This review reports some recent advances on the use of dendrimer-based systems for cancer therapy. Dendrimers are emerging as promising carriers or stabilizers for drugs and nanoparticles（NPs） due to their highly br...This review reports some recent advances on the use of dendrimer-based systems for cancer therapy. Dendrimers are emerging as promising carriers or stabilizers for drugs and nanoparticles（NPs） due to their highly branched 3-dimensional globular shape, internal hydrophobic cavity and multiple peripheral functional groups. The fabricated nanoplatforms loaded with therapeutic agents such as drugs,siRNAs or NPs can be further modified to have targeting specificity, antifouling properties and good biocompatibility.In particular, recent advances in the surface modifications of dendrimers and the application of dendrimers as versatile platforms for different therapeutic treatments to cancer including chemotherapy, radiotherapy, photothermal therapy,photodynamic therapy, gene therapy, and combination therapy will be introduced in detail.展开更多
基金financially supported by the Fundamental Research Funds for the Central Universities (for Shi X, Xiong Z, and Shen M)the Science and Technology Commission of Shanghai Municipality (15520711400 and 17540712000)the National Natural Science Foundation of China (81761148028 and 21773026)
文摘This review reports some recent advances on the use of dendrimer-based systems for cancer therapy. Dendrimers are emerging as promising carriers or stabilizers for drugs and nanoparticles（NPs） due to their highly branched 3-dimensional globular shape, internal hydrophobic cavity and multiple peripheral functional groups. The fabricated nanoplatforms loaded with therapeutic agents such as drugs,siRNAs or NPs can be further modified to have targeting specificity, antifouling properties and good biocompatibility.In particular, recent advances in the surface modifications of dendrimers and the application of dendrimers as versatile platforms for different therapeutic treatments to cancer including chemotherapy, radiotherapy, photothermal therapy,photodynamic therapy, gene therapy, and combination therapy will be introduced in detail.
