多喜片改善脑功能障碍记忆力减退的临床研究

通过对６３例患者８周以上的随机双盲对照试验，验证国产多喜片对改善脑功能障碍及记忆力减退的临床疗效。结果表明治疗组（多喜片）在改善临床症状，提高长谷川痴呆量表分数及临床记忆商方面明显优于安慰剂组。多喜片使用方便，毒副作用小，是一种较理想的脑功能改善剂。

浅析“多喜为癫,多怒为狂”

"多喜为癫,多怒为狂"出自刘完素所著之《素问玄机原病式》。《素问玄机原病式》中"癫"指癫狂病之癫证,"狂"指癫狂病之狂证。"多喜"常见之精神疾病:躁狂抑郁性精神病(简称躁郁症)躁狂、心气实,分裂情感性精神病(简称分裂情感症)躁狂、心气实挟痰,精神分裂症(简称精分症)偏执型前段、痰瘀酿毒侵心。"多怒"常见之精神疾病:躁郁症躁狂、肝气实,分裂情感症躁狂、肝气实挟痰,精分症偏执型前段、痰瘀酿毒侵心。尽管刘完素之癫、狂症名判别说不妥,然其所提出的癫狂病因火热说,对狂症之临床辨治却有着甚为重要的指导作用。

来福与多喜

来福与多喜,其实是我们家俩个狗狗,一个白,一个黑;一个男,一个女。白的来福,黑的是多喜,它们是兄妹,象它们的名字幸福地生活在我们的家里。它们从无忧的少年成长为青年,与它们随行相伴快乐着每一天,它们聪明温顺讨人喜欢,以它们的方式读懂人类的语言,你不喜欢它们的眼神,它会离远你,你高兴时它就把所有的本领快乐地给你表现,你与它的默契是互相信任的关系,它们也会追逐异性,血战到底,收获爱情。它听从你的指令,走在十字路口,无需牵引,它等待你给的方向,红绿灯前,它会原地不动左右顾看,

春季星光 推出蔬菜良种

美国经剑西葫芦 抗高温，抗病性强、最早熟。

室内装饰植物百宝箱

印度菩提树桑科原产印度佛教三大圣树之一,据传释迦牟尼就是在此树下悟道。在印度,人们从此树树皮中提取染科和药物。叶片轻柔,是渐受欢迎的植物。偶而往叶面上喷洒水雾可减轻红蜘蛛的危害。

The global diversification of songbirds (Oscines) and the build-up of the Sino-Himalayan diversity hotspot

Over the last decade, molecular phylogenetic studies have provided the foundation for a comprehensive analysis of the global diversification of songbirds (Oscines), which comprise nearly half of all the birds of the world. By comparing the spatial distribution of species representing basal and terminal root-path groups, this paper provides graphical illustrations of the global pattern of diversification for the major songbird clades. The worldwide expansion of songbirds started as an island radiation in the area where New Guinea is now located, but the mountains of southern China represent a principal center for more recent diversification. The paper suggests priorities and perspectives for further research aiming to understand what determines the variation in biodiversity on different spatial scales.

Plant Species Diversity along an Altitudinal Gradient of Bhabha Valley in Western Himalaya

The present study highlights the rich species diversity of higher plants in the Bhabha Valley of western Himalaya in India. The analysis of species diversity revealed that a total of 313 species of higher plants inhabit the valley with a characteristic of moist alpine shrub vegetation. The herbaceous life forms dominate and increase with increasing altitude. The major representations are from the families Asteraceae, Rosaceae, Lamiaceae and Poaceae, suggesting thereby the alpine meadow nature of the study area. The effect of altitude on species diversity displays a hump-shaped curve which may be attributed to increase in habitat diversity at the median ranges and relatively less habitat diversity at higher altitudes. The anthropogenic pressure at lower altitudes results in low plant diversity towards the bottom of the valley with most of the species being exotic in nature. Though the plant diversity is less at higher altitudinal ranges, the uniqueness is relatively high with high species replacement rates. More than 90 % of variability in the species diversity could be explained using appropriate quantitative and statistical analysis along the altitudinal gradient. The valley harbours 18 threatened and 41 endemic species, most of which occur at higher altitudinal gradients due to habitat specificity.

Root Structure,Distribution and Biomass in Five Multipurpose Tree Species of Western Himalayas

【Title】【Author】【Addresses】1The tree root distribution pattern and biomass of seventeen year old trees of Grewia optiva, Morus alba, Celtis australis, Bauhinia variegata and Robinia pseudoacacia were studied by excavation method. B. variegata roots penetrated to a maximum depth of 4.78 m, whereas, M. alba roots were found down to 1.48 m depth. Lateral spread was minimum in B. variegata （1.10 m）and maximum inR. pseudoacacia （7.33 m）. Maximum root biomass of 6.30 kg was found in R. pseudoacacia and minimum （2.43 kg） was found in M. alba. For four species viz.,G. optiva, M. alba, C. australis andR. pseudoacacia, 68%-87% root biomass occurred within top 0-30 cm soil depth, but forB. variegata this was only45%. The soil binding factor was maximum in G. optiva and minimum in B. variegata. Soil physico-chemical properties also showed wide variation. The study suggests thatB. variegata with a deep root system is the most suitable species for plantation under agroforestry systems. R. pseudoacacia and G. optiva with deep root systems, more lateral spread and high soil binding factor are suitable for plantation on degraded lands for soil conservation.

The Effect of Verbal Anchoring on the Processing of Advertising Pictorial Metaphors

Although investigating metaphors in advertising is gaining in popularity, there are still certain unresolved arguments, such as the interaction between elements of different modalities. This study,composed of three behavioral experiments, aims to identify how verbal anchoring(literal anchoring, metaphor anchoring and unrelated anchoring) influences the processing of pictorial metaphors in advertising, by observing the cognitive and affective indicators, advertising comprehension and advertising likeability. The results showed 1) that metaphors in pictorial modality were recognized more quickly than those in verbal modality, 2) that verbal anchoring facilitated participants ’ comprehending and appreciating of pictorial metaphors and 3) that literally-anchored metaphors with a moderate level of novelty yielded the most favorable cognitive responses. The study not only enriches the existing theoretical framework of multimodal metaphors in advertising, but also proposes an optimal match between pictorial metaphors and verbal elements, for advertisers and manufacturers to design effective multimodal advertisements.

Polytene chromosomes of an Indian Himalayan black fly Simulium (Nevermannia) praelargum (Diptera:Simuliidae)

High quality polytene chromosome maps （n=3） of a Himalayan Simuliid Simulium praelargum Datta, 1973 are presented and represent the first cytological description of a taxon found in the feuerborni group, subgenus Nevermannia. Polytene chromosomes one （I） and two （II） are metacentric, chromosome three （III） is submetacentric with the length of each chromosome occupying 37.25 %, 31.36 % and 31.34 % of the total complement length, respectively. Typical simuliid diagnostic intergeneric chromosomal markers are found within the polytene complement of this species. The nucleolar organizer （N.O.） is found at the base of the short arm of chromosome one （IS）, the Ring of Balbiani （R.B.）, double bubble （D.B.） and triad occur in the short arm of chromosome two （IIS）, the Parabalbiani Ring （EB.） and grey band （gb） occur in the long arm of chromosome two （IIL） and the Blister （BL） and Capsule （Ca） occur in the short arm of chromosome three （IIIS）.Terminal bands at the end of IIIS are heterochromatinized and present atypically with respect to other simuliid fauna. Populations studied so far are unique among the Simuliidae in that they exhibit chromosome structural monomorphism. These high resolution polytene chromosome maps will form the basis for future cytological characterization and phylogenetic comparisons amongst members of the feuerborni group

Effects of Topography and Land use on Woody Plant Species Composition and Beta Diversity in an Arid Trans-Himalayan Landscape, Nepal

Distribution patterns of plant species are believed to be impacted by small-scale habitat heterogeneity. However, there have been few comparative studies examining how woody vegetation composition and diversity varies with aspects of different orientations in the Trans-Himalayan region at a local scale. Here, we examined the effects of incoming solar radiation on variation in woody species composition and compared the diversity between the northeast- and southwest-facing slopes in a Trans-Himalayan valley of Nepal. We also examined the implicit interactions between slope orientation and land use in determining the compositional variations between the slopes. We selected two pairs of northeast- and southwest-facing slopes where the first pair has a similar land use and differs in exposure only(Pisang site) while the other pair has clear differences in land use in addition to slope exposure(Braka site). In each site, we sampled 72 plots(36 on each slope) in which the presence and absence of woody species, environmental variables, and disturbance were recorded. Correspondence Analysis(CA) results suggested that the woody species composition significantly varied between northeast- and southwest-facing slopes at both sites, and was significantly correlated with measured environmental variables such as radiation index, altitude, and canopy openness. In the Braka site,mean alpha diversity was significantly higher on southwest-facing slopes. In contrast, beta diversity and gamma diversity were greater on northeast-facing slopes at both sites. Our results suggest that topographic variables(e.g., radiation index) affect species composition between the slopes, likely due to their influence on small scale abiotic environmental variables. However, the effects of land use, such as livestock browsing/grazing may interact with the effects of slope exposure, effectively reducing differences in species composition within slopes but enhancing the differences in beta diversity between contrasting slopes in the Braka. We conclude that slope orientation and land use are important factors in structuring the woody species composition and diversity in the arid Trans-Himalayan region. We suggest that both environmental and land use variables should be taken into consideration in future studies on plant community structure along the cultural landscapes.

Livelihood Diversification as an Adaptation Approach to Change in the Pastoral Hindu-Kush Himalayan Region

Migratory livestock raising has been one of the most important livelihood options for people residing in high mountain areas and has made a significant contribution to the economy of the Hindu Kush Himalayan(HKH) region, both in terms of supporting households and in export earnings. However, in recent decades, changes in the socioeconomic situation and increasing climate variability have led to a need to enhance adaptation by building the resilience of local socio-ecological systems, including economic diversification and sustainable management of natural resources. Based on semistructured interviews with pastoral communities in six countries within the pastoral HKH region, this paper discusses the situation, trends and driving forces behind the diversification of pastoral livelihood. For internal diversification the study highlights the need for enhancement of pastoral livelihoods through value-adding activities in the pastoral sectors. For external diversification changes on policy changes are needed to support free out-migration, market exploitation, and multiple resource use. Finally the paper highlights the role of education in determining household adaptation strategies in the face of various socio-ecological pressures and recommends integrating innovative and indigenous knowledge to develop appropriate methods for risk management and resource management in the pastoral HKH region.

Net Primary Productivity and Species Diversity of Herbaceous Vegetation in Banj-oak (Quercus leucotri-chophora A.Camus) Forest in Kumaun Himalaya,India

Net primary productivity and species diversity of herbaceous vegetation of banj-oak （Quercus leucotrichophora A. Camus） forest in Kumaun Himalaya, India were analyzed. Across different growth forms （tall forbs, short forbs, cushion and spreading forbs, grasses）, short forbs were most dominant component during rainy season （1VI=152） and winter season （IVI=167） and grasses during the winter season （IVI=148）. Maximum above-ground production occurred during rainy season （132.5 g m-2） and minimum during winter season （2.8 g m-~）. Below-ground production was maximum （85.9 g m-x） during winter season and minimum （14.9 g m-x） during summer season. Annual net shoot production was 15o g m-~ and below-ground production was 138 g m-~. Of the total input 61% was channeled to above- ground parts and 39% to below-ground parts.

Biodiversity and Invasibility: Distribution Patterns of Invasive Plant Species in the Himalayas, Nepal

Invasive plant species are exerting a serious threat to biological diversity in many regions of the world. To understand plant invasions this study aims to test which of the two plant invasiveness hypotheses; ‘low native diversity' vs. ‘high native diversity', is supported by the regional distribution patterns of invasive plant species in the Himalayas,Nepal. This study is based on data retrieved from published literatures and herbarium specimens. The relationship between invasive plant species distribution patterns and that of native plant species is elucidated by scatter plots, as well as by generalized linear models. The native plant species and invasive plant species have similar distribution patterns and the maximum number of invasive plant species is found in the same altitudinal range where the highest richness for native tree species is found. There is a clear trend of higher invasive plant richness in regions where native tree species richness is relatively high.Consequently, the native plant richness is highest in the central phytogeographic region, followed by the eastern and the western regions, respectively. The invasive plant species also follows a similar trend.Additionally, the invasive plant species richness was positively correlated with anthropogenic factors such as human population density and the number of visiting tourists. This study supports the hypothesis that ‘high native diversity' supports or facilitates invasive plant species. Further, it indicates that nativeand invasive plant species may require similar natural conditions, but that the invasive plant species seem more dependent and influenced by anthropogenic disturbance factors.

Benefitting from Geoinformatics: Estimating Floristic Diversity of Warwan Valley in Northwestern Himalaya,India

The Himalaya harbor rich floristic diversity which is of immense scientific interest and socio-economic importance.In this study, floristic diversity of a remote alpine valley has been studied based on information extracted from remotely sensed satellite data along with field surveys undertaken during 2008-2014.Analysis of vegetation information from satellite data revealed that ~75% of the area is covered with natural vegetation which comprises lush green coniferous forests, alpine pastures and alpine scrub lands.With inputs from vegetation information extracted from satellite data, comprehensive field surveys were planned to document the floristic diversity of the region.Analysis of species composition showed a total of 285 plant species,belonging to 191 genera in 60 families.Of these, 250 species are herbs, 14 shrubs, 2 sub-shrubs and 19 trees.The dicotyledons are represented by 240 species, monocotyledons 30, gymnosperms 04, andpteriodophytes 11 species.Asteraceae is the largest family with 35 species.During the present study, 5species（Corydalis cashmeriana, Hippophae rhamnoides, Primula minutissima, Saussurea sacra and Inula orientalis） have been recorded for the first time from this Himalayan region.The study demonstrates the benefits of geo-informatics in floristic studies, particularly the robustness of remotely sensed data in identifying areas with potentially high species richness, which would be otherwise difficult in a complex mountainous terrain using traditional floristic surveys alone.The present study is expected to provide baseline scientific data for cutting edge studies relating to long term ecological research, bioprospecting, possible impacts of changing climate on vegetation and sustainable use of plant resources in this Himalayan region.

朵云印评

黄河之水天上来关崇株(广东)朱白文置于一印,古人多喜为之,其可贵处在朱白有混淆莫辨的感觉,而不是一览无余,作者在这里打了折扣。刻制这一路印章,首先是文字的可为,有些文字搭配到一块是不易做到的,就此印来说,是比较适宜做朱白两种处理的,只是作者稍欠修饰,如果左,右线条略加调整即会达到理想效果。所以一蹴而就在大师也不是屡屡得手,反复磨炼是必须的。

Synthesis of cleavable multi-functional mikto-arm star polymer by RAFT polymerization: example of an anti-cancer drug 7-ethyl-10-hydroxycamptothecin(SN-38) as functional moiety

Multi-functional mikto-arm star polymers containing three different arms [hydrophilic, SN-38-P（OEGMAs_9）11, cationizable, SN-38-P（DMAEMA）3s and hydrophobic, SN-38-P（BMA）26] were prepared by RAFT polymerization via an arm-first approach using a cleavable cross-linker. The star polymers were cleaved to the linear arms with tributylphosphine as a reducing agent. The decrease in molecular weight observed is consistent with the initial stars having approximately five arms, Blue fluorescence was observed when a solution of mikto-arm star was irradiated under a 365 nm light proving the retention of the SN-38 moiety during star formation by RAFT polymerization. Thus these polymer-drug conjugates can be considered as potential delivery vehicles for cancer therapy. The P（DMAEMA） arms can be quaternized using iodomethane, allowing star polymers to bind negatively charged small interfering RNA （siRNA） and potentially be used as a carrier for that material.

Origin area and migration route: Chloroplast DNA diversity in the arctic-alpine plant Koenigia islandica

The Hengduan Mountains(henceforth H-D Mountains) on the Tibet Plateau are a distribution and diversity center for many alpine genera. We examine patterns of genetic variation in an arctic-alpine plant to evaluate the possibility that the H-D Mountains constitute the area of origin of the species as well as to uncover postglacial migration routes. 220 individuals of the arctic-alpine plant Koenigia islandica were sampled from 26 populations distributed in western China and northern Finland. DNA haplotypes were identified using restriction site analysis of two chloroplast DNA intergene spacer regions, atpB-rbcL and trnL-trnF. We examined the geographical distribution of haplotype diversity in relation to latitude, and also compared various indices of diversity in putatively glaciated and unglaciated regions. Patterns of migration were inferred using nested clade analysis. A total of 25 haplotypes were detected. High haplotype diversity was found in the H-D Mountains. H3 and its radiated haplotypes were distributed in the Himalayas. Two haplotypes were fixed concurrently in the H-D Mountains and northern Finland. High genetic diversity of K. islandica and high species diversity of K. islandica are expected in the origin area. Our observations suggest that the H-D Mountains are not only the place of origin of K. islandica, but also the refugia for K. islandica on the Tibet Plateau. What is more, the migration route for the arctic-alpine plant K. islandica must have originated in the region defined by the H-D Mountains in western China extending northward to the Arctic circumpolar, and moved westward along the Himalayas, then northward across the Altay Mountains and the Central Siberian Plateau at different time periods.

Genetic diversification in the East Himalayas as revealed by comparative phylogeography of the black-throated bushtit and Elliot＇s laughing thrush

The Southwest Mountainous region of the eastern Himalayas is a hotspot with extraordinarily high biodiversity and endemism, but the processes that have driven this unique diversity are largely unknown. We evaluated processes that have con- tributed to the current observed high genetic diversity in this region by integrating comparative phylogeography with ecological niche modeling in a study of two representative birds of the Southwest Mountains： the black-throated bushtit Aegithalos concinnus and the Elliot＇s laughing thrush Garrulax elliotii. Mitochondrial DNA analyses revealed multiple divergent genetic lineages, which are roughly congruent with the north, south and east eco-subregion division of the Southwest Mountains. This strong geo- graphical structure in these two species suggests that lineage diversification has proceeded in situ between the eco-subregions of the Southwest Mountains. During Pleistocene glaciations, the two species responded differently to climatic fluctuations. A. con- cinnus maintained rather stable habitats, mostly evergreen forests, during glacial cycles and thus kept a stable population size and further accumulated genetic diversity. In contrast, G. elliotii, which is mostly active in shrublands, has shifted its suitable habitats with glacial cycles. This species dispersed to low elevation areas during glacial periods, which provided multiple opportunities for gene admixture. The admixture causes the mixing of previously isolated genetic lineages and thus obscures the pattern of genetic variation [Current Zoology 61 （5）： 935-942, 2015].