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合并p53突变的多重分子分型子宫内膜癌的临床特点与研究进展
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作者 侯胜迪 于欢 +1 位作者 冯定庆 凌斌 《现代妇产科进展》 2024年第12期944-947,共4页
子宫内膜癌是最常见的妇科恶性肿瘤之一。随着分子分型的推广,出现了多重分子分型的病例,其中大部分合并p53突变,多数研究对其具体的病理特征及分子特征没有明确说明,此类患者的预后尚不明确,其诊治亦无规范。这部分群体的归属与治疗问... 子宫内膜癌是最常见的妇科恶性肿瘤之一。随着分子分型的推广,出现了多重分子分型的病例,其中大部分合并p53突变,多数研究对其具体的病理特征及分子特征没有明确说明,此类患者的预后尚不明确,其诊治亦无规范。这部分群体的归属与治疗问题需得到进一步关注。本文综述了合并p53abn的多重分子分型的发生机制,并汇总既往文献中出现的合并p53abn的多重分子分型内膜癌的临床特征及病理组织学差异,并初步探讨了合并p53abn的临床意义及其对内膜癌治疗可能的影响。 展开更多
关键词 子宫内膜癌 分子分型 P53 多重分子分型
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基于多重分形谱的交流输电线路故障识别方法 被引量:12
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作者 李小鹏 丁宣文 +5 位作者 束洪春 安娜 董俊 田鑫萃 张雪飞 代月 《电力系统保护与控制》 CSCD 北大核心 2021年第14期1-10,共10页
通过对高压交流输电系统的区内、区外故障的仿真计算和分析发现:交流输电线路阻波器和母线对地电容形成的实体物理边界对高频信号具有衰减作用,使得区外故障时量测端的故障电压高频分量含量低,在不同时间段内质量分布概率相对均匀。而... 通过对高压交流输电系统的区内、区外故障的仿真计算和分析发现:交流输电线路阻波器和母线对地电容形成的实体物理边界对高频信号具有衰减作用,使得区外故障时量测端的故障电压高频分量含量低,在不同时间段内质量分布概率相对均匀。而区内故障时,量测端的故障电压高频分量含量高,在不同时间段内质量分布概率不均匀。因此利用短时窗内线路单侧故障相电压计算每次分割形成的多重分形集上各个子集质量概率分布的不均匀程度Δα来识别区内外故障。该方法仅利用单端电压就可以实现区内、外故障的判别,不受通道的影响,可靠性高,具有较大的工程意义。通过大量的PSCAD仿真实验分析得出,此方法可靠性高,耐受过渡电阻能力强,对不同故障类型和远端高阻均有较好的判别能力。 展开更多
关键词 交流输电系统 多重分型 质量分布概率 故障判别 远端高阻
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Empowerment Mechanisms and Empirical Evidence of Payment Technology in Capacity Expansion and Quality Improvement of Residents’Consumption
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作者 LI Yilin GAO Changchun GAO Han 《Journal of Donghua University(English Edition)》 CAS 2024年第6期662-676,共15页
The time-varying difference-in-difference model is used to identify the impact of payment technology on residents’consumption,and the moderation effect analysis method is used to identify its mechanism.It is found th... The time-varying difference-in-difference model is used to identify the impact of payment technology on residents’consumption,and the moderation effect analysis method is used to identify its mechanism.It is found that payment technology promotes consumption capacity expansion and quality improvement(CEQI)through three pathways of alleviating liquidity constraints,reducing transaction costs and weakening the payment of pain.The parallel and serial mechanisms of the three are further explored.The effect of payment technology on the CEQI of residents’consumption shows obvious heterogeneity due to differences in urban and rural household registration and financial literacy.Based on the empirical research results and the national conditions of China,targeted policy recommendations are proposed from the demand side,the supply side and the technological side. 展开更多
关键词 payment technology capacity expansion and quality improvement residents’consumption new quality productive force time-varying difference-in-difference moderating effect
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解线性方程组的一种并行迭代法及其收敛性
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作者 张志华 赵仕波 《成都理工学院学报》 CSCD 1998年第1期37-42,共6页
在D.P.O’Leary等(1985)和胡家赣(1992)提出的两种解线性方程组并行迭代法的基础上,构造了一种双参数多重分裂并行迭代法。同时给出该方法收敛的几个条件。
关键词 并行迭代 多重分型 H矩阵 收敛 线性方程组
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耐碳青霉烯鲍曼不动杆菌的耐药机制及分子流行病学 被引量:17
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作者 肖秀美 高爽 +2 位作者 段京京 姚贝 张捷 《中国抗生素杂志》 CAS CSCD 北大核心 2017年第8期704-710,共7页
目的碳青霉烯耐药鲍曼不动杆菌(CRAB)逐年升高的分离率和全球播散已成为极为严重的问题,本研究目的是阐明我院CRAB的耐药机制和分子流行病学特征。方法使用gyrB多重PCR方法将我院2014年7月—2015年6月分离的327株非重复醋酸钙-鲍曼不动... 目的碳青霉烯耐药鲍曼不动杆菌(CRAB)逐年升高的分离率和全球播散已成为极为严重的问题,本研究目的是阐明我院CRAB的耐药机制和分子流行病学特征。方法使用gyrB多重PCR方法将我院2014年7月—2015年6月分离的327株非重复醋酸钙-鲍曼不动杆菌复合体(ABC)鉴定到种,VITEK-2仪器法和E-test法测定抗菌药物的最低抑菌浓度(minimal inhibitory concentration MIC),PCR方法检测常见的碳青霉烯酶耐药基因、ISAba1并测序,Turton 2组多重PCR方法进行分子分型。结果327株ABC中有315株鲍曼不动杆菌(ABA)、9株皮特不动杆菌和3株医院不动杆菌,ABA、皮特和医院不动杆菌对亚胺培南的耐药率分别为91.7%、0和66.7%,耐药株主要分离自急诊科和呼吸ICU。ABA bla_(OXA-23-like)和ISAba1检出率均为91.1%,测序均为bla_(OXA-23),bla_(OXA-51-like)和ISAba1检出率分别为100%和0.3%,测序主要为bla_(OXA-66)和bla_(OXA-69),未检测到其他OXAs型、NDM、IMP、GIM、KPC、SIM、VIM和GES酶基因。Turton分子分型76.8%属于国际克隆Ⅱ型(IC Ⅱ)。结论携带bla_(OXA-23)和ISAba1的IC Ⅱ克隆是我院主要的流行克隆株,克隆播散是CRAB感染增加和暴发的重要原因。 展开更多
关键词 鲍曼不动杆菌 碳青霉烯耐药 OXAs碳青霉烯酶 插入序列 多重PCR序列分型
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eNOS基因27bpVNTR多态性与新疆哈萨克族原发性高血压的相关性研究 被引量:9
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作者 王刚 唐斌 +8 位作者 何芳 刘永平 王彩娟 孙雯剑 张帆 苏燕 李扬 席冬梅 邓峰美 《石河子大学学报(自然科学版)》 CAS 2010年第3期335-339,共5页
探讨内皮型一氧化氮合酶(eNOS)基因27bpVNTR多态性与新疆哈萨克族原发性高血压(EH)的相关性。采用流行病学的病例-对照研究方法,运用多重单碱基延伸分型技术(Multiplex sNaPshot)技术对新疆哈萨克族363名高血压患者(病例组)和370名健康... 探讨内皮型一氧化氮合酶(eNOS)基因27bpVNTR多态性与新疆哈萨克族原发性高血压(EH)的相关性。采用流行病学的病例-对照研究方法,运用多重单碱基延伸分型技术(Multiplex sNaPshot)技术对新疆哈萨克族363名高血压患者(病例组)和370名健康人(对照组)进行eNOS基因27bpVNTR多态性分析,比较基因型、等位基因在病例和对照组中的分布频率与原发性高血压的相关性分析。27bpVNTR基因型bb、aa、ab、bc在对照组和病例组中分布频率分别为78.6%、1.1%、20%、0.3%和78.5%、1.9%、19%、0.6%;等位基因a、b、c分布频率分别为11.1%、88.8%、0.1%和11.4%、88.3%、0.3%;两组eNOS的基因型频率及等位基因差异无统计学意义(P>0.05)。各指标如年龄、收缩压、舒张压、平均动脉压、脉压、体重指数、腰臀比、空腹血糖、胆固醇、甘油三酯、低密度脂蛋白、肌酐、尿酸、载脂蛋白A1/B的平均水平,两组间比较差异有统计学意义(P<0.05);高密度脂蛋白、载脂蛋白-A1、载脂蛋白-B两组间均差异无统计学意义(P>0.05)。eNOS基因27bpVNTR多态性可能与新疆哈萨克族人群EH不相关。 展开更多
关键词 内皮型一氧化氮合酶 多态性 原发性高血压 多重单碱基延伸分型技术
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广西百色地区壮族妇女脂联素基因单核苷酸多态性与骨密度的关系 被引量:7
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作者 王金花 黄秀峰 +5 位作者 周庆辉 林朝文 杨园园 韦叶生 黄昌盛 吴联滔 《解剖学报》 CAS CSCD 北大核心 2012年第1期109-113,共5页
目的探讨脂联素(APN)基因5个单核苷酸多态性(SNPs)与广西百色地区壮族妇女骨矿物质密度(BMD)的关系。方法选取壮族女性239例跟骨骨量减少患者(LBM)和83例正常骨量组(NBM)进行病例对照研究,采用多重单碱基延伸SNP分型技术对壮族女性脂联... 目的探讨脂联素(APN)基因5个单核苷酸多态性(SNPs)与广西百色地区壮族妇女骨矿物质密度(BMD)的关系。方法选取壮族女性239例跟骨骨量减少患者(LBM)和83例正常骨量组(NBM)进行病例对照研究,采用多重单碱基延伸SNP分型技术对壮族女性脂联素基因的5个位点(rs1063539、rs12495941、rs266729、rs3774261及rs710445)进行了基因分型,采用法国生产的Osteospace干式超声骨密度仪测量右侧跟骨超声振幅衰减(BUA)。结果仅rs1063539、rs12495941、rs266729及rs710445多态性分布符合Hardy-Weinberg遗传平衡定律(P>0.05)。除rs3774261在骨量正常组的分布不符合Hardy-Weinberg平衡(P<0.05)之外,其余位点在正常组和骨量减少组基因型分布均符合Hardy-Weinberg平衡(P>0.05)。其中,只有rs1063539基因型在NOR和LBM组差异存在显著性(P=0.003),CG基因型者在LBM组人数明显多于GG型(P<0.01)。调整年龄、体重、身高及体质指数后,以5个多态性位点作为自变量的多元Logistic回归显示,仅rs1063539多态性与跟骨BUA相关性有统计学意义(adjusted OR=3.210,95%CI:1.631~6.137,P=0.001),并独立于骨量减少的传统危险因素。结论APN基因第3外显子rs1063539多态性与壮族女性BMD有一定关联,其中GG型对BMD具有一定的保护作用,CG型是BMD降低的危险因素。rs12495941、rs266729、rs3774261及rs710445多态性与壮族女性BMD无相关性。 展开更多
关键词 单核苷酸多态性 骨质疏松症 遗传多态性 骨矿物质密度 多重单碱基延伸SNP分型技术 壮族 女性
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广西壮族女性碱性成纤维生长因子基因单核苷酸多态性与骨质疏松 被引量:2
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作者 林朝文 王金花 +3 位作者 周庆辉 黄秀峰 杨园园 陈秉朴 《中国组织工程研究》 CAS CSCD 2012年第50期9443-9447,共5页
背景:有研究表明碱性成纤维生长因子在骨修复中发挥重要作用,但其基因多态性与骨质疏松和骨代谢的关系至今少有报道。目的:观察碱性成纤维生长因子基因5个单核苷酸多态性与广西百色地区壮族女性骨密度的关系。方法:选取239例跟骨骨量减... 背景:有研究表明碱性成纤维生长因子在骨修复中发挥重要作用,但其基因多态性与骨质疏松和骨代谢的关系至今少有报道。目的:观察碱性成纤维生长因子基因5个单核苷酸多态性与广西百色地区壮族女性骨密度的关系。方法:选取239例跟骨骨量减少患者和83例骨量正常者进行病例-对照研究。采用单碱基延伸的单核苷酸多态性分型技术对广西百色地区322例壮族女性的脂联素基因的5个位点(rs12644427,rs3789138,rs308379,rs308442和rs3747676)进行了基因分型,采用Osteospace干式超声骨密度仪测量右侧跟骨超声振幅衰减。结果与结论:rs12644427,rs3789138,rs308379,rs308442和rs3747676多态性分布均符合Hardy-Weinberg遗传平衡定律(P>0.05)。以5个多态性位点作为自变量的多元Logistic回归显示仅rs308379多态性与跟骨骨量减少显著相关(OR=2.123,95%CI:1.004-4.491,P=0.049)。结果说明碱性成纤维生长因子基因第1内含子rs308379多态性与壮族女性骨密度可能有一定关联,其中AA型可能对骨密度具有一定的保护作用,TT型是骨密度降低的危险因素。rs308442,rs12644427,rs3789138及rs3747676多态性与壮族女性骨密度无相关性。 展开更多
关键词 单核苷酸多态性 碱性成纤维生长因子 骨质疏松症 遗传多态性 骨密度 多重单碱基延伸SNP分型技术
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广西人群miRNA-107基因多态性分布特征及其与血脂的关系 被引量:6
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作者 黄艳云 黄华佗 +3 位作者 陆玉兰 雷茗 谭昙 韦叶生 《解剖学报》 CAS CSCD 北大核心 2020年第2期284-288,共5页
目的探讨miR-107基因单核苷酸多态性(SNP)位点rs2296616 C/T在广西地区健康人群中的分布特点,对比其在不同种族间基因型及等位基因频率分布的差异,并进一步探讨rs2296616 C/T位点单核苷酸多态性(SNP)与血脂水平的相关性。方法采用多重... 目的探讨miR-107基因单核苷酸多态性(SNP)位点rs2296616 C/T在广西地区健康人群中的分布特点,对比其在不同种族间基因型及等位基因频率分布的差异,并进一步探讨rs2296616 C/T位点单核苷酸多态性(SNP)与血脂水平的相关性。方法采用多重单碱基延伸SNP分型技术(multiplex SNa Pshot)和DNA测序法,检测372例广西健康人rs2296616 C/T位点的多态性,用7600生化仪检测其血脂相关指标,并用统计学方法分别比较rs2296616C/T位点多态性在各种族人群间的分布差异及不同基因型间的血脂水平差异。结果广西人群miR-107基因rs2296616 C/T位点存在TT(91.1%)和CT(8.9%)两种基因型及T(95.6%)和C(4.4%)两种等位基因。该位点的基因型和等位基因型频率在广西人群不同性别间的比较,差异无统计学意义(P>0.05)。其基因型和等位基因频率与人类基因组单体型图(Hap Map)所公布的欧洲人、日本人、非洲人、印第安人和墨西哥人分型数据相比较,差异均有统计学意义(P<0.05),但与北京汉族人群比较,差异无统计学意义(P>0.05)。rs2296616 C/T位点两种基因型人群血脂之间比较,携带TT基因型人群的高密度脂蛋白胆固醇(HDL-C)与CT组比较,差异具有统计学意义(P<0.05)。结论广西人群miR-107基因rs2296616 C/T位点多态性与其他种族人群之间比较存在不同程度的差异;rs2296616 C/T位点多态性与HDL-C水平高低有关。 展开更多
关键词 miR-107基因 单核苷酸多态性 rs2296616 C/T位点 种族 血脂 多重单碱基延伸SNP分型技术 DNA测序法 广西人群
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Multiple Positive Solutions for Some Neutral Integral Equatious Modeling Infectious Disease 被引量:1
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作者 ZHAOHua-xiang SUNXing-wang 《Chinese Quarterly Journal of Mathematics》 CSCD 2003年第1期21-28,共8页
By using fixed point index theory of cone mapping and extension method, this paper discusses the existence of multiple positive solution of nonlinear neutral integral equatious modeling infectious disease.
关键词 neutral integral equation strict set contraction CONE
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Multi-analysis with mathematic model of 3125 non-thyrogenous masses of the neck
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作者 Yong Li Ming Gao Yun Niu Liying Zhang Yang Yu Yigong Li Xiaolong Li 《The Chinese-German Journal of Clinical Oncology》 CAS 2008年第6期319-325,共7页
Objective: To systematically analyze and summarize non-thyrogenous masses of the neck (NTMN) by consideration of new areas, a large sample size and multiple-aspect analysis. Methods: Our research involved 3125 NTM... Objective: To systematically analyze and summarize non-thyrogenous masses of the neck (NTMN) by consideration of new areas, a large sample size and multiple-aspect analysis. Methods: Our research involved 3125 NTMN cases. We summarized the proportion of various NTMN and the distribution of the neck diseases based on the new international classification. The clinical traits such as sexual proportion and age, etc, were analyzed along with the unknown primary cervical metastatic carcinomas (UPCMC), and built up a mathematical model based on the data above. Results: There were 68 different diseases identified. Among all the NTMN, the percentage of metastatic carcinomas was 63.3%. The neck masses with a focus above the clavicle comprised 62.3% of the metastatic carcinomas whose focuses were clear. Moreover, other results almost supported the "rule of 80%". There was an obvious distribution of traits at every sub level. For example, there were 23 different diseases in level Ⅲ, of which the most common was lymphoma. UPCMC made up 12.3% of all metastatic carcinomas. The clinic cases could be analyzed by our model even to form a primary diagnosis which showed a high coincident rate with clinic diagnosis. Conclusion: NTMN are complex and various, with a definite distribution in each neck level. Data relating component character, sex ratio and UPCMC et al to the clinical traits of NTMN will provide vigorous support for clinical applications. The mathematical model could be an efficient method to synthetically analyze complicate data of NTMN. 展开更多
关键词 NECK non-thyrogenous mass international classification mathematical model
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Joint inversion of gravity and multiple components of tensor gravity data 被引量:3
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作者 鲁光银 曹书锦 朱自强 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第7期1767-1777,共11页
Geological structures often exhibit smooth characteristics away from sharp discontinuities. One aim of geophysical inversion is to recover information about the smooth structures as well as about the sharp discontinui... Geological structures often exhibit smooth characteristics away from sharp discontinuities. One aim of geophysical inversion is to recover information about the smooth structures as well as about the sharp discontinuities. Because no specific operator can provide a perfect sparse representation of complicated geological models, hyper-parameter regularization inversion based on the iterative split Bregman method was used to recover the features of both smooth and sharp geological structures. A novel preconditioned matrix was proposed, which counteracted the natural decay of the sensitivity matrix and its inverse matrix was calculated easily. Application of the algorithm to synthetic data produces density models that are good representations of the designed models. The results show that the algorithm proposed is feasible and effective. 展开更多
关键词 hyper-parameter regularization full gravity gradient tensor preconditioned matrix Occam's inversion focusinginversion
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Matched Field Localization Based on CS-MUSIC Algorithm 被引量:2
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作者 GUO Shuangle TANG Ruichun +1 位作者 PENG Linhui JI Xiaopeng 《Journal of Ocean University of China》 SCIE CAS 2016年第2期254-260,共7页
The problem caused by shortness or excessiveness of snapshots and by coherent sources in underwater acoustic positioning is considered.A matched field localization algorithm based on CS-MUSIC(Compressive Sensing Multi... The problem caused by shortness or excessiveness of snapshots and by coherent sources in underwater acoustic positioning is considered.A matched field localization algorithm based on CS-MUSIC(Compressive Sensing Multiple Signal Classification) is proposed based on the sparse mathematical model of the underwater positioning.The signal matrix is calculated through the SVD(Singular Value Decomposition) of the observation matrix.The observation matrix in the sparse mathematical model is replaced by the signal matrix,and a new concise sparse mathematical model is obtained,which means not only the scale of the localization problem but also the noise level is reduced;then the new sparse mathematical model is solved by the CS-MUSIC algorithm which is a combination of CS(Compressive Sensing) method and MUSIC(Multiple Signal Classification) method.The algorithm proposed in this paper can overcome effectively the difficulties caused by correlated sources and shortness of snapshots,and it can also reduce the time complexity and noise level of the localization problem by using the SVD of the observation matrix when the number of snapshots is large,which will be proved in this paper. 展开更多
关键词 matched field processing compressed sensing CS MUSIC
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Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease 被引量:6
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作者 Hyun Jung Lee Youn Nam Kim +8 位作者 Hui Won Jang Han Ho Jeon Eun Suk Jung Soo Jung Park Sung Pil Hong Tae Il Kim Won Ho Kim Chung Mo Nam Jae Hee Cheon 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第40期5771-5778,共8页
AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD)... AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METHODS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April 2011.We also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with DAIBD.An endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was evaluated.To determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were analyzed.RESULTS:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the DAIBD.An endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ulcers.However,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD variance.Patients with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the model.CONCLUSION:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD scores.However,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak. 展开更多
关键词 Intestinal Behcet's disease Disease activityindex COLONOSCOPY ULCER Endoscopic severity
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多重分形理论的动物CT影像处理算法研究——以宠物犬为例 被引量:1
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作者 许杰 《黑龙江畜牧兽医(下半月)》 北大核心 2017年第5期86-88,共3页
为了提高动物CT影像的识别能力,获得清晰、直观的CT影像信息,提高诊断正确率和治疗效率,采用多重分形理论对动物CT影像进行分析和处理,将分形维和分形测度以及多重分形谱引入到动物影像处理过程,根据CT成像过程的边缘模糊性以及在动物... 为了提高动物CT影像的识别能力,获得清晰、直观的CT影像信息,提高诊断正确率和治疗效率,采用多重分形理论对动物CT影像进行分析和处理,将分形维和分形测度以及多重分形谱引入到动物影像处理过程,根据CT成像过程的边缘模糊性以及在动物骨骼的成像交界处分形的规律性将会被破坏的基本特征,求取奇异性指数和多重分形谱,从而判断出CT影像的边界。结果表明:结合多重分形理论算法对CT影像进行处理,能够准确地获得影像的边缘特征,效果优异。说明基于多重分形理论的CT影像处理算法是可行的,方案是可信的,有利于动物疾病的正确诊断和有效治疗。 展开更多
关键词 多重分形理论 CT影像 分型 分形测度 多重分型 边缘特征
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汉族人载脂蛋白E基因多态性与脑梗死部位及梗死灶体积的相关性研究 被引量:5
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作者 敬淮淞 周杰 +3 位作者 张苓 刘洛同 明扬 陈礼刚 《中华神经医学杂志》 CAS CSCD 北大核心 2014年第12期1248-1251,共4页
目的探讨载脂蛋白E(ApoE)基因多态性与脑梗死发生部位及梗死灶体积的相关性。方法采用病例-对照研究设计,对自2011年9月至2012年11月泸州医学院附属医院神经内、外科收治的162例脑梗死患者(脑梗死组)和同期体检的120例健康人(对... 目的探讨载脂蛋白E(ApoE)基因多态性与脑梗死发生部位及梗死灶体积的相关性。方法采用病例-对照研究设计,对自2011年9月至2012年11月泸州医学院附属医院神经内、外科收治的162例脑梗死患者(脑梗死组)和同期体检的120例健康人(对照组)的血样采用多重聚合酶连接反应-连接酶检测反应分型法(PCR-LDR)测定ApoE基因的多态性,分析不同脑梗死部位ApoE基因型分布及各等位基因频率的差异,以及各基因型与梗死灶体积的关系。结果脑梗死组和对照组之间ApoE基因型分布和等位基因频率比较差异均无统计学意义(P〉02.05)。各脑梗死部位间ApoE基因型分布和等位基因频率比较差异均无统计学意义(P〉0.05)。脑梗死组中E4/)(基因型(E4/3基因型和E4/4基因型合并)的平均梗死灶体积[(15.7±2.3)cm^3]与E3/3基因型[(10.2±2.1)cm^3]及E2/)(基因型(E2/2基因型和E2/3基因型合并)[(9.5±1.8)cm^3]比较差异具有统计学意义(P〈0.05),且E4/X基因型中大面积脑梗死比例(56%)较E3/3基因型(28.1%)及E2/X基因型(26.3%)更高,差异具有统计学意义(P〈0.05)。结论ApoE基因多态性与脑梗死发生部位无相关性,而与梗死灶体积相关,其中携E4等位基因者较易发生大面积脑梗死。 展开更多
关键词 载脂蛋白E 脑梗死 基因多态性 多重聚合酶连接反应-连接酶检测反应分型
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Multifractal methods for rapeseed nitrogen nutrition qualitative diagnosis modeling
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作者 Jian-Hui Li Fang Wang +2 位作者 Jin-Wei Li Rui-Biao Zou Gui-Ping Liao 《International Journal of Biomathematics》 2016年第4期285-297,共13页
Nutrition diagnosis plays a key role in the crop's growth, which has mainly been car- ried out in the field by agricultural workers. Currently, automatic nutrition recognition technologies have been widely used in th... Nutrition diagnosis plays a key role in the crop's growth, which has mainly been car- ried out in the field by agricultural workers. Currently, automatic nutrition recognition technologies have been widely used in this field. A procedure is proposed in this paper to diagnose nitrogen nutrition non-destructively for rapeseed qualitatively based on the multifractal theory. Twelve texture parameters are given by the method of multifractal detrended fluctuation (MF-DFA), which contains six generalized Hurst exponents and six relative multifractal parameters that are used as features of the rapeseed leaf images for identifying the two nitrogen levels, namely, the N-mezzo and the N-wane. For the base leaves, central leaves and top leaves of the rapeseed plant and the three-section mixed samples, three parameters combinations are selected to conduct the work. Five classifiers of Fisher's linear discriminant algorithm (LDA), extreme learning machine (ELM), support vector machine and kernel method (SVMKM), random decision forests (RF) and K-nearest neighbor algorithm (KNN) are employed to calculate the diagno- sis accuracy. An interesting finding is that the best diagnose accuracy is from the base leaves of the rapeseed plant. It is explained that the base leaf is the most sensitive to the nitrogen deficiency. The diagnose effect by the base leaves samples is outshining the existing result significantly for the same leaves samples. For the mixed samples, the aver- aged discriminant accuracy reaches 97.12% and 97.56% by SVMKM and RF methods with the 10-fold cross-validation respectively. The resulting high accuracy on N-levels identification shows the feasibility and efficiency of our method. 展开更多
关键词 Rapeseed leaf image nitrogen diagnosis multifractal detrended fluctuationanalysis classifiers.
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