A novel vehicle for the delivery of aspirin （ASA） was prepared from porous nano-hydroxyapafite/poly（styrene-divinylbenzene） [nano-HAP/P（St-DVB）] composite microspheres by grafting nano-HAP [Ca10（PO4）6（OH）2] ...A novel vehicle for the delivery of aspirin （ASA） was prepared from porous nano-hydroxyapafite/poly（styrene-divinylbenzene） [nano-HAP/P（St-DVB）] composite microspheres by grafting nano-HAP [Ca10（PO4）6（OH）2] onto porous P（St-DVB） micro- spheres. Four types of porous composite microspheres were prepared, each with different nano-HAP contents. The ASA-loaded composite microspheres prepared with 10% and 15% nano-HAP （mass ratio） exhibited excellent buoyancy with relatively short instantaneous floating time （within l0 min） and a long sustained floating time （12 h） in simulated gastric juice. They also offered good sustained release of ASA （up to 8 h）. Furthermore, these composite microspheres displayed good buff- ering capacity that prevented the buildup of acidity caused by hydrolysis of ASA, keeping the pH of gastric juice within the normal range （pH 0.9 to 1.5）. The results showed that porous nano-HAP/P（St-DVB） composite microspheres prepared with 10% and 15% nano-HAP could be used as a novel drug carrier for ASA, providing a sustained release dose without leading to stomach irritation, a side effect that is often associated with ASA medication.展开更多
基金financially supported by the Young Scientists Fund of the Natural Science Foundation of Heilongjiang Province (QC2011C099)Scientific Fund of Heilongjiang Province Department of Health (2009-259)+3 种基金Grant from Educational Office of Heilongjiang Province (11551178 and1154HZ11)Fund of Daqing GaoXin Qu (DQGX09YF016)the National Natural Science Foundation of China (30871007)the Natural Science Foundation of Heilongjiang Province (ZD2008-08 and LC2009C12)
文摘A novel vehicle for the delivery of aspirin （ASA） was prepared from porous nano-hydroxyapafite/poly（styrene-divinylbenzene） [nano-HAP/P（St-DVB）] composite microspheres by grafting nano-HAP [Ca10（PO4）6（OH）2] onto porous P（St-DVB） micro- spheres. Four types of porous composite microspheres were prepared, each with different nano-HAP contents. The ASA-loaded composite microspheres prepared with 10% and 15% nano-HAP （mass ratio） exhibited excellent buoyancy with relatively short instantaneous floating time （within l0 min） and a long sustained floating time （12 h） in simulated gastric juice. They also offered good sustained release of ASA （up to 8 h）. Furthermore, these composite microspheres displayed good buff- ering capacity that prevented the buildup of acidity caused by hydrolysis of ASA, keeping the pH of gastric juice within the normal range （pH 0.9 to 1.5）. The results showed that porous nano-HAP/P（St-DVB） composite microspheres prepared with 10% and 15% nano-HAP could be used as a novel drug carrier for ASA, providing a sustained release dose without leading to stomach irritation, a side effect that is often associated with ASA medication.
