AIM:To examine the efficacy of glycyrrhizin preparation(GL-p) in the treatment of a rat model of ulcerative colitis(UC).METHODS:Experimental colitis was induced by oral administration of dextran sodium sulfate.Rats wi...AIM:To examine the efficacy of glycyrrhizin preparation(GL-p) in the treatment of a rat model of ulcerative colitis(UC).METHODS:Experimental colitis was induced by oral administration of dextran sodium sulfate.Rats with colitis were intrarectally administered GL-p or saline.The extent of colitis was evaluated based on body weight gain,colon wet weight,and macroscopic damage score.The expression levels of pro-inflammatory cytokines and chemokines in the inflamed mucosa were measured by cytokine antibody array analysis.The effect of GL-p on myeloperoxidase(MPO) activity in the inflamed mucosa and purified enzyme was assayed.RESULTS:GL-p treatment significantly ameliorated the extent of colitis compared to sham treatment with saline.Cytokine antibody array analysis showed that GL-p treatment significantly decreased the expression levels of pro-inflammatory cytokines and chemokines,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α,cytokine-induced neutrophil chemoattractant-2,and monocyte chemoattractant protein-1 in the inflamed mucosa.Furthermore,GL-p inhibited the oxidative activity of mucosal and purified MPO.CONCLUSION:GL-p enema has a therapeutic effect on experimental colitis in rats and may be useful in the treatment of UC.展开更多
Method development has always been and will continue to be a core driving force of microbiome science, In this perspective, we argue that in the next decade, method development in microbiome analysis will be driven by...Method development has always been and will continue to be a core driving force of microbiome science, In this perspective, we argue that in the next decade, method development in microbiome analysis will be driven by three key changes in both ways of thinking and technological platforms: ① a shift from dissecting microbiota structure by sequencing to tracking microbiota state, function, and intercellular interaction via imaging; ② a shift from interrogating a consortium or population of cells to probing individual cells; and ③a shift from microbiome data analysis to microbiome data science. Some of the recent methoddevelopment efforts by Chinese microbiome scientists and their international collaborators that underlie these technological trends are highlighted here. It is our belief that the China Microbiome Initiative has the opportunity to deliver outstanding "Made-in-China" tools to the international research community, by building an ambitious, competitive, and collaborative program at the forefront of method development for microbiome science.展开更多
The B-meson decay constant fB is an important component for studying the B-meson decays, which can be studied through QCD sum rules. We make a detailed discussion on f B from two sum rules up to next-to- leading order...The B-meson decay constant fB is an important component for studying the B-meson decays, which can be studied through QCD sum rules. We make a detailed discussion on f B from two sum rules up to next-to- leading order, i.e. sum rules I and II, which are derived from the conventional correlator and the correlator with chiral currents respectively. It is found that these two sum rules are consistent with each other. The sum rules H involves less non-perturbative condensates as that of sum rules I, and in principle, it can be more accurate if we know the dimensionfour gluon condensate well. It is found that fB decreases with the increment of mb, and to compare with the Belle experimental data on fB, both sum rules I and H prefer smaller pole b-quark mass, mb= 4.68 ± 0.07 GeV. By varying all the input parameters within their reasonable regions and by adding all the uncertainties in quadrature, we obtain fB=172-25^+23 MeV for sum rules I and fB =214-34^26 MeV for sum rules П.展开更多
A differential paired eFuse OTP(one-time programmable)memory cell which can be configured into a 2D(two-dimensional)eFuse cell array was proposed.The sensible resistance of a programmed eFuse link is a half smaller th...A differential paired eFuse OTP(one-time programmable)memory cell which can be configured into a 2D(two-dimensional)eFuse cell array was proposed.The sensible resistance of a programmed eFuse link is a half smaller than that of the single-ended counterpart and BL datum can be sensed without a reference voltage.With this 2D array of differential paired eFuse OTP memory cells,we design a 32-bit eFuse OTP memory IP.We use a sense amplifier based D F/F circuit as the BL(bit-line)SA(sense amplifier)and design a sensing margin test circuit with a variable pull-up load.It is confirmed by the function test that the designed 32-bit OTP memory IP functions normally on 30 sample dies.展开更多
The paper proposes a novel hardware-based private information retrieval (HWPIR) protocol. By partially reshuffling previously accessed items in each round, instead of frequently reshuffling the whole database, the s...The paper proposes a novel hardware-based private information retrieval (HWPIR) protocol. By partially reshuffling previously accessed items in each round, instead of frequently reshuffling the whole database, the scheme makes better use of shuffled data copies and achieves the computation overhead at O(/N/K),where N and k are the sizes of the database and secure storage respectively. For securestorage with moderate size, e.g. k = O(/N), the overhead is 0(4/N). The result is much better than the state-of-art schemes (as compared to e.g. O(log2N)). Without increasing response time and communication cost, the proposed protocol is truly practicable regardless of the database size. The security and preformance of the protocol is formally analyzed.展开更多
In the university education, the mathematical teaching is an important and indispensable part. And now the integration of the mathematical culture in the university teaching is the effective method to improve the time...In the university education, the mathematical teaching is an important and indispensable part. And now the integration of the mathematical culture in the university teaching is the effective method to improve the timeliness of the teaching and the enthusiasm of the students, and it also can effectively alleviate the problem of the disconnection in the university mathematical teaching, with the successful implementation of the transition. The university mathematics has very high demands in the teaching contents, the teaching ideas and the teaching methods, so the reasonable integration of the mathematical culture into the university mathematics is very important. The mathematical culture in the teaching of college mathematics is discussed and analyzed in this paper.展开更多
Planting date is a critical component of soybean [Glycine max (L.) Merr.] production, under dry land conditions in the Southeastern Coastal Plain. The objectives of this study were to 1. Evaluate the effect of plant...Planting date is a critical component of soybean [Glycine max (L.) Merr.] production, under dry land conditions in the Southeastern Coastal Plain. The objectives of this study were to 1. Evaluate the effect of planting date on plant leaf area index (LAI) and normalized difference vegetation index (NDVI) at 60 and 90 days after planting (DAP), plant height and grain yield, and 2. Determine the optimum planting period by integrating the responses from vegetation growth to yield for soybean maturity group (MG) IV-VIII under dry land conditions in the Southeastern Coastal Plain. Planting dates were scheduled about 14-days intervals from late April to mid-July (2008) or late July (2009). Greatest grain yield for MG IV was obtained from planting in around mid-May in both years. The yield was greater for MG V planted in May and greater for MG VI-VIII planted in late April and May, but started to decline for planting in early June. Plant LAI and NDVI at 60 DAP were affected by both planting date and precipitation, but were poorly correlated with grain yield. However, plant LAI and NDVI were well correlated with yield and were greater for May planting dates at 90 DAP. These indiccs declined for soybean planted after May. Mature plant height decreased more rapidly with delayed planting. These results indicate that plant growth and yield decreased after May planting. Optimum planting period for all MGs was early to mid-May.展开更多
Since its installation on the International Space Station(ISS)in mid-May 2011,the Alpha Magnetic Spectrometer(AMS)has spent over two years on orbit,fully operational,collecting an enormous amount of data including the...Since its installation on the International Space Station(ISS)in mid-May 2011,the Alpha Magnetic Spectrometer(AMS)has spent over two years on orbit,fully operational,collecting an enormous amount of data including the temperatures from the on-board 1118 sensors for thermal control.A large database is continuously updated and analyzed to understand the thermal behavior of the experiment in the space environment and its interaction with the ISS.This paper specifies the design,building,analysis and testing of the thermal control system and its various components for an overview of the AMS thermal control system and its space environment.Also given are some examples of analysis and correlation of the space environmental and ISS parameters with the thermal behaviors of various AMS components.展开更多
Surface plasmon resonance(SPR) nanosensors based on metallic nanohole arrays have been widely reported to detect binding interactions in biological specimens. A simple and effective method for constructing nanoscale a...Surface plasmon resonance(SPR) nanosensors based on metallic nanohole arrays have been widely reported to detect binding interactions in biological specimens. A simple and effective method for constructing nanoscale arrays is essential for the development of SPR nanosensors. In this work, we report a one-step method to fabricate nanohole arrays by thermal nanoimprinting in the matrix of IPS(Intermediate Polymer Stamp). No additional etching process or supporting substrate is required. The preparation process is simple, time-saving and compatible for roll-to-roll process, potentially allowing mass production. Moreover, the nanohole arrays were integrated into detection platform as SPR sensors to investigate different types of biological binding interactions. The results demonstrate that our one-step method can be used to efficiently fabricate large-area and uniform nanohole arrays for biochemical sensing.展开更多
Because of the importance of grouped data, many scholars have been devoted to the study of this kind of data. But, few documents have been concerned with the thresh-old parameter. In this paper, we assume that the thr...Because of the importance of grouped data, many scholars have been devoted to the study of this kind of data. But, few documents have been concerned with the thresh-old parameter. In this paper, we assume that the threshold parameter is smaller than the first observing point. Then, on the basis of the two-parameter exponential distribution, the maximum likelihood estimations of both parameters are given, the sufficient and necessary conditions for their existence and uniqueness are argued, and the asymptotic properties of the estimations are also presented, according to which approximate confidence intervals of the parameters are derived. At the same time, the estimation of the parameters is generalized, and some methods are introduced to get explicit expressions of these generalized estimations. Also, a special case where the first failure time of the units is observed is considered.展开更多
We are concerned with robust estimation procedures to estimate the parameters in partially linear models with large-dimensional covariates. To enhance the interpretability, we suggest implementing a noncon- cave regul...We are concerned with robust estimation procedures to estimate the parameters in partially linear models with large-dimensional covariates. To enhance the interpretability, we suggest implementing a noncon- cave regularization method in the robust estimation procedure to select important covariates from the linear component. We establish the consistency for both the linear and the nonlinear components when the covariate dimension diverges at the rate of o(√n), where n is the sample size. We show that the robust estimate of linear component performs asymptotically as well as its oracle counterpart which assumes the baseline function and the unimportant covariates were known a priori. With a consistent estimator of the linear component, we estimate the nonparametric component by a robust local linear regression. It is proved that the robust estimate of nonlinear component performs asymptotically as well as if the linear component were known in advance. Comprehensive simulation studies are carried out and an application is presented to examine the finite-sample performance of the proposed procedures.展开更多
文摘AIM:To examine the efficacy of glycyrrhizin preparation(GL-p) in the treatment of a rat model of ulcerative colitis(UC).METHODS:Experimental colitis was induced by oral administration of dextran sodium sulfate.Rats with colitis were intrarectally administered GL-p or saline.The extent of colitis was evaluated based on body weight gain,colon wet weight,and macroscopic damage score.The expression levels of pro-inflammatory cytokines and chemokines in the inflamed mucosa were measured by cytokine antibody array analysis.The effect of GL-p on myeloperoxidase(MPO) activity in the inflamed mucosa and purified enzyme was assayed.RESULTS:GL-p treatment significantly ameliorated the extent of colitis compared to sham treatment with saline.Cytokine antibody array analysis showed that GL-p treatment significantly decreased the expression levels of pro-inflammatory cytokines and chemokines,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α,cytokine-induced neutrophil chemoattractant-2,and monocyte chemoattractant protein-1 in the inflamed mucosa.Furthermore,GL-p inhibited the oxidative activity of mucosal and purified MPO.CONCLUSION:GL-p enema has a therapeutic effect on experimental colitis in rats and may be useful in the treatment of UC.
基金We are grateful to the support from the National Natural Science Foundation of China (NSFC) (31425002, 91231205, 81430011, 61303161, 31470220, and 31327001), and the Frontier Science Research Program, the Soil-Microbe System Function and Regulation Program, and the Science and Technology Service Network Initiative (STS) from the Chinese Academy of Sciences (CAS).
文摘Method development has always been and will continue to be a core driving force of microbiome science, In this perspective, we argue that in the next decade, method development in microbiome analysis will be driven by three key changes in both ways of thinking and technological platforms: ① a shift from dissecting microbiota structure by sequencing to tracking microbiota state, function, and intercellular interaction via imaging; ② a shift from interrogating a consortium or population of cells to probing individual cells; and ③a shift from microbiome data analysis to microbiome data science. Some of the recent methoddevelopment efforts by Chinese microbiome scientists and their international collaborators that underlie these technological trends are highlighted here. It is our belief that the China Microbiome Initiative has the opportunity to deliver outstanding "Made-in-China" tools to the international research community, by building an ambitious, competitive, and collaborative program at the forefront of method development for microbiome science.
基金Supported by Natural Science Foundation Project of CQ CSTC under Grant No.2008BB0298by Natural Science Foundation of China under Grant Nos.10805082 and 11075225by the Fundamental Research Funds for the Central Universities under Grant No.CDJZR101000616
文摘The B-meson decay constant fB is an important component for studying the B-meson decays, which can be studied through QCD sum rules. We make a detailed discussion on f B from two sum rules up to next-to- leading order, i.e. sum rules I and II, which are derived from the conventional correlator and the correlator with chiral currents respectively. It is found that these two sum rules are consistent with each other. The sum rules H involves less non-perturbative condensates as that of sum rules I, and in principle, it can be more accurate if we know the dimensionfour gluon condensate well. It is found that fB decreases with the increment of mb, and to compare with the Belle experimental data on fB, both sum rules I and H prefer smaller pole b-quark mass, mb= 4.68 ± 0.07 GeV. By varying all the input parameters within their reasonable regions and by adding all the uncertainties in quadrature, we obtain fB=172-25^+23 MeV for sum rules I and fB =214-34^26 MeV for sum rules П.
基金Project supported by the Second Stage of Brain Korea 21 Projectssupported by Industrial Strategic Technology Development Program funded by the Ministry of Knowledge Economy (MKE,Korea)(10039239,"Development of Power Management System SoC Supporting Multi-Battery-Cells and Multi-Energy-Sources for Smart Phones and Smart Devices")
文摘A differential paired eFuse OTP(one-time programmable)memory cell which can be configured into a 2D(two-dimensional)eFuse cell array was proposed.The sensible resistance of a programmed eFuse link is a half smaller than that of the single-ended counterpart and BL datum can be sensed without a reference voltage.With this 2D array of differential paired eFuse OTP memory cells,we design a 32-bit eFuse OTP memory IP.We use a sense amplifier based D F/F circuit as the BL(bit-line)SA(sense amplifier)and design a sensing margin test circuit with a variable pull-up load.It is confirmed by the function test that the designed 32-bit OTP memory IP functions normally on 30 sample dies.
文摘The paper proposes a novel hardware-based private information retrieval (HWPIR) protocol. By partially reshuffling previously accessed items in each round, instead of frequently reshuffling the whole database, the scheme makes better use of shuffled data copies and achieves the computation overhead at O(/N/K),where N and k are the sizes of the database and secure storage respectively. For securestorage with moderate size, e.g. k = O(/N), the overhead is 0(4/N). The result is much better than the state-of-art schemes (as compared to e.g. O(log2N)). Without increasing response time and communication cost, the proposed protocol is truly practicable regardless of the database size. The security and preformance of the protocol is formally analyzed.
文摘In the university education, the mathematical teaching is an important and indispensable part. And now the integration of the mathematical culture in the university teaching is the effective method to improve the timeliness of the teaching and the enthusiasm of the students, and it also can effectively alleviate the problem of the disconnection in the university mathematical teaching, with the successful implementation of the transition. The university mathematics has very high demands in the teaching contents, the teaching ideas and the teaching methods, so the reasonable integration of the mathematical culture into the university mathematics is very important. The mathematical culture in the teaching of college mathematics is discussed and analyzed in this paper.
文摘Planting date is a critical component of soybean [Glycine max (L.) Merr.] production, under dry land conditions in the Southeastern Coastal Plain. The objectives of this study were to 1. Evaluate the effect of planting date on plant leaf area index (LAI) and normalized difference vegetation index (NDVI) at 60 and 90 days after planting (DAP), plant height and grain yield, and 2. Determine the optimum planting period by integrating the responses from vegetation growth to yield for soybean maturity group (MG) IV-VIII under dry land conditions in the Southeastern Coastal Plain. Planting dates were scheduled about 14-days intervals from late April to mid-July (2008) or late July (2009). Greatest grain yield for MG IV was obtained from planting in around mid-May in both years. The yield was greater for MG V planted in May and greater for MG VI-VIII planted in late April and May, but started to decline for planting in early June. Plant LAI and NDVI at 60 DAP were affected by both planting date and precipitation, but were poorly correlated with grain yield. However, plant LAI and NDVI were well correlated with yield and were greater for May planting dates at 90 DAP. These indiccs declined for soybean planted after May. Mature plant height decreased more rapidly with delayed planting. These results indicate that plant growth and yield decreased after May planting. Optimum planting period for all MGs was early to mid-May.
文摘Since its installation on the International Space Station(ISS)in mid-May 2011,the Alpha Magnetic Spectrometer(AMS)has spent over two years on orbit,fully operational,collecting an enormous amount of data including the temperatures from the on-board 1118 sensors for thermal control.A large database is continuously updated and analyzed to understand the thermal behavior of the experiment in the space environment and its interaction with the ISS.This paper specifies the design,building,analysis and testing of the thermal control system and its various components for an overview of the AMS thermal control system and its space environment.Also given are some examples of analysis and correlation of the space environmental and ISS parameters with the thermal behaviors of various AMS components.
基金financially supported by the National Natural Science Foundation of China (31430061, 61401149, and U1604177)Ministry of Agriculture of China (2016ZX08009-003)the Program of China’s 1000-talents Plan
文摘Surface plasmon resonance(SPR) nanosensors based on metallic nanohole arrays have been widely reported to detect binding interactions in biological specimens. A simple and effective method for constructing nanoscale arrays is essential for the development of SPR nanosensors. In this work, we report a one-step method to fabricate nanohole arrays by thermal nanoimprinting in the matrix of IPS(Intermediate Polymer Stamp). No additional etching process or supporting substrate is required. The preparation process is simple, time-saving and compatible for roll-to-roll process, potentially allowing mass production. Moreover, the nanohole arrays were integrated into detection platform as SPR sensors to investigate different types of biological binding interactions. The results demonstrate that our one-step method can be used to efficiently fabricate large-area and uniform nanohole arrays for biochemical sensing.
文摘Because of the importance of grouped data, many scholars have been devoted to the study of this kind of data. But, few documents have been concerned with the thresh-old parameter. In this paper, we assume that the threshold parameter is smaller than the first observing point. Then, on the basis of the two-parameter exponential distribution, the maximum likelihood estimations of both parameters are given, the sufficient and necessary conditions for their existence and uniqueness are argued, and the asymptotic properties of the estimations are also presented, according to which approximate confidence intervals of the parameters are derived. At the same time, the estimation of the parameters is generalized, and some methods are introduced to get explicit expressions of these generalized estimations. Also, a special case where the first failure time of the units is observed is considered.
基金supported by National Institute on Drug Abuse(Grant Nos.R21-DA024260 and P50-DA10075)National Natural Science Foundation of China(Grant Nos.11071077,11371236,11028103,11071022 and 11028103)+2 种基金Innovation Program of Shanghai Municipal Education CommissionPujiang Project of Science and Technology Commission of Shanghai Municipality(Grant No.12PJ1403200)Program for New Century Excellent Talents,Ministry of Education of China(Grant No.NCET-12-0901)
文摘We are concerned with robust estimation procedures to estimate the parameters in partially linear models with large-dimensional covariates. To enhance the interpretability, we suggest implementing a noncon- cave regularization method in the robust estimation procedure to select important covariates from the linear component. We establish the consistency for both the linear and the nonlinear components when the covariate dimension diverges at the rate of o(√n), where n is the sample size. We show that the robust estimate of linear component performs asymptotically as well as its oracle counterpart which assumes the baseline function and the unimportant covariates were known a priori. With a consistent estimator of the linear component, we estimate the nonparametric component by a robust local linear regression. It is proved that the robust estimate of nonlinear component performs asymptotically as well as if the linear component were known in advance. Comprehensive simulation studies are carried out and an application is presented to examine the finite-sample performance of the proposed procedures.