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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing
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作者 Haolan Ren Fei Zheng +1 位作者 Tingwei Cao Qiang Wang 《Atmospheric and Oceanic Science Letters》 2025年第1期39-45,共7页
Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in c... Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate models.Previous studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC simulations.In this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its collapse.Through a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s variability.The traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of AMOC.The results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter slowly.However,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale. 展开更多
关键词 Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning
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Effects of parameters of asphalt concrete surfacing on mechanical property of paving layer 被引量:6
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作者 钱振东 黄卫 《Journal of Southeast University(English Edition)》 EI CAS 2003年第1期79-82,共4页
The important parameters that influence the mechanical property of the pavinglayer on an orthotropic steel bridge deck are the paving layer thickness and modulus of the asphaltconcrete surfacing. Three important indic... The important parameters that influence the mechanical property of the pavinglayer on an orthotropic steel bridge deck are the paving layer thickness and modulus of the asphaltconcrete surfacing. Three important indices that control the typical failures of the paving layerare the maximum tensile stress of paving layer, the maximum shear stress between the steel deck andthe paving layer, and the maximum deflection on the paving surface. In this paper, the analyticalmodel of paving systems on orthotropic steel bridge deck is established, and the finite elementmethod is adopted to study the stress and strain of paving system. With the variation of asphaltconcrete modulus in high or low temperature season, the influences of paving layer thickness onthree control indices are researched. The results provide a theoretical basis for the determinationof thickness of the paving layer on the steel bridge deck. 展开更多
关键词 paving layer othotropic steel deck stress strain surface deflection finite element
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Gain and Noise Properties of Bidirectional EDFAs 被引量:1
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作者 毛庆和 王劲松 +2 位作者 于虹 孙小菡 张明德 《Journal of Southeast University(English Edition)》 EI CAS 1998年第2期34-39,共6页
The rate equation model is setup for the signal gain, pump absorption and output noise spectrum of bidirectional EDFA (Bi EDFA) including numbers of signals, pumps of arbitrary direction, amplified spontaneous emissi... The rate equation model is setup for the signal gain, pump absorption and output noise spectrum of bidirectional EDFA (Bi EDFA) including numbers of signals, pumps of arbitrary direction, amplified spontaneous emission (ASE) and inherent loss. The influence of erbium doped fiber length, input signal power, pump style and pump power on the gain characteristics of Bi EDFA is analyzed. Forward and backward noise figure for different pump style versus bidirectional input signal power is investigated. 展开更多
关键词 erbium doped fiber bidirectional amplifier GAIN noise figure
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On the Construction of a Cognition-oriented College-English Teaching Model 被引量:1
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作者 杨劲松 邓志勇 《Sino-US English Teaching》 2007年第3期6-10,17,共6页
This paper analyzes the negative influence of traditional English instruction as well as obsession with bilingual teaching, and sets forth a three-step development strategy in line with the cognitive characteristics o... This paper analyzes the negative influence of traditional English instruction as well as obsession with bilingual teaching, and sets forth a three-step development strategy in line with the cognitive characteristics of learners. 展开更多
关键词 Cognition-oriented college English teaching model
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An Improved Description of Characteristics Length in Substrate Current Model for Submicron and Deep-Submicron LDD MOSFET's
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作者 于春利 杨林安 郝跃 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2004年第9期1084-1090,共7页
A novel substrate current model is proposed for submicron and deep-submicron li ghtly-doped-drain (LDD) n-MOSFET,with the emphasis on accurate description of the characteristics length by taking the effects of channe... A novel substrate current model is proposed for submicron and deep-submicron li ghtly-doped-drain (LDD) n-MOSFET,with the emphasis on accurate description of the characteristics length by taking the effects of channel length and bias int o account.This is due to that the characteristics lenth significantly affects th e maximum lateral electric field and the length of velocity saturation region,bo th of which are very important in modeling the drain current and the substrate c urrent.The comparison between simulations and experiments shows a good predictio n of the model for submicron and deep-submicron LDD MOSFET.Moreover,the analyti cal model is suitable for descgn of devices as it is low in computation consumpt ion. 展开更多
关键词 LDD MOSFET substra te current characteristics length maximum lateral electric field
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On methods of "dual-way enjoyable teaching" of College English 被引量:1
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作者 王丹 《Sino-US English Teaching》 2010年第5期26-29,共4页
English teaching in big classes, for Chinese college students, is the main channel to learn and practice English. In the process of a successful classroom teaching, students and teachers are required to cooperate with... English teaching in big classes, for Chinese college students, is the main channel to learn and practice English. In the process of a successful classroom teaching, students and teachers are required to cooperate with each other and mutually complete teaching activities in an enjoyable and harmonious atmosphere. This paper analyzes the current situation of College English teaching in China, and discusses the application of the methodology of "dual-way enjoyable teaching" in big classes, indicating that the classroom activities should be designed to enliven the class atmosphere, which is also the effective way to realize the aim of enjoyable teaching and enjoyable learning. 展开更多
关键词 College English methodology of "dual-way enjoyable teaching" classroom activities
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Defect image segmentation using multilevel thresholding based on firefly algorithm with opposition-learning 被引量:3
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作者 陈恺 戴敏 +2 位作者 张志胜 陈平 史金飞 《Journal of Southeast University(English Edition)》 EI CAS 2014年第4期434-438,共5页
To segment defects from the quad flat non-lead QFN package surface a multilevel Otsu thresholding method based on the firefly algorithm with opposition-learning is proposed. First the Otsu thresholding algorithm is ex... To segment defects from the quad flat non-lead QFN package surface a multilevel Otsu thresholding method based on the firefly algorithm with opposition-learning is proposed. First the Otsu thresholding algorithm is expanded to a multilevel Otsu thresholding algorithm. Secondly a firefly algorithm with opposition-learning OFA is proposed.In the OFA opposite fireflies are generated to increase the diversity of the fireflies and improve the global search ability. Thirdly the OFA is applied to searching multilevel thresholds for image segmentation. Finally the proposed method is implemented to segment the QFN images with defects and the results are compared with three methods i.e. the exhaustive search method the multilevel Otsu thresholding method based on particle swarm optimization and the multilevel Otsu thresholding method based on the firefly algorithm. Experimental results show that the proposed method can segment QFN surface defects images more efficiently and at a greater speed than that of the other three methods. 展开更多
关键词 quad flat non-lead QFN surface defects opposition-learning firefly algorithm multilevel Otsu thresholding algorithm
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An Innovative Project of Wheat Breeding
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作者 李邦发 《Agricultural Science & Technology》 CAS 2013年第12期1779-1782,1825,共5页
The objectives of wheat breeding in Sichuan and Chongqing were incon- sistent with the requirements of wheat production in 1980s. The new direction, to breed new wheat variety with high and stable yield, good quality,... The objectives of wheat breeding in Sichuan and Chongqing were incon- sistent with the requirements of wheat production in 1980s. The new direction, to breed new wheat variety with high and stable yield, good quality, resistance to dis- eases, tolerance to spike sprouting, large head, white and big grain and outstanding commercial property, was put out in this article based on the development of wheat production, market economy and the needs of people. Depending on the selection and breeding work of Mianyang Institute of Agricultural Sciences for more than 20 years, new wheat varieties Mianyang 25, Mianyang 26, Mianyang 27, Mianyang 28, Mianyang 31, Xikemai 1 and Xikemai 6 were developed successively, which made a great contribution to the wheat breeding wheat breeding and production in SJchuan and even in China and the national food security. 展开更多
关键词 WHEAT Commodity variety Breeding direction Replacement in wheat variety Food security
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The Asymptotic Stability for a Class of Nonlinear Large Sceale System
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作者 武玉强 初学导 《Chinese Quarterly Journal of Mathematics》 CSCD 1992年第2期41-45,共5页
This paper an cited instances in illustration of the incorrectness of the criteria of asymptotic stability of a class of nonlinear large seale system that L_j·T·Grujie gave in paper [1] by the comparison the... This paper an cited instances in illustration of the incorrectness of the criteria of asymptotic stability of a class of nonlinear large seale system that L_j·T·Grujie gave in paper [1] by the comparison theory and then corrected it,and has given the sufficient conditions of the asymptotic stability. 展开更多
关键词 asymptotically stable vector norm irreducible M-matrix
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Vertical vibration of a large diameter pipe pile considering transverse inertia effect of pile 被引量:10
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作者 郑长杰 刘汉龙 +1 位作者 丁选明 周航 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第4期891-897,共7页
Considering the transverse inertia effect of pile, the vertical soil layer is studied. The wave propagations in the outer and inner soil dynamic response of a large diameter pipe pile in viscoelastic are simulated by ... Considering the transverse inertia effect of pile, the vertical soil layer is studied. The wave propagations in the outer and inner soil dynamic response of a large diameter pipe pile in viscoelastic are simulated by three-dimensional elastodynamic theory and those in the pile are simulated by Rayleigh-Love rod theory. The vertical and radial displacements of the outer and inner soil are obtained by utilizing Laplace transform technique and differentiation on the governing equations of soils. Then, based on the continuous conditions between the pile and soils, the displacements of the pile are derived. The frequency domain velocity admittance and time domain velocity response of the pile top are also presented. The solution is compared to a classical rod model solution to verify the validity. The influences of the radii and Poisson ratio of pile on the transverse inertia effect of pile are analyzed. The parametric study shows that Poisson ratio and outer radius of pile have significant influence on the transverse inertia effect of large diameter pipe piles, while the inner radius has little effect. 展开更多
关键词 large diameter pipe pile vertical vibration Rayleigh-Love rod transverse inertia effect
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Micro-Pulse Lidar Measurements of Aerosol Vertical Structure over the Loess Plateau 被引量:27
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作者 HUANG Jian-Ping HUANG Zhong-Wei BI Jian-Rong ZHANG Wu ZHANG Lei 《Atmospheric and Oceanic Science Letters》 2008年第1期8-11,共4页
Knowledge of the vertical distribution of aerosols in the free troposphere is important for estimating their impact on climate. In this study, direct observations of the vertical distribution of aerosols in the free t... Knowledge of the vertical distribution of aerosols in the free troposphere is important for estimating their impact on climate. In this study, direct observations of the vertical distribution of aerosols in the free troposphere are made using surface Micro-Pulse Lidar (MPL) measurements. The MPL measurements were made at the Loess Plateau (35.95°N, 104.1°E), which is near the major dust source regions of the Taklimakan and Gobi deserts. The vertical distribution of the MPL backscattering suggested that nondust aerosols floated from ground level to an altitude of approximately 9 km around the source regions. Early morning hours are characterized by a shallow aerosol layer of a few hundred meters thick. As the day progresses, strong convective eddies transport the aero- sols vertically to more than 1500 m. 展开更多
关键词 LIDAR AEROSOL vertical structure Loess Plateau
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Extending application of asymmetric semi-circular bend specimen to investigate mixed mode Ⅰ/Ⅱ fracture behavior of granite 被引量:4
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作者 WU Qiu-hong XIE Cheng-long +4 位作者 XIE You-sheng ZHAO Yan-lin LI Xue-feng LIU Jie WENG Lei 《Journal of Central South University》 SCIE EI CAS CSCD 2022年第4期1289-1304,共16页
The asymmetric semi-circular bend(ASCB)specimen has been proposed to investigate the cracking behavior in different geo and construction materials and attracted the attention of researchers due to its advantages.Howev... The asymmetric semi-circular bend(ASCB)specimen has been proposed to investigate the cracking behavior in different geo and construction materials and attracted the attention of researchers due to its advantages.However,there are few studies on the fracture toughness determination of rock materials.In this work,a series of fracture tests were performed with the ASCB specimens made of granite.The onset of fracture,crack initiation angle and crack propagating trajectory was analyzed in detail combined with several mixed mode fracture criteria.The influence of the crack length on the mode Ⅰ/Ⅱ fracture toughness was studied.A comparison between the fracture toughness ratios predicted by varying criteria and experimental results was conducted.The relationship between experimentally determined crack initiation angles and curves of the generalized maximum tangential stress(GMTS)criterion was obtained.The fracture process of the specimen was recorded with the high-speed camera.The shortcomings of the ASCB specimens for the fracture toughness determination of rock materials were discussed.The results may provide a reference for analysis of mixed mode I and II fracture behavior of brittle materials. 展开更多
关键词 asymmetric semi-circular bend specimen rock fracture toughness crack growth trajectory crack initiation angle semi-circular bending generalized maximum tangential stress criterion
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Two different periods of high dust weather frequency in northern China 被引量:4
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作者 FAN Ke XIE Zhi-Ming XU Zhi-Qing 《Atmospheric and Oceanic Science Letters》 CSCD 2016年第4期263-269,共7页
This study reveals that, during the period 1966-2014, dust weather frequency (DWF) in northern China (north of 30°N) features two high-DWF periods, in 1966-1979 (PI) and 2000-2014 (P2), when the linear tr... This study reveals that, during the period 1966-2014, dust weather frequency (DWF) in northern China (north of 30°N) features two high-DWF periods, in 1966-1979 (PI) and 2000-2014 (P2), when the linear trend of DWF is removed during the study period. Here, DWF denotes the number of days of dust weather events in the spring season (March-April-May), including dust haze, blowing dust, and dust storms, which occurred in northern China. The results show that the DWF is much higher in PI than in P2, with increased DWF distributed over southern Xinjiang, the central part of northern China. The main cause is the SST difference in the Atlantic and Pacific between the two periods. It is also found that a meridional teleconnection over East Asia in PI and a zonal wave-like pattern over Eurasia in P2 at 200 hPa play a significant role in the interannual variability in the two periods, respectively. SST over the subtropical North Atlantic (extratropical SST between the Norwegian and Barents seas) may partly contribute to the upper-level meridional (zonal) teleconnection in PI (P2). 展开更多
关键词 Dust weather frequency northern China meridionalteleconnection zonal wave-like pattern North AtlanticSST
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Flow-induced Noise and Vibration Analysis of a Piping Elbow with/without a Guide Vane 被引量:4
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作者 Tao Zhang Yong'ou Zhang +1 位作者 Huajiang Ouyang Tao Guo 《Journal of Marine Science and Application》 2014年第4期394-401,共8页
The effect of a guide vane installed at the elbow on flow-induced noise and vibration is investigated in the range of Reynolds numbers from 1.70×10^5 to 6.81×10^5, and the position of guide vane is determine... The effect of a guide vane installed at the elbow on flow-induced noise and vibration is investigated in the range of Reynolds numbers from 1.70×10^5 to 6.81×10^5, and the position of guide vane is determined by publications. The turbulent flow in the piping elbow is simulated with large eddy simulation (LES). Following this, a hybrid method of combining LES and Lighthill's acoustic analogy theory is used to simulate the hydrodynamic noise and sound sources are solved as volume sources in code Actran. In addition, the flow-induced vibration of the piping elbow is investigated based on a fluid-structure interaction (FSI) code. The LES results indicate that the range of vortex zone in the elbow without the guide vane is larger than the case with the guide vane, and the guide vane is effective in reducing flow-induced noise and vibration in the 90° piping elbow at different Reynolds numbers. 展开更多
关键词 flow-induced noise flow-induced vibration piping elbow guide vane large eddy simulation fluid structure interaction Actran
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Experimental and numerical assessment of energy absorption capacity of thin-walled Al 5083 tube produced by PTCAP process 被引量:4
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作者 A.HOSSEINI D.RAHMATABADI +1 位作者 R.HASHEMI H.AKBARI 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2020年第5期1238-1248,共11页
The energy absorption capacity of the Al5083 thin-walled tube produced by parallel tubular angular pressing(PTCAP) process was evaluated. Also, microstructure, mechanical properties, and anisotropy coefficients were s... The energy absorption capacity of the Al5083 thin-walled tube produced by parallel tubular angular pressing(PTCAP) process was evaluated. Also, microstructure, mechanical properties, and anisotropy coefficients were studied in the peripheral and axial directions. Results showed that values of energy absorption decreased with processing pass increasing and the values for the unprocessed, first and second passes were obtained to be 167, 161.4 and 160.7 J, respectively. The differences between the simulation results for the energy absorption values and their experimental values for the unprocessed, the first and the second PTCAP passes samples are about 5%, 10%, and 13%, respectively. The energy absorption capacity was related to the anisotropy coefficient and microstructure. The results demonstrated that grain refinement occurred and ultimate tensile strength(UTS) and microhardness after the first and second PTCAP passes were enhanced, while the increase rate in the first pass was much severer. Also, by applying PTCAP, the deformation modes were altered, such that the deformation mode of the annealed tube was quite symmetrical and circular while for the first and second passes there have been triple and double lobes diamond. The results of the numerical simulation for the deformation mode of the annealed and PTCAPed tubes were consistent with the experimental results. The deformation mode of tubes is dependent on their mechanical properties and variation of the mechanical properties during PTCAP process. 展开更多
关键词 energy absorption Al 5083 ultra-fine grained aluminum alloy thin-walled tube severe plastic deformation anisotropy coefficient
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Quantitative assessment of flight safety under atmospheric icing conditions 被引量:3
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作者 Zhou Li Xu Haojun +1 位作者 Su Chen Lin Min 《High Technology Letters》 EI CAS 2012年第1期90-95,共6页
A quantitative assessment method is proposed to sense the specific effects of atmospheric icing conditions on flight safety. A six degree-of-freedom computational flight dynamics model is used to study the effects of ... A quantitative assessment method is proposed to sense the specific effects of atmospheric icing conditions on flight safety. A six degree-of-freedom computational flight dynamics model is used to study the effects of ice accretion on aircraft dynamics, and a pilot model is also involved. In order to investigate icing severity under different icing conditions, support vector regression is applied in establishing relationship between aircraft icing parameter and weather conditions. Considering the characteristics of aircraft icing accidents, a risk probability assessment model optimized by the particle swarm method is developed to measure the safety level. In particular, angle of attack is chosen as a critical parameter in this method. Results presented in the paper for a series of simulation show that this method captures the basic effects of atmospheric icing conditions on flight safety, which may provide an important theoretical reference for icing accidents avoidance. 展开更多
关键词 atmospheric icing conditions flight safety quantitative assessment risk probability supportvector regression particle swarm optimization
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A Theoretical Analysis of the Bearing Performance of Vertically Loaded Large-Diameter Pipe Pile Groups 被引量:3
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作者 DING Xuanming ZHANG Ting +1 位作者 LI Ping CHENG Ke 《Journal of Ocean University of China》 SCIE CAS 2016年第1期57-68,共12页
This paper aims to present a theoretical method to study the bearing performance of vertically loaded large-diameter pipe pile groups.The interactions between group piles result in different bearing performance of bot... This paper aims to present a theoretical method to study the bearing performance of vertically loaded large-diameter pipe pile groups.The interactions between group piles result in different bearing performance of both a single pile and pile groups.Considering the pile group effect and the skin friction from both outer and inner soils,an analytical solution is developed to calculate the settlement and axial force in large-diameter pipe pile groups.The analytical solution was verified by centrifuge and field testing results.An extensive parametric analysis was performed to study the bearing performance of the pipe pile groups.The results reveal that the axial forces in group piles are not the same.The larger the distance from central pile,the larger the axial force.The axial force in the central pile is the smallest,while that in corner piles is the largest.The axial force on the top of the corner piles decreases while that in the central pile increases with increasing of pile spacing and decreasing of pile length.The axial force in side piles varies little with the variations of pile spacing,pile length,and shear modulus of the soil and is approximately equal to the average load shared by one pile.For a pile group,the larger the pile length is,the larger the influence radius is.As a result,the pile group effect is more apparent for a larger pile length.The settlement of pile groups decreases with increasing of the pile number in the group and the shear modulus of the underlying soil. 展开更多
关键词 pile group effect bearing performance large-diameter pipe pile SETTLEMENT rigid foundation
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Revisiting the response of western North Pacific tropical cyclone intensity change to vertical wind shear in different directions
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作者 Xiuji Liang Qingqing Li 《Atmospheric and Oceanic Science Letters》 CSCD 2021年第3期42-48,共7页
The effect of vertical wind shear(VWS)directions on the change in western North Pacific tropical cyclone(TC)intensity is revisited in this study.Results show that the differences in the correlations between VWS in dif... The effect of vertical wind shear(VWS)directions on the change in western North Pacific tropical cyclone(TC)intensity is revisited in this study.Results show that the differences in the correlations between VWS in different orientations and the change in TC nondimensional intensity highly diminish,although slight differences are still present.The subtle differences in the correlations are likely associated with different synoptic-scale patterns at upper and lower levels.This result suggests that,in addition to thermodynamic effects,dynamic roles of the synoptic-scale patterns associated with the VWS should also be taken into account when the authors examine how VWS in different directions affects TC intensity change. 展开更多
关键词 Tropical cyclone Intensity change Vertical wind shear direction Large-scale pattern
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Energy efficiency enhancement of two-way amplifier forward relaying with channel estimation error 被引量:1
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作者 师晓晔 葛建华 +1 位作者 李靖 张沉思 《Journal of Central South University》 SCIE EI CAS 2014年第3期987-992,共6页
In order to save energy consumption of two-way amplifier forward(AF) relaying with channel estimation error, an energy efficiency enhancement scheme is proposed in this work. Firstly, through the analysis of two-way A... In order to save energy consumption of two-way amplifier forward(AF) relaying with channel estimation error, an energy efficiency enhancement scheme is proposed in this work. Firstly, through the analysis of two-way AF relaying mode with channel estimation error, the resultant instantaneous SNRs at end nodes is obtained. Then, by using a high SNR approximation, outage possibility is acquired and its simple closed-form expression is represented. Specially, for using the energy resource more efficiently, a low-complexity power allocation and transmission mode selection policy is proposed to enhance the energy efficiency of two-way AF relay system. Finally, relay priority region is identified in which cooperative diversity energy gain can be achieved. The computer simulations are presented to verify our analytical results, indicating that the proposed policy outperforms direct transmission by an energy gain of 3 dB at the relative channel estimation error less than 0.001. The results also show that the two-way AF relaying transmission loses the two-way AF relaying transmission loses its superiority to direct transmission in terms of energy efficiency when channel estimation error reaches 0.03. 展开更多
关键词 AMPLIFY-AND-FORWARD channel estimation error cooperative energy gain energy efficiency outage probability two-way relay
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SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer 被引量:20
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作者 Shu-Jing Yu Jie-Kai Yu +3 位作者 Wei-Ting Ge Han-Guang Hu Ying Yuan Shu Zheng 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第15期2028-2036,共9页
AIM: To investigate the expression of markers that are correlated with the prognosis of colorectal cancer (CRC) patients. METHODS: One hundred and fifty-six CRC patientswere followed up for more than 3 years after rad... AIM: To investigate the expression of markers that are correlated with the prognosis of colorectal cancer (CRC) patients. METHODS: One hundred and fifty-six CRC patientswere followed up for more than 3 years after radical surgery. Immunohistochemical (IHC) analysis was performed to detect the expression of 14 pathway-related markers (p53, APC, p21ras, E-cadherin, endothelin-B receptor, Shp2, ADCY-2, SPARCL1, neuroligin1, hsp27, mmp-9, MAPK, MSH2 and rho) in specimens from these patients. Bioinformatics analysis involving a Support Vector Machine (SVM) was used to determine the best prognostic model from combinations of these markers. RESULTS: Seven markers (SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK) were significantly related to the prognosis and clinical pathological features of the CRC patients (P < 0.05). Prognostic models were established through SVM from combinations of these 7 markers and proved able to differentiate patients with dissimilar survival, especially in stage Ⅱ/Ⅲ patients. According to the best prognostic model, the p53/SPARCL1 model, patients having high p53 and low SPARCL1 expression had about 50% lower 3-year survival than others (P < 0.001). CONCLUSION: SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are potential prognostic markers in CRC. A p53/SPARCL1 bioinformatics model may be used as a supplement to tumor-nodes-metastasis staging. 展开更多
关键词 Colorectal cancer Prognosis SPARCL1 P53 BIOINFORMATICS
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