For high viscosity bulk-copolymerization of octamethylcyclotetrasiloxane and amino-silicone monomer, a multisyphon flow physical model was established.Based on the free volume and chemical reaction kinetic theories, a...For high viscosity bulk-copolymerization of octamethylcyclotetrasiloxane and amino-silicone monomer, a multisyphon flow physical model was established.Based on the free volume and chemical reaction kinetic theories, a new computational model was developed to simulate the multisyphon flow model. As to the new model, the united influence of reaction and diffusion was reviewed and analyzed. The new model was used to simulate bulk- copolymerization of octamethylcyclotetrasiloxane and amino-silicone monomer and agreed well with the results.展开更多
Background:Interpersonal coordination is an essential aspect of daily life,and crucial to performance in cooperative and competitive team sports.While empirical research has investigated interpersonal coordination usi...Background:Interpersonal coordination is an essential aspect of daily life,and crucial to performance in cooperative and competitive team sports.While empirical research has investigated interpersonal coordination using a wide variety of analytical tools and frameworks,to date very few studies have employed multifractal techniques to study the nature of interpersonal coordination across multiple spatiotemporal scales.In the present study we address this gap.Methods:We investigated the dynamics of a simple dyadic interpersonal coordination task where each participant manually controlled a virtual object in relation to that of his or her partner.We tested whether the resulting hand-movement time series exhibits multi-scale properties and whether those properties are associated with successful performance.Results:Using the formalism of multifractals,we show that the performance on the coordination task is strongly multi-scale,and that the multi-scale properties appear to arise from interaction-dominant dynamics.Further,we find that the measure of across-scale interactions,multifractal spectrum width,predicts successful performance at the level of the dyad.Conclusion:The results are discussed with respect to the implications of multifractals and interaction-dominance for understanding control in an interpersonal context.展开更多
The ionosphere is composed of a large number of electrons and ions, which are produced by the photoionization effect of the solar radiation on the neutral atmosphere. The altitude range of ionosphere is about 60–1000...The ionosphere is composed of a large number of electrons and ions, which are produced by the photoionization effect of the solar radiation on the neutral atmosphere. The altitude range of ionosphere is about 60–1000 km and varies with local time and other factors （e.g., solar and geomagnetic activity）. Although the ionosphere varies over multiply timescales, the diurnal variation is in the dominant position due to the sun’s photoionization effect.展开更多
The rational construction of active targeting liposomes will provide an important structural support for its effective brain targeting.However,there is no clear understanding of the structure-activity relationship of ...The rational construction of active targeting liposomes will provide an important structural support for its effective brain targeting.However,there is no clear understanding of the structure-activity relationship of active targeting liposomes.Combining multiscale computational simulation and experimental verification,we established a computational model of RVGP modified PEGylated liposomes(RVGP-PEG-L)and investigated the role of PEG and molecular interaction mechanism of carrier-ligand-receptor.The result indicated that the complex network conformation formed by PEG with 42 monomers(42 PEG)above the density of 8%was the molecular basis for PEG-L to achieve long-circulation function.The lowest monomer number of PEG linker to ensure the targeting ability of RVGP was 42.However,the pose of RVGP binding to nAChR changed after it was linked with PEG-L due to the restraint of PEG chain,leading to a decrease of binding free energy.Increasing the monomer number of PEG linker or improving the non-polarity of polymers was a potential strategy to enhance the combination of RVGP-PEG-L with nAChR on the targeting cell.展开更多
文摘For high viscosity bulk-copolymerization of octamethylcyclotetrasiloxane and amino-silicone monomer, a multisyphon flow physical model was established.Based on the free volume and chemical reaction kinetic theories, a new computational model was developed to simulate the multisyphon flow model. As to the new model, the united influence of reaction and diffusion was reviewed and analyzed. The new model was used to simulate bulk- copolymerization of octamethylcyclotetrasiloxane and amino-silicone monomer and agreed well with the results.
文摘Background:Interpersonal coordination is an essential aspect of daily life,and crucial to performance in cooperative and competitive team sports.While empirical research has investigated interpersonal coordination using a wide variety of analytical tools and frameworks,to date very few studies have employed multifractal techniques to study the nature of interpersonal coordination across multiple spatiotemporal scales.In the present study we address this gap.Methods:We investigated the dynamics of a simple dyadic interpersonal coordination task where each participant manually controlled a virtual object in relation to that of his or her partner.We tested whether the resulting hand-movement time series exhibits multi-scale properties and whether those properties are associated with successful performance.Results:Using the formalism of multifractals,we show that the performance on the coordination task is strongly multi-scale,and that the multi-scale properties appear to arise from interaction-dominant dynamics.Further,we find that the measure of across-scale interactions,multifractal spectrum width,predicts successful performance at the level of the dyad.Conclusion:The results are discussed with respect to the implications of multifractals and interaction-dominance for understanding control in an interpersonal context.
文摘The ionosphere is composed of a large number of electrons and ions, which are produced by the photoionization effect of the solar radiation on the neutral atmosphere. The altitude range of ionosphere is about 60–1000 km and varies with local time and other factors （e.g., solar and geomagnetic activity）. Although the ionosphere varies over multiply timescales, the diurnal variation is in the dominant position due to the sun’s photoionization effect.
基金National Natural Science Foundation of China(Grant No.81202469)
文摘The rational construction of active targeting liposomes will provide an important structural support for its effective brain targeting.However,there is no clear understanding of the structure-activity relationship of active targeting liposomes.Combining multiscale computational simulation and experimental verification,we established a computational model of RVGP modified PEGylated liposomes(RVGP-PEG-L)and investigated the role of PEG and molecular interaction mechanism of carrier-ligand-receptor.The result indicated that the complex network conformation formed by PEG with 42 monomers(42 PEG)above the density of 8%was the molecular basis for PEG-L to achieve long-circulation function.The lowest monomer number of PEG linker to ensure the targeting ability of RVGP was 42.However,the pose of RVGP binding to nAChR changed after it was linked with PEG-L due to the restraint of PEG chain,leading to a decrease of binding free energy.Increasing the monomer number of PEG linker or improving the non-polarity of polymers was a potential strategy to enhance the combination of RVGP-PEG-L with nAChR on the targeting cell.
