Background: Multinucleate cell angiohistiocytoma is an infrequent and most likely non-neoplastic disorder usually seen in acral regions in elderly women. It presents clinically as asymptomatic red-to-brown tumors, wit...Background: Multinucleate cell angiohistiocytoma is an infrequent and most likely non-neoplastic disorder usually seen in acral regions in elderly women. It presents clinically as asymptomatic red-to-brown tumors, with a tendency to confluence. It must be distinguished from other diverse cutaneous lesions, notably dermatofibroma, Kaposi sarcoma, and angiofibroma. Methods: We report the clinical, histopathological, and immunohistochemical findings of five patients, all women aged between 51 and 78 years. All except the first presented lesions on both of the lower limbs. None of the patients developed spontaneous resolution of the lesions and one was successfully treated by cryosurgery. Comments: Multinucleate cells are characteristic, but neither exclusive nor pathognomonic, of multinucleate cell angiohistiocytoma,since they can also appear in other inflammatory, neoplastic, or reactive processes. The presence of these cells and vascular proliferation in dermis media are the principal histopathological findings in this infrequent entity. In immunohistochemical studies, the multinucleate cells are often positive for vimentin and factor XIIIa.展开更多
Introduction. Multinucleate cell angiohistiocytoma is a rare entity. We report two unusual cases of this lesion. Case report. A 39 year-old man had presented since two years an arciform papular eruption of the forehea...Introduction. Multinucleate cell angiohistiocytoma is a rare entity. We report two unusual cases of this lesion. Case report. A 39 year-old man had presented since two years an arciform papular eruption of the forehead. A 40 year-old woman had a disseminated maculo-papular eruption since three years. Histological examination of skin samples of the two patients showed a dermal small vessel proliferation, associated with multinucleate cells, and confirmed the diagnosis of multinucleate cell angiohistiocytoma. Discussion. Our cases, typical histologically, have unusual clinical presentation (first case observed in a man, and the second in a disseminated form). Multinucleate cell angiohistiocytoma is a rare benign vascular proliferation individualized in 1985. Clinically, the lesion consists in small circumscribed papules. Acral sites and notably of the dorsum of the hands are the more frequent topography. It generally occurs in women aged over 50 years. Histologically, there is a dermal proliferation of capillaries and venules,and a fibrosis associated with the interstitial mononucleate cells and multinucleate cells.展开更多
We report the case of a 68- year- old female with reactive angioendotheliomatosis (RAE). This case highlights the benign course of this condition and suggests that this entity might be an intravascular histiocytosis.
Multinucleate cell angiohistiocytoma (MCAH) was first described by Smith and Wilson- Jones in 1985. It is an uncommon entity but probably underdiagnosed because of lack of recognition by clinicians and pathologists. W...Multinucleate cell angiohistiocytoma (MCAH) was first described by Smith and Wilson- Jones in 1985. It is an uncommon entity but probably underdiagnosed because of lack of recognition by clinicians and pathologists. We report a 47- year- old man with asymptomatic grouped violaceous papules on the dorsum of the hands for 3 years. The histopathological and immunopathological features of ou case revealed characteristics of MCAH similar to the initial description of Smith and Wilson- Jones and other reports.展开更多
血管淋巴样增生伴嗜酸性粒细胞增多症（angiolymPhoid hyperplasia with eosinopilia,ALHE）是一种在临床上比较少见的疾病,由Wells和Whimster在1969年首先报道[1,2],以增生的毛细血管伴大量的嗜酸性粒细胞和淋巴细胞浸润为特征.由于对...血管淋巴样增生伴嗜酸性粒细胞增多症（angiolymPhoid hyperplasia with eosinopilia,ALHE）是一种在临床上比较少见的疾病,由Wells和Whimster在1969年首先报道[1,2],以增生的毛细血管伴大量的嗜酸性粒细胞和淋巴细胞浸润为特征.由于对该疾病的认识不一,文献报道曾使用过多种名称,如炎性血管瘤样结节病变、假性或非典型性化脓性肉芽肿、上皮样血管瘤（EpithelioidHemangioma）、组织细胞样血管瘤等.我们遇到1例现报告如下：展开更多
文摘Background: Multinucleate cell angiohistiocytoma is an infrequent and most likely non-neoplastic disorder usually seen in acral regions in elderly women. It presents clinically as asymptomatic red-to-brown tumors, with a tendency to confluence. It must be distinguished from other diverse cutaneous lesions, notably dermatofibroma, Kaposi sarcoma, and angiofibroma. Methods: We report the clinical, histopathological, and immunohistochemical findings of five patients, all women aged between 51 and 78 years. All except the first presented lesions on both of the lower limbs. None of the patients developed spontaneous resolution of the lesions and one was successfully treated by cryosurgery. Comments: Multinucleate cells are characteristic, but neither exclusive nor pathognomonic, of multinucleate cell angiohistiocytoma,since they can also appear in other inflammatory, neoplastic, or reactive processes. The presence of these cells and vascular proliferation in dermis media are the principal histopathological findings in this infrequent entity. In immunohistochemical studies, the multinucleate cells are often positive for vimentin and factor XIIIa.
文摘Introduction. Multinucleate cell angiohistiocytoma is a rare entity. We report two unusual cases of this lesion. Case report. A 39 year-old man had presented since two years an arciform papular eruption of the forehead. A 40 year-old woman had a disseminated maculo-papular eruption since three years. Histological examination of skin samples of the two patients showed a dermal small vessel proliferation, associated with multinucleate cells, and confirmed the diagnosis of multinucleate cell angiohistiocytoma. Discussion. Our cases, typical histologically, have unusual clinical presentation (first case observed in a man, and the second in a disseminated form). Multinucleate cell angiohistiocytoma is a rare benign vascular proliferation individualized in 1985. Clinically, the lesion consists in small circumscribed papules. Acral sites and notably of the dorsum of the hands are the more frequent topography. It generally occurs in women aged over 50 years. Histologically, there is a dermal proliferation of capillaries and venules,and a fibrosis associated with the interstitial mononucleate cells and multinucleate cells.
文摘We report the case of a 68- year- old female with reactive angioendotheliomatosis (RAE). This case highlights the benign course of this condition and suggests that this entity might be an intravascular histiocytosis.
文摘Multinucleate cell angiohistiocytoma (MCAH) was first described by Smith and Wilson- Jones in 1985. It is an uncommon entity but probably underdiagnosed because of lack of recognition by clinicians and pathologists. We report a 47- year- old man with asymptomatic grouped violaceous papules on the dorsum of the hands for 3 years. The histopathological and immunopathological features of ou case revealed characteristics of MCAH similar to the initial description of Smith and Wilson- Jones and other reports.
文摘血管淋巴样增生伴嗜酸性粒细胞增多症（angiolymPhoid hyperplasia with eosinopilia,ALHE）是一种在临床上比较少见的疾病,由Wells和Whimster在1969年首先报道[1,2],以增生的毛细血管伴大量的嗜酸性粒细胞和淋巴细胞浸润为特征.由于对该疾病的认识不一,文献报道曾使用过多种名称,如炎性血管瘤样结节病变、假性或非典型性化脓性肉芽肿、上皮样血管瘤（EpithelioidHemangioma）、组织细胞样血管瘤等.我们遇到1例现报告如下：
