Multi-model approach can significantly improve the prediction performance of soft sensors in the process with multiple operational conditions.However,traditional clustering algorithms may result in overlapping phenome...Multi-model approach can significantly improve the prediction performance of soft sensors in the process with multiple operational conditions.However,traditional clustering algorithms may result in overlapping phenomenon in subclasses,so that edge classes and outliers cannot be effectively dealt with and the modeling result is not satisfactory.In order to solve these problems,a new feature extraction method based on weighted kernel Fisher criterion is presented to improve the clustering accuracy,in which feature mapping is adopted to bring the edge classes and outliers closer to other normal subclasses.Furthermore,the classified data are used to develop a multiple model based on support vector machine.The proposed method is applied to a bisphenol A production process for prediction of the quality index.The simulation results demonstrate its ability in improving the data classification and the prediction performance of the soft sensor.展开更多
This paper expounded in detail the principle of energy spectrum analysis based on discrete wavelet transformation and multiresolution analysis. In the aspect of feature extraction method study, with investigating the ...This paper expounded in detail the principle of energy spectrum analysis based on discrete wavelet transformation and multiresolution analysis. In the aspect of feature extraction method study, with investigating the feature of impact factor in vibration signals and considering the non-placidity and non-linear of vibration diagnosis signals, the authors import wavelet analysis and fractal theory as the tools of faulty signal feature description. Experimental results proved the validity of this method. To some extent, this method provides a good approach of resolving the wholesome problem of fault feature symptom description.展开更多
Doxorubicin(DOX)is a widely employed tumor therapy,yet its substantial toxic side effects pose a considerable challenge.Bletilla striata has demonstrated efficacy in preventing and treating these toxic side effects in...Doxorubicin(DOX)is a widely employed tumor therapy,yet its substantial toxic side effects pose a considerable challenge.Bletilla striata has demonstrated efficacy in preventing and treating these toxic side effects in clinical practice,with polysaccharides identified as the principal active component.In the present study,16 fractions of B.striata polysaccharides(BsPs)were extracted using diverse methods,including hot-water extraction(HWE),ultrasonic-assisted extraction(UAE),enzyme-assisted extraction(EAE),dilute acid-water extraction(ACWE),and dilute alkali-water extraction(ALWE).These extractions were subsequently precipitated at final ethanol concentrations of 80%and 95%,respectively.The investigation encompassed yields,total carbohydrate content(TCC),total protein content(TPC),preliminary structural properties,and anti-DOX myocardial cytotoxic activity.Results indicated that the extraction method significantly influenced the physicochemical properties,associated functional properties,and anti-DOX myocardial cytotoxic activity of BsPs.HWE and UAE yielded higher BsPs quantities.The relative molecular weight(RMW)distribution of BsPs differed notably between HWE or UAE,EAE,ACWE,and ALWE.The RMW of primary BsPs obtained from HWE and UAE(1.9×10^(7)-1.7×10^(7) Da)exceeded that from EAE(7.5×10^(3)-2.8×10^(4) Da)and ALWE(5.1×10^(4)-1.7×10^(4) Da),with smaller molecular weights primarily precipitated by higher ethanol concentrations.BsPs were composed of Man and Glu,with partial fractions containing small amounts of Gal or Ara,displaying varying molar ratios.Notably,BsPs from ACWE exhibited the most significant structural differences,lacking 1,4-α-D-Glcp and a triple-helical structure.Furthermore,BsPs obtained from HWE,UAE,and EAE demonstrated heightened anti-DOX myocardial cytotoxic activity compared to other methods.This study underscored the influence of extraction methods on BsPs’structure and myocardial protective activity,offering a foundation for exploring structural diversity and employing specific extraction methods to extract polysaccharides with robust myocardial protective properties efficiently.展开更多
基金Supported by the National Natural Science Foundation of China(61273070)the Foundation of Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Multi-model approach can significantly improve the prediction performance of soft sensors in the process with multiple operational conditions.However,traditional clustering algorithms may result in overlapping phenomenon in subclasses,so that edge classes and outliers cannot be effectively dealt with and the modeling result is not satisfactory.In order to solve these problems,a new feature extraction method based on weighted kernel Fisher criterion is presented to improve the clustering accuracy,in which feature mapping is adopted to bring the edge classes and outliers closer to other normal subclasses.Furthermore,the classified data are used to develop a multiple model based on support vector machine.The proposed method is applied to a bisphenol A production process for prediction of the quality index.The simulation results demonstrate its ability in improving the data classification and the prediction performance of the soft sensor.
文摘This paper expounded in detail the principle of energy spectrum analysis based on discrete wavelet transformation and multiresolution analysis. In the aspect of feature extraction method study, with investigating the feature of impact factor in vibration signals and considering the non-placidity and non-linear of vibration diagnosis signals, the authors import wavelet analysis and fractal theory as the tools of faulty signal feature description. Experimental results proved the validity of this method. To some extent, this method provides a good approach of resolving the wholesome problem of fault feature symptom description.
基金Science and Technology Foundation of Guizhou Province(Grant No.QKHJC-ZK[2023]YB524)Science and Technology Plan Project of Guizhou,China(Grant No.QKPTRC[2019]035)+2 种基金Science and Technology Foundation of Guizhou Province(Grant No.QKH[2019]1346)Science and Technology Department of Zunyi city of Guizhou province of China(Grant No.[2020]7)Undergraduate Training Program for Innovation and Entrepreneurship of Zunyi Medical University(Grant No.S202310661248).
文摘Doxorubicin(DOX)is a widely employed tumor therapy,yet its substantial toxic side effects pose a considerable challenge.Bletilla striata has demonstrated efficacy in preventing and treating these toxic side effects in clinical practice,with polysaccharides identified as the principal active component.In the present study,16 fractions of B.striata polysaccharides(BsPs)were extracted using diverse methods,including hot-water extraction(HWE),ultrasonic-assisted extraction(UAE),enzyme-assisted extraction(EAE),dilute acid-water extraction(ACWE),and dilute alkali-water extraction(ALWE).These extractions were subsequently precipitated at final ethanol concentrations of 80%and 95%,respectively.The investigation encompassed yields,total carbohydrate content(TCC),total protein content(TPC),preliminary structural properties,and anti-DOX myocardial cytotoxic activity.Results indicated that the extraction method significantly influenced the physicochemical properties,associated functional properties,and anti-DOX myocardial cytotoxic activity of BsPs.HWE and UAE yielded higher BsPs quantities.The relative molecular weight(RMW)distribution of BsPs differed notably between HWE or UAE,EAE,ACWE,and ALWE.The RMW of primary BsPs obtained from HWE and UAE(1.9×10^(7)-1.7×10^(7) Da)exceeded that from EAE(7.5×10^(3)-2.8×10^(4) Da)and ALWE(5.1×10^(4)-1.7×10^(4) Da),with smaller molecular weights primarily precipitated by higher ethanol concentrations.BsPs were composed of Man and Glu,with partial fractions containing small amounts of Gal or Ara,displaying varying molar ratios.Notably,BsPs from ACWE exhibited the most significant structural differences,lacking 1,4-α-D-Glcp and a triple-helical structure.Furthermore,BsPs obtained from HWE,UAE,and EAE demonstrated heightened anti-DOX myocardial cytotoxic activity compared to other methods.This study underscored the influence of extraction methods on BsPs’structure and myocardial protective activity,offering a foundation for exploring structural diversity and employing specific extraction methods to extract polysaccharides with robust myocardial protective properties efficiently.
