An altemative algorithm for mitigating GPS multipath was presented by integrating unscented Kalman filter （UKF） and wavelet transform with particle filter. Within consideration of particle degeneracy, UKF was taken ...An altemative algorithm for mitigating GPS multipath was presented by integrating unscented Kalman filter （UKF） and wavelet transform with particle filter. Within consideration of particle degeneracy, UKF was taken for drawing particle. To remove the noise from raw data and data processing error, adaptive wavelet filtering with threshold was adopted while data preprocessing and drawing particle. Three algorithms, named EKF-PF, UKF-PF and WM-UKF-PF, were performed for comparison. The proposed WM-UKF-PF algorithm gives better error minimization, and significantly improves performance of multipath mitigation in terms of SNR and coefficient even though it has computation complexity. It is of significance for high-accuracy positioning and non-stationary deformation analysis.展开更多
A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and wa...A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases(PI3 K) signaling pathway were detected via next-generation sequencing(NGS)-based liquid biopsy, including a p. G1007 R missense mutation in exon 21 of PIK3 CA(33.61%), a p.L70 fs frameshift mutation in exon 3 of phosphatase and tension homolog deleted on chromosome ten(PTEN)(49.14%), and a p. D1542 Y missense mutation in exon 32 of mammalian target of rapamycin(m TOR)(1.66%). Therefore, only the m TOR inhibitor everolimus was administered to the patient. Partial remission(PR) was observed after 2 months, and sustained stable disease(SD) was observed after a year and a half. Subsequent sequencing showed that the mutation ratio of PIK3 CA decreased to 4.17%, and that the PTEN and m TOR mutations disappeared, which revealed the significant curative effect of everolimus. We report the first case of successful monotherapy treatment using everolimus in a patient with advanced breast cancer bearing mutations in genes involved in the PI3 K/ARK/m TOR signaling pathway. The success of this case highlights the invaluable clinical contribution of NGS-based liquid biopsy, as it successfully provided an optimal therapeutic target for the patient with advanced breast cancer.展开更多
The multi-linear variable separation approach method is very useful to solve (2+1)-dimensional integrable systems. In this letter, we extend this method to solve (1+1)-dimensional Boiti system, (2+1)-dimensional Burge...The multi-linear variable separation approach method is very useful to solve (2+1)-dimensional integrable systems. In this letter, we extend this method to solve (1+1)-dimensional Boiti system, (2+1)-dimensional Burgers system, (2+1)-dimensional breaking soliton system, and (2+1)-dimensional Maccari system. Some new exact solutions are obtained and the universal formula obtained from many (2+1)-dimensional systems is extended or modified.展开更多
基金Project(51174206)supported by the National Natural Science Foundation of ChinaProject(2013AA12A201)supported by the National Hi-tech Research and Development Program of China+1 种基金Project(2012ZDP08)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(SZBF2011-6-B35)supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),China
文摘An altemative algorithm for mitigating GPS multipath was presented by integrating unscented Kalman filter （UKF） and wavelet transform with particle filter. Within consideration of particle degeneracy, UKF was taken for drawing particle. To remove the noise from raw data and data processing error, adaptive wavelet filtering with threshold was adopted while data preprocessing and drawing particle. Three algorithms, named EKF-PF, UKF-PF and WM-UKF-PF, were performed for comparison. The proposed WM-UKF-PF algorithm gives better error minimization, and significantly improves performance of multipath mitigation in terms of SNR and coefficient even though it has computation complexity. It is of significance for high-accuracy positioning and non-stationary deformation analysis.
文摘A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases(PI3 K) signaling pathway were detected via next-generation sequencing(NGS)-based liquid biopsy, including a p. G1007 R missense mutation in exon 21 of PIK3 CA(33.61%), a p.L70 fs frameshift mutation in exon 3 of phosphatase and tension homolog deleted on chromosome ten(PTEN)(49.14%), and a p. D1542 Y missense mutation in exon 32 of mammalian target of rapamycin(m TOR)(1.66%). Therefore, only the m TOR inhibitor everolimus was administered to the patient. Partial remission(PR) was observed after 2 months, and sustained stable disease(SD) was observed after a year and a half. Subsequent sequencing showed that the mutation ratio of PIK3 CA decreased to 4.17%, and that the PTEN and m TOR mutations disappeared, which revealed the significant curative effect of everolimus. We report the first case of successful monotherapy treatment using everolimus in a patient with advanced breast cancer bearing mutations in genes involved in the PI3 K/ARK/m TOR signaling pathway. The success of this case highlights the invaluable clinical contribution of NGS-based liquid biopsy, as it successfully provided an optimal therapeutic target for the patient with advanced breast cancer.
文摘The multi-linear variable separation approach method is very useful to solve (2+1)-dimensional integrable systems. In this letter, we extend this method to solve (1+1)-dimensional Boiti system, (2+1)-dimensional Burgers system, (2+1)-dimensional breaking soliton system, and (2+1)-dimensional Maccari system. Some new exact solutions are obtained and the universal formula obtained from many (2+1)-dimensional systems is extended or modified.
