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多水平模型在生物等效性评价中的应用(Ⅱ) 被引量:1
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作者 刘巧兰 沈卓之 +2 位作者 李晓松 陈峰 杨珉 《中华流行病学杂志》 CAS CSCD 北大核心 2010年第3期333-339,共7页
探讨多变量多水平模型在生物等效性评价中的应用价值。以4×4交叉试验设计的国产和进口罗格列酮药物生物等效性评价为研究实例,研究多变量多水平模型在同时评价多个指标等效性时方差分量的分解方式,并探讨在多变量多水平框架下评... 探讨多变量多水平模型在生物等效性评价中的应用价值。以4×4交叉试验设计的国产和进口罗格列酮药物生物等效性评价为研究实例,研究多变量多水平模型在同时评价多个指标等效性时方差分量的分解方式,并探讨在多变量多水平框架下评价平均、群体和个体等效性评价的可行性。多变量多水平模型考虑了罗格列酮药物指标In(AUC)和In(Gmax)的相关性,在两个指标出现一个平均等效而另一个平均不等效的矛盾结果时,通过联合检验最终判断两个指标联合具有平均等效性。根据多变量多水平模型方差分量,进一步获得了国产和进口罗格列酮药物具有群体和个体等效性。结论:多变量多水平模型可将多个相关指标纳入同一个模型中,考虑了指标之间的相关性,可改善误差结构,对同时评价多个指标生物等效性提供了统计学方法的发展思路。 展开更多
关键词 多变量多水平模型 生物等效性 4×4交叉试验设计 方差分
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Social demographic factors and leisure time physical activity influencing the self-rated health and happiness of Chinese people
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作者 Cheng-Xiang Liu An-Ni Zhang +2 位作者 Hai-Yan Jiang Ling Wang Hui Xie 《TMR Integrative Nursing》 2019年第5期173-180,共8页
Background and aims:The holistic definition of health is not merely the absence of disease or infirmity,but a state of complete physical,mental,and social well-being.However,related research on the influencing factor ... Background and aims:The holistic definition of health is not merely the absence of disease or infirmity,but a state of complete physical,mental,and social well-being.However,related research on the influencing factor of self-rated health and happiness have generally remained separate.Therefore,this study aimed to 1)find individual level determinants of the two facets of health;and 2)investigate the covariance of the two facets of health within individual levels.Methods:Multivariate multilevel analysis of self-rated health and happiness at level 1,were nested within 10,968 people at level 2.Data were obtained from the 2015 Chinese General Social Survey.Results:Lower happiness and self-rated health were found in 1)females;2)the elderly;3)people with a lower educational level;4)people who were presently single;5)people with a lower self-rated economic status;6)people who resided in urban areas;and 7)people with sedentary lifestyles as compared to those in other categories of the same variable.After adjusting the related individual level determinants,the correlation coefficient of two facets of health at the individual level is 0.19,which indicates that no robust covariance was observed.Conclusions:The current study indicates the existence of disparity in the subjective physical and psychological dimensions of health among the elderly in China.Our findings emphasize the importance of paying attention to different aspects of health simultaneously in investigations and the benefits of leisure time activities. 展开更多
关键词 Older people Self-rated health Subjective well-being Multivariate multilevel model
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