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中国家鸡多起源及相关分子生物学研究
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作者 梁勇 康乐 +1 位作者 姜庆林 张细权 《中国家禽》 北大核心 2015年第14期1-6,共6页
中国家鸡起源和遗传分化的研究有助于了解我国家鸡品种资源种质特性,并开展其保存与发展工作。本文结合家鸡起源的考古学、古生态学及社会学依据,利用分子生物学方法对我国家鸡多起源、功能性分化及可能存在的遗传背景进行了阐述。认为... 中国家鸡起源和遗传分化的研究有助于了解我国家鸡品种资源种质特性,并开展其保存与发展工作。本文结合家鸡起源的考古学、古生态学及社会学依据,利用分子生物学方法对我国家鸡多起源、功能性分化及可能存在的遗传背景进行了阐述。认为红色原鸡不同亚群间的线粒体DNA多态性分析将有利于在家鸡群体中确定原始单倍型;同时,我国家鸡多起源研究时应注重对北方品种的分析,且分析方法上应注重以单倍型簇为单位的频率分析;我国山东和河南及周边地区可能是我国家鸡独立起源的区域及南方家鸡受到东南亚品种影响。 展开更多
关键词 家鸡 多起源 考古学 MTDNA
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卵巢上皮性癌多起源学说的研究进展 被引量:1
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作者 王丽丽 郭红燕 《中国微创外科杂志》 CSCD 北大核心 2015年第12期1117-1120,共4页
卵巢上皮性癌是致死率最高的妇科恶性肿瘤,缺乏有效的早期诊断及筛查方法是预后差的主要原因,与卵巢上皮性癌的异质性及来源的多样性存在密切关系。传统的上皮性癌来源学说认为上皮性卵巢癌来自卵巢表面生发上皮,"第二苗勒管系统学... 卵巢上皮性癌是致死率最高的妇科恶性肿瘤,缺乏有效的早期诊断及筛查方法是预后差的主要原因,与卵巢上皮性癌的异质性及来源的多样性存在密切关系。传统的上皮性癌来源学说认为上皮性卵巢癌来自卵巢表面生发上皮,"第二苗勒管系统学说"对上述观点提出质疑,"二元论"学说彻底颠覆了传统的理论,但上述理论均存在局限性。近年来,卵巢上皮性癌多起源学说逐渐成为讨论热点。 展开更多
关键词 卵巢上皮性癌 输卵管来源 多起源学说
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阿波罗起源述略——“东方说”与“北方说” 被引量:3
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作者 王绍辉 《东北师大学报(哲学社会科学版)》 CSSCI 北大核心 2010年第3期83-88,共6页
阿波罗是古希腊神话中最为复杂、受崇拜最为广泛的神明。对阿波罗起源的探讨,"东方说"与"北方说"是两种重要观点。由于这两家学说相关证据的缺乏,兼顾阿波罗所体现的外来因素和希腊本土文明特征的"多起源说&qu... 阿波罗是古希腊神话中最为复杂、受崇拜最为广泛的神明。对阿波罗起源的探讨,"东方说"与"北方说"是两种重要观点。由于这两家学说相关证据的缺乏,兼顾阿波罗所体现的外来因素和希腊本土文明特征的"多起源说"的提法亦逐渐得到学界的认同,但对于阿波罗这位深刻影响着希腊宗教乃至整个西方思想的重要神明起源的进一步研究,尚有待于更多文献与考古材料的释读与发掘。 展开更多
关键词 阿波罗 东方说 北方说 多起源
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卵巢上皮性癌起源的鉴定方法 被引量:1
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作者 许欣 张春妤 郭红燕 《实用妇产科杂志》 CAS CSCD 北大核心 2017年第10期747-750,共4页
既往认为卵巢上皮性癌起源于卵巢生发上皮,导致对卵巢上皮性癌的早期诊断局限于卵巢本身,使得早期诊断困难,出现预后差、致死率高等结果。目前通过对卵巢上皮性癌的临床特征及分子研究发现其是一种高度异质性的妇科恶性肿瘤,可能起源自... 既往认为卵巢上皮性癌起源于卵巢生发上皮,导致对卵巢上皮性癌的早期诊断局限于卵巢本身,使得早期诊断困难,出现预后差、致死率高等结果。目前通过对卵巢上皮性癌的临床特征及分子研究发现其是一种高度异质性的妇科恶性肿瘤,可能起源自输卵管上皮、异位子宫内膜恶变等部位或由阑尾黏液性癌、原发腹膜癌等肿瘤转移而来。在临床工作中需要通过临床特征、形态学及免疫组化染色判断卵巢上皮性癌的起源部位,除卵巢组织外,还应对输卵管、阑尾等邻近器官进行全面广泛取材,了解不同起源部位肿瘤的生物学特征,将来为个体化治疗提供依据。 展开更多
关键词 卵巢上皮性癌 多起源学说 鉴定方法
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12例多中心起源食管癌的外科诊治分析
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作者 陈海生 陆松华 +2 位作者 景仕银 杨长刚 吴斌 《内蒙古中医药》 2013年第2期69-70,共2页
目的:探讨食管多中心起源性癌的诊断方法和手术并发症,提高术前诊断率及外科治疗方法。方法:回顾性分析我科2002年1月~2006年12月,12例食管多中心起源性癌的临床治疗资料。结果:术前确诊7例,内腔镜检查诊断率58.3%(7/12),X线钡餐检查... 目的:探讨食管多中心起源性癌的诊断方法和手术并发症,提高术前诊断率及外科治疗方法。方法:回顾性分析我科2002年1月~2006年12月,12例食管多中心起源性癌的临床治疗资料。结果:术前确诊7例,内腔镜检查诊断率58.3%(7/12),X线钡餐检查诊断率25.0%(3/12),术中及术后确诊3例(3/12)。本组12例均行手术治疗,手术无死亡。结论:本病术前诊断主要依靠内镜检查及X线钡餐检查确认,CT检查明确病灶浸润情况。术前检查应考虑有多中心起源可能,不满足于单一病灶的发现,以避免多发灶的漏诊,并积极进行外科治疗,有望改善治疗效果。 展开更多
关键词 食管癌 多起源
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粒毛盘菌属种间关系的分子系统学初探 被引量:9
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作者 叶明 庄文颖 《菌物系统》 CSCD 北大核心 2002年第3期340-345,共6页
粒毛盘菌属包括晶杯菌科中子囊盘表面具有毛状物,毛状物全表面具有颗粒状纹饰以及外囊盘被结构为矩胞组织的部分种类,种间形态解剖结构多样,研究采用ITS15.8S rDNAITS2序列分析的方法探讨该属种间的系统发育关系。在供试的粒毛盘菌15... 粒毛盘菌属包括晶杯菌科中子囊盘表面具有毛状物,毛状物全表面具有颗粒状纹饰以及外囊盘被结构为矩胞组织的部分种类,种间形态解剖结构多样,研究采用ITS15.8S rDNAITS2序列分析的方法探讨该属种间的系统发育关系。在供试的粒毛盘菌15个分类单元中,14个以89%的支持强度值相聚在一起,其中Lachnum clandestinum与 L. fuscescens关系最近,其支持强度值为100%;其次为L. controversum 与L. spartinae,其支持强度值为97%;而姊妹群L. euterpes,L. pteridophyllum,L. singerianum和L. lushanense彼此关系较远,其支持强度值均小于50%;L. sclerotii位于系统发育树的最外侧,为供试15个分类单元中距离最远的一个,结果表明粒毛盘菌属可能是多起源的。 展开更多
关键词 序列分析 多起源 晶杯菌科 ITS1-5.85rDNA-ITS2
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婴幼儿恶性间叶瘤 被引量:2
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作者 李文英 吴承宣 赵芝泉 《影像诊断与介入放射学》 1995年第3期214-218,共2页
恶性间叶瘤多起源于软组织,国内文献报导甚少,新生儿患者更为罕见,我院遇到一例,现报导如下。 患儿男,系双胞胎之一,产后发现左下肢偏外侧有一鹅蛋大小在马铃薯状肿块而来院就诊。 体格检查:患儿体重约3kg,一般情况良好,发育正常,两上... 恶性间叶瘤多起源于软组织,国内文献报导甚少,新生儿患者更为罕见,我院遇到一例,现报导如下。 患儿男,系双胞胎之一,产后发现左下肢偏外侧有一鹅蛋大小在马铃薯状肿块而来院就诊。 体格检查:患儿体重约3kg,一般情况良好,发育正常,两上肢和右下肢未见异常,活动自如。 展开更多
关键词 婴幼儿 恶性间叶瘤 软组织肿块 左下肢 新生儿患者 马铃薯 活组织检查 灵壁县 多起源 病理学诊断
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Biogeography of the leafhopper subfamily Stegelytrinae(Hemiptera:Cicadellidae),based on a cluster analysis of geographical distribution in areas of endemism combined with phylogeny of the subfamily
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作者 魏琮 程若琳 张雅林 《Entomotaxonomia》 CSCD 北大核心 2012年第4期575-586,共12页
Biogeography of the leaflaopper subfamily Stegelytrinae Baker is studied based on an analysis of geographical distribution of this subfamily worldwide using a cluster analysis of the zoological distribution of areas o... Biogeography of the leaflaopper subfamily Stegelytrinae Baker is studied based on an analysis of geographical distribution of this subfamily worldwide using a cluster analysis of the zoological distribution of areas of endemism as well as the phylogeny of representatives of this subfamily. Results show that the Stegelytrinae mainly occur in the Oriental Region and in the Mediterranean area of the Palaearctic Region, and this extends to the east side of both Wallaee's and Weber's lines. Eleven areas of endemism of this subfamily are recognized. The proportions of endemic taxa in different areas of endemism are generally very high in comparison with other leaflaopper groups, but distinct differences could be found among the different areas of endemism of Stegelytrinae. This subfamily is most intensively diversified in the Indochina Peninsula (INCN). This is the stegelytrine distribution center, having the highest biodiversity at both genetic and species levels. The dendrogram of endemic areas of Stegelytrinae constructed using cluster analysis of the zoological distribution of Stegelytrinae at generic level shows the endemic areas of Stegelytrinae can be divided into 4 large groups. Relationships among different endemic areas of Stegelytrinae correspond largely to the geologic history of related areas, which indicates that the evolution and vicariance of this subfamily have been closely related to the history of continental drift and climate changes. It is deduced that the presumed monophyletic Stegelytrinae originated in the Oriental Region after North America had separated from Eurasia; this is the case in the monophyletic genera group which is supported by the lateral frontal sutures extending dorsally well beyond the corresponding ocellus. In addition, two expanding traces of the Stegelytrinae are presumed, which remain plausible explanations for the dispersal of Stegelytrinae: (1) New Guinea (and probably (+ Australia)) - Kalimantan - Sumatra - Malay Peninsula - Indochina Peninsula - Central and Southern China - (Southwestern China + Nepal + Northeastern India) - (Northwestern India + Eastern Afghanistan); and (2) Indochina Peninsula- Central and Southern China- (Western Asia + Mediterranean Sea coastal area). 展开更多
关键词 distribution biodiversity origin historical biogeography
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Study on Origin and Evolution of Polyploids in Parakmeria Hu et Cheng Using LEAFY Gene
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作者 王震 段焰青 李青青 《Agricultural Science & Technology》 CAS 2013年第5期699-702,756,共5页
[Objective] This study aimed to explore the origin and evolution of poly- poids in Parakmeria Hu et Cheng through LEAFY gene clone and sequence analysis. [Method] In this study, LEAFY gene in Parakmeria species and it... [Objective] This study aimed to explore the origin and evolution of poly- poids in Parakmeria Hu et Cheng through LEAFY gene clone and sequence analysis. [Method] In this study, LEAFY gene in Parakmeria species and its relative genera was cloned and sequenced using molecular biology methods. With reference to LEAFY gene sequence published by NCBI, the origin pattern of polypoids in Parakmeria was explored and reasons for the distribution layout of different polypoids were analyzed through sequence alignment and phylogenetic analysis. [Result] Different Magnoliaceae species can be distinguished using the LEAFY gene, and there was a length polymorphism found in the 3+ end of the LEAFY gene, which can be used to divide Magnoliaceae plants of different species or in different genera, thus of high application value. [Conclusion] Most Parakmeria tetraploids are produced by polyploidization of homologous chromosomes, while Parakmeria hexaploids are chiefly produced by both polyploidization of homologous chromosomes and heterologous hybridization. 展开更多
关键词 Parakmeria Hu et Cheng LEAFY gene Phylogenetic evolution Polyploid origin
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Synthetic and biological studies on a cyclopolypeptide of plant origin 被引量:1
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作者 Rajiv DAHIYA Akhilesh KUMAR 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2008年第5期391-400,共10页
Objective:A natural cyclic peptide previously isolated from Citrus medica was synthesized by coupling of tetrapep-tide units Boc-Leu-Pro-Trp-Leu-OMe and Boc-Ile-Ala-Ala-Gly-OMe after proper deprotection at carboxyl an... Objective:A natural cyclic peptide previously isolated from Citrus medica was synthesized by coupling of tetrapep-tide units Boc-Leu-Pro-Trp-Leu-OMe and Boc-Ile-Ala-Ala-Gly-OMe after proper deprotection at carboxyl and amino terminals followed by cyclization of linear octapeptide segment. Methods:Solution phase technique was adopted for the synthesis of cyclooctapeptide-sarcodactylamide. Required tetrapeptide units were prepared by coupling of Boc-protected dipeptides viz. Boc-Leu-Pro-OH and Boc-Ile-Ala-OH with respective dipeptide methyl esters Trp-Leu-OMe and Ala-Gly-OMe. Cyclization of linear octapeptide unit was done by p-nitrophenyl ester method. The structure of synthesized cyclopolypeptide was elucidated by FTIR,1H NMR,13C NMR,FABMS spectral data and elemental analysis. The newly synthesized peptide was evaluated for dif-ferent pharmacological activities including antimicrobial,anthelmintic and cytotoxic activities. Results:Synthesis of sarcodac-tylamide was accomplished with >78% yield utilizing dicyclohexylcarbodiimide(DCC) as coupling agent. Newly synthesized peptide possessed potent cytotoxic activity against Dalton's lymphoma ascites(DLA) and Ehrlich's ascites carcinoma(EAC) cell lines,in addition to moderate anthelmintic activity against earthworms Megascoplex konkanensis,Pontoscotex corethruses and Eudrilus sp. Moreover,cyclopolypeptide displayed good antimicrobial activity against pathogenic fungi Candida albicans and Gram-negative bacteria Pseudomonas aeruginosa,in comparison to standard drugs griseofulvin and ciprofloxacin. Conclusion:Solution phase technique employing DCC and triethylamine(TEA) as base proved to be effective for the synthesis of natural cyclooctapeptide. N-methyl morpholine(NMM) was found to be a better base for the cyclization of linear octapeptide unit in comparison to TEA and pyridine. 展开更多
关键词 Cyclic octapeptide Citrus medica var. sarcodactylis Sarcodactylamide Peptide synthesis Anthelmintic activity Antimicrobial activity CYTOTOXICITY
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A combination algorithm of Chaos optimization and genetic algorithm and its application in maneuvering multiple targets data association
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作者 王建华 张琳 刘维亭 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2007年第4期470-473,共4页
The most important problem in targets tracking is data association which may be represented as a sort of constraint combinational optimization problem. Chaos optimization and adaptive genetic algorithm were used to de... The most important problem in targets tracking is data association which may be represented as a sort of constraint combinational optimization problem. Chaos optimization and adaptive genetic algorithm were used to deal with the problem of multi-targets data association separately. Based on the analysis of the limitation of chaos optimization and genetic algorithm, a new chaos genetic optimization combination algorithm was presented. This new algorithm first applied the "rough" search of chaos optimization to initialize the population of GA, then optimized the population by real-coded adaptive GA. In this way, GA can not only jump out of the "trap" of local optimal results easily but also increase the rate of convergence. And the new method can also avoid the complexity and time-consumed limitation of conventional way. The simulation results show that the combination algorithm can obtain higher correct association percent and the effect of association is obviously superior to chaos optimization or genetic algorithm separately. This method has better convergence property as well as time property than the conventional ones. 展开更多
关键词 data association chaos optimization genetic algorithm maneuvering multiple targets tracking
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A stress-rifting origin of Grand Canyon
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作者 Chunan Tang Chunyan Bao +1 位作者 Sanzhong Li Kaiwen Xia 《Science Bulletin》 SCIE EI CAS CSCD 2016年第6期495-504,共10页
The Grand Canyon is a massive rift in the Colorado Plateau. How and when it developed has been debated for nearly 150 years. Most geologists believe the unusual landscape was primarily shaped by water erosion.Here we ... The Grand Canyon is a massive rift in the Colorado Plateau. How and when it developed has been debated for nearly 150 years. Most geologists believe the unusual landscape was primarily shaped by water erosion.Here we propose a stress-rifting model to provide an alternative explanation for the origin of Grand Canyon.This paper adopts a brittle–ductile double layer model to simulate the deformation and rifting of the plateau due to the mantle-melting-induced expansion. Our results show that the uplift induced by thermal expansion and its associated horizontal extension can cause open fractures that extend from the brittle surface to the underlying ductile layer in a top-down way. In addition, we find that episodic uplift can deepen and connect multiple fractures together to form a larger fracture network. Our findings suggest that the formation of the Grand Canyon might have been driven by plateau uplift and its associated rifting under crustal extension, wherein water erosion played only a minor role in shaping the course of the Colorado River. The new paradigm provides simpler explanations to some of the long-standing geological mysteries surrounding the canyon. 展开更多
关键词 UPLIFT RIFT Water erosion Thermal expansion CANYON
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Autotriploid origin of Carassius auratus as revealed by chromosomal locus analysis 被引量:2
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作者 Qinbo Qin Juan Wang +2 位作者 Min Hu Shengnan Huang Shaojun Liu 《Science China(Life Sciences)》 SCIE CAS CSCD 2016年第6期622-626,共5页
In the Dongting water system, the Carassius auratus(Crucian carp) complex is characterized by the coexistence of diploid forms(2n=100, 2n CC) and polyploid forms. Chromosomal and karyotypic analyses have suggested tha... In the Dongting water system, the Carassius auratus(Crucian carp) complex is characterized by the coexistence of diploid forms(2n=100, 2n CC) and polyploid forms. Chromosomal and karyotypic analyses have suggested that the polyploid C. auratus has a triploid(3n=150, 3n CC) and a tetraploid origin(4n=200), respectively. However, there is a lack of direct genetic evidence to support this conclusion. In this paper, analysis of the 5S r DNA chromosomal locus revealed that the 3n CC is of triploid origin. Analysis of the species-specific chromosomal centromere locus revealed that 3n CC individuals possess three sets of C. auratus-derived chromosomes. Our results provide direct cytogenetic evidence suggesting that individuals with 150 chromosomes are of autotriploid origin within the C. auratus complex. It marks an important contribution to the study of polyploidization and the evolution of vertebrates. 展开更多
关键词 autotriploids chromosomal loci polyploidization evolution
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Neutrinos,supernovae,and the origin of the heavy elements
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作者 YongZhong Qian 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS CSCD 2018年第4期1-6,共6页
Stars of~8-100 M_⊙end their lives as core-collapse supernovae(SNe). In the process they emit a powerful burst of neutrinos,produce a variety of elements, and leave behind either a neutron star or a black hole. The w... Stars of~8-100 M_⊙end their lives as core-collapse supernovae(SNe). In the process they emit a powerful burst of neutrinos,produce a variety of elements, and leave behind either a neutron star or a black hole. The wide mass range for SN progenitors results in diverse neutrino signals, explosion energies, and nucleosynthesis products. A major mechanism to produce nuclei heavier than iron is rapid neutron capture, or the r process. This process may be connected to SNe in several ways. A brief review is presented on current understanding of neutrino emission, explosion, and nucleosynthesis of SNe. 展开更多
关键词 neutrino supernova nucleosynthesis the r process
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