在地球磁层顶附近观测到的通量传输事件(Flux Transfer Event,FTE)—般被认为是瞬态局域磁重联的产物,是太阳风质量、动量和能量进入地球内磁层的重要通道.重构FTE的磁场结构可促进对其形成、演化过程及其与周围等离子体环境相互作用的...在地球磁层顶附近观测到的通量传输事件(Flux Transfer Event,FTE)—般被认为是瞬态局域磁重联的产物,是太阳风质量、动量和能量进入地球内磁层的重要通道.重构FTE的磁场结构可促进对其形成、演化过程及其与周围等离子体环境相互作用的理解.Grad-Shafranov重构法和磁通量绳拟合法等传统磁场重构方法适用于满足特定物理条件的磁场结构.基于平面线性插值原理,设计了一种不受具体物理条件限定的二维FTE磁场结构重构法.模型测试以及对THEMIS和Cluster卫星簇分别观测到的两个FTE的实际应用表明,在合适的多卫星位形条件下,该方法能快速有效重构出FTE的磁场空间分布,有助于推测FTE的磁场线位形,理解卫星测量数据的时间变化,以及分析等离子体物理量相对于FTE的磁场空间分布特征.展开更多
Objective: In a chromatographic cycle, the adsorption process is a critical unit operation that has a significant impact on downstream processes and, ultimately, the quality of the final products. The development of a...Objective: In a chromatographic cycle, the adsorption process is a critical unit operation that has a significant impact on downstream processes and, ultimately, the quality of the final products. The development of a rapid method to determine the endpoints of adsorption processes in a large-scale manufacturing is of substantial importance for herbal medicine(HM) manufacturers.Methods: In this study, the adsorption of saponins on a macroporous resin column chromatograph, a critical unit operation in Panax notoginseng(Burkill) F.H.Chen injection manufacturing, was considered as an example. The evaluation results of in-line ultraviolet and visible spectra combined with various multivariate analysis methods, including the moving block standard deviation(MBSD), difference between the moving block average and the target spectrum(DMBA-TS), soft-independent modeling of class analogy(SIMCA), and partial least-squares discriminant analysis(PLS-DA), were compared.Results: MBSD was unsuitable for adsorption processes. The relative standard errors of prediction between the predicted and experimental endpoints were 13.2%, 4.67%, and 5.71% using DMBA-TS, SIMCA, and PLS-DA, respectively.Conclusions: Among the considered analysis methods, SIMCA and PLS-DA were more effective for endpoint determination. The results of this study provide a more comprehensive overview of the effectiveness of various multivariate analysis methods to facilitate the selection of the most suitable method. This study was also conducive to address the issues of the in-line detection of adsorption endpoints to guide practical HM manufacturing.展开更多
Prestack depth migration of multicomponent seismic data improves the imaging accuracy of subsurface complex geological structures. An accurate velocity field is critical to accurate imaging. Gaussian beam migration wa...Prestack depth migration of multicomponent seismic data improves the imaging accuracy of subsurface complex geological structures. An accurate velocity field is critical to accurate imaging. Gaussian beam migration was used to perform multicomponent migration velocity analysis of PP- and PS-waves. First, PP- and PS-wave Gaussian beam prestack depth migration algorithms that operate on common-offset gathers are presented to extract offsetdomain common-image gathers of PP- and PS-waves. Second, based on the residual moveout equation, the migration velocity fields of P- and S-waves are updated. Depth matching is used to ensure that the depth of the target layers in the PP- and PS-wave migration profiles are consistent, and high-precision P- and S-wave velocities are obtained. Finally, synthetic and field seismic data suggest that the method can be used effectively in multiwave migration velocity analysis.展开更多
AIM： To investigate the expression of Popeye domain containing 3 （Popdc3） and its correlation with clinicopathological features and prognosis of gastric cancer.METHODS： The method of immunohistochemistry was used ...AIM： To investigate the expression of Popeye domain containing 3 （Popdc3） and its correlation with clinicopathological features and prognosis of gastric cancer.METHODS： The method of immunohistochemistry was used to investigate the expression of Popdc3 in 306 cases of human gastric cancer and 84 noncancerous gastric tissues. Simultaneously, the relationship between Popdc3 expression and the survival of the patients was retrospectively analyzed.RESULTS： Popdc3 was detected in 72 （85.71%） of 84 human nontumor mucosa. High expression of Popdc3protein was detected in 78 （25.49%） of 306 human gastric cancer cases, and low expression was detected in 228 （74.51%）. Low expression of Popdc3 correlated with depth of invasion （P 〈 0.0001）, regional lymph nodes （P 〈 0.0001） and distant metastasis （P =0.02）, and tumor, nodes, metastasis （TNM） stages （P 〈 0.0001）. On multivariate analysis, only the patient＇s gender, regional lymph node metastasis, distant metastasis, TNM stages, and the expression of Popdc3 were independent prognostic factors in patients with gastric cancer. The Kaplan-Meier plot showed that low Popdc3 expression had a much more significant effect on the survival of those patients with early-stage tumors X^2 = 104.741, P 〈 0.0001）, with a 〉 51.9% reduction in the three-year survival compared with high Popdc3 expression. In late stages, the difference was also significant X^2 = 5.930, P = 0.015）, with a 32.6% reduction in the three-year survival.CONCLUSION： Reduced expression of Popdc3 may play a significant role in the carcinogenesis and progression of gastric cancer. Popdc3 may be an independent prognostic factor.展开更多
AIM:To investigate the clinical features and survival of patients treated for cholangiocarcinoma in our institution and to analyze the factors affecting their survival.METHODS:This retrospective cohort study assessed ...AIM:To investigate the clinical features and survival of patients treated for cholangiocarcinoma in our institution and to analyze the factors affecting their survival.METHODS:This retrospective cohort study assessed patients diagnosed with cholangiocarcinoma between January 1997 and December 2007 at the University Malaya Medical Centre in Malaysia.The clinical data and associated outcomes were collected using a structured proforma.RESULTS:Of the 69 patients diagnosed with cholangiocarcinoma,38 (55%) were male;mean patient age was 61 years.Twelve patients (17%) had intrahepatic,38 (55%) had perihilar and 19 (28%) had distal tumors.Only 12 patients underwent curative surgery,including seven R0 resections.Only one patient died within 30 d after surgery.The overall median survival was 4 mo,whereas the median survival of R0 resected patients was 16 mo.The overall 1-,2-and 3-year cumulative survival rates were 67%,17% and 17%,respectively.Survival rates were significantly associated with curative resection (P=0.002),intrahepatic tumor (P=0.003),negative margin status (P=0.013),early tumor stage (P=0.016),higher tumor differentiation (P=0.032) and absence of jaundice (P=0.038).Multivariate analysis showed that tumor location was a significant independent predictor of patient survival.CONCLUSION:Curative,margin-negative resection of early stage,well-differentiated intrahepatic tumors is associated with improved patient survival.展开更多
文摘在地球磁层顶附近观测到的通量传输事件(Flux Transfer Event,FTE)—般被认为是瞬态局域磁重联的产物,是太阳风质量、动量和能量进入地球内磁层的重要通道.重构FTE的磁场结构可促进对其形成、演化过程及其与周围等离子体环境相互作用的理解.Grad-Shafranov重构法和磁通量绳拟合法等传统磁场重构方法适用于满足特定物理条件的磁场结构.基于平面线性插值原理,设计了一种不受具体物理条件限定的二维FTE磁场结构重构法.模型测试以及对THEMIS和Cluster卫星簇分别观测到的两个FTE的实际应用表明,在合适的多卫星位形条件下,该方法能快速有效重构出FTE的磁场空间分布,有助于推测FTE的磁场线位形,理解卫星测量数据的时间变化,以及分析等离子体物理量相对于FTE的磁场空间分布特征.
基金supported by the National Natural Science Foundation of China(82104383)National S&T Major Project of China(2012ZX09101201-003)
文摘Objective: In a chromatographic cycle, the adsorption process is a critical unit operation that has a significant impact on downstream processes and, ultimately, the quality of the final products. The development of a rapid method to determine the endpoints of adsorption processes in a large-scale manufacturing is of substantial importance for herbal medicine(HM) manufacturers.Methods: In this study, the adsorption of saponins on a macroporous resin column chromatograph, a critical unit operation in Panax notoginseng(Burkill) F.H.Chen injection manufacturing, was considered as an example. The evaluation results of in-line ultraviolet and visible spectra combined with various multivariate analysis methods, including the moving block standard deviation(MBSD), difference between the moving block average and the target spectrum(DMBA-TS), soft-independent modeling of class analogy(SIMCA), and partial least-squares discriminant analysis(PLS-DA), were compared.Results: MBSD was unsuitable for adsorption processes. The relative standard errors of prediction between the predicted and experimental endpoints were 13.2%, 4.67%, and 5.71% using DMBA-TS, SIMCA, and PLS-DA, respectively.Conclusions: Among the considered analysis methods, SIMCA and PLS-DA were more effective for endpoint determination. The results of this study provide a more comprehensive overview of the effectiveness of various multivariate analysis methods to facilitate the selection of the most suitable method. This study was also conducive to address the issues of the in-line detection of adsorption endpoints to guide practical HM manufacturing.
基金supported by the National Special Fund of China(No.2011ZX05035-001-006HZ,2011ZX05008-006-22,2011ZX05049-01-02,and 2011ZX05019-003)the National Natural Science Foundation of China(No.41104084)the PetroChina Innovation Foundation(No.2011D-5006-0303)
文摘Prestack depth migration of multicomponent seismic data improves the imaging accuracy of subsurface complex geological structures. An accurate velocity field is critical to accurate imaging. Gaussian beam migration was used to perform multicomponent migration velocity analysis of PP- and PS-waves. First, PP- and PS-wave Gaussian beam prestack depth migration algorithms that operate on common-offset gathers are presented to extract offsetdomain common-image gathers of PP- and PS-waves. Second, based on the residual moveout equation, the migration velocity fields of P- and S-waves are updated. Depth matching is used to ensure that the depth of the target layers in the PP- and PS-wave migration profiles are consistent, and high-precision P- and S-wave velocities are obtained. Finally, synthetic and field seismic data suggest that the method can be used effectively in multiwave migration velocity analysis.
基金Supported by Health Technology Fund of Yunnan Province, China,No.2010NS066
文摘AIM： To investigate the expression of Popeye domain containing 3 （Popdc3） and its correlation with clinicopathological features and prognosis of gastric cancer.METHODS： The method of immunohistochemistry was used to investigate the expression of Popdc3 in 306 cases of human gastric cancer and 84 noncancerous gastric tissues. Simultaneously, the relationship between Popdc3 expression and the survival of the patients was retrospectively analyzed.RESULTS： Popdc3 was detected in 72 （85.71%） of 84 human nontumor mucosa. High expression of Popdc3protein was detected in 78 （25.49%） of 306 human gastric cancer cases, and low expression was detected in 228 （74.51%）. Low expression of Popdc3 correlated with depth of invasion （P 〈 0.0001）, regional lymph nodes （P 〈 0.0001） and distant metastasis （P =0.02）, and tumor, nodes, metastasis （TNM） stages （P 〈 0.0001）. On multivariate analysis, only the patient＇s gender, regional lymph node metastasis, distant metastasis, TNM stages, and the expression of Popdc3 were independent prognostic factors in patients with gastric cancer. The Kaplan-Meier plot showed that low Popdc3 expression had a much more significant effect on the survival of those patients with early-stage tumors X^2 = 104.741, P 〈 0.0001）, with a 〉 51.9% reduction in the three-year survival compared with high Popdc3 expression. In late stages, the difference was also significant X^2 = 5.930, P = 0.015）, with a 32.6% reduction in the three-year survival.CONCLUSION： Reduced expression of Popdc3 may play a significant role in the carcinogenesis and progression of gastric cancer. Popdc3 may be an independent prognostic factor.
文摘AIM:To investigate the clinical features and survival of patients treated for cholangiocarcinoma in our institution and to analyze the factors affecting their survival.METHODS:This retrospective cohort study assessed patients diagnosed with cholangiocarcinoma between January 1997 and December 2007 at the University Malaya Medical Centre in Malaysia.The clinical data and associated outcomes were collected using a structured proforma.RESULTS:Of the 69 patients diagnosed with cholangiocarcinoma,38 (55%) were male;mean patient age was 61 years.Twelve patients (17%) had intrahepatic,38 (55%) had perihilar and 19 (28%) had distal tumors.Only 12 patients underwent curative surgery,including seven R0 resections.Only one patient died within 30 d after surgery.The overall median survival was 4 mo,whereas the median survival of R0 resected patients was 16 mo.The overall 1-,2-and 3-year cumulative survival rates were 67%,17% and 17%,respectively.Survival rates were significantly associated with curative resection (P=0.002),intrahepatic tumor (P=0.003),negative margin status (P=0.013),early tumor stage (P=0.016),higher tumor differentiation (P=0.032) and absence of jaundice (P=0.038).Multivariate analysis showed that tumor location was a significant independent predictor of patient survival.CONCLUSION:Curative,margin-negative resection of early stage,well-differentiated intrahepatic tumors is associated with improved patient survival.
