Objective:The lack of a simple criterion for gastric carcinoma creates a persistent challenge for clinicians trying to provide patients with useful prognostic information.The aim of this study was to identify baseline...Objective:The lack of a simple criterion for gastric carcinoma creates a persistent challenge for clinicians trying to provide patients with useful prognostic information.The aim of this study was to identify baseline prognostic factors,and use this information to establish a simple criterion to predict outcome in gastric carcinoma.Methods:Between 2005 and 2010, 155 patients with gastric carcinoma,were enrolled.Clinicopathologic prognostic factors were evaluated by univariate and multivariate analysis.Results:Of the 155 patients,48(30.9%)died.Three independent poor prognostic factors were identified by multivariate analysis:gross type>or=3(hazard ratio[HR],1.564;95%CI,1.067 to 2.294),peritoneal dissemination (HR,3.750;95%CI,1.760 to 7.989)and lymphatic duct invasion(HR,3.578;95%CI,1.422 to 9.004).One point was added for each category among three independent prognostic factors.Prognostic score(PS)was determined by an aggregate of these points for each category.There existed a significant difference between survival of patients with PS 0 or 1 and 2(P< 0.0001).Conclusion:Three poor prognostic factors were identified and a simple criteria was devised.Information from this analysis can be used to predict prognosis of gastric carcinoma with a strict stratification.展开更多
文摘Objective:The lack of a simple criterion for gastric carcinoma creates a persistent challenge for clinicians trying to provide patients with useful prognostic information.The aim of this study was to identify baseline prognostic factors,and use this information to establish a simple criterion to predict outcome in gastric carcinoma.Methods:Between 2005 and 2010, 155 patients with gastric carcinoma,were enrolled.Clinicopathologic prognostic factors were evaluated by univariate and multivariate analysis.Results:Of the 155 patients,48(30.9%)died.Three independent poor prognostic factors were identified by multivariate analysis:gross type>or=3(hazard ratio[HR],1.564;95%CI,1.067 to 2.294),peritoneal dissemination (HR,3.750;95%CI,1.760 to 7.989)and lymphatic duct invasion(HR,3.578;95%CI,1.422 to 9.004).One point was added for each category among three independent prognostic factors.Prognostic score(PS)was determined by an aggregate of these points for each category.There existed a significant difference between survival of patients with PS 0 or 1 and 2(P< 0.0001).Conclusion:Three poor prognostic factors were identified and a simple criteria was devised.Information from this analysis can be used to predict prognosis of gastric carcinoma with a strict stratification.
