In this paper, we review the current state- of-the-art techniques used for understanding the inner workings of the brain at a systems level. The neural activity that governs our everyday lives involves an intricate co...In this paper, we review the current state- of-the-art techniques used for understanding the inner workings of the brain at a systems level. The neural activity that governs our everyday lives involves an intricate coordination of many processes that can be attributed to a variety of brain regions. On the surface, many of these functions can appear to be controlled by specific anatomical structures; however, in reality, numerous dynamic networks within the brain contribute to its function through an interconnected web of neuronal and synaptic pathways. The brain, in its healthy or pathological state, can therefore be best understood by taking a systems-level approach. While numerous neuroengineering technologies exist, we focus here on three major thrusts in the field of systems neuroengineering: neuroimaging, neural interfacing, and neuromodulation. Neuroimaging enables us to delineate the structural and functional organization of the brain, which is key in understanding how the neural system functions in both normal and disease states. Based on such knowledge, devices can be used either to communicate with the neural system, as in neural interface systems, or to modulate brain activity, as in neuromodulation systems. The consideration of these three fields is key to the development and application of neuro-devices. Feedback-based neuro-devices require the ability to sense neural activity (via a neuroimaging modality) through a neural interface (invasive or noninvasive) and ultimately to select a set of stimulation parameters in order to alter neural function via a neuromodulation modality. Systems neuroengineering refers to the use of engineering tools and technologies to image, decode, and modulate the brain in order to comprehend its functions and to repair its dysfunction. Interactions between these fields will help to shape the future of systems neuroengineering--to develop neurotechniques for enhancing the understanding of whole- brain function and dysfunction, and the management of neurological and mental disorders.展开更多
Different areas of cognitive science traditionally perceived the mind as an abstract information processing entity, whose interactions with the outside world should be of small or no relevance at all. However, a recen...Different areas of cognitive science traditionally perceived the mind as an abstract information processing entity, whose interactions with the outside world should be of small or no relevance at all. However, a recent embodied cognition perspective, view cognitive processes as deeply embedded into the body's interactions with the world. In support of such contention, lots of empirical evidence has been brought and thusly different claims proposed. In this paper, we present the computer based neurocognitive task of sustained attention which is a dual task with many characteristics that obviously mirror some of the above claims. In this regard, we take into consideration both on-line and off-line aspects of the embodied cognition and point out how processing efficiency and attentional functioning are crucial vehicles in bringing perception into effective action (embodied cognition). Furthermore, there is plenty of evidence about the bidirectional relationship between the attentional/cognitive functioning and emotion regulation as well. This rises new possibilities in looking at the cognitive bias modification approaches and brain-cognitive training procedures for human beings without perceiving them as disembodied minds or complex machines but instead proactive and physically involved in the real world. We argue that such cognitive training approaches even though at first glance seemed as mere technical and machine oriented procedures, should be regarded as humanistic in its nature which perfectly mirror the Merleau-Ponty's concept of "embodied subjectivity." Finally, we explain how such approaches can be successfully combined with the neurobiological accounts and effectively implemented into clinical practice (self-regulation, self-directed neuroplasticity, effortful control, behavior change).展开更多
Some studies document that odorants influence in sympathetic and parasympathetic nervous systems, and neurophysiological brain activity. Odors compounds can act on the neuroendocrine system, neurotransmitters and neur...Some studies document that odorants influence in sympathetic and parasympathetic nervous systems, and neurophysiological brain activity. Odors compounds can act on the neuroendocrine system, neurotransmitters and neuromodulators, influencing psychological behavior as well as body function. The study was conducted in 20 individuals in each test to analyze the effects of essential oil inhalation on psychomotor performance in the healthy volunteers. Two tests were performed in the present study (1) SLCT (six letter cancellation test) and (2) DLST (digit letter substitution test). These tests were carded out for the assessment of psychopharmacological activity of essential oil of Rosa damascena Mill., in healthy young human individuals belonging to the age group 18 to 22 years. The results of the psychomotor performance test in healthy human individuals revealed that there was improvement in psychomotor functions.展开更多
A new control law is proposed to asymptotically stabilize the chaotic neuron system based on LaSalleinvariant principle.The control technique does not require analytical knowledge of the system dynamics and operateswi...A new control law is proposed to asymptotically stabilize the chaotic neuron system based on LaSalleinvariant principle.The control technique does not require analytical knowledge of the system dynamics and operateswithout an explicit knowledge of the desired steady-state position.The well-known modified Hodgkin-Huxley (MHH)and Hindmarsh-Rose (HR) model neurons are taken as examples to verify the implementation of our method.Simulationresults show the proposed control law is effective.The outcome of this study is significant since it is helpful to understandthe learning process of a human brain towards the information processing,memory and abnormal discharge of the brainneurons.展开更多
The brain of the domestic pig(Sus scrofa domesticus)has drawn considerable attention due to its high similarities to that of humans.However,the cellular compositions of the pig brain(PB)remain elusive.Here we investig...The brain of the domestic pig(Sus scrofa domesticus)has drawn considerable attention due to its high similarities to that of humans.However,the cellular compositions of the pig brain(PB)remain elusive.Here we investigated the single-nucleus transcriptomic profiles of five regions of the PB(frontal lobe,parietal lobe,temporal lobe,occipital lobe,and hypothalamus)and identified 21 cell subpopulations.The cross-species comparison of mouse and pig hypothalamus revealed the shared and specific gene expression patterns at the single-cell resolution.Furthermore,we identified cell types and molecular pathways closely associated with neurological disorders,bridging the gap between gene mutations and pathogenesis.We reported,to our knowledge,the first single-cell atlas of domestic pig cerebral cortex and hypothalamus combined with a comprehensive analysis across species,providing extensive resources for future research regarding neural science,evolutionary developmental biology,and regenerative medicine.展开更多
基金supported in part by the US National Institutes of Health (NIH) (EB006433, EY023101, EB008389,and HL117664)the US National Science Foundation (NSF) (CBET1450956, CBET-1264782, and DGE-1069104),to Bin He
文摘In this paper, we review the current state- of-the-art techniques used for understanding the inner workings of the brain at a systems level. The neural activity that governs our everyday lives involves an intricate coordination of many processes that can be attributed to a variety of brain regions. On the surface, many of these functions can appear to be controlled by specific anatomical structures; however, in reality, numerous dynamic networks within the brain contribute to its function through an interconnected web of neuronal and synaptic pathways. The brain, in its healthy or pathological state, can therefore be best understood by taking a systems-level approach. While numerous neuroengineering technologies exist, we focus here on three major thrusts in the field of systems neuroengineering: neuroimaging, neural interfacing, and neuromodulation. Neuroimaging enables us to delineate the structural and functional organization of the brain, which is key in understanding how the neural system functions in both normal and disease states. Based on such knowledge, devices can be used either to communicate with the neural system, as in neural interface systems, or to modulate brain activity, as in neuromodulation systems. The consideration of these three fields is key to the development and application of neuro-devices. Feedback-based neuro-devices require the ability to sense neural activity (via a neuroimaging modality) through a neural interface (invasive or noninvasive) and ultimately to select a set of stimulation parameters in order to alter neural function via a neuromodulation modality. Systems neuroengineering refers to the use of engineering tools and technologies to image, decode, and modulate the brain in order to comprehend its functions and to repair its dysfunction. Interactions between these fields will help to shape the future of systems neuroengineering--to develop neurotechniques for enhancing the understanding of whole- brain function and dysfunction, and the management of neurological and mental disorders.
文摘Different areas of cognitive science traditionally perceived the mind as an abstract information processing entity, whose interactions with the outside world should be of small or no relevance at all. However, a recent embodied cognition perspective, view cognitive processes as deeply embedded into the body's interactions with the world. In support of such contention, lots of empirical evidence has been brought and thusly different claims proposed. In this paper, we present the computer based neurocognitive task of sustained attention which is a dual task with many characteristics that obviously mirror some of the above claims. In this regard, we take into consideration both on-line and off-line aspects of the embodied cognition and point out how processing efficiency and attentional functioning are crucial vehicles in bringing perception into effective action (embodied cognition). Furthermore, there is plenty of evidence about the bidirectional relationship between the attentional/cognitive functioning and emotion regulation as well. This rises new possibilities in looking at the cognitive bias modification approaches and brain-cognitive training procedures for human beings without perceiving them as disembodied minds or complex machines but instead proactive and physically involved in the real world. We argue that such cognitive training approaches even though at first glance seemed as mere technical and machine oriented procedures, should be regarded as humanistic in its nature which perfectly mirror the Merleau-Ponty's concept of "embodied subjectivity." Finally, we explain how such approaches can be successfully combined with the neurobiological accounts and effectively implemented into clinical practice (self-regulation, self-directed neuroplasticity, effortful control, behavior change).
文摘Some studies document that odorants influence in sympathetic and parasympathetic nervous systems, and neurophysiological brain activity. Odors compounds can act on the neuroendocrine system, neurotransmitters and neuromodulators, influencing psychological behavior as well as body function. The study was conducted in 20 individuals in each test to analyze the effects of essential oil inhalation on psychomotor performance in the healthy volunteers. Two tests were performed in the present study (1) SLCT (six letter cancellation test) and (2) DLST (digit letter substitution test). These tests were carded out for the assessment of psychopharmacological activity of essential oil of Rosa damascena Mill., in healthy young human individuals belonging to the age group 18 to 22 years. The results of the psychomotor performance test in healthy human individuals revealed that there was improvement in psychomotor functions.
基金Supported by the National Natural Science Foundation of China under Grant Nos. 10862001 and 10947011the Construction of Key Laboratories in Universities of Guangxi under Grant No. 200912
文摘A new control law is proposed to asymptotically stabilize the chaotic neuron system based on LaSalleinvariant principle.The control technique does not require analytical knowledge of the system dynamics and operateswithout an explicit knowledge of the desired steady-state position.The well-known modified Hodgkin-Huxley (MHH)and Hindmarsh-Rose (HR) model neurons are taken as examples to verify the implementation of our method.Simulationresults show the proposed control law is effective.The outcome of this study is significant since it is helpful to understandthe learning process of a human brain towards the information processing,memory and abnormal discharge of the brainneurons.
基金the China Postdoctoral Science Foundation(2017M622795)the Science,Technology and Innovation Commission of Shenzhen Municipality(JCYJ20180507183628543)the Fundamental Research Funds for the Central Universities(2662018PY025 and 2662017PY105)。
文摘The brain of the domestic pig(Sus scrofa domesticus)has drawn considerable attention due to its high similarities to that of humans.However,the cellular compositions of the pig brain(PB)remain elusive.Here we investigated the single-nucleus transcriptomic profiles of five regions of the PB(frontal lobe,parietal lobe,temporal lobe,occipital lobe,and hypothalamus)and identified 21 cell subpopulations.The cross-species comparison of mouse and pig hypothalamus revealed the shared and specific gene expression patterns at the single-cell resolution.Furthermore,we identified cell types and molecular pathways closely associated with neurological disorders,bridging the gap between gene mutations and pathogenesis.We reported,to our knowledge,the first single-cell atlas of domestic pig cerebral cortex and hypothalamus combined with a comprehensive analysis across species,providing extensive resources for future research regarding neural science,evolutionary developmental biology,and regenerative medicine.