背景：延髓内的血清素能（5-羟色胺[5-hydroxytrytamine，5-HT]）神经元广泛地延伸到脑干的自主神经核、呼吸神经核及脊髓中，协助调节机体功能。既往发现，死于婴儿猝死综合征（sudden infant death syndrome，SIDS）的婴儿髓部5-HT受...背景：延髓内的血清素能（5-羟色胺[5-hydroxytrytamine，5-HT]）神经元广泛地延伸到脑干的自主神经核、呼吸神经核及脊髓中，协助调节机体功能。既往发现，死于婴儿猝死综合征（sudden infant death syndrome，SIDS）的婴儿髓部5-HT受体存在异常，而这可能是某些SIDS病例的发病原因。展开更多
Background: The association of multiple cutaneous granular tumors with systemic defects is extremely rare. To date, 14 cases have been described. Case report: A 14-year-old boy presented multiple nodular lesions on hi...Background: The association of multiple cutaneous granular tumors with systemic defects is extremely rare. To date, 14 cases have been described. Case report: A 14-year-old boy presented multiple nodular lesions on his arms and legs; facial dysmorphism and joint hypermobility were also present. Histopathologic examination of two nodules showed granular cell tumors. We review the literature regarding multiple granular cell cutaneous tumors in children with associated somatic defects and genetic syndromes. Conclusions: The combination of multiple cutaneous granular tumors with alterations in other organs is not only fortuitous, justifying the proposal of a distinct syndrome, termed “ Bakos’s syndrome” after the author who first described this association. The relation with neurofibromatosis type 1 is discussed, and an association is suggested with the range of variants of this syndrome.展开更多
文摘背景：延髓内的血清素能（5-羟色胺[5-hydroxytrytamine，5-HT]）神经元广泛地延伸到脑干的自主神经核、呼吸神经核及脊髓中，协助调节机体功能。既往发现，死于婴儿猝死综合征（sudden infant death syndrome，SIDS）的婴儿髓部5-HT受体存在异常，而这可能是某些SIDS病例的发病原因。
文摘Background: The association of multiple cutaneous granular tumors with systemic defects is extremely rare. To date, 14 cases have been described. Case report: A 14-year-old boy presented multiple nodular lesions on his arms and legs; facial dysmorphism and joint hypermobility were also present. Histopathologic examination of two nodules showed granular cell tumors. We review the literature regarding multiple granular cell cutaneous tumors in children with associated somatic defects and genetic syndromes. Conclusions: The combination of multiple cutaneous granular tumors with alterations in other organs is not only fortuitous, justifying the proposal of a distinct syndrome, termed “ Bakos’s syndrome” after the author who first described this association. The relation with neurofibromatosis type 1 is discussed, and an association is suggested with the range of variants of this syndrome.
