Objective： The aim of this study was to investigate the efficacy of weekly docetaxel （TXT）, cisplatin （DDP） combined with continuous infusion of low dose fluorouracil （FU） on advanced gastric carcinoma. Methods...Objective： The aim of this study was to investigate the efficacy of weekly docetaxel （TXT）, cisplatin （DDP） combined with continuous infusion of low dose fluorouracil （FU） on advanced gastric carcinoma. Methods： Forty patients with advanced gastric carcinoma were randomly divided into two groups： the research group and the control group with 20 cases in each group. Patients in the research group were given TXT 40 mg/m^2 on dl and d8 plus DDP 30 mg/m^2 on days 1, 3. FU 200 mg/m^2 was infused continually from day 1-14. Patients in control group received ELF regimen therapy. Etoposide （VP- 16） 120 mg/m^2, calcium folinate （CF） 200 mg/m^2, and FU 500 mg/m^2 were given on days 1 and 3. Twenty-eight days were regarded as one cycle. At least two cycles must be completed. The short-term efficacy, adverse reaction, quality of life （QOL）, and overall survival （OS） were recorded. Results： The clinical efficacy could be evaluated in 19 patients of research group and 17 patients in control group. The efficacy of research group was significantly better than that in control group （52.63% vs 17.65%, χ^2 = 4.760, P = 0.041）. However, the difference was not significant in the frequency of adverse reaction, QOL, median survival time, and OS between the two groups （P 〉 0.05）. Conclusion： The short-term efficacy of weekly docetaxel and cisplatin plus low dose FU was better than traditional ELF regimen in the treatment of advanced gastric cancer. It had some value for clinical application.展开更多
A rapid and simple procedure for synthesis of 2,6-di（naphthalene thioureido carbamino）pyridine fluorescine anion acceptor by the reaction between pyridine-2,6-dicarbohydrazide obtained from 2,6-dimethylpyridine afte...A rapid and simple procedure for synthesis of 2,6-di（naphthalene thioureido carbamino）pyridine fluorescine anion acceptor by the reaction between pyridine-2,6-dicarbohydrazide obtained from 2,6-dimethylpyridine after three-step reaction and 1-napbthyl isothiocyanate is described, and all reactions could be carried out under microwave heating condition.展开更多
The polysaccharides from pumpkin fruit （PP） were obtained and purified by hot-water extraction, anion-exchange chromatography, and gel column chromatography. The physicochemical properties of PP were determined by g...The polysaccharides from pumpkin fruit （PP） were obtained and purified by hot-water extraction, anion-exchange chromatography, and gel column chromatography. The physicochemical properties of PP were determined by gel filtration chromatography, gas chromatography, fourier transform infrared （FTIR） spectroscopy, and nuclear magnetic resonance （NMR） spectroscopy. Results indicated that the molecular weight of PP was about 23 kDa and PP was composed of D-Arabinose, D-Marmose, D-Glucose, and D-Galactose with a molar ratio of 1 ： 7.79 ： 70.32 ： 7.05. FTIR and NMR spectra indicated that PP was the polysaccharide containing pyranose ring. Additionally, PP protected islets cells from streptozotocin （STZ） injury in vitro via increasing the levels of super-oxide dismutase （SOD） and malondialdehyde （MDA） and reducing the production of NO. The experiment of reverse transcriptase-polymerase chain reaction further proved that PP inhibited apoptosis via modulating the expression of Bax/Bcl-2 in STZ-damaged islet cells. In conclusion, PP could be explored as a novel agent for the treatment of diabetes mellitus.展开更多
文摘Objective： The aim of this study was to investigate the efficacy of weekly docetaxel （TXT）, cisplatin （DDP） combined with continuous infusion of low dose fluorouracil （FU） on advanced gastric carcinoma. Methods： Forty patients with advanced gastric carcinoma were randomly divided into two groups： the research group and the control group with 20 cases in each group. Patients in the research group were given TXT 40 mg/m^2 on dl and d8 plus DDP 30 mg/m^2 on days 1, 3. FU 200 mg/m^2 was infused continually from day 1-14. Patients in control group received ELF regimen therapy. Etoposide （VP- 16） 120 mg/m^2, calcium folinate （CF） 200 mg/m^2, and FU 500 mg/m^2 were given on days 1 and 3. Twenty-eight days were regarded as one cycle. At least two cycles must be completed. The short-term efficacy, adverse reaction, quality of life （QOL）, and overall survival （OS） were recorded. Results： The clinical efficacy could be evaluated in 19 patients of research group and 17 patients in control group. The efficacy of research group was significantly better than that in control group （52.63% vs 17.65%, χ^2 = 4.760, P = 0.041）. However, the difference was not significant in the frequency of adverse reaction, QOL, median survival time, and OS between the two groups （P 〉 0.05）. Conclusion： The short-term efficacy of weekly docetaxel and cisplatin plus low dose FU was better than traditional ELF regimen in the treatment of advanced gastric cancer. It had some value for clinical application.
文摘A rapid and simple procedure for synthesis of 2,6-di（naphthalene thioureido carbamino）pyridine fluorescine anion acceptor by the reaction between pyridine-2,6-dicarbohydrazide obtained from 2,6-dimethylpyridine after three-step reaction and 1-napbthyl isothiocyanate is described, and all reactions could be carried out under microwave heating condition.
基金supported by the Natural Science Foundation Committee of China(NSFC 81202467)the Natural Science Foundation of Jiangsu Province in China(BK2012232)+2 种基金the Natural Science Research Project of Universities in Jiangsu Province of China(11KJB350004,06KJD310150,12KJB310012)the Natural Science Foundation of Nantong City of China(BK2011044)a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘The polysaccharides from pumpkin fruit （PP） were obtained and purified by hot-water extraction, anion-exchange chromatography, and gel column chromatography. The physicochemical properties of PP were determined by gel filtration chromatography, gas chromatography, fourier transform infrared （FTIR） spectroscopy, and nuclear magnetic resonance （NMR） spectroscopy. Results indicated that the molecular weight of PP was about 23 kDa and PP was composed of D-Arabinose, D-Marmose, D-Glucose, and D-Galactose with a molar ratio of 1 ： 7.79 ： 70.32 ： 7.05. FTIR and NMR spectra indicated that PP was the polysaccharide containing pyranose ring. Additionally, PP protected islets cells from streptozotocin （STZ） injury in vitro via increasing the levels of super-oxide dismutase （SOD） and malondialdehyde （MDA） and reducing the production of NO. The experiment of reverse transcriptase-polymerase chain reaction further proved that PP inhibited apoptosis via modulating the expression of Bax/Bcl-2 in STZ-damaged islet cells. In conclusion, PP could be explored as a novel agent for the treatment of diabetes mellitus.
