Cord blood thyroid-stimulating hormone level is elevated in neonates who had undergone more perinatal stresses. The present study aimed to evaluate the cord blood acid-base status in neonates with elevated thyroid-sti...Cord blood thyroid-stimulating hormone level is elevated in neonates who had undergone more perinatal stresses. The present study aimed to evaluate the cord blood acid-base status in neonates with elevated thyroid-stimulating hormone level. Study design: The study population consisted of 2366 singleton, term pregnancies. Subjects were categorized by their cord blood thyroid-stimulating hormone level into four quartiles, and cord blood acid-base parameters were compared among the four groups. The correlations between cord acid-base parameters and thyroid-stimulating hormone level were also studied. Results: Cord blood pH was significantly lower in the highest (arterial, 7.27 ± 0.08; venous, 7.32 ± 0.07) and second highest thyroid-stimulating hormone quartile groups (arterial, 7.29 ± 0.07; venous, 7.34 ± 0.06) compared to the lowest quartile group (arterial, 7.30 ± 0.06; venous, 7.35 ± 0.05). Incidences of cord arterial pH ≤ 7.20 were 4.7% , 6.8% , 10.9% , and 17.3% in lowest to the highest thyroid-stimulating hormone quartile groups, respectively. There was a significant negative correlation between cord blood thyroid-stimulating hormone level and cord arterial and venous pH (r = - 0.26, P < 0.001). When stratified according to the mode of delivery, the negative correlations remained significant in neonates delivered vaginally and by intrapartum emergency cesarean section but not in neonates delivered by elective cesarean section. Conclusion: Incidence of cord blood acidosis is significantly higher in neonates with elevated thyroid-stimulating hormone level. This findings support the postulation that stress-induced elevation of cord blood thyroid-stimulating hormone level may be mediated through intrapartum fetal hypoxia.展开更多
Objective:Polycystic ovary syndrome(PCOS),a common endocrine-metabolic dysfunction in reproductive-aged women,may be involved in compromised pregnancy and offspring outcomes.This study aimed to investigate whether mat...Objective:Polycystic ovary syndrome(PCOS),a common endocrine-metabolic dysfunction in reproductive-aged women,may be involved in compromised pregnancy and offspring outcomes.This study aimed to investigate whether maternal PCOS affects fetal growth,fetal development,and placental features.Methods:This retrospective case-control study included 60 pregnant women with PCOS(PCOS group)and 120 healthy pregnant women without PCOS(control group).Fetal magnetic resonance imaging(MRI)was performed followed by an ultrasound examination and indications for imaging,including known or suspected fetal pathology,history of fetal abnormality in previous pregnancy or in a family member,and concern for placenta accreta.Fetal MRI images were analyzed for head cir-cumference(HC),abdomen circumference(AC),lung-to-liver signal intensity ratio(LLSIR,a prenatal marker of fetal lung maturity),lengths of liver and kidney diameters in fetuses,and placental relative signal intensity on T2-weighted single-shot fast spin echo(SSFSE)imaging(rSISSFSE),and placental relative apparent diffusion coefficient value(rADC).Data on height and weight of offspring were collected through telephone follow-up.Results:Compared to the control group,the PCOS group showed the following characteristics:(1)smaller biparietal diameter and femur length in fetuses(P=0.026 and P=0.005,respectively),(2)smaller HC in fetuses(evident after 32 weeks;P=0.044),(3)lower LLSIR and smaller dorsoventral length of liver in fetuses(evident before 32 weeks;P=0.005 and P=0.019,respec-tively),and(4)smaller placental thickness(evident before 32 weeks;P=0.017).No significant differences in placental rSISSFSE or rADC were observed between the groups(all P>0.05).No significant differences in height and weight of offspring during childhood existed between the groups(all P>0.05).Conclusions:There exist alterations of fetal growth,fetal development,and placental features from women with PCOS.展开更多
文摘Cord blood thyroid-stimulating hormone level is elevated in neonates who had undergone more perinatal stresses. The present study aimed to evaluate the cord blood acid-base status in neonates with elevated thyroid-stimulating hormone level. Study design: The study population consisted of 2366 singleton, term pregnancies. Subjects were categorized by their cord blood thyroid-stimulating hormone level into four quartiles, and cord blood acid-base parameters were compared among the four groups. The correlations between cord acid-base parameters and thyroid-stimulating hormone level were also studied. Results: Cord blood pH was significantly lower in the highest (arterial, 7.27 ± 0.08; venous, 7.32 ± 0.07) and second highest thyroid-stimulating hormone quartile groups (arterial, 7.29 ± 0.07; venous, 7.34 ± 0.06) compared to the lowest quartile group (arterial, 7.30 ± 0.06; venous, 7.35 ± 0.05). Incidences of cord arterial pH ≤ 7.20 were 4.7% , 6.8% , 10.9% , and 17.3% in lowest to the highest thyroid-stimulating hormone quartile groups, respectively. There was a significant negative correlation between cord blood thyroid-stimulating hormone level and cord arterial and venous pH (r = - 0.26, P < 0.001). When stratified according to the mode of delivery, the negative correlations remained significant in neonates delivered vaginally and by intrapartum emergency cesarean section but not in neonates delivered by elective cesarean section. Conclusion: Incidence of cord blood acidosis is significantly higher in neonates with elevated thyroid-stimulating hormone level. This findings support the postulation that stress-induced elevation of cord blood thyroid-stimulating hormone level may be mediated through intrapartum fetal hypoxia.
基金Project supported by the National Natural Science Foundation of China(Nos.81874480 and 81873837)the Zhejiang Province Science Foundation for Distinguished Young Scholars(No.LR16H040001),China。
文摘Objective:Polycystic ovary syndrome(PCOS),a common endocrine-metabolic dysfunction in reproductive-aged women,may be involved in compromised pregnancy and offspring outcomes.This study aimed to investigate whether maternal PCOS affects fetal growth,fetal development,and placental features.Methods:This retrospective case-control study included 60 pregnant women with PCOS(PCOS group)and 120 healthy pregnant women without PCOS(control group).Fetal magnetic resonance imaging(MRI)was performed followed by an ultrasound examination and indications for imaging,including known or suspected fetal pathology,history of fetal abnormality in previous pregnancy or in a family member,and concern for placenta accreta.Fetal MRI images were analyzed for head cir-cumference(HC),abdomen circumference(AC),lung-to-liver signal intensity ratio(LLSIR,a prenatal marker of fetal lung maturity),lengths of liver and kidney diameters in fetuses,and placental relative signal intensity on T2-weighted single-shot fast spin echo(SSFSE)imaging(rSISSFSE),and placental relative apparent diffusion coefficient value(rADC).Data on height and weight of offspring were collected through telephone follow-up.Results:Compared to the control group,the PCOS group showed the following characteristics:(1)smaller biparietal diameter and femur length in fetuses(P=0.026 and P=0.005,respectively),(2)smaller HC in fetuses(evident after 32 weeks;P=0.044),(3)lower LLSIR and smaller dorsoventral length of liver in fetuses(evident before 32 weeks;P=0.005 and P=0.019,respec-tively),and(4)smaller placental thickness(evident before 32 weeks;P=0.017).No significant differences in placental rSISSFSE or rADC were observed between the groups(all P>0.05).No significant differences in height and weight of offspring during childhood existed between the groups(all P>0.05).Conclusions:There exist alterations of fetal growth,fetal development,and placental features from women with PCOS.
