The single fault and multiple fault detections for multiple-valued logic circuits are studied in this paper. Firstly, it is shown that the cardinality of optimal single fault test set for fanout-free m-valued circuits...The single fault and multiple fault detections for multiple-valued logic circuits are studied in this paper. Firstly, it is shown that the cardinality of optimal single fault test set for fanout-free m-valued circuits with n primary inputs is not more than n + 1, for linear tree circuits is two, and for multiplication modulo circuits is two if n is an odd number or if n is an even number and m ＞ 3, where the optimal test set of a circuit has minimal number of test vectors. Secondly,it is indicated that the cardinality of optimal multiple fault test set for linear tree circuits with n primary inputs is 1 + [n/(m - 1)], for multiplication modulo circuits is n+ 1, for fanout-free circuits that consist of 2-input linear tree circuits and 2-input multiplication modulo circuits is not greater than n+ 1, where [x] denotes the smallest integer greater than or equal to x. Finally,the single fault location approaches of linear tree circuits and multiplication modulo circuits are presented, and all faults in the two types of circuits can be located by using a test set with n + 1 vectors.展开更多
A scheme is proposed for generating maximally entangled states for two or more three-level atoms. In the scheme the atoms are sent through a two-mode cavity one by one and interact with the two-cavity modes sequential...A scheme is proposed for generating maximally entangled states for two or more three-level atoms. In the scheme the atoms are sent through a two-mode cavity one by one and interact with the two-cavity modes sequentially. The required experimental techniques are within the scope of what can be obtained in the microwave cavity QED setup.展开更多
A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and wa...A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases(PI3 K) signaling pathway were detected via next-generation sequencing(NGS)-based liquid biopsy, including a p. G1007 R missense mutation in exon 21 of PIK3 CA(33.61%), a p.L70 fs frameshift mutation in exon 3 of phosphatase and tension homolog deleted on chromosome ten(PTEN)(49.14%), and a p. D1542 Y missense mutation in exon 32 of mammalian target of rapamycin(m TOR)(1.66%). Therefore, only the m TOR inhibitor everolimus was administered to the patient. Partial remission(PR) was observed after 2 months, and sustained stable disease(SD) was observed after a year and a half. Subsequent sequencing showed that the mutation ratio of PIK3 CA decreased to 4.17%, and that the PTEN and m TOR mutations disappeared, which revealed the significant curative effect of everolimus. We report the first case of successful monotherapy treatment using everolimus in a patient with advanced breast cancer bearing mutations in genes involved in the PI3 K/ARK/m TOR signaling pathway. The success of this case highlights the invaluable clinical contribution of NGS-based liquid biopsy, as it successfully provided an optimal therapeutic target for the patient with advanced breast cancer.展开更多
Multiple fractured horizontal well(MFHW) is widely applied in the development of shale gas. To investigate the gas flow characteristics in shale, based on a new dual mechanism triple continuum model, an analytical sol...Multiple fractured horizontal well(MFHW) is widely applied in the development of shale gas. To investigate the gas flow characteristics in shale, based on a new dual mechanism triple continuum model, an analytical solution for MFHW surrounded by stimulated reservoir volume(SRV) was presented. Pressure and pressure derivative curves were used to identify the characteristics of flow regimes in shale. Blasingame type curves were established to evaluate the effects of sensitive parameters on rate decline curves, which indicates that the whole flow regimes could be divided into transient flow, feeding flow, and pseudo steady state flow. In feeding flow regime, the production of gas well is gradually fed by adsorbed gases in sub matrix, and free gases in matrix. The proportion of different gas sources to well production is determined by such parameters as storability ratios of triple continuum, transmissibility coefficients controlled by dual flow mechanism and fracture conductivity.展开更多
In order to understand the influence of brittleness and confining stress on rock cuttability,the indentation tests were carried out by a conical pick on the four types of rocks.Then,the experimental results were utili...In order to understand the influence of brittleness and confining stress on rock cuttability,the indentation tests were carried out by a conical pick on the four types of rocks.Then,the experimental results were utilized to take regression analysis.The eight sets of normalized regression models were established for reflecting the relationships of peak indentation force(PIF)and specific energy(SE)with brittleness index and uniaxial confining stress.The regression analyses present that these regression models have good prediction performance.The regressive results indicate that brittleness indices and uniaxial confining stress conditions have non-linear effects on the rock cuttability that is determined by PIF and SE.Finally,the multilayer perceptual neural network was used to measure the importance weights of brittleness index and uniaxial confining stress upon the influence for rock cuttability.The results indicate that the uniaxial confining stress is more significant than brittleness index for influencing the rock cuttability.展开更多
We investigate electronic properties of a hierarchical multilayer structure consisting of stacking of barriers and wells. The structure is formed in a sequence of generations, each of which is constructed with the sam...We investigate electronic properties of a hierarchical multilayer structure consisting of stacking of barriers and wells. The structure is formed in a sequence of generations, each of which is constructed with the same pattern but with the previous generation as the basic building blocks. We calculate the transmission spectrum which shows the multifractal behavior for systems with large generation index. From the analysis of the average resistivity and the multifractal structure of the wavefunctions, we show that there exist different types of states exhibiting extended, localized and intermediate characteristics. The degree of localization is sensitive to the variation of the structural parameters.Suggestion of the possible experimental realization is discussed.展开更多
Multistage superimposed deformation has been discussed systematically based on the progress of the stratigraphic sequences of the northeastern margin of Yangtze Block.The new-discovered first stage deformation of thos...Multistage superimposed deformation has been discussed systematically based on the progress of the stratigraphic sequences of the northeastern margin of Yangtze Block.The new-discovered first stage deformation of those sequences occurred from the middle Triassic to the end of early Jurassic together with development of regional folding, which was resulted from the deep detachment shearing tending toward NW-WNW. The folds dip to east and fall down toward west, and were superimposed by the main stage folding.Thereafter, a series of folds were developed with axes trending toward northeast.Consequently normal folds occurred on the normal limbs while overturned fold on the overturned limbs during the first stage folding. The detachment or thrust was formed from late Jurassic to early Cretaceous. Due to the uplifting of Dabie and the Wannan Mountains in the north and south sides, the bi-directional thrusting belt was formed by gravity flowing from the Mountains toward the center of the basin along the north side of Xuancheng and south side of Guichi. The deformation geodynamics was discussed simply based on the newly recognized information about the tectonic evolution.展开更多
The multifractality of energy and thermal dissipation of fully developed intermittent turbulence is investigated in the urban canopy layer under unstable conditions by the singularity spectrum for the fractal dimensio...The multifractality of energy and thermal dissipation of fully developed intermittent turbulence is investigated in the urban canopy layer under unstable conditions by the singularity spectrum for the fractal dimensions of sets of singularities characterizing multifractals. In order to obtain high-order moment properties of smallscale turbulent dissipation in the inertial range, an ultrasonic anemometer with a high sampling frequency of 100 Hz was used. The authors found that the turbulent signal could be singular everywhere. Moreover, the singular exponents of energy and thermal dissipation rates are most frequently encountered at around 0.2, which is significantly smaller than the singular exponents for a wind tunnel at a moderate Reynolds number. The evidence indicates a higher intermittency of turbulence in the urban canopy layer at a high Reynolds number, which is demonstrated by the data with high temporal resolution. Furthermore, the temperature field is more intermittent than the velocity field. In addition, a large amount of samples could be used for verification of the results.展开更多
A decoding method complemented by Maximum Likelihood (ML) detection for V-BLAST (Verti- cal Bell Labs Layered Space-Time) system is presented. The ranked layers are divided into several groups. ML decoding is performe...A decoding method complemented by Maximum Likelihood (ML) detection for V-BLAST (Verti- cal Bell Labs Layered Space-Time) system is presented. The ranked layers are divided into several groups. ML decoding is performed jointly for the layers within the same group while the Decision Feedback Equalization (DFE) is performed for groups. Based on the assumption of QPSK modulation and the quasi-static flat fading channel, simulations are made to testify the performance of the proposed algorithm. The results show that the algorithm outperforms the original V-BLAST detection dramatically in Symbol Error Probability (SEP) per- formance. Specifically, Signal-to-Noise Ratio (SNR) improvement of 3.4dB is obtained for SEP of 10?2 (4×4 case), with a reasonable complexity maintained.展开更多
This paper analyzes multiple structural changes by GMDH （Group Meth- ods of Data Handling）, which have obvious advantages. Our method extends the model of Lumsdaine ＆ Papell[1] （1997）, and it could be applied to ...This paper analyzes multiple structural changes by GMDH （Group Meth- ods of Data Handling）, which have obvious advantages. Our method extends the model of Lumsdaine ＆ Papell[1] （1997）, and it could be applied to the case of more than two structural changes. Because of simultaneously considering every structural change of the hypothesis, it is likely to be of particular relevance in practice. And it can decrease large investigation costs by MATLAB programming. What is more, we can select the criterion value of F incremental statistic to control the significance of the breaks, based on kinds of investigation intentions. And the empirical evidences on Shenzhen Composite Index are presented to illustrate the usefulness of our method.展开更多
基金Supported by the National Natural Science Foundation of China (No.60006002) Education Department of Guangdong Province of China (No. Z02019)
文摘The single fault and multiple fault detections for multiple-valued logic circuits are studied in this paper. Firstly, it is shown that the cardinality of optimal single fault test set for fanout-free m-valued circuits with n primary inputs is not more than n + 1, for linear tree circuits is two, and for multiplication modulo circuits is two if n is an odd number or if n is an even number and m ＞ 3, where the optimal test set of a circuit has minimal number of test vectors. Secondly,it is indicated that the cardinality of optimal multiple fault test set for linear tree circuits with n primary inputs is 1 + [n/(m - 1)], for multiplication modulo circuits is n+ 1, for fanout-free circuits that consist of 2-input linear tree circuits and 2-input multiplication modulo circuits is not greater than n+ 1, where [x] denotes the smallest integer greater than or equal to x. Finally,the single fault location approaches of linear tree circuits and multiplication modulo circuits are presented, and all faults in the two types of circuits can be located by using a test set with n + 1 vectors.
基金The project supported by Fok Ying Tung Education Foundation under Grant No. 81008, National Natural Science Foundation of China under Grant Nos, 60008003 and 10225421, and Funds from Puzhou University
文摘A scheme is proposed for generating maximally entangled states for two or more three-level atoms. In the scheme the atoms are sent through a two-mode cavity one by one and interact with the two-cavity modes sequentially. The required experimental techniques are within the scope of what can be obtained in the microwave cavity QED setup.
文摘A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases(PI3 K) signaling pathway were detected via next-generation sequencing(NGS)-based liquid biopsy, including a p. G1007 R missense mutation in exon 21 of PIK3 CA(33.61%), a p.L70 fs frameshift mutation in exon 3 of phosphatase and tension homolog deleted on chromosome ten(PTEN)(49.14%), and a p. D1542 Y missense mutation in exon 32 of mammalian target of rapamycin(m TOR)(1.66%). Therefore, only the m TOR inhibitor everolimus was administered to the patient. Partial remission(PR) was observed after 2 months, and sustained stable disease(SD) was observed after a year and a half. Subsequent sequencing showed that the mutation ratio of PIK3 CA decreased to 4.17%, and that the PTEN and m TOR mutations disappeared, which revealed the significant curative effect of everolimus. We report the first case of successful monotherapy treatment using everolimus in a patient with advanced breast cancer bearing mutations in genes involved in the PI3 K/ARK/m TOR signaling pathway. The success of this case highlights the invaluable clinical contribution of NGS-based liquid biopsy, as it successfully provided an optimal therapeutic target for the patient with advanced breast cancer.
基金Project(2011ZX05015)supported by Important National Science and Technology Specific Projects of the "Twelfth Five-years" Plan Period,China
文摘Multiple fractured horizontal well(MFHW) is widely applied in the development of shale gas. To investigate the gas flow characteristics in shale, based on a new dual mechanism triple continuum model, an analytical solution for MFHW surrounded by stimulated reservoir volume(SRV) was presented. Pressure and pressure derivative curves were used to identify the characteristics of flow regimes in shale. Blasingame type curves were established to evaluate the effects of sensitive parameters on rate decline curves, which indicates that the whole flow regimes could be divided into transient flow, feeding flow, and pseudo steady state flow. In feeding flow regime, the production of gas well is gradually fed by adsorbed gases in sub matrix, and free gases in matrix. The proportion of different gas sources to well production is determined by such parameters as storability ratios of triple continuum, transmissibility coefficients controlled by dual flow mechanism and fracture conductivity.
基金Project(51904333) supported by the National Natural Science Foundation of China。
文摘In order to understand the influence of brittleness and confining stress on rock cuttability,the indentation tests were carried out by a conical pick on the four types of rocks.Then,the experimental results were utilized to take regression analysis.The eight sets of normalized regression models were established for reflecting the relationships of peak indentation force(PIF)and specific energy(SE)with brittleness index and uniaxial confining stress.The regression analyses present that these regression models have good prediction performance.The regressive results indicate that brittleness indices and uniaxial confining stress conditions have non-linear effects on the rock cuttability that is determined by PIF and SE.Finally,the multilayer perceptual neural network was used to measure the importance weights of brittleness index and uniaxial confining stress upon the influence for rock cuttability.The results indicate that the uniaxial confining stress is more significant than brittleness index for influencing the rock cuttability.
文摘We investigate electronic properties of a hierarchical multilayer structure consisting of stacking of barriers and wells. The structure is formed in a sequence of generations, each of which is constructed with the same pattern but with the previous generation as the basic building blocks. We calculate the transmission spectrum which shows the multifractal behavior for systems with large generation index. From the analysis of the average resistivity and the multifractal structure of the wavefunctions, we show that there exist different types of states exhibiting extended, localized and intermediate characteristics. The degree of localization is sensitive to the variation of the structural parameters.Suggestion of the possible experimental realization is discussed.
文摘Multistage superimposed deformation has been discussed systematically based on the progress of the stratigraphic sequences of the northeastern margin of Yangtze Block.The new-discovered first stage deformation of those sequences occurred from the middle Triassic to the end of early Jurassic together with development of regional folding, which was resulted from the deep detachment shearing tending toward NW-WNW. The folds dip to east and fall down toward west, and were superimposed by the main stage folding.Thereafter, a series of folds were developed with axes trending toward northeast.Consequently normal folds occurred on the normal limbs while overturned fold on the overturned limbs during the first stage folding. The detachment or thrust was formed from late Jurassic to early Cretaceous. Due to the uplifting of Dabie and the Wannan Mountains in the north and south sides, the bi-directional thrusting belt was formed by gravity flowing from the Mountains toward the center of the basin along the north side of Xuancheng and south side of Guichi. The deformation geodynamics was discussed simply based on the newly recognized information about the tectonic evolution.
基金supported by the National Natural Science Foundation of China(Grant Nos.11472272 and 91215302)the Special Fund for Meteorological Research in the Public Interest(Grant No.GYHY201206041)
文摘The multifractality of energy and thermal dissipation of fully developed intermittent turbulence is investigated in the urban canopy layer under unstable conditions by the singularity spectrum for the fractal dimensions of sets of singularities characterizing multifractals. In order to obtain high-order moment properties of smallscale turbulent dissipation in the inertial range, an ultrasonic anemometer with a high sampling frequency of 100 Hz was used. The authors found that the turbulent signal could be singular everywhere. Moreover, the singular exponents of energy and thermal dissipation rates are most frequently encountered at around 0.2, which is significantly smaller than the singular exponents for a wind tunnel at a moderate Reynolds number. The evidence indicates a higher intermittency of turbulence in the urban canopy layer at a high Reynolds number, which is demonstrated by the data with high temporal resolution. Furthermore, the temperature field is more intermittent than the velocity field. In addition, a large amount of samples could be used for verification of the results.
基金Supported by the National Natural Science Foundation of China (No.60172029).
文摘A decoding method complemented by Maximum Likelihood (ML) detection for V-BLAST (Verti- cal Bell Labs Layered Space-Time) system is presented. The ranked layers are divided into several groups. ML decoding is performed jointly for the layers within the same group while the Decision Feedback Equalization (DFE) is performed for groups. Based on the assumption of QPSK modulation and the quasi-static flat fading channel, simulations are made to testify the performance of the proposed algorithm. The results show that the algorithm outperforms the original V-BLAST detection dramatically in Symbol Error Probability (SEP) per- formance. Specifically, Signal-to-Noise Ratio (SNR) improvement of 3.4dB is obtained for SEP of 10?2 (4×4 case), with a reasonable complexity maintained.
文摘This paper analyzes multiple structural changes by GMDH （Group Meth- ods of Data Handling）, which have obvious advantages. Our method extends the model of Lumsdaine ＆ Papell[1] （1997）, and it could be applied to the case of more than two structural changes. Because of simultaneously considering every structural change of the hypothesis, it is likely to be of particular relevance in practice. And it can decrease large investigation costs by MATLAB programming. What is more, we can select the criterion value of F incremental statistic to control the significance of the breaks, based on kinds of investigation intentions. And the empirical evidences on Shenzhen Composite Index are presented to illustrate the usefulness of our method.
