Traumatic intracranial pseudoaneurysms （TIPA） are rare and pseudoaneurysm of P3 segment of the posterior cerebral artery （PCA） is extremely rarely reported. A 27-year-old man suffered from blunt head injury and un...Traumatic intracranial pseudoaneurysms （TIPA） are rare and pseudoaneurysm of P3 segment of the posterior cerebral artery （PCA） is extremely rarely reported. A 27-year-old man suffered from blunt head injury and underwent diagnostic procedure with head CT scans, cerebral CT angiograms （CTA） and digital subtraction angiograms （DSA）. An abnormal high-density lesion was detected at the left side of quadrigeminal cistern and a pseudoaneurysm showed at the P3 segment of PCA. The pseudoaneurysm was successfully treated with parent artery occlusion （PAO）. Making an exact preoperative diagnosis of traumatic intracranial pseudoaneurysms is of great importance. Endovascular techniques allow a safe approach to complex intracranial lesion, so endovascular management of PCA pseudoaneurysms becomes safe and effective. However, the pseudoaneurysm may not be amenable to coil placement under some conditions, thus, occlusion of the parent vessel may be a preferable treatment.展开更多
Objective:To observe the effects of electroacupuncture(EA)with three frequencies(100 Hz,2 Hz,and 2 Hz/100 Hz)on the apoptosis of neurons and c-Jun N-terminal kinase(JNK)signaling pathway in the hippocampus of rats wit...Objective:To observe the effects of electroacupuncture(EA)with three frequencies(100 Hz,2 Hz,and 2 Hz/100 Hz)on the apoptosis of neurons and c-Jun N-terminal kinase(JNK)signaling pathway in the hippocampus of rats with vascular dementia(VD),and explore the mechanism of EA intervention for VD.Methods:Fifty male Sprague-Dawley rats were randomly divided into a model group,a sham operation group,a 100 Hz EA group,a 2 Hz EA group,and a 2 Hz/100 Hz EA group,with ten rats in each group.The VD model rats were established by repeated ischemia-reperfusion of bilateral common carotid arteries.The rats in the EA groups received EA intervention at Baihui(GV20),Dazhui(GV14),Geshu(BL17)and Zusanli(ST36),once a day for 14 d.Afterward,Morris water maze was used to examine the learning and memory performances of the rats in each group,hematoxylin-eosin staining to observe the histomorphological changes in the hippocampal CA1 region,terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling to test the apoptosis of neurons in the hippocampal CA1 region,and Western blot to detect the protein expression levels of JNK,phosphorylated JNK(p-JNK),Caspase-8,and Caspase-3 in the hippocampus tissue.Results:Compared with the sham operation group,the escape latency of the model group in water maze test was prolonged;the number of crossing the original platform was decreased(P<0.01);the hippocampal neurons were severely damaged and the number of surviving neurons was decreased(P<0.01),whereas the number of apoptotic neurons was increased(P<0.01);the protein expression levels of JNK,p-JNK,Caspase-8,and Caspase-3 in the hippocampus were significantly increased(P<0.01).Compared with the model group,the escape latency of each EA group was significantly shortened;the number of crossing the original platform was significantly increased(P<0.01);the damage of hippocampal neurons was alleviated,the number of surviving neurons was increased(P<0.01),and the number of apoptotic neurons was decreased(P<0.01);the protein expression levels of JNK,p-JNK,Caspase-8,and Caspase-3 in the hippocampus were decreased(P<0.01).The results in the 2 Hz EA group and the 2 Hz/100 Hz EA group were superior to those in the 100 Hz EA group.Conclusion:EA with the three frequencies(100 Hz,2 Hz,and 2 Hz/100 Hz)can improve the learning and memory performances in VD rats subjected to ischemia-reperfusion,its mechanism may be related to the inhibition of neuronal apoptosis and the regulation of the related protein expression of JNK signaling pathway,and the intervention effects of EA with 2 Hz and 2 Hz/100 Hz are more significant.展开更多
Objective： To investigate the biomechanical effect of major extremity vessels to choose appropriate repair methods for vascular injuries of the extremities. Methods ： The data of 385 patients （337 males and 48 fem...Objective： To investigate the biomechanical effect of major extremity vessels to choose appropriate repair methods for vascular injuries of the extremities. Methods ： The data of 385 patients （337 males and 48 females, aged 18-71 years, mean = 32.6 years ） including 403 injured vessels, who suffered from vascular injuries of the extremities and were treated in our hospital from October 1960 to August 2005, were studied retrospectively in this article. We compared the results of different repair methods for the defect of vessels and evaluated different injured vessels for repairing arterial injuries with anastomosis and venous graft, respectively. Results： A significant difference was found between the defect lengths of the arteries repaired with anastomosis and venous graft （ P 〈 0. 0001 ）. The upper limits of the confidence interval in the defect lengths of the brachial artery, the femoral artery and the popliteal artery were 3.43 cm, 2. 38 cm and 2. 42 cm, respectively, when repaired with anastomosis. The lower limits were 2.16 cm, 2.16 cm and 1. 63 cm, respectively, when repaired with venous graft. The defect length of each artery repaired with venous graft had linear correlation with the graft length. Conclusion - Because of the longitudinal biomechanical difference of different options of repair arterial injuries. human peripheral vessels, are necessary for different arterial injuries.展开更多
文摘Traumatic intracranial pseudoaneurysms （TIPA） are rare and pseudoaneurysm of P3 segment of the posterior cerebral artery （PCA） is extremely rarely reported. A 27-year-old man suffered from blunt head injury and underwent diagnostic procedure with head CT scans, cerebral CT angiograms （CTA） and digital subtraction angiograms （DSA）. An abnormal high-density lesion was detected at the left side of quadrigeminal cistern and a pseudoaneurysm showed at the P3 segment of PCA. The pseudoaneurysm was successfully treated with parent artery occlusion （PAO）. Making an exact preoperative diagnosis of traumatic intracranial pseudoaneurysms is of great importance. Endovascular techniques allow a safe approach to complex intracranial lesion, so endovascular management of PCA pseudoaneurysms becomes safe and effective. However, the pseudoaneurysm may not be amenable to coil placement under some conditions, thus, occlusion of the parent vessel may be a preferable treatment.
文摘Objective:To observe the effects of electroacupuncture(EA)with three frequencies(100 Hz,2 Hz,and 2 Hz/100 Hz)on the apoptosis of neurons and c-Jun N-terminal kinase(JNK)signaling pathway in the hippocampus of rats with vascular dementia(VD),and explore the mechanism of EA intervention for VD.Methods:Fifty male Sprague-Dawley rats were randomly divided into a model group,a sham operation group,a 100 Hz EA group,a 2 Hz EA group,and a 2 Hz/100 Hz EA group,with ten rats in each group.The VD model rats were established by repeated ischemia-reperfusion of bilateral common carotid arteries.The rats in the EA groups received EA intervention at Baihui(GV20),Dazhui(GV14),Geshu(BL17)and Zusanli(ST36),once a day for 14 d.Afterward,Morris water maze was used to examine the learning and memory performances of the rats in each group,hematoxylin-eosin staining to observe the histomorphological changes in the hippocampal CA1 region,terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling to test the apoptosis of neurons in the hippocampal CA1 region,and Western blot to detect the protein expression levels of JNK,phosphorylated JNK(p-JNK),Caspase-8,and Caspase-3 in the hippocampus tissue.Results:Compared with the sham operation group,the escape latency of the model group in water maze test was prolonged;the number of crossing the original platform was decreased(P<0.01);the hippocampal neurons were severely damaged and the number of surviving neurons was decreased(P<0.01),whereas the number of apoptotic neurons was increased(P<0.01);the protein expression levels of JNK,p-JNK,Caspase-8,and Caspase-3 in the hippocampus were significantly increased(P<0.01).Compared with the model group,the escape latency of each EA group was significantly shortened;the number of crossing the original platform was significantly increased(P<0.01);the damage of hippocampal neurons was alleviated,the number of surviving neurons was increased(P<0.01),and the number of apoptotic neurons was decreased(P<0.01);the protein expression levels of JNK,p-JNK,Caspase-8,and Caspase-3 in the hippocampus were decreased(P<0.01).The results in the 2 Hz EA group and the 2 Hz/100 Hz EA group were superior to those in the 100 Hz EA group.Conclusion:EA with the three frequencies(100 Hz,2 Hz,and 2 Hz/100 Hz)can improve the learning and memory performances in VD rats subjected to ischemia-reperfusion,its mechanism may be related to the inhibition of neuronal apoptosis and the regulation of the related protein expression of JNK signaling pathway,and the intervention effects of EA with 2 Hz and 2 Hz/100 Hz are more significant.
文摘Objective： To investigate the biomechanical effect of major extremity vessels to choose appropriate repair methods for vascular injuries of the extremities. Methods ： The data of 385 patients （337 males and 48 females, aged 18-71 years, mean = 32.6 years ） including 403 injured vessels, who suffered from vascular injuries of the extremities and were treated in our hospital from October 1960 to August 2005, were studied retrospectively in this article. We compared the results of different repair methods for the defect of vessels and evaluated different injured vessels for repairing arterial injuries with anastomosis and venous graft, respectively. Results： A significant difference was found between the defect lengths of the arteries repaired with anastomosis and venous graft （ P 〈 0. 0001 ）. The upper limits of the confidence interval in the defect lengths of the brachial artery, the femoral artery and the popliteal artery were 3.43 cm, 2. 38 cm and 2. 42 cm, respectively, when repaired with anastomosis. The lower limits were 2.16 cm, 2.16 cm and 1. 63 cm, respectively, when repaired with venous graft. The defect length of each artery repaired with venous graft had linear correlation with the graft length. Conclusion - Because of the longitudinal biomechanical difference of different options of repair arterial injuries. human peripheral vessels, are necessary for different arterial injuries.
