Macrolide antibiotics have been widely used in clinic due to their good antibacterial effects and high safety, but the drug-resistant bacteria appear constantly. To solve the problem of drug resistance in pathogens, s...Macrolide antibiotics have been widely used in clinic due to their good antibacterial effects and high safety, but the drug-resistant bacteria appear constantly. To solve the problem of drug resistance in pathogens, scholars obtain the third generation of macrolide antibiotics, ketolide antibiotics, which are developed by modifying the structure of macrolide antibiotics, thereby efficiently solving the problem. Ketolide antibiotics are a type of erythromycin derivatives with macrolide structure, and the typical drugs mainly include telithromycin, cethromycin and solithromycin, etc . This paper briefly introduced the recent progress of ketolide antibiotics, with an attempt to provide help to the research and development of new macrolide antibiotics.展开更多
This paper summarizes the progress on the total syntheses riod from 2006 to 2010. The overview focuses on the first of natural products accomplished in rnainland China during the petotal synthesis of natural products ...This paper summarizes the progress on the total syntheses riod from 2006 to 2010. The overview focuses on the first of natural products accomplished in rnainland China during the petotal synthesis of natural products of contemporary interest includ- ing alkaloids, cyclopeptides and cyclic depsipeptides, macrolides, terpenoids and steroids, saponins and glycosides. The development of novel synthetic strategies and methodologies, and application of new selective synthetic methods in the total syntheses of natural products are included as well.展开更多
基金Supported by National Sci-tech Support Plant during Twelfth Five-Year Plan(2015BAD1101)Earmarked Fund for China Agriculture Research System(CAR-38)~~
文摘Macrolide antibiotics have been widely used in clinic due to their good antibacterial effects and high safety, but the drug-resistant bacteria appear constantly. To solve the problem of drug resistance in pathogens, scholars obtain the third generation of macrolide antibiotics, ketolide antibiotics, which are developed by modifying the structure of macrolide antibiotics, thereby efficiently solving the problem. Ketolide antibiotics are a type of erythromycin derivatives with macrolide structure, and the typical drugs mainly include telithromycin, cethromycin and solithromycin, etc . This paper briefly introduced the recent progress of ketolide antibiotics, with an attempt to provide help to the research and development of new macrolide antibiotics.
基金the National Natural Science Foundation of China (20832005,21072160,20902075)the National Basic Research Program (973 Program) of China (2010CB833200)+2 种基金the Natural Science Foundation of Fujian Province of China (2009J05037)the Specialized Research Fund for the Doctoral Program of Higher Education(20090121120007)the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education of China for financial support
文摘This paper summarizes the progress on the total syntheses riod from 2006 to 2010. The overview focuses on the first of natural products accomplished in rnainland China during the petotal synthesis of natural products of contemporary interest includ- ing alkaloids, cyclopeptides and cyclic depsipeptides, macrolides, terpenoids and steroids, saponins and glycosides. The development of novel synthetic strategies and methodologies, and application of new selective synthetic methods in the total syntheses of natural products are included as well.
