A Fully Integrated CMOS Readout Circuit for Particle Detectors

Novel schemes for a charge sensitive amplifier （CSA） and a CR-（RC）, semi-Gaussian shaper in a fully integrated CMOS readout circuit for particle detectors are presented. The CSA is designed with poly-resistors as feedback components to reduce noise. Compared with conventional CSA, the input referred equivalent noise charge（ENC） is simulated to be reduced from 5036e to 2381e with a large detector capacitance of 150pF at the cost of 0.5V output swing loss. The CR-（RC）,semi-Gaussian shaper uses MOS transistors in the triode region in series with poly-resistors to compensate process variation without much linearity reduction.

An Ultra-Low-Power Embedded EEPROM for Passive RFID Tags

An ultra-low-power,256-bit EEPROM is designed and implemented in a Chartered 0.35μm EEPROM process. The read state power consumption is optimized using a new sense amplifier structure and an optimized control circuit. Block programming/erasing is achieved using an improved control circuit. An on silicon program/erase/read access time measurement design is given. For a power supply voltage of 1.8V,an average power consumption of 68 and 0.6μA for the program/erase and read operations,respectively,can be achieved at 640kHz.

Novel General-Purpose Sense Amplifier-Based Flip-Flop and Its Further Speed Improvement by Pseudo-PMOS Dynamic Technique

A novel general purpose sense amplifier based flip flop is proposed.Compared to other flip flops,the proposed flip flop has faster operating speed under the approximately same power consumption,and needs fewer transistors and consumes smaller area.Moreover,it eliminates the glitch problem.By using pseudo PMOS dynamic technique,its performance is further improved.

Design of Tensile Strained InGaAsP/InGaAsP MQW for 1.55μm Polarization Independent Semiconductor Optical Amplifier

The theoretical optimization of tensile strained InGaAsP/InGaAsP MQW for 1.55μm windows polarization-independent semiconductor optical amplifier is reported.The valence-band structure of the MQW is calculated by using k·p method,in which 6×6 Luttinger effective-mass Hamiltonian is taken into account.The polarization dependent optical gain is calculated with various well width,strain,and carrier density.

Etiological Analysis of 3 Cases of Gonorrhea with Spectinomycin Treatment Failure

Objectives: To report three cases of gonorrhea withspectinomycin treatment failure, and to analyze thepossible causes.Methods: Identification of the three Neisseriagonorrhoeae isolates was made by an oxidase test anda rapid carbohydrate utilization test. The sensitivitytesting was performed by an agar dilution method.Results: All three isolates were identified as Ngonorrhoeae strains by positive oxidase test andbecause they only utilized glucose in the carbohydrateutilization test. All three strains were resistant tociprofloxacin and susceptible to ceftriaxoneSpectinomycin-resistant strains were found in onlytwo of the three patients, including one penicillinase-producing N. gonorrhoeae (PPNG). The third patienthad a spectinomycin sensitive strain, which was alsoPPNG and tetracycline resistant (TRNG). Based onthe medical history, spectinomycin treatment failurefor the third patient was due to inadequate injection.Conclusion: The causes of spectinomycin treatmentfailure of gonorrhea include spectinomycin resistanceand inadequate injection.

Bioinformatics Analysis on B cell Epitopes of Rice Allergen RAG1

[Objective] To predict the secondary structure and B cell epitopes of the rice major allergen RAG1. [Method] The amino acid sequence of rice allergen RAG1 was acquired from Expasy protein database. The secondary structure of RAG1 was predicted by DNAStar Protean software with Gamier-Robson program, Chou-Fasman program and Karplus-Schulz program; the B cell epitopes of RAG1 was predicted with the Kyte Doolittle hydrophilic program, Emini surface accessibility program and Jameson-Wolf antigenic index program. [Result] The predictions on secondary structure and B cell epitopes showed that the regions of 33-44, 119-129, 155-163 were the dominant B cell epitopes. [Conclusion] This study predicted the potential dominant B cell epitopes in rice allergen RAG1 by comprehensive use of multi-methods and multi-parameters, and provided a theoretical basis for further researches on identification, antigen modification and epitope vaccine design of RAG1 B cell epitopes.

PARAMETRIC SENSITIVITY AND RUNAWAY IN FIXED BED REACTORS

This paper presents a comprehensive treatment of the parametric sensitivity and runaway in fixed bed reactors with one dimensional pseudo homogeneous dispersion model (ODDM). In this case, we find the existence of multiplicity and determine the runaway criterion through the critical isodisper sion curve. The calculated results indicate when the axial dispersion is relatively small, the impact of the axial dispersion on the parametric sensitivity may be neglected; but when the axial dispersion is large, this impact must be considered.

A Low-Power,Single-Poly,Non-Volatile Memory for Passive RFID Tags

Single-poly,576bit non-volatile memory is designed and implemented in an SMIC 0.18μm standard CMOS process for the purpose of reducing the cost and power of passive RFID tag chips. The memory bit cell is designed with conventional single-poly pMOS transistors, based on the bi-directional Fowler-Nordheim tunneling effect, and the typical program/erase time is 10ms for every 16bits. A new ,single-ended sense amplifier is proposed to reduce the power dissipation in the current sensing scheme. The average current consumption of the whole memory chip is 0.8μA for the power supply voltage of 1.2V at a reading rate of 640kHz.

A Low-Power Super-Performance Four-Way Set-Associative CMOS Cache Memory

A 1.8-V 64-kb four-way set-associative CMOS cache memory implemented by 0.18μm/1.8V 1P6M logic CMOS technology for a super performance 32-b RISC microprocessor is presented.For comparison,a conventional parallel access cache with the same storage and organization is also designed and simulated using the same technology.Simulation results indicate that by using sequential access,power reduction of 26% on a cache hit and 35% on a cache miss is achieved.High-speed approaches including modified current-mode sense amplifier and split dynamic tag comparators are adopted to achieve fast data access.Simulation results indicate that a typical clock to data access of 2.7ns is achieved...

On a unique behavior of freshwater bacteria

Magnetic sensitivity has been found in bacteria from freshwater sites around Pavia, Italy.

Performance enhancement of IMC-PID controller design for stable and unstable second-order time delay processes

An IMC-PID controller was proposed for unstable second-order time delay system which shows the characteristics of inverse response(RHP zero). A plot of Ms versus λ was suggested to calculate the suitable tuning parameter λ, which provides a trade-off between performance and robustness. Six different forms of process models were selected from literature to show the applicability of the present method. Performance of controller was calculated by ITAE and total variation TV and compared with recently published tuning rules. Undesirable overshoot was removed by using a set-point weighting parameter. Robustness was tested by introducing a perturbation into the various model parameters and closed-loop results show that the designed controller is robust in the case of model uncertainty. The proposed method shows an overall better closed-loop response as compared to other recently reported methods.

Susceptibility Assessment of Landslides Caused by the Wenchuan Earthquake Using a Logistic Regression Model

The Wenchuan earthquake on May 12,2008 caused numerous collapses,landslides,barrier lakes,and debris flows.Landslide susceptibility mapping is important for evaluation of environmental capacity and also as a guide for post-earthquake reconstruction.In this paper,a logistic regression model was developed within the framework of GIS to map landslide susceptibility.Qingchuan County,a heavily affected area,was selected for the study.Distribution of landslides was prepared by interpretation of multi-temporal and multi-resolution remote sensing images(ADS40 aerial imagery,SPOT5 imagery and TM imagery,etc.) and field surveys.The Certainly Factor method was used to find the influencial factors,indicating that lithologic groups,distance from major faults,slope angle,profile curvature,and altitude are the dominant factors influencing landslides.The weight of each factor was determined using a binomial logistic regression model.Landslide susceptibility mapping was based on spatial overlay analysis and divided into five classes.Major faults have the most significant impact,and landslides will occur most likely in areas near the faults.Onethird of the area has a high or very high susceptibility,located in the northeast,south and southwest,including 65.3% of all landslides coincident with the earthquake.The susceptibility map can reveal the likelihood of future failures,and it will be useful for planners during the rebuilding process and for future zoning issues.

Isolation and Identification of Drug-resistant Escherichia coli Strains from Chickens

[Objective] This study aimed to isolate and identify the drug-resistant Es- cherichia coli strains from chickens. [Method] E. coli strains were isolated from the fecal samples collected from five chicken farms around Shangqiu City, and verified by biochemical and pathogenic assay. [Result] Among the 35 isolated E. coli stains, 11 E. coil stains were sensitive to florfenicol, amikacin, neomycin and gentamicin; 12 E. coli stains were moderately sensitive to ciprofloxacin, doxycycline and norfloxacin; 15 E. coil stains were resistant against erythromycin, penicillin and streptomycin. [Conclusion] Strengthening biosecurity measures, rationally using vaccine and choosing effective antibiotics are the most cost-efficient methods to control E. coli.

Sensitive factors research for track-bridge interaction of Long-span X-style steel-box arch bridge on high-speed railway

X-style arch bridge on high-speed railways(HSR)is one kind of complicated long-span structure,and the track-bridge interaction is essential to ensure the safety and smoothness of HSR.Taking an X-style steel-box arch bridge with a main span of450 m on HSR under construction for example,a new integrative mechanic model of rail-stringer-cross beam-suspenderpier-foundation coupling system was established,adopting the nonlinear spring element simulating the longitudinal resistance between track and bridge.The transmission law of continuous welded rail(CWR)on the X-style arch bridge was researched,and comparative study was carried out to discuss the influence of several sensitive factors,such as the temperature load case,the longitudinal resistance model,the scheme of longitudinal restraint conditions,the introverted inclination of arch rib,the stiffness of pier and abutment and the location of the rail expansion device.Calculating results indicate that the longitudinal resistance has a significant impact upon the longitudinal forces of CWR on this kind of bridge,while the arch rib’s inclination has little effect.Besides,temperature variation of arch ribs and suspenders should be taken into account in the calculation.Selecting the restraint system without longitudinally-fixed bearing and setting the rail expansion devices on both ends are more reasonable.

Mesalamine hypersensitivity and Kounis syndrome in a pediatric ulcerative colitis patient

5-aminosalicylic acid （mesalamine） rarely induces hyper- sensitivity reactions. If chest pain associated with atypical electrocardiographic changes are seen during its administration, one should always bear in mind type I variant of Kounis syndrome. This variant includes patients, of any age, with normal coronary arteries, without predisposing factors for coronary artery disease, in whom the acute release of inflammatory mediators from mast cells can induce either sudden coronary artery narrowing, without increase of cardiac enzymes and troponins, or coronary artery spasm that progresses to acute myocardial infarction, with elevated cardiac enzymes and troponins.

Solubility of Emodin in Alcohols

Emodin is a kind of anthraquiones with pharmaceutical activities.The solubilities of emodin in ethanol,1-octanol,and ethanol+1-octanol at different temperatures were measured using an analytical method.The solubility of emodin in these solvents increased with an increase in temperature.With the temperature deviating from room temperature,the dependence of the solubility of emodin on temperature became a lot more remarkable.The solubility of emodin in ethanol was more sensitive to temperature than that in 1-octanol.The solubility data of emodin in the same species of solvent at different temperatures was correlated with an empirical equation.The calculated results agreed with the experimental data well.

Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis

AIM:Irritable bowel syndrome(IBS)is a functional bowel disorder characterized by visceral hypersensitivity and altered bowel motility.There is increasing evidence suggesting the role of inflammation in the pathogenesis of IBS,which addresses the possibility that formerly established rat model of colitis could be used as an IBS model after the inflammation subsided. METHODS:Colitis was induced by intracolonic instillation of 4% acetic acid in male Sprague-Dawley rats.The extent of inflammation was assessed by histological examination and myeloperoxidase(MPO)activity assay.After subsidence of colitis,the rats were subjected to rectal distension and restraint stress,then the abdominal withdrawal reflex and the number of stress-induced fecal output were measured, respectively. RESULTS:At 2 days post-induction of colitis,the colon showed characteristic inflammatory changes in histology and 8-fold increase in MPO activity.At 7 days post-induction of colitis,the histological features and MPO activity returned to normal.The rats at 7 days post-induction of colitis showed hypersensitive response to rectal distension without an accompaning change in rectal compliance,and defecated more stools than control animals when under stress.CONCLUSION: These results concur largely with the characteristic features of IBS, visceral hypersensitivity and altered defecation pattern in the absence of detectable disease, suggesting that this animal model is a methodologically convenient and useful model for studying a subset of IBS.

Mutations around interferon sensitivity-determining region:A pilot resistance report of hepatitis C virus 1b in a Hong Kong population

AIM： To explore mutations around the interferon sensitivity-determining region （ISDR） which are associated with the resistance of hepatitis C virus lb （HCV-lb） to interferon-α treatment. METHODS： Thirty-seven HCV-lb samples were obtained from Hong Kong patients who had completed the combined interferon-α/ribavirin treatment for more than one year with available response data. Nineteen of them were sustained virological responders, while 18 were non-responders. The amino acid sequences of the extended ISDR （eISDR） covering 64 amino acids upstream and 67 amino acids downstream from the previously reported ISDR were analyzed. RESULTS： One amino acid variation （I2268V, P = 0.023） was significantly correlated with treatment outcome in this pilot study with a limited number of patients, while two amino acid variations （R2260H, P = 0.05 and $2278T, P = 0.05） were weakly associated with treat- ment outcome. The extent of amino acid variations within the ISDR or eISDR was not correlated with treat- ment outcome as previously reported. CONCLUSION： Three amino acid mutations near but outside of ISDR may associate with interferon treatment resistance of HCV-lb patients in Hong Kong.

A unified approach of PID controller design for unstable processes with time delay

This paper addresses a unified approach of the PID controller design for low as well as high order unstable processes with time delay.The design method is based on the direct synthesis(DS)approach to achieve the enhanced load disturbance rejection.To improve the servo response,a two-degree of freedom control scheme has been considered.A suitable guideline has been provided to select the desired reference model in the DS scheme.The direct synthesis controller has been approximated to the PID controller using the frequency response matching method.A consistently better performance has been obtained in comparison with the recently reported methods.

THE SENSITIVITY TEST STUDY OF AIR-SEA SURFACE FLUX MODEL

In this article, a sensitivity test of air-sea surface flux model was carried out with the field observation data of Project “South China Sea Air-Sea Flux Measurement in 2000”. The results show that sensible heat fluxes are sensitive to observation errors, increasing the error of model calculation; In contrast, the latent heat flux and momentum flux are not as sensitive to observation errors as the sensible heat, and their calculated results are reliable. The test result also verifies the rationality of the surface flux values calculated and the conclusions can be used to detect errors in observed data.