Purpose: To report the visual prognosis and longterm complications in patients with multifocal choroiditis and panuveitis (MCP). Methods: A retrospective stud y was performed with patients who met inclusion criteria f...Purpose: To report the visual prognosis and longterm complications in patients with multifocal choroiditis and panuveitis (MCP). Methods: A retrospective stud y was performed with patients who met inclusion criteria for MCP at the Uveitis Clinic, Royal Victoria Hospital, McGill University, Montreal, Canada. Informatio n collected included duration of follow-up, visual acuity (VA) measured at each clinical visit, ocular and systemic treatment and ocular complications observed during follow-up. Results: Nineteen patients (37 eyes) with MCP with a mean fo llow-up of 76.9 months were studied. Kaplan-Meier survival analysis showed a d ecrease in the proportion of patients with a final VA ≥20/40 over time. Cystoid macular oedema was seen in 29.7%of the eyes and was the most frequent macular abnormality observed in our group. On the other hand, choroidal neovascularizati on was detected in only six (16.2%) of the eyes, but was related to VA < 20/200 in four of these eyes. Glaucoma was detected in 10.8%of the eyes. Cataract (po sterior subcapsular and/or nuclear) was the most common longterm complication, o ccurring in 40%of affected eyes. Cataract surgery improved the VA in 83.3%of t hese eyes. Conclusion: The visual acuity of patients with MCP decreases with tim e. Visual loss can occur from complications following the inflammation itself an d/or iatrogenic induced by the chronic use of corticosteroids.展开更多
Purpose Evaluation of visual acuity outcomes of photody-namic therapy with verteporfin for s ubfoveal choroidal neo-vascularization(CNV)secondary to multifocal choroiditi s.Design Open-label,prospective,in terventiona...Purpose Evaluation of visual acuity outcomes of photody-namic therapy with verteporfin for s ubfoveal choroidal neo-vascularization(CNV)secondary to multifocal choroiditi s.Design Open-label,prospective,in terventional case series.Methods Thirteen patients(13eyes)diagnosed with sub-foveal CNV associated with multifocal choroiditis at the Eye Clinics of Trieste and Udine were considered for the study.Inclusion criteria were the p resence of subfoveal CNV no larger than 5,400μm in greatest linear dimension and best-corrected visual acuity,S nellen equivalent,of approximately 20/400or better.The primary outcome was the number of eyes that had fewer than8letters lost(less than approximately 1.5lines)at the 12-month examination compared with the baseline examination.Secondary out-comes included fluorescein angiographic features such as progression and CNV size.Results Ba seline and final best-corrected visual acuity were 0.52logarithm of the minimal angle of resolution(20/62 -2 Snellen equivalent )and 0.55logarithm of the minimal angle of resolution(20/62 -2 Snellen equivalent ),respectively.By the 12-month visit,one patient (7.7%)had gained at least 1.5lines,two patients(15.4%)had lost 1.5or more lines,and no pati ent lost 3or more lines of visual acuity,whereas 10patients(84.6%)showed less than 1.5-line change.Me an CNV area was 0.69mm 2 and 0.63mm 2 at baseline and at the12-month visit,respectively.By th e month 12examination,patients had received an average of 1.7treatments.Con-clusions Photodynamic therapy may b e considered a viable therapeutic option for subfoveal CN V associated with multi-focal choroiditis at least for a 1-year period.Further studies with longer follow-up are needed to c onfirm these results.展开更多
文摘Purpose: To report the visual prognosis and longterm complications in patients with multifocal choroiditis and panuveitis (MCP). Methods: A retrospective stud y was performed with patients who met inclusion criteria for MCP at the Uveitis Clinic, Royal Victoria Hospital, McGill University, Montreal, Canada. Informatio n collected included duration of follow-up, visual acuity (VA) measured at each clinical visit, ocular and systemic treatment and ocular complications observed during follow-up. Results: Nineteen patients (37 eyes) with MCP with a mean fo llow-up of 76.9 months were studied. Kaplan-Meier survival analysis showed a d ecrease in the proportion of patients with a final VA ≥20/40 over time. Cystoid macular oedema was seen in 29.7%of the eyes and was the most frequent macular abnormality observed in our group. On the other hand, choroidal neovascularizati on was detected in only six (16.2%) of the eyes, but was related to VA < 20/200 in four of these eyes. Glaucoma was detected in 10.8%of the eyes. Cataract (po sterior subcapsular and/or nuclear) was the most common longterm complication, o ccurring in 40%of affected eyes. Cataract surgery improved the VA in 83.3%of t hese eyes. Conclusion: The visual acuity of patients with MCP decreases with tim e. Visual loss can occur from complications following the inflammation itself an d/or iatrogenic induced by the chronic use of corticosteroids.
文摘Purpose Evaluation of visual acuity outcomes of photody-namic therapy with verteporfin for s ubfoveal choroidal neo-vascularization(CNV)secondary to multifocal choroiditi s.Design Open-label,prospective,in terventional case series.Methods Thirteen patients(13eyes)diagnosed with sub-foveal CNV associated with multifocal choroiditis at the Eye Clinics of Trieste and Udine were considered for the study.Inclusion criteria were the p resence of subfoveal CNV no larger than 5,400μm in greatest linear dimension and best-corrected visual acuity,S nellen equivalent,of approximately 20/400or better.The primary outcome was the number of eyes that had fewer than8letters lost(less than approximately 1.5lines)at the 12-month examination compared with the baseline examination.Secondary out-comes included fluorescein angiographic features such as progression and CNV size.Results Ba seline and final best-corrected visual acuity were 0.52logarithm of the minimal angle of resolution(20/62 -2 Snellen equivalent )and 0.55logarithm of the minimal angle of resolution(20/62 -2 Snellen equivalent ),respectively.By the 12-month visit,one patient (7.7%)had gained at least 1.5lines,two patients(15.4%)had lost 1.5or more lines,and no pati ent lost 3or more lines of visual acuity,whereas 10patients(84.6%)showed less than 1.5-line change.Me an CNV area was 0.69mm 2 and 0.63mm 2 at baseline and at the12-month visit,respectively.By th e month 12examination,patients had received an average of 1.7treatments.Con-clusions Photodynamic therapy may b e considered a viable therapeutic option for subfoveal CN V associated with multi-focal choroiditis at least for a 1-year period.Further studies with longer follow-up are needed to c onfirm these results.
