the ratio reached to over 2, after the complex of Al-EGCG started polymerization, the ratio in the polymer was 2:1. In pH 6.2 buffer solution, the complex behavior of C with Al3+ was the same as that of EGCG, with a little difference for EC. When the ratio of Al3+ to EC was <1, the complex in ratio was 1:2, but, the complex polymerized when the ratio of Al3+ to EC was >1. It was found that the ratio of Al3+ to EC in the polymer was 1:1. Polymerization of Al-catechin complexes might reduce aluminum absorption in the intestine. Kow value was also employed to study the properties of aluminum species in tea infusion (at gastric and intestine pH condition) and the effect of catechins and tea polyphenols on Kow in buffer solution. Results showed that Kow value rose much higher at the intestine pH than at the gastric pH. Tea polyphenols and catechins could greatly reduce aluminum Kow value in acetic buffer, indicating that these compounds may reduce aluminum absorption during tea intake.展开更多
Purpose: The purpose of this study was to investigate the impact of acute exercise on reaction time and response preparation during a Go/No Go Task in children with attention deficit hyperactivity disorder (ADHD). ...Purpose: The purpose of this study was to investigate the impact of acute exercise on reaction time and response preparation during a Go/No Go Task in children with attention deficit hyperactivity disorder (ADHD). Methods: Nineteen children with ADHD (aged between 8 and 12 years old) undertook a 30-min intervention that consisted of treadmill running or video-watching presented in a counterbalanced order on different days. A Go/No Go Task was administrated after exercise or video-watching. Results: The results indicated a shorter reaction time and smaller contingent negative variation (CNV) 2 amplitude following exercise relative to the video-watching. For event related potential (ERP) analyses, greater CNV l and CNV 2 amplitudes in response to No Go stimuli in com- parison to Go stimuli was observed in the video-watching session only. Conclusion: These findings suggest that acute exercise may benefit children with ADHD by developing appropriate response preparation, particularly in maintaining a stable motor preparatory set prior to performing the given task.展开更多
Background: Attention deficit hyperactivity disorder (ADHD) is a common childhood disorder that affects approximately 11% of children in the United States. Research supports that a single session of exercise benefi...Background: Attention deficit hyperactivity disorder (ADHD) is a common childhood disorder that affects approximately 11% of children in the United States. Research supports that a single session of exercise benefits cognitive performance by children, and a limited number of studies have demonstrated that these effects can also be realized by children with ADHD. The purpose of this study was to examine the effect of acute exercise on cognitive performance by children with and without ADHD. Methods: Children with and without ADHD were asked to perform cognitive tasks on 2 days following treatment conditions that were assigned in a random, counterbalanced order. The treatment conditions consisted of a 30-min control condition on 1 day and a moderate intensity exercise condition on the other day. Results: Exercise significantly benefited performance on all three conditions of the Stroop Task, but did not significantly affect performance on the Tower of London or the Trail Making Test. Conclusion: children with and without ADHD realize benefits in speed of processing and inhibitory control in response to a session of acute exercise, but do not experience benefits in planning or set shifting.展开更多
AIM: To create a rabbit model of pediatric nonalcoholic steatohepatitis (NASH) and to evaluate the role of adiponectin in the process. METHODS: Thirty-two specific pathogen-free male New Zealand rabbits were divid...AIM: To create a rabbit model of pediatric nonalcoholic steatohepatitis (NASH) and to evaluate the role of adiponectin in the process. METHODS: Thirty-two specific pathogen-free male New Zealand rabbits were divided randomly into three groups: (1) the normal control group (n = 10) was fed with standard diet for 12 wk; (2) the model group A (n = 11); and (3) model group B (n = 11) were fed with a highfat diet (standard diet + 10% lard + 2% cholesterol) for 8 and 12 wk, respectively. Hepatic histological changes were observed and biochemical parameters as well as serum levels of adiponectin, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α were measured. RESULTS: Typical histological hepatic lesions of NASH were observed in both model groups described as liver steatosis, liver inflammatory infiltration, cytologic ballooning, perisinusoidal fibrosis and overall fibrosis. Compared with the normal control group, there were significant increases in model groups A and B in weight gain (1097.2 ± 72.3, 1360.5± 107.6 vs 928.0 ±58.1, P 〈 0.05, P 〈 0.01), liver weight (93.81±6.64, 104.6±4.42 vs 54.4±1.71, P 〈 0.01), Lg (ALT) (1.9±0.29, 1.84± 0.28 vs 1.60±0.17, P 〈 0.01), and Lg (TG) (1.03 ±0.24, 1.16 ±0.33 vs 0.00 ±0.16, P 〈 0.01). Weight gain was much more in model group B than in model group A (1360.5± 107.6 vs 1097.2 ±72.3, P 〈 0.05). But, there was no significant difference between the two groups concerning the other indexes. Pro-inflammatory cytokines (IL-6 and TNF-α) increased in model group B compared with that of control and model group A (IL-6:1.86±0.21 vs 1.41 ±0.33, 1.38± 0.42, P 〈 0.01; TNF-α: 1.18±0.07 vs 0.66 ±0.08, 0.86 ±0.43, P 〈 0.01, P 〈 0.05), whereas serum adiponectin and IL-10 decreased in model groups compared with that in the control (adiponectin: A: 21.87±4.84 and B: 21.48 ±4.60 vs 27.36 ±7.29, P 〈 0.05. IL-10: A: 1.72± 0.38 and B: 1.83 ±0.39 vs 2.26±0.24, P 〈 0.01). Lg (TC) and the degree of liver fatty infiltration was an independent determinant of serum adiponectin level analyzed by stepwise multiple regressions, resulting in 29.4% of variances. CONCLUSION: This rabbit model produces the key features of pediatric NASH and may provide a realistic model for future studies. Adiponectin level partially reflects the severity of liver steatosis, but not the degree of liver inflammation.展开更多
The link between media culture and its real world effect has been a hot topic for many years. Many people believe that media have an obviously bad effect on children. More than 1000 studies conducted in the past 40 ye...The link between media culture and its real world effect has been a hot topic for many years. Many people believe that media have an obviously bad effect on children. More than 1000 studies conducted in the past 40 years show that excessive exposure to media violence causes the violent behavior in real life. Some other researches prove that media contain heavy messages that promote unhealthy habits or antisocial behaviors. This might be true. However, people often overstate the effects of media on children. Media are not the only elements that can lead to children's violence, antisocial behavior and bad habits. Other factors, like society, parents, communities, can also influence their behavior. In fact, if we can control the exposure to media in moderation, our children can benefit a lot from media culture.展开更多
AIM:To evaluate the role of genetic factors in the pathogenesis of idiopathic infant cholestasis.METHODS:We performed a case-control study,in-cluding 78 infants with idiopathic infant cholestasis and 113 healthy infan...AIM:To evaluate the role of genetic factors in the pathogenesis of idiopathic infant cholestasis.METHODS:We performed a case-control study,in-cluding 78 infants with idiopathic infant cholestasis and 113 healthy infants as controls.Genomic DNA was extracted from peripheral venous blood leukocytes us-ing phenol chloroform methodology.Polymerase chain reaction was used to amplify the multidrug resistance protein 3(MDR3)R652G fragment,and products were sequenced using the ABI 3100 Sequencer.RESULTS:The R652G single nucleotide polymorphism(SNP)was significantly more frequent in healthy infants(allele frequency 8.0%)than in patients(allele frequency 2.60%)(P < 0.05),odds ratio,0.29;95% confidence interval,0.12-0.84.The conjugated bilirubin in patients with the AG genotype was significantly lower than in those with the AA genotype(44.70 ± 6.15 μmol/L vs 95.52 ± 5.93 μmol/L,P < 0.05).CONCLUSION:MDR3 R652G is negatively correlated with idiopathic infant cholestasis.Children with the R652G SNP in Guangxi of China may have reduced susceptibility to infant intrahepatic cholestasis.展开更多
Objective : Evaluate the application values of ^99mTc-2 β [ N, N'-bis ( 2-mercaptoethyl ) ethylenediamiino ] methyl, 3 β -(4-chlorophenyl) tropane ( TRODAT-1 ) dopamine transporter (DAT) SPECT imaging in c...Objective : Evaluate the application values of ^99mTc-2 β [ N, N'-bis ( 2-mercaptoethyl ) ethylenediamiino ] methyl, 3 β -(4-chlorophenyl) tropane ( TRODAT-1 ) dopamine transporter (DAT) SPECT imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. Methods:Ten autistic children and ten healthy controls were examined with ^99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of ^99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striaturn and cerebellum [ ( STR-BKG)/BKG ]. Results : There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children ( P = 0. 562) and in normal controls ( P = 0. 573 ) ; dopamine transporter in brain of patients with autism increased more significantly than that in normal controls ( P = 0. 017). Conclusion : Dopaminergic nervous system is dysfunction in human brain with children autism, and DAT ^99mTc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children autism.展开更多
The main problems in three-dimensional gravity inversion are the non-uniqueness of the solutions and the high computational cost of large data sets. To minimize the high computational cost, we propose a new sorting me...The main problems in three-dimensional gravity inversion are the non-uniqueness of the solutions and the high computational cost of large data sets. To minimize the high computational cost, we propose a new sorting method to reduce fluctuations and the high frequency of the sensitivity matrix prior to applying the wavelet transform. Consequently, the sparsity and compression ratio of the sensitivity matrix are improved as well as the accuracy of the forward modeling. Furthermore, memory storage requirements are reduced and the forward modeling is accelerated compared with uncompressed forward modeling. The forward modeling results suggest that the compression ratio of the sensitivity matrix can be more than 300. Furthermore, multiscale inversion based on the wavelet transform is applied to gravity inversion. By decomposing the gravity inversion into subproblems of different scales, the non-uniqueness and stability of the gravity inversion are improved as multiscale data are considered. Finally, we applied conventional focusing inversion and multiscale inversion on simulated and measured data to demonstrate the effectiveness of the proposed gravity inversion method.展开更多
At present, the Portuguese education system promotes the development of new literacies in all education levels in response to new requirements of the digital world which imply changes in children's education. In fact...At present, the Portuguese education system promotes the development of new literacies in all education levels in response to new requirements of the digital world which imply changes in children's education. In fact, reading and writing are no longer limited exclusively to books, rather they are associated with diversified digital media integrating text, sound, image, and video. In this context, we developed an exploratory study in a kindergarten with the children and their family members. Data were collected through participant observation, children conversational interviews, and digital narratives produced by children. Data analysis is based on content analysis with NVivo software support. The emergence of literacy is evident in verbal interactions in peer-group work, in contact with the written text, in "writing" in various media, and in sharing knowledge, discoveries, and digital narratives produced in an online community (http://janelajardim.ning.com). This paper presents: (1) a systematic literature review in the field of digital narrative and emergent literacy; (2) the description of children's activities concerning interactive multimodal narrative; (3) the results of this work; and (4) the conclusion about contribution of multimodal narratives to the emergence of reading, writing, and digital skills展开更多
The fresh leaves of China green tea, Camellia sinensis, were collected from Fuyang, Zhejiang Province, China, in April. The tea polyphenols was extracted by four different methods (homogenized with distilled water at...The fresh leaves of China green tea, Camellia sinensis, were collected from Fuyang, Zhejiang Province, China, in April. The tea polyphenols was extracted by four different methods (homogenized with distilled water at room temperature, homogenized with 0.3% citric acid (w/v) at room temperature, 5- min boiling and homogenized with distilled water at room temperature, homogenized with 85℃ distilled water), and after preserving at room temperature, the change of the Epigallocatechin gallate (EGCG) contents of the extracts was investigated. Results indicated that the EGCG content of homogenate extracted with 85℃ distilled water was the highest before the extract was preserved, followed by that of the extract homogenized with 0.3% citric acid at room temperature. During preservation, EGCG content changed obviously. The EGCG contents of homogenates extracted with distilled water at room temperature and 85℃ distilled water declined quickly and separately reduced to 21.52% and 54.6% of their initial contents after preservation for 12 h. The EGCG contents extracted by 0.3% citric acid (w/v) solvent at room temperature and 5- min boiling/homogenized with distilled water at room temperature declined relatively slowly ,and separately reduced to 76.9% and 85.16% of their initial contents after preservation for 12 h. It was also found that the citric acid can prevent the degradation of EGCG and the extract solution color is light green展开更多
When a child abuse situation arises, the responsible agencies and entities in charge of response should be capable of providing a fast and personalized solution for the good of the child. This need leads the authors t...When a child abuse situation arises, the responsible agencies and entities in charge of response should be capable of providing a fast and personalized solution for the good of the child. This need leads the authors to consider the formation of dynamic virtual organizations tailored to each particular abuse case. In the authors' approach the partner selection of these collaborative networks is done through a software tool that combines two technologies from the field of artificial intelligence, specifically multi-agent systems and expert systems. In addition, these partners come from the breeding environment constituted by all the agencies or individuals, either in a region or locality, which have the potential of response.展开更多
Usually, data on road traffic accidents in Algeria are not available to researchers. Fortunately, MICS4mthe Multiple Indicator Cluster Survey conducted by UNICEF during 2012-2013 has introduced a module on accidents a...Usually, data on road traffic accidents in Algeria are not available to researchers. Fortunately, MICS4mthe Multiple Indicator Cluster Survey conducted by UNICEF during 2012-2013 has introduced a module on accidents among children less than 15 years. In Algeria, the MICS4 survey targeted a sample of 28,000 households distributed over the national territory. These are the main results of polynomial logistic regression: Children in the richest quintile (B = .562, p 〈 .05), are much less exposed than children in the poorest quintile. The odd ratio is 1.75. Compared to children aged 12 to 14, the younger children of 0-2 years (B = -1.059, p 〈 .05), are three times less exposed (odd ratio = .347) to road traffic accidents; and children of 9-11 years (B = .520, p 〈 .05), are most exposed with an odd ratio of 1.68. For territorial planning areas, with the South being taken as a reference category, the risk of traffic accidents for a child is the lowest in the West Highlanders (B = -1.257, p 〈 .05), followed by the North Center (B = -1.163, p 〈 .05), the East Highlands (B = -1.053, p 〈 .05), the Northwest (B = -1.034, p 〈 .05), and the Northeast (B = -.805, p 〈 .05). Odd ratio values are respectively .29, .313, .349, .356, and .447.展开更多
In order to reveal difference of phenolic substances and the content in the different varieties of pomegranate fruit and different mature period. The article uses 3 different fruit color phenotype (white, red, green...In order to reveal difference of phenolic substances and the content in the different varieties of pomegranate fruit and different mature period. The article uses 3 different fruit color phenotype (white, red, green) pomegranate cultivars as materials, the peel were determined by high performance liquid chromatography respectively (composition and content of phenolic compounds in the seeds and juice). Results shows that the varieties of pomegranate peel and seeds were detected in 13 kinds of phenols, juice was detected in 12 type, and which did not detect epicatechin. At the same time, there was a significant difference in different parts of different varieties of pomegranate phenolic content.展开更多
We report a 16-day-old boy who had transposition of great arteries combined with interrupted aortic arch (IAA). The boy developed cyanotic lips and body bruising 2 h after birth. Color Doppler sonography showed transp...We report a 16-day-old boy who had transposition of great arteries combined with interrupted aortic arch (IAA). The boy developed cyanotic lips and body bruising 2 h after birth. Color Doppler sonography showed transposition of great arteries. The patient underwent total surgical correction of the transfection and defects. We summarized our experience in the perioperative management of the patient, including maintenance of body temperature, close intraoperative monitoring, anesthesia management, cardiopulmonary bypass (CPB) management and so on.展开更多
The paper argues that the three women are all tragic characters and their tragedies lie in the fact that they only function as stones in Paul's life road to art and the world of men and their suffering from the impri...The paper argues that the three women are all tragic characters and their tragedies lie in the fact that they only function as stones in Paul's life road to art and the world of men and their suffering from the imprisonment of the patriarchal society. The alleged tragic hero, Paul, is patriarchal, self-centered, and sometimes even sadistic. This paper gives respective analysis of the Victorian morality and industrial civilization. Mrs. Morel is pitifully diagnosed with Oedipus complex, which enables her to be a powerful hermaphrodite and gains access to power Miriam is also imprisoned by Victorian morality, but her world is not purely spiritual. Paul just cannot see the physical aspect of her, so he refuses to enter her world. Clara is the woman who makes Paul a real man, but Paul only sees the physical aspect of her. So Paul's patriarchal character is revealed in the discussion of these three women. This paper explores the cause of these women's struggle and points out that the problems these characters face still exist and need to be solved today展开更多
Objective:Caudal epidural analgesia has become very common analgesic technique in paediatric surgery.Adding tramadol to bupivacaine for caudal injection prolongs duration of analgesia with minimal side effects.The aim...Objective:Caudal epidural analgesia has become very common analgesic technique in paediatric surgery.Adding tramadol to bupivacaine for caudal injection prolongs duration of analgesia with minimal side effects.The aim of the study was to investigate the different effects of caudal bupivacaine versus bupivacaine with thamadol for postoperative analgesia in paediatric cancer patients.Methods:A prospective randomized controlled trial was conducted over 40 paediatric cancer patients who were recruited from Children Cancer Hospital of Egypt(57357 Hospital).Patients were randomized into 2 groups:bupivacaine group(group B,20 patients) to receive single shot caudal block of 1 mL/kg 0.1875% bupivacaine;tramadol group(group T,20 patients) prepared as group B with the addition of 1 mg/kg caudal tramadol.Results:The mean duration of analgesia was significantly longer among group T than group B [(24 ± 13.7) hours versus(7 ± 3.7) hours respectively with P = 0.001].Group T showed a significantly lower mean FLACC score than group B(2.2 ± 0.9 versus 3.6 ± 0.6 with P = 0.002).The difference in FLACC score was comparable on arrival,and after 2 and 4 hours.At 8 and 12 hours the group B recorded significantly higher scores(P = 0.002 and 0.0001 respectively).There were no significant differences between the groups as regards sedation score [the median in both groups was 1(0-1) with P value = o.8].No one developed facial flush or pruritis.Conclusion:Caudal injection of low dose tramadol 1 mg/kg with bupivacaine 0.1875% is proved to be effective,long standing technique for postoperative analgesia in major paediatric cancer surgery and almost devoid of side effect.展开更多
基金The National Natural Science Foundation of China(No.61300167)the Open Project Program of State Key Laboratory for Novel Software Technology of Nanjing University(No.KFKT2015B17)+3 种基金the Natural Science Foundation of Jiangsu Province(No.BK20151274)Qing Lan Project of Jiangsu Provincethe Open Project Program of Key Laboratory of Intelligent Perception and Systems for High-Dimensional Information of Ministry of Education(No.JYB201606)the Program for Special Talent in Six Fields of Jiangsu Province(No.XYDXXJS-048)
文摘In order to improve the performance of the attribute reduction algorithm to deal with the noisy and uncertain large data, a novel co-evolutionary cloud-based attribute ensemble multi-agent reduction(CCAEMR) algorithm is proposed.First, a co-evolutionary cloud framework is designed under the M apReduce mechanism to divide the entire population into different co-evolutionary subpopulations with a self-adaptive scale. Meanwhile, these subpopulations will share their rewards to accelerate attribute reduction implementation.Secondly, a multi-agent ensemble strategy of co-evolutionary elitist optimization is constructed to ensure that subpopulations can exploit any correlation and interdependency between interacting attribute subsets with reinforcing noise tolerance.Hence, these agents are kept within the stable elitist region to achieve the optimal profit. The experimental results show that the proposed CCAEMR algorithm has better efficiency and feasibility to solve large-scale and uncertain dataset problems with complex noise.
文摘Tea is one of the most popular beverages, consumed by over two thirds of the world’s population; but the aluminum accumulation property of tea plant is becoming the focus of many researches because of aluminum’s known adverse effect on human health. Investigation of the interactions of catechins with Al3+ showed that during the interaction of catechins with Al3+, the UV-vis spectrum of catechins was changed. Absorption of EGCG at 274 nm decreased and increased at 322 nm; EC and C’s at 278 nm changed little. The ratio of Al3+ to EGCG was 1:1 in pH 5.0 buffer solution; in pH 6.2 buffer solution, the ratio in the Al-EGCG complex was 1:1. Interestingly, while the ratio reached to over 2, after the complex of Al-EGCG started polymerization, the ratio in the polymer was 2:1. In pH 6.2 buffer solution, the complex behavior of C with Al3+ was the same as that of EGCG, with a little difference for EC. When the ratio of Al3+ to EC was <1, the complex in ratio was 1:2, but, the complex polymerized when the ratio of Al3+ to EC was >1. It was found that the ratio of Al3+ to EC in the polymer was 1:1. Polymerization of Al-catechin complexes might reduce aluminum absorption in the intestine. Kow value was also employed to study the properties of aluminum species in tea infusion (at gastric and intestine pH condition) and the effect of catechins and tea polyphenols on Kow in buffer solution. Results showed that Kow value rose much higher at the intestine pH than at the gastric pH. Tea polyphenols and catechins could greatly reduce aluminum Kow value in acetic buffer, indicating that these compounds may reduce aluminum absorption during tea intake.
基金particularly supported by the "Aim for the Top University Plan" of the National Taiwan Normal University and Ministry of Education,Taiwan,Chinaby the Ministry of Science and Technology (Taiwan,China) under grant NSC102-2410-H-003-128
文摘Purpose: The purpose of this study was to investigate the impact of acute exercise on reaction time and response preparation during a Go/No Go Task in children with attention deficit hyperactivity disorder (ADHD). Methods: Nineteen children with ADHD (aged between 8 and 12 years old) undertook a 30-min intervention that consisted of treadmill running or video-watching presented in a counterbalanced order on different days. A Go/No Go Task was administrated after exercise or video-watching. Results: The results indicated a shorter reaction time and smaller contingent negative variation (CNV) 2 amplitude following exercise relative to the video-watching. For event related potential (ERP) analyses, greater CNV l and CNV 2 amplitudes in response to No Go stimuli in com- parison to Go stimuli was observed in the video-watching session only. Conclusion: These findings suggest that acute exercise may benefit children with ADHD by developing appropriate response preparation, particularly in maintaining a stable motor preparatory set prior to performing the given task.
文摘Background: Attention deficit hyperactivity disorder (ADHD) is a common childhood disorder that affects approximately 11% of children in the United States. Research supports that a single session of exercise benefits cognitive performance by children, and a limited number of studies have demonstrated that these effects can also be realized by children with ADHD. The purpose of this study was to examine the effect of acute exercise on cognitive performance by children with and without ADHD. Methods: Children with and without ADHD were asked to perform cognitive tasks on 2 days following treatment conditions that were assigned in a random, counterbalanced order. The treatment conditions consisted of a 30-min control condition on 1 day and a moderate intensity exercise condition on the other day. Results: Exercise significantly benefited performance on all three conditions of the Stroop Task, but did not significantly affect performance on the Tower of London or the Trail Making Test. Conclusion: children with and without ADHD realize benefits in speed of processing and inhibitory control in response to a session of acute exercise, but do not experience benefits in planning or set shifting.
基金Supported by The funds for programs of Zhejiang Provincial Natural Science, No.Y2080047Major Programs of Zhejiang Provincial Medical and Health Science and Technology & Chinese Ministry of Health, No.WKJ2008-2-026Special Major Programs of Zhejiang Provincial Science and Technology, No. 2008c03002-1
文摘AIM: To create a rabbit model of pediatric nonalcoholic steatohepatitis (NASH) and to evaluate the role of adiponectin in the process. METHODS: Thirty-two specific pathogen-free male New Zealand rabbits were divided randomly into three groups: (1) the normal control group (n = 10) was fed with standard diet for 12 wk; (2) the model group A (n = 11); and (3) model group B (n = 11) were fed with a highfat diet (standard diet + 10% lard + 2% cholesterol) for 8 and 12 wk, respectively. Hepatic histological changes were observed and biochemical parameters as well as serum levels of adiponectin, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α were measured. RESULTS: Typical histological hepatic lesions of NASH were observed in both model groups described as liver steatosis, liver inflammatory infiltration, cytologic ballooning, perisinusoidal fibrosis and overall fibrosis. Compared with the normal control group, there were significant increases in model groups A and B in weight gain (1097.2 ± 72.3, 1360.5± 107.6 vs 928.0 ±58.1, P 〈 0.05, P 〈 0.01), liver weight (93.81±6.64, 104.6±4.42 vs 54.4±1.71, P 〈 0.01), Lg (ALT) (1.9±0.29, 1.84± 0.28 vs 1.60±0.17, P 〈 0.01), and Lg (TG) (1.03 ±0.24, 1.16 ±0.33 vs 0.00 ±0.16, P 〈 0.01). Weight gain was much more in model group B than in model group A (1360.5± 107.6 vs 1097.2 ±72.3, P 〈 0.05). But, there was no significant difference between the two groups concerning the other indexes. Pro-inflammatory cytokines (IL-6 and TNF-α) increased in model group B compared with that of control and model group A (IL-6:1.86±0.21 vs 1.41 ±0.33, 1.38± 0.42, P 〈 0.01; TNF-α: 1.18±0.07 vs 0.66 ±0.08, 0.86 ±0.43, P 〈 0.01, P 〈 0.05), whereas serum adiponectin and IL-10 decreased in model groups compared with that in the control (adiponectin: A: 21.87±4.84 and B: 21.48 ±4.60 vs 27.36 ±7.29, P 〈 0.05. IL-10: A: 1.72± 0.38 and B: 1.83 ±0.39 vs 2.26±0.24, P 〈 0.01). Lg (TC) and the degree of liver fatty infiltration was an independent determinant of serum adiponectin level analyzed by stepwise multiple regressions, resulting in 29.4% of variances. CONCLUSION: This rabbit model produces the key features of pediatric NASH and may provide a realistic model for future studies. Adiponectin level partially reflects the severity of liver steatosis, but not the degree of liver inflammation.
文摘The link between media culture and its real world effect has been a hot topic for many years. Many people believe that media have an obviously bad effect on children. More than 1000 studies conducted in the past 40 years show that excessive exposure to media violence causes the violent behavior in real life. Some other researches prove that media contain heavy messages that promote unhealthy habits or antisocial behaviors. This might be true. However, people often overstate the effects of media on children. Media are not the only elements that can lead to children's violence, antisocial behavior and bad habits. Other factors, like society, parents, communities, can also influence their behavior. In fact, if we can control the exposure to media in moderation, our children can benefit a lot from media culture.
基金Supported by Guangxi Scientifi c Research and Technological Development Projects Funding(Ministry Science& Technology of Guangxi,No.0816004-6)
文摘AIM:To evaluate the role of genetic factors in the pathogenesis of idiopathic infant cholestasis.METHODS:We performed a case-control study,in-cluding 78 infants with idiopathic infant cholestasis and 113 healthy infants as controls.Genomic DNA was extracted from peripheral venous blood leukocytes us-ing phenol chloroform methodology.Polymerase chain reaction was used to amplify the multidrug resistance protein 3(MDR3)R652G fragment,and products were sequenced using the ABI 3100 Sequencer.RESULTS:The R652G single nucleotide polymorphism(SNP)was significantly more frequent in healthy infants(allele frequency 8.0%)than in patients(allele frequency 2.60%)(P < 0.05),odds ratio,0.29;95% confidence interval,0.12-0.84.The conjugated bilirubin in patients with the AG genotype was significantly lower than in those with the AA genotype(44.70 ± 6.15 μmol/L vs 95.52 ± 5.93 μmol/L,P < 0.05).CONCLUSION:MDR3 R652G is negatively correlated with idiopathic infant cholestasis.Children with the R652G SNP in Guangxi of China may have reduced susceptibility to infant intrahepatic cholestasis.
文摘Objective : Evaluate the application values of ^99mTc-2 β [ N, N'-bis ( 2-mercaptoethyl ) ethylenediamiino ] methyl, 3 β -(4-chlorophenyl) tropane ( TRODAT-1 ) dopamine transporter (DAT) SPECT imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. Methods:Ten autistic children and ten healthy controls were examined with ^99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of ^99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striaturn and cerebellum [ ( STR-BKG)/BKG ]. Results : There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children ( P = 0. 562) and in normal controls ( P = 0. 573 ) ; dopamine transporter in brain of patients with autism increased more significantly than that in normal controls ( P = 0. 017). Conclusion : Dopaminergic nervous system is dysfunction in human brain with children autism, and DAT ^99mTc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children autism.
基金This work was supported by the Key National Research Project of China (Nos. 2017YFC0601900 and 2016YFC0303100) and the Key Program of National Natural Science Foundation of China (Nos. 41530320 and 41774125).
文摘The main problems in three-dimensional gravity inversion are the non-uniqueness of the solutions and the high computational cost of large data sets. To minimize the high computational cost, we propose a new sorting method to reduce fluctuations and the high frequency of the sensitivity matrix prior to applying the wavelet transform. Consequently, the sparsity and compression ratio of the sensitivity matrix are improved as well as the accuracy of the forward modeling. Furthermore, memory storage requirements are reduced and the forward modeling is accelerated compared with uncompressed forward modeling. The forward modeling results suggest that the compression ratio of the sensitivity matrix can be more than 300. Furthermore, multiscale inversion based on the wavelet transform is applied to gravity inversion. By decomposing the gravity inversion into subproblems of different scales, the non-uniqueness and stability of the gravity inversion are improved as multiscale data are considered. Finally, we applied conventional focusing inversion and multiscale inversion on simulated and measured data to demonstrate the effectiveness of the proposed gravity inversion method.
文摘At present, the Portuguese education system promotes the development of new literacies in all education levels in response to new requirements of the digital world which imply changes in children's education. In fact, reading and writing are no longer limited exclusively to books, rather they are associated with diversified digital media integrating text, sound, image, and video. In this context, we developed an exploratory study in a kindergarten with the children and their family members. Data were collected through participant observation, children conversational interviews, and digital narratives produced by children. Data analysis is based on content analysis with NVivo software support. The emergence of literacy is evident in verbal interactions in peer-group work, in contact with the written text, in "writing" in various media, and in sharing knowledge, discoveries, and digital narratives produced in an online community (http://janelajardim.ning.com). This paper presents: (1) a systematic literature review in the field of digital narrative and emergent literacy; (2) the description of children's activities concerning interactive multimodal narrative; (3) the results of this work; and (4) the conclusion about contribution of multimodal narratives to the emergence of reading, writing, and digital skills
文摘The fresh leaves of China green tea, Camellia sinensis, were collected from Fuyang, Zhejiang Province, China, in April. The tea polyphenols was extracted by four different methods (homogenized with distilled water at room temperature, homogenized with 0.3% citric acid (w/v) at room temperature, 5- min boiling and homogenized with distilled water at room temperature, homogenized with 85℃ distilled water), and after preserving at room temperature, the change of the Epigallocatechin gallate (EGCG) contents of the extracts was investigated. Results indicated that the EGCG content of homogenate extracted with 85℃ distilled water was the highest before the extract was preserved, followed by that of the extract homogenized with 0.3% citric acid at room temperature. During preservation, EGCG content changed obviously. The EGCG contents of homogenates extracted with distilled water at room temperature and 85℃ distilled water declined quickly and separately reduced to 21.52% and 54.6% of their initial contents after preservation for 12 h. The EGCG contents extracted by 0.3% citric acid (w/v) solvent at room temperature and 5- min boiling/homogenized with distilled water at room temperature declined relatively slowly ,and separately reduced to 76.9% and 85.16% of their initial contents after preservation for 12 h. It was also found that the citric acid can prevent the degradation of EGCG and the extract solution color is light green
文摘When a child abuse situation arises, the responsible agencies and entities in charge of response should be capable of providing a fast and personalized solution for the good of the child. This need leads the authors to consider the formation of dynamic virtual organizations tailored to each particular abuse case. In the authors' approach the partner selection of these collaborative networks is done through a software tool that combines two technologies from the field of artificial intelligence, specifically multi-agent systems and expert systems. In addition, these partners come from the breeding environment constituted by all the agencies or individuals, either in a region or locality, which have the potential of response.
文摘Usually, data on road traffic accidents in Algeria are not available to researchers. Fortunately, MICS4mthe Multiple Indicator Cluster Survey conducted by UNICEF during 2012-2013 has introduced a module on accidents among children less than 15 years. In Algeria, the MICS4 survey targeted a sample of 28,000 households distributed over the national territory. These are the main results of polynomial logistic regression: Children in the richest quintile (B = .562, p 〈 .05), are much less exposed than children in the poorest quintile. The odd ratio is 1.75. Compared to children aged 12 to 14, the younger children of 0-2 years (B = -1.059, p 〈 .05), are three times less exposed (odd ratio = .347) to road traffic accidents; and children of 9-11 years (B = .520, p 〈 .05), are most exposed with an odd ratio of 1.68. For territorial planning areas, with the South being taken as a reference category, the risk of traffic accidents for a child is the lowest in the West Highlanders (B = -1.257, p 〈 .05), followed by the North Center (B = -1.163, p 〈 .05), the East Highlands (B = -1.053, p 〈 .05), the Northwest (B = -1.034, p 〈 .05), and the Northeast (B = -.805, p 〈 .05). Odd ratio values are respectively .29, .313, .349, .356, and .447.
文摘In order to reveal difference of phenolic substances and the content in the different varieties of pomegranate fruit and different mature period. The article uses 3 different fruit color phenotype (white, red, green) pomegranate cultivars as materials, the peel were determined by high performance liquid chromatography respectively (composition and content of phenolic compounds in the seeds and juice). Results shows that the varieties of pomegranate peel and seeds were detected in 13 kinds of phenols, juice was detected in 12 type, and which did not detect epicatechin. At the same time, there was a significant difference in different parts of different varieties of pomegranate phenolic content.
文摘We report a 16-day-old boy who had transposition of great arteries combined with interrupted aortic arch (IAA). The boy developed cyanotic lips and body bruising 2 h after birth. Color Doppler sonography showed transposition of great arteries. The patient underwent total surgical correction of the transfection and defects. We summarized our experience in the perioperative management of the patient, including maintenance of body temperature, close intraoperative monitoring, anesthesia management, cardiopulmonary bypass (CPB) management and so on.
文摘The paper argues that the three women are all tragic characters and their tragedies lie in the fact that they only function as stones in Paul's life road to art and the world of men and their suffering from the imprisonment of the patriarchal society. The alleged tragic hero, Paul, is patriarchal, self-centered, and sometimes even sadistic. This paper gives respective analysis of the Victorian morality and industrial civilization. Mrs. Morel is pitifully diagnosed with Oedipus complex, which enables her to be a powerful hermaphrodite and gains access to power Miriam is also imprisoned by Victorian morality, but her world is not purely spiritual. Paul just cannot see the physical aspect of her, so he refuses to enter her world. Clara is the woman who makes Paul a real man, but Paul only sees the physical aspect of her. So Paul's patriarchal character is revealed in the discussion of these three women. This paper explores the cause of these women's struggle and points out that the problems these characters face still exist and need to be solved today
文摘Objective:Caudal epidural analgesia has become very common analgesic technique in paediatric surgery.Adding tramadol to bupivacaine for caudal injection prolongs duration of analgesia with minimal side effects.The aim of the study was to investigate the different effects of caudal bupivacaine versus bupivacaine with thamadol for postoperative analgesia in paediatric cancer patients.Methods:A prospective randomized controlled trial was conducted over 40 paediatric cancer patients who were recruited from Children Cancer Hospital of Egypt(57357 Hospital).Patients were randomized into 2 groups:bupivacaine group(group B,20 patients) to receive single shot caudal block of 1 mL/kg 0.1875% bupivacaine;tramadol group(group T,20 patients) prepared as group B with the addition of 1 mg/kg caudal tramadol.Results:The mean duration of analgesia was significantly longer among group T than group B [(24 ± 13.7) hours versus(7 ± 3.7) hours respectively with P = 0.001].Group T showed a significantly lower mean FLACC score than group B(2.2 ± 0.9 versus 3.6 ± 0.6 with P = 0.002).The difference in FLACC score was comparable on arrival,and after 2 and 4 hours.At 8 and 12 hours the group B recorded significantly higher scores(P = 0.002 and 0.0001 respectively).There were no significant differences between the groups as regards sedation score [the median in both groups was 1(0-1) with P value = o.8].No one developed facial flush or pruritis.Conclusion:Caudal injection of low dose tramadol 1 mg/kg with bupivacaine 0.1875% is proved to be effective,long standing technique for postoperative analgesia in major paediatric cancer surgery and almost devoid of side effect.