目的 理清低密度校验(Low-Density Parity-Check, LDPC)码的交替方向乘子(Alternating Direction Method of Multipliers, ADMM)译码方法中向量到校验多胞体投影操作的复杂度。方法 比较基于割查找的欧几里德投影算法和快速近似欧几里...目的 理清低密度校验(Low-Density Parity-Check, LDPC)码的交替方向乘子(Alternating Direction Method of Multipliers, ADMM)译码方法中向量到校验多胞体投影操作的复杂度。方法 比较基于割查找的欧几里德投影算法和快速近似欧几里德投影算法2种典型投影算法的投影结果、算法特点、时间复杂度以及基本操作次数。结果与结论快速近似欧几里德投影算法各种操作的次数低于基于割查找的欧几里德投影算法,表明前者的时间复杂度低于后者。展开更多
Objective:To explore the effects of dopamine receptor D2(DRD2)on astrocytic dedifferentiation based on SOX2-regulated genes in neural stem cells(NSCs)and astrocytes.Methods:Immunofluorescence staining and SOX2-GFP mic...Objective:To explore the effects of dopamine receptor D2(DRD2)on astrocytic dedifferentiation based on SOX2-regulated genes in neural stem cells(NSCs)and astrocytes.Methods:Immunofluorescence staining and SOX2-GFP mice were used to examine the lineage differentiation of SOX2-positive cells during the development of cerebral cortex.Primary NSCs/astrocytes culture,ChIP-seq and Western Blot were adopted to analyze and verify the expression of candidate genes.Pharmacological manipulation,neurosphere formation,photochemical ischemia,immunofluorescence staining and behavior tests were adopted to evaluate the effects of activating DRD2 signaling on astrocytic dedifferentiation.Results:Immunofluorescence staining demonstrated the NSC-astrocyte switch of SOX2-expression in the normal development of cerebral cortex.ChIP-seq revealed enrichment of DRD2 signaling by SOX2-bound enhancers in NSCs and SOX2-bound promoters in astrocytes.Western Blot and immunofluorescence staining verified the expression of DRD2 in NSCs and reactive astrocytes.Application of quinagolide hydrocholoride(QH),an agonist of DRD2,significantly promoted astrocytic dedifferentiation both in vitro and in vivo following ischemia.In addition,quinagolide hydrocholoride treatment improved locomotion recovery.Conclusion:Activating DRD2 signaling facilitates astrocytic dedifferentiation and may be used to treat ischemic stroke.展开更多
可再生能源大规模、高密度的接入显著改变了电力系统静/动态特性,对系统建模、仿真、分析和控制带来了挑战。该文针对含不确定性的电力系统稳定性分析问题,引入微分包含理论,建立一种随机激励下电力系统低频振荡分析模型。针对含不确定...可再生能源大规模、高密度的接入显著改变了电力系统静/动态特性,对系统建模、仿真、分析和控制带来了挑战。该文针对含不确定性的电力系统稳定性分析问题,引入微分包含理论,建立一种随机激励下电力系统低频振荡分析模型。针对含不确定性的电力系统稳定性问题,采用线性多胞体(polytopic linear differential inclusion,PLDI)微分方法,将包含不确定性的随机激励表征为有限个元素的凸包。基于凸包李雅谱诺夫(Lyapunov)函数法推导多胞体系统稳定判据,并给出强阻尼系统约束条件;进而,基于Hankel范数逼近法,给出一种适用于大规模柔性互联系统的低频振荡分析方法。以简单两机系统、10机39节点系统验证所提出方法及稳定判据。仿真结果表明,该文所提方法能准确地刻画随机激励下的电力系统本质。展开更多
文摘目的 理清低密度校验(Low-Density Parity-Check, LDPC)码的交替方向乘子(Alternating Direction Method of Multipliers, ADMM)译码方法中向量到校验多胞体投影操作的复杂度。方法 比较基于割查找的欧几里德投影算法和快速近似欧几里德投影算法2种典型投影算法的投影结果、算法特点、时间复杂度以及基本操作次数。结果与结论快速近似欧几里德投影算法各种操作的次数低于基于割查找的欧几里德投影算法,表明前者的时间复杂度低于后者。
文摘Objective:To explore the effects of dopamine receptor D2(DRD2)on astrocytic dedifferentiation based on SOX2-regulated genes in neural stem cells(NSCs)and astrocytes.Methods:Immunofluorescence staining and SOX2-GFP mice were used to examine the lineage differentiation of SOX2-positive cells during the development of cerebral cortex.Primary NSCs/astrocytes culture,ChIP-seq and Western Blot were adopted to analyze and verify the expression of candidate genes.Pharmacological manipulation,neurosphere formation,photochemical ischemia,immunofluorescence staining and behavior tests were adopted to evaluate the effects of activating DRD2 signaling on astrocytic dedifferentiation.Results:Immunofluorescence staining demonstrated the NSC-astrocyte switch of SOX2-expression in the normal development of cerebral cortex.ChIP-seq revealed enrichment of DRD2 signaling by SOX2-bound enhancers in NSCs and SOX2-bound promoters in astrocytes.Western Blot and immunofluorescence staining verified the expression of DRD2 in NSCs and reactive astrocytes.Application of quinagolide hydrocholoride(QH),an agonist of DRD2,significantly promoted astrocytic dedifferentiation both in vitro and in vivo following ischemia.In addition,quinagolide hydrocholoride treatment improved locomotion recovery.Conclusion:Activating DRD2 signaling facilitates astrocytic dedifferentiation and may be used to treat ischemic stroke.
文摘可再生能源大规模、高密度的接入显著改变了电力系统静/动态特性,对系统建模、仿真、分析和控制带来了挑战。该文针对含不确定性的电力系统稳定性分析问题,引入微分包含理论,建立一种随机激励下电力系统低频振荡分析模型。针对含不确定性的电力系统稳定性问题,采用线性多胞体(polytopic linear differential inclusion,PLDI)微分方法,将包含不确定性的随机激励表征为有限个元素的凸包。基于凸包李雅谱诺夫(Lyapunov)函数法推导多胞体系统稳定判据,并给出强阻尼系统约束条件;进而,基于Hankel范数逼近法,给出一种适用于大规模柔性互联系统的低频振荡分析方法。以简单两机系统、10机39节点系统验证所提出方法及稳定判据。仿真结果表明,该文所提方法能准确地刻画随机激励下的电力系统本质。