Reconfigurability of the electrical network in a shipboard power system （SPS） after its failure is central to the restoration of power supply and improves survivability of an SPS. The navigational process creates a ...Reconfigurability of the electrical network in a shipboard power system （SPS） after its failure is central to the restoration of power supply and improves survivability of an SPS. The navigational process creates a sequence of different operating conditions. The priority of some loads differs in changing operating conditions. After analyzing characteristics of typical SPS, a model was developed used a grade III switchboard and an environmental prioritizing agent （EPA） algorithm. This algorithm was chosen as it is logically and physically decentralized as well as multi-agent oriented. The EPA algorithm was used to decide on the dynamic load priority, then it selected the means to best meet the maximum power supply load. The simulation results showed that higher priority loads were the first to be restored. The system satisfied all necessary constraints, demonstrating the effectiveness and validity of the proposed method.展开更多
Patients with locally advanced esophageal cancer have a dismal prognosis when treated exclu- sively by surgery. This fact prompted many investigators to apply neoadjuvant treatment strategies in an e?ort to improve su...Patients with locally advanced esophageal cancer have a dismal prognosis when treated exclu- sively by surgery. This fact prompted many investigators to apply neoadjuvant treatment strategies in an e?ort to improve survival. Results from phase III randomized trials are encouraging however, they revealed 五笔字型计算机汉字输入技术 that only patients with major histopathological response will bene?t from treatment. Therefore, predic- tive molecular markers indicating response or non-response to neoadjuvant treatment would be extremely helpful in selecting patients for current and future treatment protocols. In this paper we review the role of the molecular markers ERCC1 (excision repair cross-complementing 1 gene) and c-erbB-2 (synonym: HER2/neu) in predicting response to radiochemotherapy and outcome for patients with locally advanced resectable esophageal cancers (cT2-4, Nx, M0). The results are promising and it appears that we might expect to unequivocally identify with ERCC1 and c-erbB-2 respectively, approximately up to one third of patients who ful?l the criteria for neoadjuvant treatment for locally advanced esophageal cancer but will not bene?t from our treatment protocol. Integration of such markers in the clinical setting might prevent a substantial number of patients from expensive, non-e?ective and potentially harmful therapies, and could lead to a more individualized type of combined multimodality treatment in the near future.展开更多
基金Supported by the National Natural Science Foundation of China under Grant No.60704004the Fundamental Research Funds for the Central University under Grant No.HEUCFT1005
文摘Reconfigurability of the electrical network in a shipboard power system （SPS） after its failure is central to the restoration of power supply and improves survivability of an SPS. The navigational process creates a sequence of different operating conditions. The priority of some loads differs in changing operating conditions. After analyzing characteristics of typical SPS, a model was developed used a grade III switchboard and an environmental prioritizing agent （EPA） algorithm. This algorithm was chosen as it is logically and physically decentralized as well as multi-agent oriented. The EPA algorithm was used to decide on the dynamic load priority, then it selected the means to best meet the maximum power supply load. The simulation results showed that higher priority loads were the first to be restored. The system satisfied all necessary constraints, demonstrating the effectiveness and validity of the proposed method.
文摘Patients with locally advanced esophageal cancer have a dismal prognosis when treated exclu- sively by surgery. This fact prompted many investigators to apply neoadjuvant treatment strategies in an e?ort to improve survival. Results from phase III randomized trials are encouraging however, they revealed 五笔字型计算机汉字输入技术 that only patients with major histopathological response will bene?t from treatment. Therefore, predic- tive molecular markers indicating response or non-response to neoadjuvant treatment would be extremely helpful in selecting patients for current and future treatment protocols. In this paper we review the role of the molecular markers ERCC1 (excision repair cross-complementing 1 gene) and c-erbB-2 (synonym: HER2/neu) in predicting response to radiochemotherapy and outcome for patients with locally advanced resectable esophageal cancers (cT2-4, Nx, M0). The results are promising and it appears that we might expect to unequivocally identify with ERCC1 and c-erbB-2 respectively, approximately up to one third of patients who ful?l the criteria for neoadjuvant treatment for locally advanced esophageal cancer but will not bene?t from our treatment protocol. Integration of such markers in the clinical setting might prevent a substantial number of patients from expensive, non-e?ective and potentially harmful therapies, and could lead to a more individualized type of combined multimodality treatment in the near future.
