This study retrospectively analyzed the medication prescriptions of children diagnosed with attention-deficit/hyperactivity disorder(ADHD) in Ningbo Psychiatric Hospital and Ningbo Women and Children’s Hospital from ...This study retrospectively analyzed the medication prescriptions of children diagnosed with attention-deficit/hyperactivity disorder(ADHD) in Ningbo Psychiatric Hospital and Ningbo Women and Children’s Hospital from March 2018 to September 2020 and compared the drug retention rate of methylphenidate hydrochloride and atomoxetine hydrochloride. The prescription automatic screening system was used to screen the prescriptions in children with ADHD. Kaplan-Meier regression analysis was used to compare prescription retention rates between the two regimens after adjusting for gender, age, body weight, and prescription cost. The mean age of the methylphenidate hydrochloride group was 8.75 ± 2.16 years, and the monthly prescription cost was 327.37 ± 146.64 RMB. The average age of the atomoxetine group was 8.33 ± 1.73 years, and the monthly prescription cost was 363.15 ± 154.90 ￥. There were some differences in the age of enrollment and the monthly prescription cost between the two regimens(all P < 0.01). Moreover, the retention rate of methylphenidate hydrochloride was higher compared with atomoxetine hydrochloride within 18 months. Kaplan-Meier regression analysis showed that this trend was significant(Tarone-ware, Chi-square value = 14.893, P < 0.001). Prescription costs might be a factor affecting drug retention. This study found that the retention rates were decreased month by month in children with ADHD, and after 5 months, the retention rates were 52.20% and 41.22%, respectively, far below the recommended levels of the guidelines.展开更多
Objective： To observe the effect of acupuncture for children with attention deficit hyperactivity disorder （ADHD）. Methods： A total of 36 cases were recruited in this study. Before treatment, a Chinese medical con...Objective： To observe the effect of acupuncture for children with attention deficit hyperactivity disorder （ADHD）. Methods： A total of 36 cases were recruited in this study. Before treatment, a Chinese medical constitution survey was conducted on these children. Based on the survey findings, the children were divided in different groups for acupuncture intervention. Additionally, the heart rate variability and attention were detected respectively before treatment, in the 12th and 24th week after treatment. Results： ADHD kids commonly manifest as a body constitution of yang predominance and heat exuberance. The kids＇ Body Mass Indexes （BMI） are moderately correlated with attention deficit disorder （ADD）. After the treatment of 24 weeks, the ADHD scores were reduced from （10.94±1.98） to （8.56±2.48）, showing a statistical significance （P〈0.05）; in addition, the low frequency/high frequency （LF/HF） and normalized low frequency （nLF） between the two groups were also statistically different （P〈0.05）. Conclusion： Most ADHD kids present with a body constitution of yang predominance and heat exuberance. A well-controlled BMI is helpful for ADHD treatment. Acupuncture can be a supplementary therapy to improve the ADHD symptoms.展开更多
基金Natural Science Foundation of Ningbo(Grant No.2018A610245)。
文摘This study retrospectively analyzed the medication prescriptions of children diagnosed with attention-deficit/hyperactivity disorder(ADHD) in Ningbo Psychiatric Hospital and Ningbo Women and Children’s Hospital from March 2018 to September 2020 and compared the drug retention rate of methylphenidate hydrochloride and atomoxetine hydrochloride. The prescription automatic screening system was used to screen the prescriptions in children with ADHD. Kaplan-Meier regression analysis was used to compare prescription retention rates between the two regimens after adjusting for gender, age, body weight, and prescription cost. The mean age of the methylphenidate hydrochloride group was 8.75 ± 2.16 years, and the monthly prescription cost was 327.37 ± 146.64 RMB. The average age of the atomoxetine group was 8.33 ± 1.73 years, and the monthly prescription cost was 363.15 ± 154.90 ￥. There were some differences in the age of enrollment and the monthly prescription cost between the two regimens(all P < 0.01). Moreover, the retention rate of methylphenidate hydrochloride was higher compared with atomoxetine hydrochloride within 18 months. Kaplan-Meier regression analysis showed that this trend was significant(Tarone-ware, Chi-square value = 14.893, P < 0.001). Prescription costs might be a factor affecting drug retention. This study found that the retention rates were decreased month by month in children with ADHD, and after 5 months, the retention rates were 52.20% and 41.22%, respectively, far below the recommended levels of the guidelines.
文摘Objective： To observe the effect of acupuncture for children with attention deficit hyperactivity disorder （ADHD）. Methods： A total of 36 cases were recruited in this study. Before treatment, a Chinese medical constitution survey was conducted on these children. Based on the survey findings, the children were divided in different groups for acupuncture intervention. Additionally, the heart rate variability and attention were detected respectively before treatment, in the 12th and 24th week after treatment. Results： ADHD kids commonly manifest as a body constitution of yang predominance and heat exuberance. The kids＇ Body Mass Indexes （BMI） are moderately correlated with attention deficit disorder （ADD）. After the treatment of 24 weeks, the ADHD scores were reduced from （10.94±1.98） to （8.56±2.48）, showing a statistical significance （P〈0.05）; in addition, the low frequency/high frequency （LF/HF） and normalized low frequency （nLF） between the two groups were also statistically different （P〈0.05）. Conclusion： Most ADHD kids present with a body constitution of yang predominance and heat exuberance. A well-controlled BMI is helpful for ADHD treatment. Acupuncture can be a supplementary therapy to improve the ADHD symptoms.
