基于多效应协同的城市公园系统规划方法研究--以泗县为例

城市公园绿地是城市绿地系统的重要组成部分,它具有生态、景观、游憩和防灾避险的功能,城市公园绿地的合理布局能够改善城市人居环境,使公园绿地功能得到有效发挥。本文应用协同学的理论,提出了由基础层面、功能层面和指导层面三方面协同构成的理论方法,以多功能协同为重点,协调城市公园绿地四个功能子系统之间有序布局,并从基础层面分析城市自然人文因素对公园绿地基础骨架的影响,从指导层面分析相关规划政策等的调控作用。最后,以泗县为例,通过三个层面协同叠加,构建合理的城市公园绿地空间结构。

Efficient oxidation of cinnamon oil to natural benzaldehyde over β-cyclodextrin-functionalized MWCNTs

We have designed and prepared β-cyclodextrin （β-CD）-functionalized multi-walled nanotubes （MWCNTs-g-CD） for the oxidation of cinnamon oil to natural benzaldehyde under aqueous condi- tions. The synergistic effect of combining MWCNTs with β-CD led to a remarkable increase in the performance of the MWCNTs-g-CD for the catalytic oxidation of cinnamaldehyde, which exhibited 95% cinnamaldehyde conversion and 85% selectivity to natural benzaldehyde with a short reaction time of 10 rain. The MWCNTs-g-CD also exhibited outstanding recyclability with good stability, showing no discernible decrease in their catalytic activity over five reaction cycles.

Amide-linked covalent organic frameworks as efficient heterogeneous photocatalysts in water

Semiconductor photocatalysts play an indispensable role in the photocatalytic process.Two-dimensional covalent organic frameworks(2D-COFs),as a kind of innovative photocatalyst,have garnered tremendous attention.Herein,we report an amide-linked 2D-COF(COF-JLU19)with outstanding photocatalytic performance in water,designed through a multi-synergistic approach.The synergistic effects of the high porosity,photoactive framework,high wettability,and stability of COF-JLU19 led to an unprecedented enhancement in the photocatalytic activity and recyclability in water upon illumination by visible light.More importantly,amide-linked 2D-COF based electrospinning membranes were prepared,which also exhibited superior photocatalytic activity for the degradation of Rhodamine B in water with sunlight.This study highlights the potential of the multi-synergistic approach as a universal rule for developing COF-based photocatalysts to address environmental and energy challenges.

Synergistic effects of a curcumin analogue and docetaxel on growth inhibition of human prostate cancer cells

Cancer of the prostate gland is a leading cause of death. In the present study, we studied the effects and mechanisms of curcumin analogue E10, docetaxel or their combination on prostate cancer （PC）-3 cells. Treatment of PC-3 cells with El0 or docetaxel resulted in growth inhibition in a concentration-reliant fashion. Combinations of E10 and docetaxel inhibited the growth of PC-3 cells in a synergistic manner. Effects of a combination of E10 and docetaxel were associated with synergistic inhibition of the transcriptional activity of nuclear factor-kappa B （NF-KB）, and robust reductions in the levels of B-cell lymphoma-2 （Bcl-2） were found in PC-3 cells treated with a combination of E10 and docetaxel. Our data indicated that the effects of El0 in combination with docetaxel on PC-3 cells were associated with inhibition of NF-r,B and Bcl-2. Further studies using suitable animal models are necessary to determine the in vivo effect of this combination.

Exploring the Scale Effects of Trade-offs and Synergies of Multifunctional Cultivated Land——Evidence from Wuhan Metropolitan Area

The purpose of this paper is to explore the trade-offs and synergies of multifunctional cultivated land(MCL) at multiple scales. The study area is Wuhan Metropolitan Area, China. The entropy method and the method of Spearman’s rank correlation were employed for the analysis of combined land use/cover data, administrative division data, population data and statistical yearbook data, from the multi-scale perspectives of cities, counties and townships. The results showed that:(1) The multi-functionality of cultivated land had obvious spatial differences and its overall spatial patterns were relatively robust, which did not change very much at the single scale.(2) At each single scale, the MCL’s trade-offs and synergies had spatial heterogeneity.(3) Scale effects existed in the MCL’s trade-offs and synergies. From the prefecture-level city scale, to the county scale, and to the township scale, the MCL’s trade-offs were changed to synergies, and some synergic relationships were enhanced. This article contributes to the literature by deepening the multiscale analysis of trade-offs and synergies of multifunctional cultivated land. The conclusions might provide a basis for helping policy-makers to implement protection measures for the multi-functionality of cultivated land at the right spatial scale, and to promote the higher-level synergies of multifunctional cultivated land to realize its sustainable use.

Preparation and evaluation of doxorubicin-luminespib co-loaded multivesicular liposomes

A combinational therapeutic system that simultaneously administrates various pathways is preferred for anti-cancer treatment.In the present study,we successfully constructed a co-delivery system,multivesicular liposomes(MVLs)co-encapsulating doxorubicin(DOX)and luminespib(AUY922).A simple and accurate dual-wavelength spectrophotometric method was established for the determination of DOX and AUY922 in liposomal formulation.MVL-loading drugs were prepared by a multi-emulsion solvent evaporation method,which exhibited excellent physicochemical properties,such as particle size of 3–8μm and high entrapment efficiency above 95%for DOX and 73%for AUY922.The synergetic cytotoxic effect for these two drugs was evaluated in MDA-MB-231 cells.The in vitro antitumor studies demonstrated the superior anti-proliferation activity of DOX and AUY922 with a combination index of 0.43,indicating a great synergistic effect.The experimental data suggested that combinational use of DOX and AUY922 within liposomes could be an effective way to develop efficient treatments of cancers.