不宁腿综合征(restless legs syndrome,RLS)是一种常见的神经系统疾病,特点是不舒服的腿部冲动,在运动或起身行走时缓解,并在夜间症状加重。RLS的发病机制仍不清楚,但随着病理生理学研究的进展,发现可能涉及中枢神经系统的多巴胺功能障...不宁腿综合征(restless legs syndrome,RLS)是一种常见的神经系统疾病,特点是不舒服的腿部冲动,在运动或起身行走时缓解,并在夜间症状加重。RLS的发病机制仍不清楚,但随着病理生理学研究的进展,发现可能涉及中枢神经系统的多巴胺功能障碍,以及其他未确定的促进机制,特别是缺铁和慢性肾功能障碍。有家族史的遗传易感性很常见。RLS增强的特点是症状的严重性更强,症状发生的时间更早,而且常常是症状从腿部扩散至手臂或身体其他区域。一些RLS患者通过非药物措施,如按摩和温水浴,可以充分控制症状。一线治疗方案包括对体内铁储存减少的人进行铁补充治疗,或使用加巴喷丁、普瑞巴林,以及多巴胺激动剂,如普拉克索、罗匹尼罗和罗替戈汀。二线疗法包括曲马多、羟考酮和美沙酮等阿片类药物。RLS严重影响患者的生活质量,且仍是一个非常需要创新的治疗领域,需要有更多新的、有生物依据的治疗方法。展开更多
This study sought to investigate whether low dose dobutamine MRI can detect residual myocardial viability in patients with chronic myocardial infarction and left ventricular dysfunction. Methods. Eleven patients with ...This study sought to investigate whether low dose dobutamine MRI can detect residual myocardial viability in patients with chronic myocardial infarction and left ventricular dysfunction. Methods. Eleven patients with chronic myocardial infarction and left ventricular dysfunction were employed for identification of viable myocardium by cine MRI during dobutamine infusion. All patients underwent coronary angiography and left ventriculography, 18 FDG PET, MRI at rest and stress.The systolic wall thickening measured at rest and during stress was compared with the results of 18 FDG PET, respectively. Results. A significant difference of either dobutamine induced systolic wall thickening (SWth stress ) or dobutamine induced contractile reserve (ΔSWth= SWth stress - SWth rest ) was present between viable and scar regions (1 0±0 3 versus -0 3 ±0 1, P<0 01; 1 0±0 3 versus -0 2±0 2, P<0 01). Conclusions. Dobutamine induced contractile reserve can be predicted in the regions of akinesia or dyskinesia at rest when systolic wall thickening was 1 0 mm during dobutamine stimulation.展开更多
文摘不宁腿综合征(restless legs syndrome,RLS)是一种常见的神经系统疾病,特点是不舒服的腿部冲动,在运动或起身行走时缓解,并在夜间症状加重。RLS的发病机制仍不清楚,但随着病理生理学研究的进展,发现可能涉及中枢神经系统的多巴胺功能障碍,以及其他未确定的促进机制,特别是缺铁和慢性肾功能障碍。有家族史的遗传易感性很常见。RLS增强的特点是症状的严重性更强,症状发生的时间更早,而且常常是症状从腿部扩散至手臂或身体其他区域。一些RLS患者通过非药物措施,如按摩和温水浴,可以充分控制症状。一线治疗方案包括对体内铁储存减少的人进行铁补充治疗,或使用加巴喷丁、普瑞巴林,以及多巴胺激动剂,如普拉克索、罗匹尼罗和罗替戈汀。二线疗法包括曲马多、羟考酮和美沙酮等阿片类药物。RLS严重影响患者的生活质量,且仍是一个非常需要创新的治疗领域,需要有更多新的、有生物依据的治疗方法。
文摘This study sought to investigate whether low dose dobutamine MRI can detect residual myocardial viability in patients with chronic myocardial infarction and left ventricular dysfunction. Methods. Eleven patients with chronic myocardial infarction and left ventricular dysfunction were employed for identification of viable myocardium by cine MRI during dobutamine infusion. All patients underwent coronary angiography and left ventriculography, 18 FDG PET, MRI at rest and stress.The systolic wall thickening measured at rest and during stress was compared with the results of 18 FDG PET, respectively. Results. A significant difference of either dobutamine induced systolic wall thickening (SWth stress ) or dobutamine induced contractile reserve (ΔSWth= SWth stress - SWth rest ) was present between viable and scar regions (1 0±0 3 versus -0 3 ±0 1, P<0 01; 1 0±0 3 versus -0 2±0 2, P<0 01). Conclusions. Dobutamine induced contractile reserve can be predicted in the regions of akinesia or dyskinesia at rest when systolic wall thickening was 1 0 mm during dobutamine stimulation.
