In multiple system atrophy (MSA), symptoms associated with dysfunctions of the brainstem and autonomic nervous system are important prognostic factors. We inv estigated brainstem involvement in 12 patients with MSA wi...In multiple system atrophy (MSA), symptoms associated with dysfunctions of the brainstem and autonomic nervous system are important prognostic factors. We inv estigated brainstem involvement in 12 patients with MSA with predominant cerebel lar symptoms (MSA C) (mean age, 56.3 ±9.9 years, median disease duration, 3 ye ars), and 11 controls (57.6 ±12.0 years) matched for age using diffusion weig hted MR imaging (DWI). We demonstrated that apparent diffusion coefficients (ADC s) in the pons and middle cerebellar peduncle of MSA C patients are significant ly higher than those of normal controls even though the patients are in the earl y stage of the disease. Furthermore, we demonstrated that increased ADC values c orrelated well with the disease duration. The current study demonstrated that DWI is a useful noninvasive method for the quantitative evaluation of the brainstem involvement in MSA C patients.展开更多
Chelsea Therapeutics公司向FDA提交了Northera^TM（屈昔多巴，droxidopa）的新药上市申请（NDA）。本品是一种口服的去甲肾上腺素合成前体，用于治疗原发性自主神经衰竭（帕金森病、多系统萎缩症和单纯性自主神经衰竭）、多巴胺-β-羟...Chelsea Therapeutics公司向FDA提交了Northera^TM（屈昔多巴，droxidopa）的新药上市申请（NDA）。本品是一种口服的去甲肾上腺素合成前体，用于治疗原发性自主神经衰竭（帕金森病、多系统萎缩症和单纯性自主神经衰竭）、多巴胺-β-羟化酶缺乏和非糖尿病性自主神经病患者的有症状的神经性直立性低血压（neurogenic orthostatic hypotension，NOH）。展开更多
文摘In multiple system atrophy (MSA), symptoms associated with dysfunctions of the brainstem and autonomic nervous system are important prognostic factors. We inv estigated brainstem involvement in 12 patients with MSA with predominant cerebel lar symptoms (MSA C) (mean age, 56.3 ±9.9 years, median disease duration, 3 ye ars), and 11 controls (57.6 ±12.0 years) matched for age using diffusion weig hted MR imaging (DWI). We demonstrated that apparent diffusion coefficients (ADC s) in the pons and middle cerebellar peduncle of MSA C patients are significant ly higher than those of normal controls even though the patients are in the earl y stage of the disease. Furthermore, we demonstrated that increased ADC values c orrelated well with the disease duration. The current study demonstrated that DWI is a useful noninvasive method for the quantitative evaluation of the brainstem involvement in MSA C patients.
