阿尔茨海默症（AD）是主要的神经退行性疾病之一，全球数百万人因该病健康受到不同程度的影响。寻找新的、更精确的诊断方法对于该病的早期诊断尤为关键。MandalPK博士和他的同事们共同研究开发出一种完全无刨的大脑成像技术，利用该技...阿尔茨海默症（AD）是主要的神经退行性疾病之一，全球数百万人因该病健康受到不同程度的影响。寻找新的、更精确的诊断方法对于该病的早期诊断尤为关键。MandalPK博士和他的同事们共同研究开发出一种完全无刨的大脑成像技术，利用该技术可以测出脑内某些特殊化学物质的变化，这为病变于大脑海马区AD的早期诊断拉开了序幕。研究论文发表于《阿尔茨海默症》杂志（Journal of Alzheimer‘S Disease）。展开更多
The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the...The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop new technologies for measuring every spike from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organizing principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral tasks and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic knowledge, and imagination are generated and organized. Our own experiences suggest that the bottleneck of the Brain Project is not only at merely developing additional new technologies, but also the lack of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive knowledge from various investigators working in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyzing large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research.展开更多
文摘阿尔茨海默症（AD）是主要的神经退行性疾病之一，全球数百万人因该病健康受到不同程度的影响。寻找新的、更精确的诊断方法对于该病的早期诊断尤为关键。MandalPK博士和他的同事们共同研究开发出一种完全无刨的大脑成像技术，利用该技术可以测出脑内某些特殊化学物质的变化，这为病变于大脑海马区AD的早期诊断拉开了序幕。研究论文发表于《阿尔茨海默症》杂志（Journal of Alzheimer‘S Disease）。
基金Georgia Research Alliance for funding the Brain Decoding Initiative (2007 present)Yunnan Province Department of Science and Technology for the support of our work
文摘The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop new technologies for measuring every spike from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organizing principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral tasks and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic knowledge, and imagination are generated and organized. Our own experiences suggest that the bottleneck of the Brain Project is not only at merely developing additional new technologies, but also the lack of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive knowledge from various investigators working in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyzing large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research.
