In order to scientifically evaluate the values of Cucurbita moschata cultivars, main botanical characters including the initial flowering date, the first fruiting node, fruit length, fruit stem length, stem diameter, ...In order to scientifically evaluate the values of Cucurbita moschata cultivars, main botanical characters including the initial flowering date, the first fruiting node, fruit length, fruit stem length, stem diameter, internode length, the transverse and longitudinal diameters of the largest leaf, single fruit weight, flesh thickness and soluble solid content of 41 cultivars were measured for conducting diversity, correlation and cluster analysis. The results revealed that the pumpkin cultivars showed large variations in fruit stem length, single fruit weight, fruit length and flesh thickness, but small variations in initial flowering date. Significant, even highly significant correlations were found among the tested traits. Cluster analysis demonstrated that the 41 old Cucurbita moschata cultivars were divided into three groups, of which multiple traits of Group 1 were better than those in the other two groups. High similarities existed in three groups and the cultivars in each group. This research provided basis for selecting excellent traits and parents for the breeding of hybrids.展开更多
Starting from the configuration of the optical prime code, a kind of key signature code for the optical code-division multiple access (OCDMA) system, based on the linear congruence theory in the finite Galois field,...Starting from the configuration of the optical prime code, a kind of key signature code for the optical code-division multiple access (OCDMA) system, based on the linear congruence theory in the finite Galois field, the correlation properties of the basic prime code, the extended prime code and the modified prime code are mathematically analyzed, the distribution of cross-correlation values is given and the overlap area of "1"s in the case of periodically circularly shifting is indicated. It is mathematically demonstrated that the maximum cross-correlation of the basic prime code is 2, and that of the extended prime code and the modified prime code is 1. The integrated correlation analysis process is proposed. The signal-interfere ratio (SIR) and the BER performance of the systems employing different signature codes are calculated, respectively, and the performances of OCDMA systems employing different signature codes mode are compared.展开更多
Taking the time varying nature of wireless channels into account, two user selection schemes with lower complexity are developed for multiple-input multiple-output broadcast (MIMO BC)systems. According to the relati...Taking the time varying nature of wireless channels into account, two user selection schemes with lower complexity are developed for multiple-input multiple-output broadcast (MIMO BC)systems. According to the relationship between coherence time and Doppler frequency, an information frame is divided into several segments. At the beginning of each segment, the user selection is carded out with the greedy selection algorithm. In the simplified user selection algorithms employing the temporal correlation (SUSTC), the selection results are applied for all the remaining slots in each segment. But in the improved simplified user selection algorithms employing the temporal correlation(ISUSTC), at the remaining slots, users are kept with favorable channel conditions selected at the previous slot, and other users are updated from the candidate pool to communicate simultaneously. Simulations show that compared with the greedy user selection method, the proposed algorithms can reduce the selection complexity with a little sum capacity loss.展开更多
The analysis result of absolute degree of grey incidence for multivariate time series is often inconsistent with the qualitative analysis. To overcome this shortage, a multivariate absolute degree of grey incidence ba...The analysis result of absolute degree of grey incidence for multivariate time series is often inconsistent with the qualitative analysis. To overcome this shortage, a multivariate absolute degree of grey incidence based on distribution characteristics of points is proposed. Based on the geometric description of multivariate time se- ries, the neighborhood extrema are extracted in the different regions, and a characteristic point set is constructed. Then according to the distribution of the characteristic point set, a characteristic point sequence reflecting the ge- ometric features of multivariate time series is obtained. The incidence analysis between multivariate time series is transformed into the relational analysis between characteristic point sequences, and a grey incidence model is established. The model possesses the properties of translational invariance, transpose and rank transform invari- ance, and satisfies the grey incidence analysis axioms. Finally, two cases are studied and the results prove the ef- fectiveness of the model.展开更多
Objective. To investigate the relationship of plasma homocysteine (Hcy) level to stroke and genetic factor to elevated plasma Hcy level.Methods. The plasma Hcy level was measured by capillary electrophoresis- ultravio...Objective. To investigate the relationship of plasma homocysteine (Hcy) level to stroke and genetic factor to elevated plasma Hcy level.Methods. The plasma Hcy level was measured by capillary electrophoresis- ultraviolet detection and the gene polymorphism of N5, N10 - methylenetetrahydrofolate reductase (MTHFR) was studied with PCR - RFLP assay in 43 patients with cortical cerebral infarction and 42 healthy controls.Results. The plasma Hcy level of the patients ( 19. 3 + 6. 0 μ mol/L) was markedly higher than that of the controls (13.7 + 5.4 μ mol/L) ( t = 4. 16, P < 0. 001). There are 3 genotypes, C/C, C/T and T/T, about base - variation of MTHFR gene at locus 677. The plasma Hcy level of the subjects with T/T genotype was higher than that of subjects with other genotypes. However, the frequencies of each genotype and allele were not significantly different between the patients and the controls.Conclusions. The elevated plasma Hcy level is a risk factor for atherothrombotic cerebral infarction, and is related to the C→T mutation at locus 677 of MTHFR gene.展开更多
Using correlation and path analysis, the genetic correlation between weight traits and morphological traits was determined in the marine gastropod Glossaulax reiniana. A total of 100 G. reiniana individuals from a wil...Using correlation and path analysis, the genetic correlation between weight traits and morphological traits was determined in the marine gastropod Glossaulax reiniana. A total of 100 G. reiniana individuals from a wild population were used. Shell width (X1), shell height (X2), umbo-callus height (X3), body width (X4), operculum length (X5), operculum width (X6), body weight (Y1) and soft-tissue weight (Y2) were measured, and the correlation coefficient matrix calculated. Morphological traits were used as independent variables and weight traits as dependent variables for path coefficient analysis. Path coefficients, correlation indices and determination coefficients were also determined. Results indicate that the correlation coefficients associated with each morphological and weight trait were all highly significant (P〈0.01). After deleting redundant independent variables, the following optimum multiple regression equations were obtained using stepwise multiple regression analysis: Y1=-29.317+0.362X2+0.349X4+ 1.190)(5 for body weight; and Y2=-17.292+0.166X1+0.171X2+0.703X5, for soft-tissue weight. Operculum height had the highest positive direct correlation with both body weight and soft-tissue weight, which was in accordance with the test results obtained from determinate coefficient analysis. The indication of high genetic correlations between weight traits and morphological traits will provide valuable information for G. reiniana breeding programs.展开更多
AIM: To evaluate the effect of single nucleotide poly- morphisms of interleukin (IL)-28B, rs12979860 on progression and treatment response in chronic hepatitis C. METHODS: Patients (n = 64; 37 men, 27 women; mean...AIM: To evaluate the effect of single nucleotide poly- morphisms of interleukin (IL)-28B, rs12979860 on progression and treatment response in chronic hepatitis C. METHODS: Patients (n = 64; 37 men, 27 women; mean age, 44 + 12 years) with chronic hepatitis C, genotype 1, received treatment with peg-interferon plus ribavirin. Genotyping of rs12979860 was per- formed on peripheral blood DNA. Histopathological assessment of necroinflammatory grade and fibrosis stage were scored using the METAVIR system on a liver biopsy sample before treatment. Serum viral load, ami- notransferase activity, and insulin level were measured. Insulin resistance index, body mass index, waist/hip ratio, percentage of body fat and fibrosis progression rate were calculated. Applied dose of interferon and ribavirin, platelet and neutrophil count and hemoglobin level were measured. RESULTS: A sustained virological response (SVR) was significantly associated with IL28B polymorphism (CC vs -l-r allele: odds ratio (OR), 25; CC vs CT allele: OR, 5.4), inflammation activity (G 〈 1 vs G 〉 1: OR, 3.9), fibrosis (F 〈 1 vs F 〉 1: OR, 5.9), platelet count (〉 200 × 109/L vs 〈 200 ×109/L: OR, 4.7; OR in patients with genotype CT: 12.8), fatty liver (absence vs presence of steatosis: OR, 4.8), insulin resistance index (〈 2.5 vs 〉 2.5: OR, 3.9), and baseline HCV viral load (〈 106 IU/mL vs 〉 106 IU/mL: OR, 3.0). There was no association with age, sex, aminotransferases activity, body mass index, waist/hip ratio, or percentage body fat. There was borderline significance (P = 0.064) of increased fibrosis in patients with the I-I allele, and no differences in the insulin resistance index between groups of patients with CC, CT and -IF alleles (P = 0.12). Spearman's rank correlation coefficient between insulin resistance and stage of fibrosis and body mass index was r = 0.618 and r = 0.605, respectively (P 〈 0.001). Significant dif- ferences were found in the insulin resistance index (P = 0.01) between patients with and without steatosis. Patients with the C-I- allele and absence of a SVR had a higher incidence of requiring threshold dose reduction of interferon (P = 0.07). CONCLUSION: IL28B variation is the strongest host factor not related to insulin resistance that determines outcome of antiviral therapy. Baseline platelet count predicts the outcome of antiviral therapy in CT allele patients.展开更多
A search algorithm for the detection of a direct path signal in the presence of dense multipath in indoor environment using UWB is Woposed. This algorithm is based on signal correlation and differential coefficient. S...A search algorithm for the detection of a direct path signal in the presence of dense multipath in indoor environment using UWB is Woposed. This algorithm is based on signal correlation and differential coefficient. Statistical analysis of the algorithm is given out and computer simulation results are presented to validate the effectiveness of the algorithm. The results based on the algorithm pml3osed are compared with those based on Maximum Likelihood Estimator(MLE) and Peak Tracking(PT) in the simulation which shows that this algorithm achieves the highest accuracy in most cases and gives out relatively stable results in different Signal Noise Ratio(SNR).展开更多
Follicle stimulating hormone β (FSHβ) of Japanese flounder (Paralichthys olivaceus) plays a key role in the regulation of gonadal development.This study aimed to investigate molecular genetic characteristics of the ...Follicle stimulating hormone β (FSHβ) of Japanese flounder (Paralichthys olivaceus) plays a key role in the regulation of gonadal development.This study aimed to investigate molecular genetic characteristics of the FSHβ gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of FSHβ on reproductive traits in Japanese flounder.We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the FSHβ gene in 60 individuals.We identified only an SNP (T/C) in the coding region of exon3 of FSHβ.The SNP (T/C) did not lead to amino acid changes at the position 340 bp of FSHβ gene.Statistical analysis showed that the SNP was significantly associated with testosterone (T) level and gonadosomatic index (GSI) (P<0.05).Individuals with genotype TC of the SNP had significantly higher serum T levels and GSI (P<0.05) than that of genotype CC.Therefore, FSHβ gene could be a useful molecular marker in selection for prominent reproductive trait in Japanese Flounder.展开更多
Formulation of different ecological zone plans according to the corresponding protection targets and the necessity of proper conservation policy is one of the measures to achieve the goal of ecological conservation in...Formulation of different ecological zone plans according to the corresponding protection targets and the necessity of proper conservation policy is one of the measures to achieve the goal of ecological conservation in China.In order to clarify the interrelation among key ecological zone plans,this paper carried out the research on spatial relation of priority areas of biodiversity conservation and three key ecological areas(key ecological function areas,key regions of ecological service function,national nature reserves)and the research on ecological conditions,based on multi-scale ecological spatial theme information,which incorporates elements like ecological quality and type,and by the aid of spatial information analysis and GIS modeling.The results showed a contrastively fine spatial consistency with 68.8%of priority areas of biodiversity conservation overlapping with three key ecological areas.Although the environment in priority areas of biodiversity conservation were in good conditions,protection pressure is also increasing,powerful supervision and protection should not be ignored.The environmental conditions in the overlapping areas,as a whole,were superior to those in the non-overlapping areas.Since two areas have different characteristics,targeted protection measures should be formulated based on this difference,which will be very important for biodiversity conservation in priority areas of biodiversity conservation.展开更多
The design of optimal heterogeneous catalysts for N_(2)-to-NH_(3) conversion is often dictated by the scaling relations,which result in a volcano curve that poses a limit on the catalytic performance.Herein,we reveal ...The design of optimal heterogeneous catalysts for N_(2)-to-NH_(3) conversion is often dictated by the scaling relations,which result in a volcano curve that poses a limit on the catalytic performance.Herein,we reveal a bowl active site that can break the scaling relations,through investigating the catalytic mechanisms of N_(2)-to-NH_(3) conversion on the lanthanide intermetallic electride catalyst LaRuSi by first-principles modeling.This bowl active site,composed of four surface La cations and one subsurface Si atom rich in electrons,plays the key role in enabling efficient catalysis.With adaptive electrostatic and orbital interactions,the bowl active site promotes the adsorption and activation of N_(2) that delivers facile cleavage of N-N bond,while destabilizes the adsorptions of ^(*)NH_(x)(x=1,2,3)species,which facilitates the release of the final NH_(3) product.By comparison with other electride catalysts isostructural to LaRuSi,we confirm the breaking of scaling relations between the adsorptions of ^(*)NH_(x) species and that of^(*)N on the bowl active site.Thus,this bowl active site presents a design concept that breaks the scaling relations for highly efficient heterogeneous catalysis of N_(2)-to-NH_(3) conversion.展开更多
TO THE EDITORWe read with interest the article published by Nguyen et al in the World Journal of Gastroenterology, showing an association between short MUC6 alleles and H pjloff infection. These results, together with...TO THE EDITORWe read with interest the article published by Nguyen et al in the World Journal of Gastroenterology, showing an association between short MUC6 alleles and H pjloff infection. These results, together with previous observations by Vinall et al, reinforce the role of mucin genes (MUC6 and MUC1) VNTR polymorphisms for the variability in individual susceptibility to H pylori infection that cannot be explained by differences in environmental factors.展开更多
A class of plateaued functions has been got by using the Maiorana-McFarland construction. A variety of desirable criteria for functions with cryptographic application eouht be satisfied: balancedness, high nonlineari...A class of plateaued functions has been got by using the Maiorana-McFarland construction. A variety of desirable criteria for functions with cryptographic application eouht be satisfied: balancedness, high nonlinearity, correlation immunity of reasonably high order, strict avalanche criterion, non-existence of non-zero linear struetures, good glnbal avalanche characteristics, etc.展开更多
AIM: To investigate prevalence of C/onorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. METHODS: Consecutive patients w...AIM: To investigate prevalence of C/onorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than nonnfected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.展开更多
Three japonica rice varieties were soaked in 110 mg/L paclobutrazol solution for 48 h and then directly seeded, and seeds soaked with clean water were used as a control group. The analysis of dry weights of various or...Three japonica rice varieties were soaked in 110 mg/L paclobutrazol solution for 48 h and then directly seeded, and seeds soaked with clean water were used as a control group. The analysis of dry weights of various organs and agronomic traits showed that soaking of japonica seeds with paclobutrazol had little impact on the correlation between dry weights of various organs, but there were still significant differences between cultivars. The correlation coefficients between lengths of the first and second nodes with filled grain weight changed from 0.024 and 0.056 in the CK to -0.116 and -0.042 correspondingly after presoaking with paclobutrazol. Therefore, paclobutrezol reduces the effect of stem-sheath weight on filled grain weight, and as a result, photosynthetic product could not be effectively transported in maturation stage of rice.展开更多
Retrotransposons are present in all plant genomes and play important roles in genome size,genome structure remodeling,gene function and genome evolution.Me07Em02 marked by sequence-related amplified polymorphism (SRAP...Retrotransposons are present in all plant genomes and play important roles in genome size,genome structure remodeling,gene function and genome evolution.Me07Em02 marked by sequence-related amplified polymorphism (SRAP) is verified,recovered,sequenced and analyzed,which closely link to the flesh color around the stone.By comparison with the peach genome Peach v1.0,a part of the sequence of copia-like retrotransposons is obtained.With the aid of DANMAN and DNASTAR sequence analysis software,BLASTn alignment is carried out in the peach genome database and GenBank.The whole genome sequence of the copialike retrotransposon in the peach is located at 9 939 764~9 944 771 bp in Scaffold-1 of Peach v1.0,with a total length of 5 008 bp.The LTR on both sides is exactly the same,the length is 444 bp,and the largest ORF box is located at the 487~4 545 bp of the sequence,encoding 1 535 amino acids.The amino acid sequence was submitted to GenBank for Protein BLAST alignment,The results showed that this sequence also has the typical amino acid sequence characteristics of the copia-like retrotransposon.At the same time,the method of peach retrotransposon labeling is preliminarily established,and the genetic diversity of the peach is analyzed.展开更多
AIM: The goal of the current work was to analyse the prevalence of the +49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene (CTLA4) in Hungarian patients with Crohn's disease (CD) and ulcerative colitis ...AIM: The goal of the current work was to analyse the prevalence of the +49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene (CTLA4) in Hungarian patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism (SNP). The genotypes were determined by using PCR/RFLP test. RESULTS: The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively. CONCLUSION: The results of the current study show that carriage of the +49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population.展开更多
Genetic diversity of 50 cucumber (Cucumis sativus L.) accessions from American, Holland, Japan and China was detected and evaluated using RAPD markers. 25 selected primers produced 215 scorable polymorphic RAPD bands ...Genetic diversity of 50 cucumber (Cucumis sativus L.) accessions from American, Holland, Japan and China was detected and evaluated using RAPD markers. 25 selected primers produced 215 scorable polymorphic RAPD bands and the ratio of polymorphism is 86.98%. Four main groups of cucumber accessions could be distinguished from UPGMA analysis: Occidental cucumber, South-China cucumber, North-China cucumber and Xishuangbanna cucumber. Our result confirmed that cucumber is a narrow-based germplasm, nevertheless RAPD analysis was stili useful in cucumber genotypic differentiation. More significantly, Xishuangbanna cucumber (Cucumis sativus L. Var Xishuangbannanesis Qi et Yuan), a mutation of cucumber, was clustered together to a special group in the study, which implied its special status in cucumber germplasm.展开更多
基金Supported by Special Fund for Agro-scientific Research in the Public Interest from the Ministry of Agriculture of China(201303112)the 12th National Five-year Plan for Science and Technology Program of Rural Areas(2012BAD02B03-17)~~
文摘In order to scientifically evaluate the values of Cucurbita moschata cultivars, main botanical characters including the initial flowering date, the first fruiting node, fruit length, fruit stem length, stem diameter, internode length, the transverse and longitudinal diameters of the largest leaf, single fruit weight, flesh thickness and soluble solid content of 41 cultivars were measured for conducting diversity, correlation and cluster analysis. The results revealed that the pumpkin cultivars showed large variations in fruit stem length, single fruit weight, fruit length and flesh thickness, but small variations in initial flowering date. Significant, even highly significant correlations were found among the tested traits. Cluster analysis demonstrated that the 41 old Cucurbita moschata cultivars were divided into three groups, of which multiple traits of Group 1 were better than those in the other two groups. High similarities existed in three groups and the cultivars in each group. This research provided basis for selecting excellent traits and parents for the breeding of hybrids.
文摘Starting from the configuration of the optical prime code, a kind of key signature code for the optical code-division multiple access (OCDMA) system, based on the linear congruence theory in the finite Galois field, the correlation properties of the basic prime code, the extended prime code and the modified prime code are mathematically analyzed, the distribution of cross-correlation values is given and the overlap area of "1"s in the case of periodically circularly shifting is indicated. It is mathematically demonstrated that the maximum cross-correlation of the basic prime code is 2, and that of the extended prime code and the modified prime code is 1. The integrated correlation analysis process is proposed. The signal-interfere ratio (SIR) and the BER performance of the systems employing different signature codes are calculated, respectively, and the performances of OCDMA systems employing different signature codes mode are compared.
基金The National High Technology Research and Develop-ment Program of China(863 Program)(No.2006AA01Z268)the NationalNatural Science Foundation of China(No.60496311).
文摘Taking the time varying nature of wireless channels into account, two user selection schemes with lower complexity are developed for multiple-input multiple-output broadcast (MIMO BC)systems. According to the relationship between coherence time and Doppler frequency, an information frame is divided into several segments. At the beginning of each segment, the user selection is carded out with the greedy selection algorithm. In the simplified user selection algorithms employing the temporal correlation (SUSTC), the selection results are applied for all the remaining slots in each segment. But in the improved simplified user selection algorithms employing the temporal correlation(ISUSTC), at the remaining slots, users are kept with favorable channel conditions selected at the previous slot, and other users are updated from the candidate pool to communicate simultaneously. Simulations show that compared with the greedy user selection method, the proposed algorithms can reduce the selection complexity with a little sum capacity loss.
基金Supported by the National Natural Science Foundation of China(71101043,70901041,71171113)the Joint Research Project of National Natural Science Foundation of China and Royal Society of UK(71111130211)+4 种基金the Major Program of National Funds of Social Science of China(10ZD&014,11&ZD168)the Doctoral Fundof Ministry of Education of China(20093218120032,200802870020)the Qinglan Project for Excellent Youth Teacherin Jiangsu Province(China)Research Funding in Nanjing University of Aeronautics and Astronautics(NR2011002)the Central University Scientific Research Expenses of HoHai University(2011B09914,2010B11114)~~
文摘The analysis result of absolute degree of grey incidence for multivariate time series is often inconsistent with the qualitative analysis. To overcome this shortage, a multivariate absolute degree of grey incidence based on distribution characteristics of points is proposed. Based on the geometric description of multivariate time se- ries, the neighborhood extrema are extracted in the different regions, and a characteristic point set is constructed. Then according to the distribution of the characteristic point set, a characteristic point sequence reflecting the ge- ometric features of multivariate time series is obtained. The incidence analysis between multivariate time series is transformed into the relational analysis between characteristic point sequences, and a grey incidence model is established. The model possesses the properties of translational invariance, transpose and rank transform invari- ance, and satisfies the grey incidence analysis axioms. Finally, two cases are studied and the results prove the ef- fectiveness of the model.
基金This study was supported by"333 Talent Project " funds of Jiangsu Province in 1999.
文摘Objective. To investigate the relationship of plasma homocysteine (Hcy) level to stroke and genetic factor to elevated plasma Hcy level.Methods. The plasma Hcy level was measured by capillary electrophoresis- ultraviolet detection and the gene polymorphism of N5, N10 - methylenetetrahydrofolate reductase (MTHFR) was studied with PCR - RFLP assay in 43 patients with cortical cerebral infarction and 42 healthy controls.Results. The plasma Hcy level of the patients ( 19. 3 + 6. 0 μ mol/L) was markedly higher than that of the controls (13.7 + 5.4 μ mol/L) ( t = 4. 16, P < 0. 001). There are 3 genotypes, C/C, C/T and T/T, about base - variation of MTHFR gene at locus 677. The plasma Hcy level of the subjects with T/T genotype was higher than that of subjects with other genotypes. However, the frequencies of each genotype and allele were not significantly different between the patients and the controls.Conclusions. The elevated plasma Hcy level is a risk factor for atherothrombotic cerebral infarction, and is related to the C→T mutation at locus 677 of MTHFR gene.
基金Supported by the Modern Agro-Industry Technology Research System(No.CARS-48)
文摘Using correlation and path analysis, the genetic correlation between weight traits and morphological traits was determined in the marine gastropod Glossaulax reiniana. A total of 100 G. reiniana individuals from a wild population were used. Shell width (X1), shell height (X2), umbo-callus height (X3), body width (X4), operculum length (X5), operculum width (X6), body weight (Y1) and soft-tissue weight (Y2) were measured, and the correlation coefficient matrix calculated. Morphological traits were used as independent variables and weight traits as dependent variables for path coefficient analysis. Path coefficients, correlation indices and determination coefficients were also determined. Results indicate that the correlation coefficients associated with each morphological and weight trait were all highly significant (P〈0.01). After deleting redundant independent variables, the following optimum multiple regression equations were obtained using stepwise multiple regression analysis: Y1=-29.317+0.362X2+0.349X4+ 1.190)(5 for body weight; and Y2=-17.292+0.166X1+0.171X2+0.703X5, for soft-tissue weight. Operculum height had the highest positive direct correlation with both body weight and soft-tissue weight, which was in accordance with the test results obtained from determinate coefficient analysis. The indication of high genetic correlations between weight traits and morphological traits will provide valuable information for G. reiniana breeding programs.
文摘AIM: To evaluate the effect of single nucleotide poly- morphisms of interleukin (IL)-28B, rs12979860 on progression and treatment response in chronic hepatitis C. METHODS: Patients (n = 64; 37 men, 27 women; mean age, 44 + 12 years) with chronic hepatitis C, genotype 1, received treatment with peg-interferon plus ribavirin. Genotyping of rs12979860 was per- formed on peripheral blood DNA. Histopathological assessment of necroinflammatory grade and fibrosis stage were scored using the METAVIR system on a liver biopsy sample before treatment. Serum viral load, ami- notransferase activity, and insulin level were measured. Insulin resistance index, body mass index, waist/hip ratio, percentage of body fat and fibrosis progression rate were calculated. Applied dose of interferon and ribavirin, platelet and neutrophil count and hemoglobin level were measured. RESULTS: A sustained virological response (SVR) was significantly associated with IL28B polymorphism (CC vs -l-r allele: odds ratio (OR), 25; CC vs CT allele: OR, 5.4), inflammation activity (G 〈 1 vs G 〉 1: OR, 3.9), fibrosis (F 〈 1 vs F 〉 1: OR, 5.9), platelet count (〉 200 × 109/L vs 〈 200 ×109/L: OR, 4.7; OR in patients with genotype CT: 12.8), fatty liver (absence vs presence of steatosis: OR, 4.8), insulin resistance index (〈 2.5 vs 〉 2.5: OR, 3.9), and baseline HCV viral load (〈 106 IU/mL vs 〉 106 IU/mL: OR, 3.0). There was no association with age, sex, aminotransferases activity, body mass index, waist/hip ratio, or percentage body fat. There was borderline significance (P = 0.064) of increased fibrosis in patients with the I-I allele, and no differences in the insulin resistance index between groups of patients with CC, CT and -IF alleles (P = 0.12). Spearman's rank correlation coefficient between insulin resistance and stage of fibrosis and body mass index was r = 0.618 and r = 0.605, respectively (P 〈 0.001). Significant dif- ferences were found in the insulin resistance index (P = 0.01) between patients with and without steatosis. Patients with the C-I- allele and absence of a SVR had a higher incidence of requiring threshold dose reduction of interferon (P = 0.07). CONCLUSION: IL28B variation is the strongest host factor not related to insulin resistance that determines outcome of antiviral therapy. Baseline platelet count predicts the outcome of antiviral therapy in CT allele patients.
基金Supported by the Education Depart ment Fund of Science and Technology Research (No.104086)
文摘A search algorithm for the detection of a direct path signal in the presence of dense multipath in indoor environment using UWB is Woposed. This algorithm is based on signal correlation and differential coefficient. Statistical analysis of the algorithm is given out and computer simulation results are presented to validate the effectiveness of the algorithm. The results based on the algorithm pml3osed are compared with those based on Maximum Likelihood Estimator(MLE) and Peak Tracking(PT) in the simulation which shows that this algorithm achieves the highest accuracy in most cases and gives out relatively stable results in different Signal Noise Ratio(SNR).
基金supported by the open-fund of Key Laboratory of Fisheries Genetic Resources and Aquaculture,Chinese Academy of Fisheries Sciences of China (2008B1207)New Teacher Special Fund of Doctor of Ministry of Education of China (20090132120006)
文摘Follicle stimulating hormone β (FSHβ) of Japanese flounder (Paralichthys olivaceus) plays a key role in the regulation of gonadal development.This study aimed to investigate molecular genetic characteristics of the FSHβ gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of FSHβ on reproductive traits in Japanese flounder.We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the FSHβ gene in 60 individuals.We identified only an SNP (T/C) in the coding region of exon3 of FSHβ.The SNP (T/C) did not lead to amino acid changes at the position 340 bp of FSHβ gene.Statistical analysis showed that the SNP was significantly associated with testosterone (T) level and gonadosomatic index (GSI) (P<0.05).Individuals with genotype TC of the SNP had significantly higher serum T levels and GSI (P<0.05) than that of genotype CC.Therefore, FSHβ gene could be a useful molecular marker in selection for prominent reproductive trait in Japanese Flounder.
基金Under the auspices of Public Science and Technology Research Funds of Environment(No.201009021,2011467026,2012467044)National Key Technology R&D Program of China(No.2012BAH32B03)National Natural Science Foundation of China(No.41171318,41001160)
文摘Formulation of different ecological zone plans according to the corresponding protection targets and the necessity of proper conservation policy is one of the measures to achieve the goal of ecological conservation in China.In order to clarify the interrelation among key ecological zone plans,this paper carried out the research on spatial relation of priority areas of biodiversity conservation and three key ecological areas(key ecological function areas,key regions of ecological service function,national nature reserves)and the research on ecological conditions,based on multi-scale ecological spatial theme information,which incorporates elements like ecological quality and type,and by the aid of spatial information analysis and GIS modeling.The results showed a contrastively fine spatial consistency with 68.8%of priority areas of biodiversity conservation overlapping with three key ecological areas.Although the environment in priority areas of biodiversity conservation were in good conditions,protection pressure is also increasing,powerful supervision and protection should not be ignored.The environmental conditions in the overlapping areas,as a whole,were superior to those in the non-overlapping areas.Since two areas have different characteristics,targeted protection measures should be formulated based on this difference,which will be very important for biodiversity conservation in priority areas of biodiversity conservation.
文摘The design of optimal heterogeneous catalysts for N_(2)-to-NH_(3) conversion is often dictated by the scaling relations,which result in a volcano curve that poses a limit on the catalytic performance.Herein,we reveal a bowl active site that can break the scaling relations,through investigating the catalytic mechanisms of N_(2)-to-NH_(3) conversion on the lanthanide intermetallic electride catalyst LaRuSi by first-principles modeling.This bowl active site,composed of four surface La cations and one subsurface Si atom rich in electrons,plays the key role in enabling efficient catalysis.With adaptive electrostatic and orbital interactions,the bowl active site promotes the adsorption and activation of N_(2) that delivers facile cleavage of N-N bond,while destabilizes the adsorptions of ^(*)NH_(x)(x=1,2,3)species,which facilitates the release of the final NH_(3) product.By comparison with other electride catalysts isostructural to LaRuSi,we confirm the breaking of scaling relations between the adsorptions of ^(*)NH_(x) species and that of^(*)N on the bowl active site.Thus,this bowl active site presents a design concept that breaks the scaling relations for highly efficient heterogeneous catalysis of N_(2)-to-NH_(3) conversion.
文摘TO THE EDITORWe read with interest the article published by Nguyen et al in the World Journal of Gastroenterology, showing an association between short MUC6 alleles and H pjloff infection. These results, together with previous observations by Vinall et al, reinforce the role of mucin genes (MUC6 and MUC1) VNTR polymorphisms for the variability in individual susceptibility to H pylori infection that cannot be explained by differences in environmental factors.
基金the National Natural Science Foundation of China,Foundation of National Laboratory for Modern Communications
文摘A class of plateaued functions has been got by using the Maiorana-McFarland construction. A variety of desirable criteria for functions with cryptographic application eouht be satisfied: balancedness, high nonlinearity, correlation immunity of reasonably high order, strict avalanche criterion, non-existence of non-zero linear struetures, good glnbal avalanche characteristics, etc.
基金Supported by The Korean Society of Gastroenterology Research Fund, No. 2005-1
文摘AIM: To investigate prevalence of C/onorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than nonnfected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.
文摘Three japonica rice varieties were soaked in 110 mg/L paclobutrazol solution for 48 h and then directly seeded, and seeds soaked with clean water were used as a control group. The analysis of dry weights of various organs and agronomic traits showed that soaking of japonica seeds with paclobutrazol had little impact on the correlation between dry weights of various organs, but there were still significant differences between cultivars. The correlation coefficients between lengths of the first and second nodes with filled grain weight changed from 0.024 and 0.056 in the CK to -0.116 and -0.042 correspondingly after presoaking with paclobutrazol. Therefore, paclobutrezol reduces the effect of stem-sheath weight on filled grain weight, and as a result, photosynthetic product could not be effectively transported in maturation stage of rice.
文摘Retrotransposons are present in all plant genomes and play important roles in genome size,genome structure remodeling,gene function and genome evolution.Me07Em02 marked by sequence-related amplified polymorphism (SRAP) is verified,recovered,sequenced and analyzed,which closely link to the flesh color around the stone.By comparison with the peach genome Peach v1.0,a part of the sequence of copia-like retrotransposons is obtained.With the aid of DANMAN and DNASTAR sequence analysis software,BLASTn alignment is carried out in the peach genome database and GenBank.The whole genome sequence of the copialike retrotransposon in the peach is located at 9 939 764~9 944 771 bp in Scaffold-1 of Peach v1.0,with a total length of 5 008 bp.The LTR on both sides is exactly the same,the length is 444 bp,and the largest ORF box is located at the 487~4 545 bp of the sequence,encoding 1 535 amino acids.The amino acid sequence was submitted to GenBank for Protein BLAST alignment,The results showed that this sequence also has the typical amino acid sequence characteristics of the copia-like retrotransposon.At the same time,the method of peach retrotransposon labeling is preliminarily established,and the genetic diversity of the peach is analyzed.
基金Supported by the grants of Hungarian Science Foundation (OTKA T 0495X9)Hungarian Ministry of Health (ETT 497/2006)by the National Office for Research and Technology, "Pazmany Peter" program. (RET- II 08/2005)
文摘AIM: The goal of the current work was to analyse the prevalence of the +49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene (CTLA4) in Hungarian patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism (SNP). The genotypes were determined by using PCR/RFLP test. RESULTS: The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively. CONCLUSION: The results of the current study show that carriage of the +49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population.
基金This work was supported by Beijing Natural Science Funds
文摘Genetic diversity of 50 cucumber (Cucumis sativus L.) accessions from American, Holland, Japan and China was detected and evaluated using RAPD markers. 25 selected primers produced 215 scorable polymorphic RAPD bands and the ratio of polymorphism is 86.98%. Four main groups of cucumber accessions could be distinguished from UPGMA analysis: Occidental cucumber, South-China cucumber, North-China cucumber and Xishuangbanna cucumber. Our result confirmed that cucumber is a narrow-based germplasm, nevertheless RAPD analysis was stili useful in cucumber genotypic differentiation. More significantly, Xishuangbanna cucumber (Cucumis sativus L. Var Xishuangbannanesis Qi et Yuan), a mutation of cucumber, was clustered together to a special group in the study, which implied its special status in cucumber germplasm.